Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations

Tolulope O. Ajala,Olufunke D. Akin-Ajani,Chinemerem Ihuoma-Chidi,Oluwatoyin A. Odeku 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.6

Chrysophyllum mucilage obtained from the fruit of Chrysophyllum albidum (Family Sapotaceae) has been characterised and evaluated as a binding agent in comparison with methylcellulose in paracetamol tablet formulations. Chrysophyllum mucilage was characterised using elemental and proximate analyses as well as material properties. The Heckel and Kawakita plots were used to assess the compressional properties and the tablet properties were evaluated using tensile strength, friability, disintegration and dissolution times. The results showed the presence of calcium, magnesium, potassium, sodium, manganese, iron, copper, zinc and absence of heavy metals from the mucilage. The mucilage exhibited excellent flow and swelling properties, but poor water solubility. The viscosity of chrysophyllum mucilage increased with decrease in temperature in a similar manner with methylcellulose. C. albidum mucilage when used as a binder in paracetamol tablet formulation induced faster onset of plastic deformation and higher amount of total plastic deformation than methylcellulose. The results of the tablet properties showed that the tensile strength, disintegration and dissolution times, increased with increase in binder concentration while friability decreased. Tablets containing chrysophyllum mucilage as binder also had lower tensile strength, disintegration and dissolution times but higher friability values than those containing methylcellulose. However, tablets containing chrysophyllum mucilage at low concentrations conformed to pharmacopeial standard on disintegration indicating its potential usefulness as binder for immediate release tablets. Thus, C. albidum mucilage could be used as an alternative binding agent in pharmaceutical tablets.

점액질에 따른 한지 sheet의 열화 거동

이민형(Min-Hyung Lee),김강재(Kang-Jae Kim),엄태진(Tae-Jin Eom) 한국펄프·종이공학회 2011 한국펄프·종이공학회 학술발표논문집 Vol.2011 No.4

Hanji(Korean traditional paper) is made from bark of paper mulberry(Broussonetia kaeinoki). For a long time, Hanji has been used in various fields, such as paintings, printing paper, as specialty paper. The utilization of Hanji will become more and more diverse. One of the characteristic properties of Hanji is a long life time comparing to western paper. The mucilage which must be used in Hanji manufacturing should effect the conservation properties of Hanji. The effectiveness of the mucilage in aging of Hanji was evaluated in this paper. Strength properties of thermal aged Hanji made with synthetic mucilage decreased more slowly than those of Hanji made with natural mucilage. As prolonged aging time, all Hanji made mucilage increased oxidation index. But, Hanji made with PAM was most stable in oxidation of cellulose.

Isolation of a Pestalotiopsis Species Degrading Mucilage from Fruit of Opuntia ficus-indica var. Saboten

Huh, Yoon-Hee,Ko, Young-Hwan The Korean Society for Applied Biological Chemistr 2007 Journal of Applied Biological Chemistry (J. Appl. Vol.50 No.4

The high molecular-weight mucilage extracted and purified from cactus fruit of Opuntia ficus-indica var. Saboten was degraded by the cell-free culture filtrate of a fungus isolated from soil. TLC analysis of the polymeric mucilage after incubation with the fungal culture filtrate confirmed its degradation. When the degradation products were tested for their qualitative reactions with ninhydrin and phenol-sulfuric acid, only phenol-sulfuric acid gave positive development, and ninhydrin did not show any observable color reaction. This coloring reaction suggested the presence of a carbohydrate without an amino group within the mucilage. Analyses by HPLC and liquid gel permeation chromatography on sephadex G-100 also provided additional information on degradation of the mucilage by the fungal culture filtrate. The sequences of ITS-5.8S rDNA from the fungal isolate that was cultivated for the preparation of mucilage-degrading enzyme showed 99% similarity to those of Pestalotiopsis aquatica.

난과식물의 생약학적 연구

도정애 梨花女子大學校 藥學硏究所 1994 藥學硏究論文集 Vol.- No.4

In order to estimate accurate originality of the important crude drugs, Gastrodia, Dendrobiurn, Bletilla and Cremastra spp. were investigated comparing their morphological, anatomical and physicochemical characteristics and antibacterial, antifungal activities. The results of the studies as follows: 1. In morphological and anatomical studies, Korean Gastrodia contained more mucilage duct and symbiotic fungi than imported Gastrodia. Korean Dendrobium contained starch grains but without starch grains in the imported Dendrobium from China enclosed with thicken silicified wall. The corm of Cremasta appendicutata contained raphides of bundles with mucilage while the bulbs of Tulipa edulis containedseveral various starch grains form. 2. In physiological and TLC analysis, crude drugs in Orchidaceae contained common constituents with fluorescence and much mucilage. 3. The EtOH extracts of Gastrodia, Dendrobium, Bletilla, Cremastra showed antibacterial activities againt B. subtilis and E. coli (Dendrobium>Gastrodia>Bletilla>Cremastra). But, no antifungal activities against C. albicans, A. niger were observed.

난과식물의 생약학적 연구

도정애,Toh, Chung-Ae 한국생약학회 1994 생약학회지 Vol.25 No.3

In order to estimate accurate originality of the important crude drugs, Gastrodia, Dendrobium, Bletilla and Cremastra spp. were investigated comparing their morphological, anatomical and physicochemical characteristics and antibacterial, antifungal activities. The results of the studies as follows: 1. In morphological and anatomical studies, Korean Gastrodia contained more mucilage duct and symbiotic fungi than imported Gastrodia. Korean Dendrobium contained starch grains but without starch grains in the imported Dendrobium from China enclosed with thicken silicified wall. The corm of Cremasta appendiculata contained raphides of bundles with mucilage while the bulbs of Tulipa edulis contained several various starch grains form. 2. In physiological and TLC analysis, crude drugs in Orchidaceae contained common constituents with fluorescence and much mucilage. 3. The EtOH extracts of Gastrodia, Dendrobium, Bletilla, Cremastra showed antibacterial activities against B. subtilis and E. coli (Dendrobium>Gastrodia>Bletilla>Cremastra). But, no antifungal activities against C. albicans, A. niger were observed.

Quality retention and shelf life extension of fresh beef using Lepidium sativum seed mucilage-based edible coating containing Heracleum lasiopetalum essential oil: an experimental and modeling study

Hassan Barzegar,Behrooz Alizadeh Behbahani,Mohammad Amin Mehrnia 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.5

The instability and strong flavor or odor ofessential oils (EO) limit their direct incorporation into foodproducts. In this study, the antioxidant and antimicrobialHeracleum lasiopetalum essential oil (HLEO) was added toLepidium sativum seed mucilage (LSSM) solution at fourconcentrations (0, 0.5, 1, and 1.5%) to develop a noveledible coating and expand its food application. HLEOloadedLSSM coating was then used to improve the shelflife and quality of beef as a model food system. The coatedand control beef samples were periodically analyzed forphysicochemical analysis, microbiological, and sensorycharacteristics over a period of 9 days at 4 C. The HLEOenrichedLSSM coating, particularly 1.5% loaded oneresulted in a significant (p\0.05) increase in oxidativeand microbiological stability and overall acceptance of thebeef samples, compared to the control counterpart. HLEOloadedLSSM coating, therefore, provides a promisingalternative to preserve the meat products under coldstorage.

몰로키아(Corchorus olitorius) 잎에서 추출한 mucilage의 이화학적 특성

정창화(Chang-hwa Jung),최인욱(In-Wook Choi),김홍만(Heung-Man Kim),석호문(Ho-Moon Seog) 한국식품과학회 2002 한국식품과학회지 Vol.34 No.5

금화규(Abelmoschus manihot jinhuakui) 추출물의 항산화 활성

전연홍 ( Yun-hong Jeon ),강상모 ( Sang-mo Kang ) 한국미용학회 2021 한국미용학회지 Vol.27 No.1

This study focuses on figuring out the possibility of functional cosmetics raw materials, especially the A. manihot jinhuakui. It uses Ethanol(95%) and water-based alkaline solvent (1 M NaOH) to extract the functional ingredients from the flowers and stems each of the A. manihot jinhuakui, and compare the antioxidant power of the extractions. We measured the antioxidant power of the ingredients extracted by water-based alkaline solvent from the flowers (WF) and stems (WS), and the ingredients extracted by Ethanol from the flowers (EF) and stems (ES). The measurements conducted through DPPH radical elimination analysis, ABTS assay, and FRAP assay, and it showed a very high antioxidant capacity. Also, we obtained through this study a large amount of polyphenol and flavonoid confirm. All extracts show antioxidant activity, especially the polyphenol content of the flower extract WF 598.59 ± 32.12 μg/mL, EF 529.0 ± 25.1 μg/mL, the stem extract WS 247.86 ± 25.14 μg/mL, ES contains 121.23 ± 15.81 μg/mL, ingredients from the flowers (WF, EF) stated higher activity than from the stem extracts (WS, ES). Collagen content did not appear in all extractions. In particular, among the flower extracts (WF, EF), WF extracted from the water-based alkaline solvent showed DPPH radical eliminate activity 0.0825 mg/ mL, excellent antioxidant activity than EF 0.834 mg/mL, WS 1.095 mg/mL, ES 1.156 mg/mL. Conclusively, this study showed increasing the radical eliminate activity of A. manihot jinhuakui's extraction using water-based alkaline solvent, moreover, it demonstrated the differently applied solvent extraction methods showed their efficacy and possibility as functional cosmetic materials in A. manihot jinhuakui, which takes into account the properties of mucilage.

Hypolipidemic and Antioxidative Effects of Dika Nut (Irvingia gabonensis) Seeds and Nkui (Trimphetta cordifolia) Stem Bark Mucilages in Triton WR-1339 Induced Hyperlipidemic Rats

Alice Louise Woguia,Judith Laure Ngondi,Thaddée Boudjeko,Christophe Rihouey,Enyong Julius Oben 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.6

Two different mucilages were extracted from dika nut (Irvingia gabonensis) kernels and nkui (Trimphetta cordifolia) stem barks and the hypolipidemic and antioxidant effects were studied on Triton WR-1339induced hyperlipidemic rats. The GC analysis revealed that, dika nut mucilage is an arabinogalactan type while nkui is a rhamnogalacturonane type. The mucilage of nkui (200 mg/kg) showed the greatest hypolipidemic effect (p<0.05). An oxidative stress marker analysis suggested that the level of malonyl dialdehyde was significantly decreased in serum by the 2 mucilages (p<0.05). There was also a significant decrease in hydroperoxide level for the tested fibers. Moreover, nkui mucilage gave the highest levels in liver homogenate and in the hemolysate and tissues (p<0.05). The results suggest that the hypolidemic effect of mucilages varies with their chemical nature. They would be effective in the prevention of increase of serum lipid levels, in the reduction of lipid peroxidation and in the improvement of antioxidant status.

Effect of mucilage from yam on activation of lymphocytic immune cells

Cheol-Min Jang,Dae-Hyuk Kweon,Jong-Hwa Lee 한국영양학회 2007 Nutrition Research and Practice Vol.1 No.2

The immunostimulating activities of mucilage fraction from yam were investigated. The proliferation of BSA-primed lymph node cells was enhanced between 4.1- to 10.9-fold compare to control, when cultured with 1 to 25 ㎍/mL of yam-mucilage fraction. It showed strong immunopotentiating activity than ginseng extract and as remarkable as Bifidobacterium adolescentis M101-4 known as a positive immunostimulator. Mitogenicity to lymph node cells was fully induced by concanavalin A and lipopolysaccharide. The proliferation of splenocytes and Peyer's patch cells was enhanced between 5.0- to 14.1-fold and 2.4- to 6.4-fold, respectively, when cultured with 1 to 25 ㎍/mL of yam-mucilage fraction. It enhanced the production of cytokines such as tumor necrosis factor-α and IL-6 in the culture of RAW 264.7 macrophage cells. In the culture of lipopolysaccharide-stimulated RAW 264.7 cells, production of cytokines was as similar as compared to controls. In unstimulated RAW 264.7 cells, both tumor necrosis factor-α and IL-6 production were enhanced between 15.6- to 60.1-fold and 2.3- to 9.1-fold, respectively. Mucilage fraction from yam is expected to be a safe immunopotentiator to maintain the host immunity and develop a physiologically functional food.