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- 주제어 : histologic subtypes (검색결과 21 건)
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Tomita, Masaki,Ayabe, Takanori,Nakamura, Eiichi Chosa Kunihide Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Recent studies revealed a relationship between ground-glass opacity (GGO) ratio on computed tomography (CT) and serum carcinoembryonic antigen (CEA) level in lung adenocarcinoma. Since an association between lepidic histologic pattern and GGO is well accepted, we investigated the link between histologic subtype and serum CEA level in resected lung adenocarcinoma. Materials and Methods: One hundred and eighty-one consecutive patients with resected lung adenocarcinoma were studied retrospectively. The histologic subtype was subdivided into 2 groups: lepidic dominant histologic subtype, including adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant invasive adenocarcinoma versus other subtypes. Results: The 5-year survival of patients with s high serum CEA level was significantly more unfavorable than that with normal levels. Similarly, there was also a relationship between the patient survival and histologic subtype, with favorable survival found in patients with the lepidic dominant histologic subtype. There was a significant relationship between serum CEA level and lepidic dominant histologic subtype overall and in p-stage I patients. Conclusions: Lung adenocarcinomas with non-lepidic dominant histologic subtype are associated with high serum CEA levels.
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( Je Byeong Chae ),( Bo Ri Kim ),( Chong Won Choi ),( Sang Woong Youn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Seborrheic keratosis (SK) is traditionally classified into 4 major histological subtypes: hyperkeratotic, acanthotic, adenoid, and irritated. This classification, however, is based on visual characteristics, which can be subjective, rather than on objective criteria based on quantified parameters. Objectives: The aim of our study was to describe the histological features of each subtype of SK with quantified values, using computer-aided image analysis and to objectively compare the differences in histopathological findings among the SK subtypes. Methods: We retrospectively collected histological photographs of 181 biopsy-proven SK lesions. The major histopathological findings of SK were quantitatively assessed using Image J software. Results: Hyperkeratosis (708.43±1095.27 μm) and papillomatosis (26.39±9.27 /μm) were predominant in the hyperkeratotic subtype, while acanthosis (489.44±346.89 μm) was relatively mild among the subtypes. Conversely, the acanthotic subtype showed pronounced acanthosis (749.25±375.13 μm) with slight hyperkeratosis (99.57±81.69 μm) and papillomatosis (6.35±7.39 /μm). The characteristic feature of the irritated subtype was prominent inflammatory cell infiltration (11.23±3.86 %). Conclusion: Our study introduced a method of computer-aided image analysis to quantify the histopathologic findings of SK and objectively proved the difference between each histological subtype.
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기저세포암의 병리조직학적 아형에 따른 임상적 특징에 대한 연구
박혜영 ( Hae Young Park ),이동윤 ( Dong Youn Lee ),이주흥 ( Joo Heung Lee ),양준모 ( Jun Mo Yang ),이일수 ( Il Soo Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.8
Background: Basal cell carcinoma (BCC) is a slow-growing, locally invasive malignant epidermal skin tumor. Several studies of differences in age, site distribution and male to female ratio have been conducted among different histological subtypes of BCC. Objective: We analyzed the five major subtypes of BCC with regard to gender, age, and anatomical distribution. Methods: We retrospectively included 246 cases of BCC diagnosed from January 2000 to March 2011. The diagnoses and classifications of histopathological subtypes (nodular, superficial, micronodular, infiltrative, or morphemic) of BCC were confirmed by three dermatologists. Gender, age at diagnosis, and location were recorded and analyzed by histopathological subtypes. Results: We recorded 246 cases (M:F=1:1.08) with a mean age of 64.0 years. Of the BCCs, 61.0% were nodular, 15.4% were superficial, 11.4% were micronodular, 10.2% were infiltrative, and 2.0% were morpheic. The nodular subtype was diagnosed at a mean age of 64.9 years, whereas the superficial subtype was diagnosed at an earlier age (60.3 years) and more frequently occurred in women (M:F=1:1.5) than the nodular subtype. Compared with the nodular subtype (4%), the superficial subtype (26.3%) occurred more frequently in the trunk (p-value<0.0001). Conclusion: The results showed differences in anatomical distribution, gender, and mean age according to histological subtypes. Superficial BCC occurred more commonly on the trunk, more often in women, and was seen in younger patients than that of the nodular subtype. (Korean J Dermatol 2011;49(8):683∼689)
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Histologic Distribution of Pulmonary Tumors in Lebanon: A 5-Year Single Institution Experience
Kourie, Hampig Raphael,Rassy, Marc,Ghorra, Claude,Naderi, Samah,Kattan, Joseph Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: To compare the current histologic distribution of lung cancer in Lebanon to the worldwide trends, according to the 2004 WHO Classification. Materials and Methods: 1,760 patients with a pulmonary pathology examination at Hotel-Dieu de France University Hospital between July 2009 and July 2014 were included. Results: Some 676 out of the total investigated patients (38.4%) had a lung tumor. In 665 (98.4%) the tumors were malignant, with a mean age at diagnosis of 63.8 years and a male/female (M/F) sex ratio of 1.7:1. Among the malignant tumors, 86.2% were epithelial tumors with a mean age at diagnosis of 64.8 years and an M/F sex ratio of 1.9. Other malignant tumors consisted of metastatic tumors (10.2%), lymphoproliferative tumors (2.1%) and mesenchymal tumors (1.5%). Most common carcinoma subtypes were adenocarcinoma (48.0%), squamous cell carcinoma (23.0%) and small cell carcinoma (13.3%). Carcinoid tumors were the only carcinoma subtype with an M/F sex ratio below 1 (0.7). Salivary gland tumors were the carcinoma with lowest mean age at diagnosis (45.5 years). Conclusions: The histologic distribution of lung tumors in Lebanon is similar to that in developed countries. We believe this resemblance is due to common smoking habits, known to be responsible for the increase of lung adenocarcinoma at the expense of other subtypes.
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단방낭종성 법랑아세포종의 적출술 후 재발 경향에 관한 연구
정영수(Young Soo Jeong),이의웅(Eui Wung Lee) 대한구강악안면외과학회 1998 대한구강악안면외과학회지 Vol.24 No.3
Since the apparent developement of ameloblastoma in the wall of a dentigerous cyst was first described by Cahn in 1933, many colleagues have reported the ameloblastoma originated odontogenic cyst. In 1970, Vickers and Gorlin published specific histologic criteria of the ameloblastoma originated odontogenic cyst, and in 1977, Robinson and Martinez referred to this variant as unicystic ameloblastoma in which the response to enucleation or curettage was found to be favorable with low recurrence rate. This lesion was divided into 3 Groups (luminal, plexiform, connective tissue invasion type) according to the histopathologic feature by Ackermann etc. in 1988, and they recommended radical treatment in connective tissue invasion type. Conservative enucleation and curettage have been reported the choice of treatment compared with conventional ameloblastoma, which has represented low recurrent rate, but the study on the prognosis after enucleation according to the histologic subtypes of the unicystic ameloblastoma has been rare. This study is to invested the recurrence and clinical features of 22 unicystic ameloblastomas which have been experienced by enucleation as treatment method from January 1990 to October 1997 in Dental College Hospital of Yonsei University. The results obtained are as follows. 1. The most common patients complains were painless or painful swelling of jaw (19 cases, 86.4%). dysthesia (2 cases, 9.1%), pus discharge (1 case, 4.5%) were next in order. 2. The most frequent age was 2nd decade which was 12 cases (54.5%), and next frequent age was 3rd decade which was 8 cases (36.5%). The average age was 20.5 years old, and sex ratio was 1.4 : 1 (male : female). 3. All 22 cases were developed in the mandible, and body area was occupied 15 cases (68.2%), ramus area was 6 cases (27.2%), and symphysis area was 1 case (4.5%). 4. Radiographically, unilocular type was 81.8%, and the cases related with impacted tooth were 15 cases (83.3%) in unilocular type and 3 cases (75%) in multilocular type. 5. According to histologic subtype by Ackermann s classification, luminal type and plexiform type were 4 cases(18.2%) respectively, connective tissue type was 12 cases (63.6%). 6. Average follow-up period was 3.4 years, and the recurrence was 1 case (4.5%) of total 22 cases, which was connective tissue invasion type (7.14%) histologically. Based on the above results, when patient s function, esthetics, and psychologic factor are considered, the enucleation was adequate primary treatment modality in any histologic type of the unicystic ameloblastoma
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단순 절제술로 치료한 기저세포암의 임상적 특징과 재발률에 관한 연구
신요섭 ( Yo Sup Shin ),박복원 ( Bok Won Park ),장예지 ( Ye Ji Jang ),조은별 ( Eun Byul Cho ),박은주 ( Eun Joo Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.3
Background: Basal cell carcinoma is the most common form of skin cancer. Surgical excision is commonly used as the therapeutic modality. However, there is insufficient data on the prognosis of Korean patients who have undergone surgical excision for basal cell carcinoma. Objective: We therefore retrospectively analyzed the effectiveness of surgical excision in patients with basal cell carcinoma and compared it with previous studies. Methods: From 2009 to 2015, we enrolled 138 patients with primary basal cell carcinoma who underwent surgical excision and analyzed the recurrence rate, clinical features, surgical procedures, and histopathological subtypes. Results: The case series comprised 138 patients (M:F=1:1.51) with a mean age of 68.7 years. Recurrence after surgical excision was diagnosed in 0 of the 138 patients with a mean follow-up period of 47.5 months (12∼93 months). The mean tumor diameter and surgical margin were 0.9 cm and 3.1 mm, respectively. Most tumors (85.5%) were of the nodular subtype. Primary closure was used most often to repair the surgical defects (44.9%). Conclusion: Surgical excision may be a satisfactory method for the treatment of primary basal cell carcinomas, especially in non-high-risk cases. (Korean J Dermatol 2018;56(3):167∼171)
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Clinical features and recurrence rate of basal cell carcinomas treated with surgical excision
( Won Joo Kwon ),( Yo Sup Shin ),( Eun Byul Cho ),( Eun Joo Park ),( Kwang Ho Kim ),( Kwang Joong Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Basal cell carcinoma (BCC) is the most common form of skin cancer. Surgical excision is commonly used as the therapeutic modality. However, there is insufficient data on the prognosis of Korean patients who have undergone surgical excision for BCC. Objectives: We therefore retrospectively analyzed the effectiveness of surgical excision in patients with BCC. Methods: From 2009 to 2015, we enrolled 138 patients with primary BCC who underwent surgical excision and analyzed the recurrence rate, clinical features, surgical procedures and histopathological subtypes. Results: The case series comprised 138 patients (M : F=1 : 1.51) with a mean age of 68.7 years. Recurrence after surgical excision was diagnosed in 0 of the 138 patients with a mean follow-up period of 47.5 months. The mean tumor diameter and surgical margin were 0.9 cm and 3.1 mm, respectively. A majority of tumors (85.5%) were of the nodular subtype. Primary closure was used most often to repair surgical defects (44.9%). Conclusion: Surgical excision may therefore be a satisfactory method for the treatment of primary BCCs, especially in non-high-risk cases.
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Suh, Young Joo,Lee, Hyun-Ju,Kim, Young Tae,Kang, Chang Hyun,Park, In Kyu,Jeon, Yoon Kyung,Chung, Doo Hyun Elsevier 2018 Lung cancer Vol.120 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Our study investigates the added value of computed tomography (CT) characteristics, histologic subtype classification of the International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS), and genetic mutation for predicting postoperative prognoses of patients who received curative surgical resections for lung adenocarcinoma.</P> <P><B>Materials and methods</B></P> <P>We retrospectively enrolled 988 patients who underwent curative resection for invasive lung adenocarcinoma between October 2007 and December 2013. Cox’s proportional hazard model was used to explore the risk of recurrence-free survival, based on the combination of conventional prognostic factors, CT characteristics, IASLC/ATS/ERS histologic subtype, and epidermal growth factor receptor (EGFR) mutations. Incremental prognostic values of CT characteristics, histologic subtype, and EGFR mutations over conventional risk factors were measured by C-statistics.</P> <P><B>Results</B></P> <P>During median follow-up period of 44.7 months (25th to 75th percentile 24.6-59.7 months), postoperative recurrence occurred in 248 patients (25.1%). In univariate Cox proportion hazard model, female sex, tumor size and stage, CT characteristics, and predominant histologic subtype were associated with tumor recurrence (P < 0.05). In multivariate Cox regression model adjusted for tumor size and stage, both CT characteristics and histologic subtype were independent tumor recurrence predictors (P < 0.05). Cox proportion hazard models combining CT characteristics or histologic subtype with size and tumor stage showed higher C-indices (0.763 and 0.767, respectively) than size and stage-only models (C-index 0.759, P > 0.05).</P> <P><B>Conclusion</B></P> <P>CT characteristics and histologic subtype have relatively limited added prognostic values over tumor size and stage in surgically resected lung adenocarcinomas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In surgically resected adenocarcinomas, prognostic factors were investigated. </LI> <LI> EGFR mutation were not associated with tumor recurrence. </LI> <LI> CT characteristics and histologic subtype were independent predictors of recurrence. </LI> <LI> Both had added prognostic values over tumor size and stage. </LI> </UL> </P>
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