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      • KCI등재

        파종성 다발성 사구종양 1례의 치험례

        최태현,손대구,김형태,여현정 대한성형외과학회 2009 Archives of Plastic Surgery Vol.36 No.4

        Purpose: Glomus tumors are neoplasms that are composed of modified smooth muscle cells of the glomus body and multiple glomus tumor comprises 10% of all glomus tumors. We report a case of disseminated multiple glomus tumors. Methods: A 14-year-old boy presented with multiple subcutaneous purple nodules on the right cheek, back, right arm, right hand dorsum, right fourth finger, and left ankle. Nodules on the back and right fourth finger were completely excised under local anesthesia and histopathologic examination was followed. Results: Histopathologic findings showed numerous dilated, cavernous-like, thin-walled vascular spaces surrounded by one or a few layers of glomus cells. On immunohistochemical examination, glomus cells stain for smooth muscle actin, and endothelial cells stain for CD31. Those revealed multiple glomangiomas. Conclusion: A review of Korean literature revealed only one reported case of disseminated multiple glomus tumors, so this is the second case to be reported in the Korean literature. In case of multiple soft tissue tumors, thorough physical examination and preoperative evaluation are needed.

      • KCI등재

        Primary Multiple Cardiac Myxomas in a Patient without the Carney Complex

        Shohei Kataoka,Masato Otsuka,Masayuki Goto,Mitsuru Kahata,Asako Kumagai,Koji Inoue,Hiroshi Koganei,Kenji Enta,Yasuhiro Ishii 한국심초음파학회 2016 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.24 No.1

        Cardiac tumors are rare, and multiple myxomas are even rarer. The latter phenomenon is mostly associated with the Carney complex, a dominantly inherited disease characterized by multiple primary cardiac myxomas, endocrinopathy, and spotty pigmentation of the skin. We report the rare case of a patient who did not have the Carney complex but had multiple primary cardiac tumors. A 78-year-old woman with a past history of breast cancer was referred to our hospital for further examination of multiple cardiac tumors. Echocardiography showed 4 tumors in the left atrium and left ventricle. We could not diagnose them preoperatively and decided to resect them surgically because they were mobile and could have caused embolism and obstruction. The postoperative pathological findings of all 4 tumors were myxomas, although the patient did not meet the diagnostic criteria of the Carney complex. Therefore, a rare case of multiple primary cardiac myxomas was diagnosed.

      • SCOPUSSCIEKCI등재

        조직학적 소견이 다른 원발성 뇌종양의 합병 : 원발성 다발성 뇌종양 Multiple Primary Brain Tumors Report of Two Cases

        김원호,신원한,박영탁,최순관,변박장,이인수,이동화 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.4

        The presence of multiple, diverse primary brain tumors is infrequent in patients without phakomatosis. We wish to report two cases of multiple primary brain tumors. The first case, a 38-year-old female, suffered from headache, bilateral hearing loss for about 6 years prior to hospitalization. Camputed tomography scan demonstrated multiple well enhanced masses in the right frontal convexity, falx and both cerebellopontine angles. These lesions were removed successfully in 3 successive operations. Histologically the tumors were diagnosed as fibroblastic meningiomas and a acoustic neurinoma. Although none of the cutaneous stigmata of von Recklinghausen's disease has been observed in her and any member of her family, we cant's exclude this case that belongs in the central form of neurofibromatosis. The 2nd case, a 71-year-old male, suffered from frontal headache with confusion for about 7 days prior to hospitalization. Computed tomography scan demonstrated a ring enhanced mass with surrounding edema in the left frontal lobe. The left frontal osteoplastic craniotomy was performed, a small mass with the dura attached could be found incidentally, and this small mass and the ring enhanced tumor in the frontal deep portion were grossly totally removed. Histologically the two tumors were diagnosed as a meningotheliomatous meningioma and a malignant astrocytoma.

      • KCI등재후보

        Review : The Current Strategy for Managing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

        ( Yusuke Niina ),( Nao Fujimori ),( Taichi Nakamura ),( Hisato Igarashi ),( Takamasa Oono ),( Kazuhiko Nakamura ),( Masaki Kato ),( Robert T. Jensen ),( Tetsuhide Ito ),( Ryoichi Takayanagi ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.3

        Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant disease presenting with pancreatic neuroendocrine tumors (pNETs), parathyroid tumors, or pitu-itary tumors. Using the PubMed database, we reviewed the literature on information regarding the proper diagnosis and treatment of MEN1-associated pNET. Many cases of MEN1-associated pNET are functioning pNETs. Gastrinomas and insulinomas tend to occur frequently in the duodenum and pancreas, respectively. In addition to diagnostic imaging, the selective arterial secretagogue injection test (SASI test) is useful for localizing functioning pNET. The standard treat-ment is surgical resection. However, in the case of a func-tioning pNET, the tumor should first be accurately located using the SASI test before an appropriate surgical method is selected. In cases of a MEN1-associated non-functioning pNET that exceeds 2 cm in diameter, the incidence of distant metastasis is significantly increased, and surgery is recom-mended. In cases of unresectable pNET, a somatostatin analog has been shown to demonstrate antitumor effects and is considered to be a promising treatment. In addition, molecular-targeted drugs have recently been found to be ef-fective in phase III clinical trials. (Gut Liver 2012;6:287-294)

      • SCOPUSSCIEKCI등재

        Relation of Multiple Neurogenic Tumors in the Spinal Canal to Neurofibromatosis

        Seol, Ho-Jun,Chung, Chun-Kee,Kim, Hyun-Jib,Lee, Yoon-Kyung,Park, Sung-Hye The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.38 No.1

        Objective : The authors characterize a syndrome of multiple neurogenic tumors in the spinal canal, which is unclassifiable by the current National Institute of Health[NIH] criteria for neurofibromatosis. Methods : We retrospectively examined cases in which two or more spinal neurogenic tumors were detected by magnetic resonance[MR] imaging and which had been pathologically confirmed. Eighteen patients were recruited between February 1986 and March 2002. According to NIH criteria, eight cases were neurofibromatosis type 1[NF1], four were type 2[NF2], and six were neither type 1 nor type 2 [Unclassifiable : UC]. The locations of lesions, clinical presentations, radiological findings, and pathological results with immunohistochemistry were reviewed. Results : In the case of NF2, three of four cases were intradural tumors. Pathological examinations revealed neurilemmomas in two of four NF2 and all of the UC cases. In the case of NF1, pathological examinations showed seven neurofibromas and one neurilemmoma. Concerning UC, the age at presentation was middle-aged to late [mean age 48.5, range 35 to 64], which contrasted with ordinary NF2, where patients tended to become symptomatic before 20years of age. The pathological examinations of UC cases revealed neurilemmoma similar to most of NF2 and the immunohistochemical study showed characteristic of NF1. Conclusion : Multiple neurogenic tumors in the spinal canal are an under-recognized disease entity. Further studies for genetic aberration in multiple spinal neurogenic tumors are needed.

      • 갑상선과 후두에 발생한 다발성 원발암 1례

        손영익,권중근,추광철 대한기관식도과학회 1997 大韓氣管食道科學會誌 Vol.3 No.1

        Multiple primary tumors in the head and neck are not uncommon, however those in the thyroid and the larynx are known to be very rare. In most cases of multiple primary tumors involving the thyroid and the larynx, lesions are observed usually simultaneously and thyroid tumors are found incidentally during the laryngeal tumor surgery. In rare cases, thyroid tumors are found metachronously after radiation therapy of laryngeal cancer. The authors recently experienced a case of multiple primary tumor involving the thyroid and the larynx, in which thyroid papillary carcinoma was the index tumor and the laryngeal squamous carcinoma was the meatachronous second tumor. Both tumors showed aggressive local extension and regional nodal meatastasis with tumor collision in the same node. The patient died of recurrent or of residual squamous carcinoma shortly after main surgical treatment index thyroid cancer.

      • KCI등재

        Multiple Neuroendocrine Tumors in Stomach and Duodenum in a Multiple Endocrine Neoplasia Type 1 Patient

        김보현,양한광,김우호 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.2

        A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous examination of the entire stomach and duodenum revealed multiple scattered, minute neuroendocrine tumors. To the best of our knowledge, this is the first case report of a patient diagnosed with gastroduodenal neuroendocrine tumors associated with multiple endocrine neoplasia type 1 (MEN 1) in whom complete histologic mapping of the whole gastrectomy specimen was performed. The presence of MEN 1–associated neuroendocrine tumors in the stomach is very rare, but should be considered in patients diagnosed with MEN 1 who present with a new tumor in the stomach.

      • KCI등재SCOPUS
      • 다발성 뇌수막종 1예

        황금철,이채혁,고영초,박효일,강윤경 인제대학교 1998 仁濟醫學 Vol.19 No.2

        수막종은 두개강내 종양 중 비교적 흔한 종양이나 다발성 수막종은 드물다. 저자들은 65세 남자로 두통과 좌측 편마비를 주소로 모 대학 병원에 입원하여 시행한 단층촬영과 자기공명영상검사에서, 우측 전두부 측격부위와 좌측 두정부 궁융부에 발생한 다발성 수막종으로 진단되어, 좌측 두정부 궁융부의 종양은 완전 제거되었으나, 우측 전두부 측격 부위의 종양이 부분적으로만 제거되어, 본원으로 전원된 후 재수술을 통하여 성공적으로 제거하였다. 병리학적 검사상 우측 측겸 부위는 비정형 수막종이고, 좌측 두정부는 소낭성 수막종이었다. Meningiomas are common intracranial tumor, but the neurosurgiral frequency of multiple meningioma is low. The authors report a case of multiple meningioma of supratentorial region. The patient was 65-year-old male and presented headache and left hemiparesis. CT and MRI revealed multiple meningioma in right parafaxial region and left parietal converxity region. The patient had underwent bilateral frontal and frontoparietal craniotomy with total removal of the left parietal tumor and partial removal of the right parafaxial tumor. He was transferred for the removal of the remanining tumor. The patient was treated sucessfully and these pathological types was different as atypical meningioma in the right parafoxial tumor and microcystic meningioma in the left parietal tumor.

      • SCOPUSKCI등재

        조기 위암과 동반된 위선암과 유암종이 같이 있는 중복종양

        김은영 ( Kim Eun Yeong ),박경찬 ( Park Gyeong Chan ),권중구 ( Kwon Jung Gu ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6

        Carcinoid tumors show variety of pathological features and some of them are admixed with adenocarcinoma. The carcinoma-carcinoid spectrum is a concept of classifying tumors based on the tumor mass differentiation which is composed of tissues of both endocrine and nonendocrine functions. When two types of tissues exist within one tumor intermingled with each other in a similar proportion, it is called composite tumor. On the other hand, collision tumor is characterized by the presence of two localized tissue types adjacently together. Gastric composite tumors are relatively rare. According to the reports on the Korean literature, there are several collision tumors, but only one case of gastric composite tumor has been cited. Reports of multiple synchronous or metachronous cancers have increased steadily during the last decades. Multiple gastric carcinoids or carcinoid tumors developed in association with gastric adenocarcinoma contribute to this trend. We report one case of gastric composite tumor simultaneously occurring with a early gastric adenocarcinoma with review of the literature. (Korean J Gastroenterol 2003;42:533-538)

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