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Discovery of Novel Bioactive Compounds from Marine Microorganisms
신희재 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Approximately 30,000 structurally diverse natural products with a vast array of bioactivities have been discovered from marine organisms including microbes, algae and invertebrates. Especially, the study of marine bacteria and their potential role in the production of bioactive metabolites is a rapidly growing field, due to the fact that a number of metabolites obtained from marine macroalgae and invertebrates such as sponges may be produced by associated marine microorganisms. Thus, marine microorganisms have attracted considerable attention due to the structural diversities and unique biological activities of their secondary metabolites. This presentation will highlight the importance of marine microorganisms in the drug discovery from marine natural products. The isolation, structure determination, and bioactivities of novel compounds from marine microorganisms will be presented.
KAUR, Kulvinder Kochar,ALLAHBADIA, Gautam,SINGH, Mandeep Korea FoodHealth Convergence Association 2019 식품보건융합연구 (KJFHC) Vol.5 No.3
The incidence of both obesity and Type 2 Diabetes Mellitus( DM) is increasing proportionately so that causes of deaths from these has overtaken from that of malnourishment. Hence it has been recommended to treat the 2 in parallel considering the role of diabesity on health. Important causes of T2DM are insulin resistance (IR) and /or inadequate insulin secretion. Protein tyrosine phosphatase 1B(PTPIB) has a negative impact in insulin signaling pathways and hence plays crucial role inT2DM,since its overexpression might induce IR. Thus PTPIB is considered a therapeutic target for both obesity and T2DM, there has been a search for novel ,promising natural inhibitors. We conducted a pubmed search for articles related to PTPIB inhibitors from natural causes be it marine sources or other natural sources. Out of 988 articles we selected 100 articles for review. Thus various bioactive molecules isolated from marine organisms that can acts as PTPIB Inhibitors and thus possess antidiabetic activity both in vitro/ in vivo studies ,besides products from fruits like Chinese raspberry or curcumin used as routine spices are described with their chemical classes, structure-activity relationships and potency as assessed by IC 50 values are discussed. More work is required to make this a reality.
김은지,오동찬,윤여준 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
The novel cyclic depsipeptides produced by marine bacterial strain belonging to the Streptomyces genus are potent antituberculosis agents. The peptides include unusual amino acid units, N-methyl-4-methoxytrytophan and β-hydroxyphenylalanine. Through genome sequencing, we have identified a 41.4-kb nonribosomal peptide synthetase (NRPS) gene for cyclic peptide core along with precursor biosynthesis and modification genes for tryptophan or phenylalanine moieties. Gene deletion and complementation allowed the confirmation of the biosynthesis and modification of the unusual amino acid moieties as well as the generation of new and potentially clinically significant derivatives.
Bile acids from a Marine Sponge-Associated Fungus Penicillium sp.
Pil, Gam Bang,Won, Ho Shik,Shin, Hee Jae Korean Magnetic Resonance Society 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.2
Chemical investigation of a marine-derived fungus, Penicillium sp. 108YD020, resulted in the discovery of six bile acid derivatives, glycocholic acid (1), glycocholic acid methyl ester (2), cholic acid (3), glycochenodeoxycholic acid (4), glycodeoxycholic acid methyl ester (5), and cholic acid methyl ester (6). The structures of six bile acid derivatives 1-6 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis.
Bile acids from a Marine Sponge-Associated Fungus Penicillium sp.
감방필,원호식,신희재 한국자기공명학회 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.2
Chemical investigation of a marine-derived fungus, Penicillium sp. 108YD020, resulted in the discovery of six bile acid derivatives, glycocholic acid (1), glycocholic acid methyl ester (2), cholic acid (3), glycochenodeoxycholic acid (4), glycodeoxycholic acid methyl ester (5), and cholic acid methyl ester (6). The structures of six bile acid derivatives 1–6 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis.
Recent progresses in marine microbial-derived antiviral natural products
Yun‑Fei Teng,Li Xu,Mei‑Yan Wei,Chang‑Yun Wang,Yu‑Cheng Gu,Chang‑Lun Shao 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.12
Viruses have always been a class of pathogenicmicroorganisms that threaten the health and safety of humanlife worldwide. However, for a long time, the treatment ofviral infections has been slow to develop, and only a fewantiviral drugs have been using clinically. Compared withthese from terrestrial environments, marine-derived microorganismscan produce active substances with more novelstructures and unique functions. From 2015 to 2019, 89antiviral compounds of 8 structural classes have been isolatedfrom marine microorganisms, of which 35 exhibit anti-H1N1 activity. This review surveys systematically marinemicrobial-derived natural products with antiviral activityand illustrates the impact of these compounds on antiviraldrug discovery research.
( Jie Wang ),( Xu-hua Nong ),( Xiao-yong Zhang ),( Xin-ya Xu ),( Muhammad Amin ),( Shu-hua Qi ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.6
Biofilm formation of Staphylococcus aureus is one of its mechanisms of drug resistance. Antibiofilm screening of 106 compounds from marine-derived fungi displayed that 12 compounds inhibited S. aureus biofilm formation by >50% at the concentration of 100 μg/ml, and only secalonic acid D (SAD) and B inhibited by >90% at 6.25 μg/ml without inhibiting cell growth after 24-h incubation. Meanwhile, it was found that the double bond between C-1 and C-10 of citrinin derivatives and the C-C connection position of two chromone monomers may be important for their anti-biofilm activities. Moreover, SAD slightly facilitated biofilm eradication and influenced its architecture. Furthermore, SAD slowed the cell growth rate in the preceding 18-h incubation and differentially regulated transcriptional expression of several genes, such as agr, isaA, icaA, and icaD, associated with biofilm formation in planktonic and biofilm cells, which may be the reason for the anti-biofilm activity of SAD. Finally, SAD acted synergistically against S. aureus growth and biofilm formation with other antibiotics. These findings indicated that various natural products from marine-derived fungi, such as SAD, could be used as a potential biofilm inhibitor against S. aureus.
( Chaeyoung Lee ),( Jung Min Park ),( Prima F. Hillman ),( Minyi Yoo ),( Hye Yeon Kim ),( Chang-seok Lee ),( Sang-jip Nam ) 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.4
Bioassay and HPLC-UV guided fractionations of the crude extract of marine-derived Streptomyces sp. SNA-077 have led to the isolation of a red pigment, undecylprodigiosin (1). The chemical structure of undecylprodigiosin (1) was revealed by the interpretation of NMR and mass spectroscopic (MS) data. Further, anti-melanogenic effects of undecylprodigiosin (1) were investigated. First, the melanin contents of undecylprodigiosin (1)-treated B16 cells were evaluated. Furthermore, undecylprodigiosin (1) significantly inhibited the key enzymes involved in melanogenesis, including tyrosinase, tyrosinase related protein-1 (TYRP-1), and dopachrome tautomerase (DCT). The mRNA and protein expression levels of Microphthalmia-associated transcriptian factor (MiTF), a critical transcription factor for tyrosinase gene expression, were also suppressed by undecylprodigiosin (1) treatment in B16 analyses. Collectively, our results suggest for the first time that undecylprodigiosin (1), a potent component isolated from an extract of marine Streptomyces sp. SNA-077, critically exerts the anti-melanogenic ability for melanin synthesis.
최동영,최혁재 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.2
Continuous increases in the incidence of neurodegenerativediseases, such as Alzheimer’s disease (AD),Parkinson’s disease (PD), and brain stroke demand theurgent development of therapeutics. Marine organisms arewell-known producers of natural products with diversestructures and pharmacological activities. Therefore,researchers have endeavored to identify marine naturalproducts with neuroprotective effects. In this regard, thisreview summarizes therapeutic targets for AD, PD, andischemic brain stroke and marine natural products withpharmacological activities on the targets according totaxonomies of marine organisms. Furthermore, severalmarine natural products on the clinical trials for the treatmentof neurological disorders are discussed.