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Muhammad Ajaz Hussain,Khawar Abbas,Muhammad Sher,Muhammad Nawaz Tahir,Wolfgang Tremel,Mohammad Saeed Iqbal,Muhammad Amin,Munair Badshah 한국고분자학회 2011 Macromolecular Research Vol.19 No.12
This article presents the synthesis of novel hydroxypropylmethylcellulose (HPMC)-aspirin (ASP) conjugates,i.e. macromolecular prodrugs, through the reaction of HPMC with ASP after its in situ activation by 4-methylbenzenesulfonyl chloride. The highly pure ASP prodrugs obtained by this homogeneous and elegant esterification method were characterized using different spectroscopic and chromatographic techniques. Nanoparticulate drug design was successfully achieved by the conversion of free hydroxyls of the polymer into acetates. Transmission electron microscopy and scanning electron microscopy showed nanoparticle formation with the major population size distribution of around 450 nm. Nevertheless, the pharmacokinetics of the HPMC conjugates were studied using high performance liquid chromatography. The pharmacokinetic data indicated that a single dose of 132.6 mg of HPMC-ASP was well tolerated in animal studies without any adverse effects. The maximum plasma concentration (C_max) of HPMC-ASP was found to be 14.6 μg·L^-1 with a t_max of 1 h. The plasma half-life and clearance and the volume of HPMC-ASP distribution were 4.6 h, 3.23 L·h^-1, and 21.8 L·kg^-1, respectively. The elimination of HPMC-ASP followed first-order kinetics with r^2 of 0.9643. The results presented in this paper show the great potential of HPMCASP as a more effective, safe, and stable prodrug.
Optimization analysis of the absorption-stabilization process for fluid catalytic cracking unit
Hussain Muhammad Saddam,Ahmed Ashfaq,Yibin Liu,Amin Muhammad Nadeem,Zahoor Tahir,Saleem Muhammad Afnan,Roh Kosan,Hussain Murid,Abu Bakar Muhammad Saifullah,박영권 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
The absorption-stabilization process (ASP), an important part of petroleum refinery used in the end-use products of petroleum (such as stable gasoline, liquid petroleum gas, and dry gas), is energy-intensive and has low product quality. Aspen Plus process simulator was used for the development of the ASP process model. The developed process model was validated with the actual plant data. The validated model was used to optimize to minimize the cost of the ASP. This work shows that the optimization analysis of the ASP can further improve the product quality and reduce thermal energy consumption. In the new process, changing feeding parameters of supplementary absorption oil, stripping tower intermediate reboiler, and feeding position of stabilization tower reduced the C3 contents of dry gas considerably and lowered the C2 and lighter contents of LPG. Additionally, the new process saved 1.32 MW of thermal energy consumption compared with the existing process. The operating cost has been reduced from 10.921 million USD annually to 9.830 million USD per year. Furthermore, the cost-saving effect of this optimization is about 9.99% (1.091 million USD per year).
Muhammad Bilal Amin,Wajahat Ali Khan,Sungyoung Lee,Young-Koo Lee 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1A
Healthcare is one of the biggest industries that consume IT Infrastructure as a necessity. A reliable reach to secure private information is the essential goal. Most of the healthcare organizations either have their own custom solutions developed or third part CRM software tailored to their needs. This culture satisfies the usability internal to the organization but lacks the ability to provide public access to the users or even to take a step ahead and collaborate with like minded institutes for research and potential growth. Emergence of cloud computing has provided us the opportunity to take a step ahead and build applications available to users on a secure platform, with ability to scale the resources depending on the requirements. The effective use of hybrid and community cloud can create rock solid foundations for healthcare IT Infrastructure. These cloud deployment models not only caters the present needs of healthcare IT Infrastructure but also opens the possibilities to build applications and provide secure and reliable access beyond the limits of organizational boundaries.
우수, 중수 : 빗물저장탱크에서의 미생물 변화와 초기 유출수 배제의 효과 분석
( Muhammad Tahir Amin ),( Mooyoung Han ) 대한상하수도학회 2007 공동추계 학술발표회 논문집 Vol.2007 No.-
Domestic Rainwater harvesting (RWH) systems have been practiced for thousands of years. Although the collection of rainwater for potable purposes is an ancient practice but is not widespread due to many reasons. Though, RWH has been receiving increased attention worldwide, as an alternative source of non-potable water, its use as potable water supply is very limited and the main reason is obviously the quality of stored rainwater in domestic tanks that believe not to meet the drinking water quality standards. Assessments of roof runoff quality that can be found in the literature do have rather differing result, while some authors concluded that rain runoff from roof surfaces is polluted other found a low pollution potential associated with roof runoff. This paper presents the results of microbial quality of stored rainwater in the underground storage tanks of two buildings in Seoul National University, Seoul. The main objectives were to find the horizontal and vertical microbial quality variation within storage tank, and the effects of first flush removal on microbial quality of rainwater. The microbial quality of stored rainwater improves from inlet to outlet point so the present design of rainwater tank with long distance between inlet and outlet points is the best but it may not be optimum when considers the vertical quality variation in tank since water at the surface of tank provided the better quality than at bottom or mid-point of water depth at inlet or outlet points and thus suggesting the outlet near the surface of tank using some kind of suction device. Also, the first flush of runoff water that occurs at the beginning of a rainfall event contains a high proportion of the pollutant load and it must be diverted for improved microbial quality of stored rainwater or should be treated in an appropriate way. Microbiological investigations have revealed interesting results and low-cost microbial disinfection such as solar disinfection of stored rainwater for drinking purposes can be viewed as future research.