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Characteristics of circulating CD31 <sup>+</sup> cells from patients with coronary artery disease
Kim, Moo Hyun,Guo, Longzhe,Kim, Han-Soo,Kim, Sung-Whan BlackWell Publishing Ltd 2014 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.18 No.11
<P>Recently, we reported the properties of CD31-expressing cells in healthy individuals. However, the characteristics of CD31-expressing cells derived from coronary artery disease (CAD) patients remain unknown. This study aimed to investigate the relationship between circulating CD31<SUP>+</SUP> cells and CAD as well as their biological characteristics. Analysis with flow cytometry revealed that CD31<SUP>+</SUP> cells (C-CD31) from the peripheral blood (PB) of CAD patients exhibited low levels of T-cell marker and high levels of macrophage marker compared with the PB-CD31<SUP>+</SUP> cells from healthy individuals (H-CD31). In addition, the expression levels of multiple pro-angiogenic and chemokine genes were significantly down-regulated in C-CD31. However, inflammatory gene <I>IL-1</I>α was highly up-regulated in C-CD31. Patients with unstable angina (UA) had significantly more CD31<SUP>+</SUP> cells in the PB than healthy control group (<I>P</I> < 0.001). Moreover, there were significant correlations between the number of CD31<SUP>+</SUP> cells and cardiovascular (CV) disease activity (<I>R</I> = 0.318, <I>P</I> = 0.006) and the number of diseased coronaries (<I>R</I> = 0.312, <I>P</I> = 0.005). For the diagnostic category of UA, the area under curve was 0.803 (<I>P</I> < 0.001). In conclusion, C-CD31 have impaired angiogenic potential and the number of circulating CD31<SUP>+</SUP> cells were correlated with CV risk. These findings may contribute to the understanding of the pathogenesis of CAD.</P>
Kim, S.W.,Kim, H.,Cho, H.J.,Lee, J.U.,Levit, R.,Yoon, Y.s. Elsevier Biomedical 2010 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.56 No.7
Objectives: This study aimed to determine if CD31 is a novel marker of a circulating angio-vasculogenic cell population and to establish the cells' therapeutic effects on experimental ischemia. Background: Emerging evidence suggested that therapeutic mechanisms underlying various bone marrow-derived cells are due to paracrine effects. Furthermore, the vasculogenic potential of these cells is under debate. CD31 is a well-known marker for endothelial cells but is also expressed in a fraction of peripheral blood (PB) mononuclear cells. Methods: CD31<SUP>+</SUP>cells were isolated from human PB by magnetic-activated cell sorting. The gene expression profile was examined by deoxyribonucleic acid microarray and real-time reverse transcriptase polymerase chain reaction. Various in vitro endothelial differentiation or vasculogenic assays were conducted. Finally, cells were directly implanted into a mouse hind limb ischemia model to test angiogenic-vasculogenic and therapeutic effects. Results: Fluorescent-activated cell sorter analysis revealed that PB-CD31<SUP>+</SUP>cells exhibited endothelial and hematopoietic stem/progenitor markers. CD31<SUP>+</SUP>cells had higher levels of expression of proangiogenic genes on microarray and real-time reverse transcriptase polymerase chain reaction and generated higher numbers of endothelial progenitor cells than CD31<SUP>-</SUP>cells did. CD31<SUP>+</SUP>cells spontaneously formed vascular tubelike structures and exhibited an endothelial cell phenotype in vitro. In a hind limb ischemia model, CD31<SUP>+</SUP>cell transplantation augmented blood perfusion and prevented limb loss. Both angiogenic cytokines and capillary density were increased, suggesting CD31<SUP>+</SUP>cells augmented neovascularization. Conclusions: CD31 is a novel marker that designates circulating angiogenic and vasculogenic cells. These cells are easily isolated from human PB and thus are a novel candidate for treatment of ischemic cardiovascular disease.
진공증착법에 의한 p-Zn0.31Cd0.69Se 박막의 성장 및 열처리 온도에 따른 물리적 성질
한동헌,윤은정,이정주,강광용 한국물리학회 2015 새물리 Vol.65 No.1
Zn0.31Cd0.69Se films were prepared on indium-tin-oxide(ITO)-coated glass substrates by using thermal evaporation. X-ray diffraction spectra showed that the Zn0.31Cd0.69Se films had a mixed ZnSe and CdSe zincblende structure with a lattice constant a = 6.077 °A and that the crystals were preferentially grown with a (111) orientation. The optical energy band gap, measured at room temperature, of the as-deposited Zn0.31Cd0.69Se film was 2.05 eV and decreased to about 2.04 eV ~ 1.96 eV upon annealing in a vacuum electric furnace at temperatures from 200 ℃ to 500 ℃. The dynamical behavior of the charge carriers in the Zn0.31Cd0.69Se film was investigated by using photoinduced discharge characteristics (PIDC) techniques. 진공증착 법으로 ITO (indium-tin-oxide) 기판 위에 Zn0.31Cd0.69Se 박막을 제작하였다. X-선 회절 분석에 의하여 박막의 살창상수는 a = 6.077 °A으로 ZnSe와 CdSe의 섬아연광 구조를 하고 있었으며, 그 성장방향은 (111) 방향으로 우선 성장됨을 알 수 있었다. 증착된 Zn0.31Cd0.69Se 박막에 대하여 실온에서 측정한 광학적인 에너지 띠 간격은 2.05 eV이었고, 열처리 온도를 증가함에 따라 감소하였으며, 200 ℃ to 500 ℃로 열처리한 박막의 광학적 에너지 띠 간격은 2.04 eV ~ 1.96 eV이었다. Zn0.31Cd0.69Se 박막 내의 전하운반자들의 동역학적 거동을 광유기 방전 특성 (PIDC: photoinduced discharge characteristics) 방법으로 조사하였다.
대장직장암에서 CD105 (Endoglin)와 범내피세포 표지자 (CD34, CD31, Factor VIII) 발현에 의한 미세혈관밀도
김진수 외 중앙대학교 의과대학 의학연구소 2007 中央醫大誌 Vol.32 No.1/2
CD105 (endoglin) has been shown to be a more useful marker to identify proliferating endothelium involved in tumor angiogenesis than panendothelial markers such as CD34, CD31, and factor VIII. We investigated CD105 and panenthothelial markers expression as possible prognostic markers in colorectal cancer. Paraffin embedded tissue from 72 patients were immunostained for CD105, CD34, CD31, and Factor VIII. Positively stained microvessels were counted in densely vascular foci (hot spot) at ×200 field in each specimen. The microvessel density (MVD) by CD105 showed a statistically significant correlation with tumor emboli, T-stage, nodal metastasis, and stage. On MVD by panendothelial markers, a statistically significant correlation showed in tumor emboli and nodal metastasis in MVD by CD34, and histologic differentiation, tumor emboli, and nodal metastasis in MVD by Factor VIII. The MVD by CD105 may be correlated with invasiveness in colorectal cancer.
( Xinqiang Zhu ),( Gang Zhou ),( Peng Ni ),( Xuetong Jiang ),( Hailong Huang ),( Jianqiang Wu ),( Xiaohong Shi ),( Xiaoling Jiang ),( Jianing Liu ) 대한소화기학회 2021 Gut and Liver Vol.15 No.2
Background/Aims: Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. Methods: The expression profiles of CD31 and D2-40 were analyzed in CRC patients with or without CRPM and in CRC cell lines with increasing metastatic potential. Overexpression and short hairpin RNA knockdown assays were performed in CRC cells, and the effects of these alterations on epithelial-mesenchymal transition (EMT) in vitro, growth of xenograft tumors in vivo, and peritoneal metastasis potential in a mouse model of CRPM were examined. Results: The expressions of CD31 and D2-40 were upregulated in CRC tumor tissues and was elevated further in tumor tissues from patients with CRPM. CD31 and D2-40 expression levels exhibited increasing trends parallel to the EMT potential of CRC cells. CD31 and D2-40 are essential for CRC cell EMT in vitro as well as for xenograft tumor growth and peritoneal metastasis in vivo. Conclusions: CD31 and D2-40 contribute to CRPM by promoting EMT and may serve as prognostic markers and therapeutic targets for CRC, particularly in patients with peritoneal metastasis. (Gut Liver 2021;15:273-283)
대장암에서 CD31과 D2-40 발현에 의한 혈관성 및 림프관성 미세혈관 밀도 측정
윤상인(Sang In Youn),김범규(Beom Gyu Kim),차성재(Seong Jae Cha),박성준(Sung Jun Park),장인택(In Taek Chang),박성일(Sung Il Park),이태진(Tae Jin Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.4
Purpose: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and D2-40 expressions as prognostic factors in colon cancer. Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer. Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003). Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer.
대장직장암에서 수술 전 생검 조직의 범내피세포와 림프관 표지자 발현의 의의
한규성(Gue Sung Han),김범규(Beom Gyu Kim),차성재(Seong Jae Cha),장인택(In Taek Chang),이태진(Tae Jin Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.2
Purpose: Panendothelial markers such as factor Ⅷ, CD34, CD31, CD105 (endoglin) and D2-40 are useful to identify proliferating endothelium that is related to tumor invasion. This study was designed to identify the correlation between the expressions of panendothelial and lymphatic vessel markers in preoperative biopsy specimens and the clinicopathologic factors. Methods: Preoperative biopsy specimens from 72 patients were immunostained for CD105, CD34, CD31, Factor Ⅷ and D2-40. The microvessel and lympathic vessel densities (MVD and LVD) were counted in dense vascular foci (hot spots) on a ×200 field in each specimen. The correlation between these factors and the clinicopathologic parameters were analyzed. Results: The MVD by CD105 showed statistically significant correlation with tumor emboli, the T-stage, nodal metastasis and the stage, and the MVD by CD34 had statistically significant correlation with tumor emboli, nodal metastasis and the stage. The lympathic vessel density (LVD) by D2-40 showed a statistically significant correlation with tumor emboli, the T-stage and nodal metastasis. Conclusion: The MVD by CD105 and the LVD by D2-40 in preoperative biopsy specimens of colorectal cancers may be useful markers for the prediction of invasiveness.