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Purpose: Panendothelial markers such as factor Ⅷ, CD34, CD31, CD105 (endoglin) and D2-40 are useful to identify proliferating endothelium that is related to tumor invasion. This study was designed to identify the correlation between the expressions of panendothelial and lymphatic vessel markers in preoperative biopsy specimens and the clinicopathologic factors. Methods: Preoperative biopsy specimens from 72 patients were immunostained for CD105, CD34, CD31, Factor Ⅷ and D2-40. The microvessel and lympathic vessel densities (MVD and LVD) were counted in dense vascular foci (hot spots) on a ×200 field in each specimen. The correlation between these factors and the clinicopathologic parameters were analyzed. Results: The MVD by CD105 showed statistically significant correlation with tumor emboli, the T-stage, nodal metastasis and the stage, and the MVD by CD34 had statistically significant correlation with tumor emboli, nodal metastasis and the stage. The lympathic vessel density (LVD) by D2-40 showed a statistically significant correlation with tumor emboli, the T-stage and nodal metastasis. Conclusion: The MVD by CD105 and the LVD by D2-40 in preoperative biopsy specimens of colorectal cancers may be useful markers for the prediction of invasiveness.
Delayed symptom presented diaphragmatic hernia patient is reported, who was suffered from Traffic accident at 20 years ago. The right pleural cavity was filled with greater omentum, stomach mid portion, duodenum first portion, right liver & left medial segment of liver and a portion of transverse colon, which were reduced safely into the peritoneal cavity, and the large right diaphragmatic aperture was repaired with Marlex mesh.