감마나이프 방사선수술 치료계획의 평가에 필수불가결한 지표들의 분석

허병익(Beong Ik Hur) 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.5

감마나이프 방사선수술(GKRS)의 핵심 목표는 병변에 처방 등선량 표면의 일치성을 최대화하고 병변 주변부 정상 조직의 방사선 효과를 최소화하는 것이다. 일치성 지표, 적용 범위, 선택성, 빔-온 시간, 기울기 지표(GI), 일치성/기울기 지표(CGI)와 같은 치료계획의 질과 관련된 다양한 종류의 지표들이 존재한다. 이 가운데 최상의 치료계획 평가 도구로서 우리는 일치성 지표, GI 및 CGI를 반드시 확인해야 한다. 특히 건강한 정상조직의 합병증과 관련된 GI 및 CGI는 일치성 지표보다 더욱더 중요하게 여겨진다. 그래서 저자는 치료계획 시스템 렉셀 감마플랜(LGP) 및 검증 방법 가변 타원체 모형화 기술(VEMT)을 사용하여 광범위하게 적용되고 있는 GI 뿐 만 아니고 CGI, 새로이 정의된 일치성/기울기 지표를 계산하고 통계적으로 분석하였다. 본 연구는 GKRS로 치료받은 두개 내 병변을 가진 10명의 환자를 대상으로 하였다. 저자는 단지 네 인자들: 처방 등선량 체적, 최대 선량의 30% 이상 체적, 병변 체적, 처방 등선량 절반의 체적 만을 가지고 LGP와 VEMT를 이용해서 지표를 계산했다. 모든 데이터는 두 가지 다른 측정기법을 비교하는데 사용되는 통계적 방법인 Paired t-test로 분석되었다. 10명의 사례에서 LGP와 VEMT 사이에 GI의 통계적 유의성은 관찰되지 않았다. GI의 차이는 -0.14에서 0.01 사이의 범위였다. LGP와 VEMT의 두 가지 방법으로 계산된 새롭게 정의된 기울기 지표 또한 통계적으로 유의하지 않았다. 저자는 LGP와 VEMT 사이에 처방 등선량 체적에 대한 통계적 차이를 발견하지 못했다. 최상의 치료계획을 결정하기 위한 또 하나의 평가 지표인 CGI도 통계적으로 유의하지 않았고 CGI의 차이는 –4에서 3까지 이었다. 똑같이 GKRS에 적합하게 새로이 정의된 일치성/기울기 지표도 통계 분석을 통해서 치료계획 평가를 위한 훌륭한 측정 기준으로 여겨진다. 통계분석 결과 VEMT는 GKRS에서 최상의 치료계획을 평가하기 위해 GI, 새로운 기울기 지표, CGI 및 새로운 CGI를 고려했을 때 LGP와 우수한 일치를 보였다. 저자는 LGP 및 VEMT를 통해서 빠르고 쉬운 평가 도구의 적용성으로 인하여 GI 뿐 만 아니라 CGI와 새로이 정의된 CGI가 널리 사용되기를 기대한다. The central goal of Gamma Knife radiosurgery(GKRS) is to maximize the conformity of the prescription isodose surface, and to minimize the radiation effect of the normal tissue surrounding the target volume. There are the various kinds of indices related with the quality of treatment plans such as conformity index, coverage, selectivity, beam-on time, gradient index(GI), and conformity/gradient index(CGI). As the best treatment plan evaluation tool, we must check by all means conformity index, GI, and CGI among them. Specially, GI and CGI related with complication of healthy normal tissue is more indispensible than conformity index. Then author calculated and statistically analysed CGI, the newly defined conformity/gradient index as well as GI being applied widely using the treatment planning system Leksell GammaPlan(LGP) and the verification method Variable Ellipsoid Modeling Technique(VEMT). In the study 10 patients with intracranial lesion treated by GKRS were included. Author computed the indices from LGP and VEMT requiring only four parameters: the prescribed isodose volume, the volume with dose > 30%, the target volume, and the volume of half the prescription isodose. All data were analyzed by paired t-test, which is statistical method used to compare two different measurement techniques. No statistical significance in GI at 10 cases was observed between LGP and VEMT. Differences in GI ranged from –0.14 to 0.01. The newly defined gradient index calculated by two methods LGP and VEMT was not statistically significant either. Author did not find out the statistical difference for the prescribed isodose volume between LGP and VEMT. CGI as the evaluation index for determining the best treatment plan is not significant statistically also. Differences in CGI ranged from –4 to 3. Similarly newly defined Conformity/Gradient index for GKRS was also estimated as the metric for the evaluation of the treatment plans through statistical analysis. Statistical analyses demonstrated that VEMT was in excellent agreement with LGP when considering GI, new gradient index, CGI, and new CGI for evaluating the best plans of GKRS. Due to the application of the fast and easy evaluation tool through LGP and VEMT author hopes CGI and newly defined CGI as well as gradient indices will be widely used.

연약지반의 상대적 침하 거동 분석

곽영준,한희수 대한지질공학회 2023 지질공학 Vol.33 No.2

Instruments are installed in soft ground improvement projects to manage economic and safe construction. When analyzing data, the amount of settlement data over time can be used to understand the overall ground settlement behavior, but it is difficult to analyze the interrelatedness between measurement points. Therefore, to analyze the relative compressive settlement behavior between measurement points, the settlement amount and velocity were processed and defined as the mean settlement difference index (  ) and the slope difference index ( ). Plotted in the mean settlement difference index - slope difference index (  -   ) coordinate system. As a result of the analysis of the relative compaction subsidence behavior between the measuring points, the relationship between the measuring points in the average subsidence difference index - slope difference index coordinate system moved to area 1 as the compaction was completed. By continuously plotting the movement path of the observation point in the corresponding coordinate system, the relative settlement behavior between the measurement points was analyzed, and it was possible to check whether the settlement behavior of the two measurement points was stable or unstable depending on the direction of the path. 연약지반 개량공사 시 계측기를 설치하여 경제적이고 안전한 시공이 이루어지도록 관리한다. 데이터 분석 시 시간에 따른 침하량 데이터를 활용하여 전체적인 지반 침하 거동을 파악할 수 있지만, 계측지점 간상호관련성을 분석하기에는 어려움이 있다. 따라서 계측지점 간의 상대적인 압밀침하 거동을 분석하기위하여, 침하량과 속도를 가공하여 평균 침하량 차이 지수와 기울기 차이 지수로 정의한 후, 평균 침하량차이 지수 - 기울기 차이 지수(  -   ) 좌표계에 도시하였다. 계측지점 간 상대적인 압밀침하 거동 분석결과 평균 침하량 차이 지수 - 기울기 차이 지수 좌표계에 나타낸 계측지점 간의 관계가 압밀이 완료됨에 따라 영역 1로 이동하였다. 관측점의 이동 경로를 해당 좌표계에 연속적으로 나타냄으로써 계측지점 간의 상대적인 압밀침하 거동관계를 분석하였으며, 이동경로 방향에 따라 두 계측지점의 압밀침하거동관계가 안정한 상태인지 불안정한 상태인지 확인할 수 있었다.

Evaluation of surface infiltration rate in Hancheon reservoir, Jeju Island, Korea

서정아(Jungah Seo),김용철(Yongcheol Kim),문덕철(Deokcheol Moon),고기원(Gi Won Koh),김용제(Yongje Kim) 대한지질학회 2014 지질학회지 Vol.50 No.3

영상처리 기법을 이용한 입경 측정시 배경 명도가 측정 정밀도에 미치는 영향

고광웅,이상용,Koh, Kwang-Uoong,Lee, Sang-Yong 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.4

In this study, experiments have been performed to examine the effects of background gray-level on the depth-of-field and on the in-focus criteria. The normalized value of contrast(VC) and the gradient indicator(GI) were used as the in-focus criteria for the small and the large size-ranges of particles, respectively. The slightly larger number of pixels were detected with the brighter background. The maximum of the normalized value of contrast(VCmax) is decreased with the brighter background and its deviation from that with the background gray-level of 160 turned out to be about $pm$15% when the background gray-level changes from 100 to 200. However, the maximum gradient indicator(GImax) changes with the background gray-level within only $pm$5%. The depth-of-field for the VC-applicable particle-size range is largely dependent on the background gray-level. On the other hand, the depth-of-field for the GI-applicable particle-size range changes only slightly with the background gray-level. To keep the normalized standard deviation of the particle size within 0.1, the background gray-level should be set 160$pm$20 for both the VC-applicable and GI-applicable ranges which cover the particle size between $10{\mu}m$ and $300{\mu}m$.

입경측정을 위한 영상처리기법에서 입자 초점면 존재 판단 기준의 설정

고광웅,김주연,이상용,Koh, Kwang Uoong,Kim, Joo Youn,Lee, Sang Yong 대한기계학회 1999 大韓機械學會論文集B Vol.23 No.3

In the present image processing technique, the concept of the gradient indicator(GI) has been introduced to find out the depth-of-field in sizing large particles ranging from $30{\mu}m$ to $30{\mu}m$ where using of the concept of the normalized contrast value(VC) is not appropriate. The gradient indicator is defined as the ratio of the local value to the maximum possible value of the gray-level gradient in an image frame. The gradient indicator decreases with the increases of the particle size and the distance from the exact focal plane. A particle is considered to be in focus when the value of the gradient indicator at its image boundary stays above a critical value. This critical gradient indicator($GI_{critical}$) is defined as the maximum gradient indicator($GI_{max}$) subtracted by a constant ${\Delta}GI$ which is to account for the particle-size effect. In the present ca.so, the value of ${\Delta}GI$ was set to 0.28 to keep the standard deviation of the measured particles mostly within 0.1. It was also confirmed that, to find the depth-of-field for small particles(${\leq}30{\mu}m$) with the same measurement accuracy, tho concept of the critical normalized contrast($VC_{critical}$) is applicable with 85% of the maximum normalized contrast value($VC_{max}$). Finally, the depth-of-field was checked for the size range between $10{\mu}m$ and $300{\mu}m$ when the both in-focus criteria ($GI_{critical}$ and $VC_{critical}$) were adopted. The change of the depth-of-field with the particle size shows good linearity in both the VC-applicable and the GI-applicable ranges with a reasonable accuracy.

Changes in Regional and Global Sagittal Parameters of the Spine during Growth in the Pediatric Population

이춘성,황창주,조재환,이동호,양재준,박세한 대한척추외과학회 2022 대한척추외과학회지 Vol.29 No.3

Study Design: Cross-sectional study. Objectives: To demonstrate normative values for various parameters of spinal sagittal global balance in the pediatric population and elucidate whether these parameters change during growth. Summary of Literature Review: While sagittal parameters for adults have been thoroughly evaluated, relatively few studies have reported normal values and changing trends of sagittal parameters in the pediatric population. Materials and Methods: A total of 200 patients aged 5–20 years were evaluated. Cervical lordosis, thoracic kyphosis, lumbar lordosis, pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), pelvic incidence–lumbar lordosis (PI-LL), C2–C7 sagittal vertical axis (SVA), C7 SVA, T1 pelvic angle (T1PA), and the spinosacral angle (SSA) were assessed. Results: Significant positive correlations were found between age and PI (r=0.297, p<0.001), SS (r=0.184, p=0.009), and PT (r=0.203, p=0.004). Among the global sagittal parameters, T1PA (r=0.345, p<0.001) demonstrated a significant association with age, whereas C7 SVA (r=−0.053, p=0.464) and SSA (r=−0.029, p=0.194) were not significantly associated. Furthermore, PI-LL was significantly smaller in the ≥12-year age group than that in the ≤11-year age group (p=0.037). Conclusions: In conclusion, PI, PT, and SS increase during growth owing to the increasing size of the pelvis. T1PA accordingly increases with an increase in pelvic parameters, whereas no other global sagittal parameters, such as C7 SVA or SSA, change during childhood. The changing trends and normative values of each parameter demonstrated in the present study should be considered when planning long-level fusion operations for pediatric patients.