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Ferná,ndez-Moreira, Vanesa,Song, Bo,Sivagnanam, Venkataragavalu,Chauvin, Anne-Sophie,Vandevyver, Caroline D. B.,Gijs, Martin,Hemmilä,, Ilkka,Lehr, Hans-Anton,Bü,nzli, Jean-Claude G. Royal Society of Chemistry 2010 The Analyst Vol.135 No.1
<P>The lanthanide binuclear helicate [Eu<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] is coupled to avidin to yield a luminescent bioconjugate <B>EuB1</B> (<I>Q</I> = 9.3%, <I>τ</I>(<SUP>5</SUP>D<SUB>0</SUB>) = 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows one to determine a luminophore/protein ratio equal to 3.2. Bio-affinity assays involving the recognition of a mucin-like protein expressed on human breast cancer MCF-7 cells by a biotinylated monoclonal antibody 5D10 to which <B>EuB1</B> is attached <I>via</I> avidin-biotin coupling demonstrate that (i) avidin activity is little affected by the coupling reaction and (ii) detection limits obtained by time-resolved (TR) luminescence with <B>EuB1</B> and a commercial Eu-avidin conjugate are one order of magnitude lower than those of an organic conjugate (FITC-streptavidin). In the second part of the paper, conditions for growing MCF-7 cells in 100–200 µm wide microchannels engraved in PDMS are established; we demonstrate that <B>EuB1</B> can be applied as effectively on this lab-on-a-chip device for the detection of tumour-associated antigens as on MCF-7 cells grown in normal culture vials. In order to exploit the versatility of the ligand used for self-assembling [Ln<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] helicates, which sensitizes the luminescence of both Eu<SUP><SMALL>III</SMALL></SUP> and Tb<SUP><SMALL>III</SMALL></SUP> ions, a dual on-chip assay is proposed in which estrogen receptors (ERs) and human epidermal growth factor receptors (Her2/<I>neu</I>) can be simultaneously detected on human breast cancer tissue sections. The Ln helicates are coupled to two secondary antibodies: ERs are visualized by red-emitting <B>EuB4</B> using goat anti-mouse IgG and Her2/<I>neu</I> receptors by green-emitting <B>TbB5</B> using goat anti-rabbit IgG. The fact that the assay is more than 6 times faster and requires 5 times less reactants than conventional immunohistochemical assays provides essential advantages over conventional immunohistochemistry for future clinical biomarker detection.</P> <P>Graphic Abstract</P><P>Lanthanide luminescent bioprobes (LLBs) combined with microfluidics and lab-on-a-chip technology lead to fast dual assays of cancerous tissue biomarkers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922124g'> </P>
Periá,ñ,ez, R.,Bezhenar, R.,Brovchenko, I.,Duffa, C.,Iosjpe, M.,Jung, K.T.,Kobayashi, T.,Lamego, F.,Maderich, V.,Min, B.I.,Nies, H.,Osvath, I.,Outola, I.,Psaltaki, M.,Suh, K.S.,de With, G. Elsevier 2016 Science of the Total Environment Vol.569 No.-
<P><B>Abstract</B></P> <P>State-of-the art dispersion models were applied to simulate <SUP>137</SUP>Cs dispersion from Chernobyl nuclear power plant disaster fallout in the Baltic Sea and from Fukushima Daiichi nuclear plant releases in the Pacific Ocean after the 2011 tsunami. Models were of different nature, from box to full three-dimensional models, and included water/sediment interactions. Agreement between models was very good in the Baltic. In the case of Fukushima, results from models could be considered to be in acceptable agreement only after a model harmonization process consisting of using exactly the same forcing (water circulation and parameters) in all models. It was found that the dynamics of the considered system (magnitude and variability of currents) was essential in obtaining a good agreement between models. The difficulties in developing operative models for decision-making support in these dynamic environments were highlighted. Three stages which should be considered after an emergency, each of them requiring specific modelling approaches, have been defined. They are the emergency, the post-emergency and the long-term phases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Models applied to simulate <SUP>137</SUP>Cs marine dispersion after nuclear accidents. </LI> <LI> Not good agreement initially found in highly dynamic environments. </LI> <LI> Difficulties in developing models for decision making after emergencies highlighted. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Periá,ñ,ez, R.,Bezhenar, R.,Brovchenko, I.,Jung, K.T.,Kamidara, Y.,Kim, K.O.,Kobayashi, T.,Liptak, L.,Maderich, V.,Min, B.I.,Suh, K.S. Elsevier Applied Science Publishers 2019 JOURNAL OF ENVIRONMENTAL RADIOACTIVITY Vol.198 No.-
<P><B>Abstract</B></P> <P>A number of marine radionuclide dispersion models (both Eulerian and Lagrangian) were applied to simulate <SUP>137</SUP>Cs releases from Fukushima Daiichi nuclear power plant accident in 2011 over the Pacific at oceanic scale. Simulations extended over two years and both direct releases into the ocean and deposition of atmospheric releases on the ocean surface were considered. Dispersion models included an embedded biological uptake model (BUM). Three types of BUMs were used: equilibrium, dynamic and allometric. Model results were compared with <SUP>137</SUP>Cs measurements in water (surface, intermediate and deep layers), sediment and biota (zooplankton, non-piscivorous and piscivorous fish). A reasonable agreement in model/model and model/data comparisons was obtained.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Marine dispersion models applied to Fukushima releases in the Pacific Ocean. </LI> <LI> Biological uptake model included within physical dispersion models. </LI> <LI> Model results compared with measurements in water, sediments and biota. </LI> <LI> Generally good agreement in model/model and model/data comparisons. </LI> </UL> </P>
Adamová,, D.,Aggarwal, M.M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahmad, N.,Ahn, S.U.,Aiola, S.,Akindinov, A.,Alam, S.N.,Albuquerque, D.S.D.,Aleksandrov, D.,Alessandro, B.,Alex North-Holland Pub. Co 2018 Physics letters. Section B Vol.776 No.-
<P><B>Abstract</B></P> <P>We report measurements of the inclusive J/<I>ψ</I> yield and average transverse momentum as a function of charged-particle pseudorapidity density d <SUB> N ch </SUB> / d η in p–Pb collisions at <SUB> s NN </SUB> = 5.02 TeV with ALICE at the LHC. The observables are normalised to their corresponding averages in non-single diffractive events. An increase of the normalised J/<I>ψ</I> yield with normalised d <SUB> N ch </SUB> / d η , measured at mid-rapidity, is observed at mid-rapidity and backward rapidity. At forward rapidity, a saturation of the relative yield is observed for high charged-particle multiplicities. The normalised average transverse momentum at forward and backward rapidities increases with multiplicity at low multiplicities and saturates beyond moderate multiplicities. In addition, the forward-to-backward nuclear modification factor ratio is also reported, showing an increasing suppression of J/<I>ψ</I> production at forward rapidity with respect to backward rapidity for increasing charged-particle multiplicity.</P>
High-energy neutrino follow-up search of gravitational wave event GW150914 with ANTARES and IceCube
Adriá,n-Martí,nez, S.,Albert, A.,André,, M.,Anghinolfi, M.,Anton, G.,Ardid, M.,Aubert, J.-J.,Avgitas, T.,Baret, B.,Barrios-Martí,, J.,Basa, S.,Bertin, V.,Biagi, S.,Bormuth, R. American Physical Society 2016 Physical Review D Vol.93 No.12
<P>We present the high-energy-neutrino follow-up observations of the first gravitational wave transient GW150914 observed by the Advanced LIGO detectors on September 14, 2015. We search for coincident neutrino candidates within the data recorded by the IceCube and ANTARES neutrino detectors. A possible joint detection could be used in targeted electromagnetic follow-up observations, given the significantly better angular resolution of neutrino events compared to gravitational waves. We find no neutrino candidates in both temporal and spatial coincidence with the gravitational wave event. Within +/- 500 s of the gravitational wave event, the number of neutrino candidates detected by IceCube and ANTARES were three and zero, respectively. This is consistent with the expected atmospheric background, and none of the neutrino candidates were directionally coincident with GW150914. We use this nondetection to constrain neutrino emission from the gravitational-wave event.</P>
Forecasting phenology under global warming.
Ibá,ñ,ez, Iné,s,Primack, Richard B,Miller-Rushing, Abraham J,Ellwood, Elizabeth,Higuchi, Hiroyoshi,Lee, Sang Don,Kobori, Hiromi,Silander, John A Royal Society of London 2010 Philosophical transactions. Biological sciences Vol.365 No.1555
<P>As a consequence of warming temperatures around the world, spring and autumn phenologies have been shifting, with corresponding changes in the length of the growing season. Our understanding of the spatial and interspecific variation of these changes, however, is limited. Not all species are responding similarly, and there is significant spatial variation in responses even within species. This spatial and interspecific variation complicates efforts to predict phenological responses to ongoing climate change, but must be incorporated in order to build reliable forecasts. Here, we use a long-term dataset (1953-2005) of plant phenological events in spring (flowering and leaf out) and autumn (leaf colouring and leaf fall) throughout Japan and South Korea to build forecasts that account for these sources of variability. Specifically, we used hierarchical models to incorporate the spatial variability in phenological responses to temperature to then forecast species' overall and site-specific responses to global warming. We found that for most species, spring phenology is advancing and autumn phenology is getting later, with the timing of events changing more quickly in autumn compared with the spring. Temporal trends and phenological responses to temperature in East Asia contrasted with results from comparable studies in Europe, where spring events are changing more rapidly than are autumn events. Our results emphasize the need to study multiple species at many sites to understand and forecast regional changes in phenology.</P>
Ferná,ndez, Ximena,Gim, Hansung B.,Gorkom, J. H. van,Yun, Min S.,Momjian, Emmanuel,Popping, Attila,Chomiuk, Laura,Hess, Kelley M.,Hunt, Lucas,Kreckel, Kathryn,Lucero, Danielle,Maddox, Natasha,Oo American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.824 No.1
<P>Our current understanding of galaxy evolution still has many uncertainties associated with the details of the accretion, processing, and removal of gas across cosmic time. The next generation of radio telescopes will image the neutral hydrogen (H I) in galaxies over large volumes at high redshifts, which will provide key insights into these processes. We are conducting the COSMOS H I Large Extragalactic Survey (CHILES) with the Karl G. Jansky Very Large Array, which is the first survey to simultaneously observe H I from z = 0 to z similar to 0.5. Here, we report the highest redshift H I 21 cm detection in emission to date of the luminous infrared galaxy COSMOS J100054.83+023126.2 at z = 0.376 with the first 178 hr of CHILES data. The total H I mass is (2.9 +/- 1.0) x 10(10) M-circle dot and the spatial distribution is asymmetric and extends beyond the galaxy. While optically the galaxy looks undisturbed, the H I distribution suggests an interaction with a candidate companion. In addition, we present follow-up Large Millimeter Telescope CO observations that show it is rich in molecular hydrogen, with a range of possible masses of (1.8-9.9) x 10(10) M-circle dot. This is the first study of the H I and CO in emission for a single galaxy beyond z similar to 0.2.</P>
Renner, Ká,roly,Henning, Sven,Mó,czó,, Já,nos,Yang, Min Soo,Choi, Hyoung Jin,Puká,nszky, Bé,la Wiley Subscription Services, Inc., A Wiley Company 2007 Polymer engineering and science Vol.47 No.8
<P>Polyamide/organophilic montmorillonite nanocomposites were prepared from two silicates with different organophilization resulting in strong and weak matrix/silicate adhesion, respectively; uncoated sodium montmorillonite was used as reference. The silicate content of the composites changed between 0 and 10 vol% in seven steps. Composite structure was characterized by X-ray diffraction and electron microscopy. Micromechanical deformation processes were followed by acoustic emission and volume strain measurements. The structure of the composites is more complicated than usually claimed; they contain individual silicate platelets, tactoids with different degree of intercalation, and larger particles. Elastic deformation and shear yielding dominates during the elongation of the specimens. The matrix polymer and the composites deform according to different mechanisms. Sound is emitted by cavitation in the former, while sound emitting processes are related tactoids and nonexfoliated particles in the composites. Acoustic events are generated mainly by the fracture of the particles. Matrix/silicate adhesion seems to be strong, debonding rarely takes place, and volume increase is initiated primarily by particle failure. The type and amount of the surfactant used for organophilization plays an important role in the determination of deformation processes and properties, since it influences both matrix/filler interaction and the inherent strength of the particles. POLYM. ENG. SCI., 47:1235–1245, 2007. © 2007 Society of Plastics Engineers</P>