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Ferná,ndez-Moreira, Vanesa,Song, Bo,Sivagnanam, Venkataragavalu,Chauvin, Anne-Sophie,Vandevyver, Caroline D. B.,Gijs, Martin,Hemmilä,, Ilkka,Lehr, Hans-Anton,Bü,nzli, Jean-Claude G. Royal Society of Chemistry 2010 The Analyst Vol.135 No.1
<P>The lanthanide binuclear helicate [Eu<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] is coupled to avidin to yield a luminescent bioconjugate <B>EuB1</B> (<I>Q</I> = 9.3%, <I>τ</I>(<SUP>5</SUP>D<SUB>0</SUB>) = 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows one to determine a luminophore/protein ratio equal to 3.2. Bio-affinity assays involving the recognition of a mucin-like protein expressed on human breast cancer MCF-7 cells by a biotinylated monoclonal antibody 5D10 to which <B>EuB1</B> is attached <I>via</I> avidin-biotin coupling demonstrate that (i) avidin activity is little affected by the coupling reaction and (ii) detection limits obtained by time-resolved (TR) luminescence with <B>EuB1</B> and a commercial Eu-avidin conjugate are one order of magnitude lower than those of an organic conjugate (FITC-streptavidin). In the second part of the paper, conditions for growing MCF-7 cells in 100–200 µm wide microchannels engraved in PDMS are established; we demonstrate that <B>EuB1</B> can be applied as effectively on this lab-on-a-chip device for the detection of tumour-associated antigens as on MCF-7 cells grown in normal culture vials. In order to exploit the versatility of the ligand used for self-assembling [Ln<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] helicates, which sensitizes the luminescence of both Eu<SUP><SMALL>III</SMALL></SUP> and Tb<SUP><SMALL>III</SMALL></SUP> ions, a dual on-chip assay is proposed in which estrogen receptors (ERs) and human epidermal growth factor receptors (Her2/<I>neu</I>) can be simultaneously detected on human breast cancer tissue sections. The Ln helicates are coupled to two secondary antibodies: ERs are visualized by red-emitting <B>EuB4</B> using goat anti-mouse IgG and Her2/<I>neu</I> receptors by green-emitting <B>TbB5</B> using goat anti-rabbit IgG. The fact that the assay is more than 6 times faster and requires 5 times less reactants than conventional immunohistochemical assays provides essential advantages over conventional immunohistochemistry for future clinical biomarker detection.</P> <P>Graphic Abstract</P><P>Lanthanide luminescent bioprobes (LLBs) combined with microfluidics and lab-on-a-chip technology lead to fast dual assays of cancerous tissue biomarkers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922124g'> </P>
Ferná,ndez, Ximena,Gim, Hansung B.,Gorkom, J. H. van,Yun, Min S.,Momjian, Emmanuel,Popping, Attila,Chomiuk, Laura,Hess, Kelley M.,Hunt, Lucas,Kreckel, Kathryn,Lucero, Danielle,Maddox, Natasha,Oo American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.824 No.1
<P>Our current understanding of galaxy evolution still has many uncertainties associated with the details of the accretion, processing, and removal of gas across cosmic time. The next generation of radio telescopes will image the neutral hydrogen (H I) in galaxies over large volumes at high redshifts, which will provide key insights into these processes. We are conducting the COSMOS H I Large Extragalactic Survey (CHILES) with the Karl G. Jansky Very Large Array, which is the first survey to simultaneously observe H I from z = 0 to z similar to 0.5. Here, we report the highest redshift H I 21 cm detection in emission to date of the luminous infrared galaxy COSMOS J100054.83+023126.2 at z = 0.376 with the first 178 hr of CHILES data. The total H I mass is (2.9 +/- 1.0) x 10(10) M-circle dot and the spatial distribution is asymmetric and extends beyond the galaxy. While optically the galaxy looks undisturbed, the H I distribution suggests an interaction with a candidate companion. In addition, we present follow-up Large Millimeter Telescope CO observations that show it is rich in molecular hydrogen, with a range of possible masses of (1.8-9.9) x 10(10) M-circle dot. This is the first study of the H I and CO in emission for a single galaxy beyond z similar to 0.2.</P>
Ferná,ndez-Alvar, E.,Allende Prieto, C.,Schlesinger, K. J.,Beers, T. C.,Robin, A. C.,Schneider, D. P.,Lee, Y. S.,Bizyaev, D.,Ebelke, G.,Malanushenko, E.,Malanushenko, V.,Oravetz, D.,Pan, K.,Simm EDP Sciences 2015 Astronomy and astrophysics Vol.577 No.-
Ferná,ndez-Avilé,s, Francisco,Sanz-Ruiz, Ricardo,Climent, Andreu M.,Badimon, Lina,Bolli, Roberto,Charron, Dominique,Fuster, Valentin,Janssens, Stefan,Kastrup, Jens,Kim, Hyo-Soo,Lü,sche American Heart Foundation 2018 Circulation research Vol.122 No.2
Sastre-Santos, Á,ngela,Parejo, Concepció,n,Martí,n-Gomis, Luis,Ohkubo, Kei,Ferná,ndez-Lá,zaro, Fernando,Fukuzumi, Shunichi Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.5
<P>New C<SUB>60</SUB> dimers 1, 2 and 3 that differ in the distance between the two balls, connected through pleiadene bridges have been synthesized. Different synthetic strategies have been used to prepare C<SUB>60</SUB> dimers 1–3. A diastereoisomeric mixture was obtained for C<SUB>60</SUB> dimer 1, which was separated by column chromatography and characterized by NMR. By CV measurements, no interaction between the two balls was found in the ground state in any type of C<SUB>60</SUB> dimer. By reduction with dimeric benzylnicotinamide [(BNA)<SUB>2</SUB>], a two electron reductant, the interaction between both C<SUB>60</SUB> units has been analyzed using electron paramagnetic resonance (EPR). For C<SUB>60</SUB> dimer 3, upon addition of 1 equivalent (BNA)<SUB>2</SUB> no electronic interaction in the C<SUB>60</SUB>˙<SUP>−</SUP>–C<SUB>60</SUB>˙<SUP>−</SUP> was observed due to the long distance between the C<SUB>60</SUB> balls (20 Å). However, for C<SUB>60</SUB> dimer 1, where the distance between radicals is shorter, 10 Å, the electronic interaction in the di(radical anion), C<SUB>60</SUB>˙<SUP>−</SUP>–C<SUB>60</SUB>˙<SUP>−</SUP> in the presence of 1 equivalent of (BNA)<SUB>2</SUB> was observed by EPR, corresponding to a triplet biradical.</P> <P>Graphic Abstract</P><P>Addition of 1 equivalent of (BNA)<SUB>2</SUB> to dimer 1 yields the C<SUB>60</SUB>˙<SUP>−</SUP>–C<SUB>60</SUB>˙<SUP>−</SUP> triplet biradical where electronic interaction is observed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm02635b'> </P>
<P>A massive envelope and a strong bipolar outflow are the two main structures characterizing the youngest protostellar systems. In order to understand the physical properties of a bipolar outflow and the relationship with those of the envelope, we obtained a mosaic map covering the whole bipolar outflow of the youngest protostellar system L1157 with about 5 '' angular resolution in CO J = 2-1 using the Combined Array for Research in Millimeter-wave Astronomy. By utilizing these observations of the whole bipolar outflow, we estimate its physical properties and show that they are consistent with multiple jets. We also constrain a preferred precession direction. In addition, we observed the central envelope structure with 2' resolution in the lambda = 1.3 and 3 mm continua and various molecular lines: (CO)-O-17, (CO)-O-18, (13)CO3 CS, CN, N2H+, CH3OH, H2O, SO, and SO2. All of the CO isotopes and CS, CN, and N2H+ have been detected and imaged. We marginally detected the features that can be interpreted as a rotating inner envelope in (CO)-O-17 and (CO)-O-18 and as an infalling outer envelope in N2H+. We also estimated the envelope and central protostellar masses and found that the dust-opacity spectral index changes with radius.</P>
Maciejewski, G.,Dimitrov, D.,Ferná,ndez, M.,Sota, A.,Nowak, G.,Ohlert, J.,Nikolov, G.,Bukowiecki, Ł.,Hinse, T. C.,Pallé,, E.,Tingley, B.,Kjurkchieva, D.,Lee, J. W.,Lee, C.-U. EDP Sciences 2016 Astronomy and astrophysics Vol.588 No.-