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Xiaoyan Zhao,Xiaowei Zhang,Hongkai Liu,Haitao Zhu,Yunping Zhu 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.6
The release of bioactive pigments could bepotentially improved by enzyme degradation of plant cellwall polysaccharides. In this study, the objective was toevaluate enzyme type (cellulase and pectinase), pH values,hydrolysis temperature and time on the release of astaxanthinfrom Haematococcus pluvialis (H. pluvialis). Theresults showed that pre-treated H. pluvialis with enzymescould improve the separation yield of astaxanthin. Pectinaserelease rate of astaxanthin from H. pluvialis wassignificantly higher than cellulase (p\0.05), and enzymehydrolysis time was also shorter. The stability study ofastaxanthin oleoresin and microcapsule during storage atdifferent temperature, oxygen and illumination was foundthat the degradation rate of astaxanthin rose with increasingtemperature and illumination time, and the retention inoxygen environment decreased. The stability of astaxanthinmicrocapsules was better than astaxanthin oleoresin.
Efficient Cu(OTf)2-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1H)-ones.
Zhu, Xiaoyan,Kang, So Rang,Xia, Likai,Lee, Jihye,Basavegowda, Nagaraj,Lee, Yong Rok ESCOM Science Publishers 2015 Molecular diversity Vol.19 No.1
<P>An efficient one-pot synthesis of various 2,3-dihydroquinazolin-4(1H)-one derivatives was accomplished using Cu(OTf)2-catalyzed multi-component reactions between isatoic anhydride, ketones, and amines. The method has several significant advantages; mild reaction conditions, easy handling, and efficiency of catalyst.</P>
Evaluation of multi-lane transverse reduction factor under random vehicle load
Xiaoyan Yang,Jinxin Gong,Bohan Xu,Jichao Zhu 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.6
This paper presents the two-, three-, and four-lane transverse reduction factor based on FEA method, probability theory, and the recently actual traffic flow data. A total of 72 composite girder bridges with various spans, number of lanes, loading mode, and bridge type are analyzed with time-varying static load FEA method by ANSYS, and the probability models of vehicle load effects at arbitrary-time point are developed. Based on these probability models, in accordance to the principle of the same exceeding probability, the multi-lane transverse reduction factor of these composite girder bridges and the relationship between the multi-lane transverse reduction factor and the span of bridge are determined. Finally, the multi-lane transverse reduction factor obtained is compared with those from AASHTO LRFD, BS5400, JTG D60 or Eurocode. The results show that the vehicle load effect at arbitrary-time point follows lognormal distribution. The two-, three-, and four-lane transverse reduction factors calculated by using FEA method and probability respectively range between 0.781 and 1.027, 0.616 and 0.795, 0.468 and 0.645. Furthermore, a correlation between the FEA and AASHTO LRFD, BS5400, JTG D60 or Eurocode transverse reduction factors is made for composite girder bridges. For the two-, three-, and four-lane bridge cases, the Eurocode code underestimated the FEA transverse reduction factors by 27%, 25% and 13%, respectively. This underestimation is more pronounced in short-span bridges. The AASHTO LRFD, BS5400 and JTG D60 codes overestimated the FEA transverse reduction factors. The FEA results highlight the importance of considering span length in determining the multi-lane transverse reduction factors when designing two-lane or more composite girder bridges. This paper will assist bridge engineers in quantifying the adjustment factors used in analyzing and designing multi-lane composite girder bridges.
An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
Zhao Qianwen,Shao Tinghui,Zhu Yuwen,Zong Gengjie,Zhang Junjie,Tang Shifan,Lin Yanshan,Ma Hongzhen,Jiang Zhifan,Xu Yong,Wu Xiaoyan,Zhang Tao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Myofibroblasts, characterized by the expression of the matricellular protein periostin (Postn), mediate the profibrogenic response during tissue repair and remodeling. Previous studies have demonstrated that systemic deficiency in myocardin-related transcription factor A (MRTF-A) attenuates renal fibrosis in mice. In the present study, we investigated the myofibroblast-specific role of MRTF-A in renal fibrosis and the underlying mechanism. We report that myofibroblast-specific deletion of MRTF-A, achieved through crossbreeding Mrtfa-flox mice with Postn-CreERT2 mice, led to amelioration of renal fibrosis. RNA-seq identified zinc finger E-Box binding homeobox 1 (Zeb1) as a downstream target of MRTF-A in renal fibroblasts. MRTF-A interacts with TEA domain transcription factor 1 (TEAD1) to bind to the Zeb1 promoter and activate Zeb1 transcription. Zeb1 knockdown retarded the fibroblast–myofibroblast transition (FMyT) in vitro and dampened renal fibrosis in mice. Transcriptomic assays showed that Zeb1 might contribute to FMyT by repressing the transcription of interferon regulatory factor 9 (IRF9). IRF9 knockdown overcame the effect of Zeb1 depletion and promoted FMyT, whereas IRF9 overexpression antagonized TGF-β-induced FMyT. In conclusion, our data unveil a novel MRTF-A–Zeb1–IRF9 axis that can potentially contribute to fibroblast–myofibroblast transition and renal fibrosis. Screening for small-molecule compounds that target this axis may yield therapeutic options for the mollification of renal fibrosis.
Hu Boran,Gao Jin,Xu Shaochen,Zhu Jiangyu,Fan Xuemei,Zhou Xiaoyan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
The metabolites that provide the aroma and flavor to wine are the products of several influences, such as grape cultivar, geographic location and associated environmental features, viticultural practices, and vinification techniques, which are central to production protocols, quality evaluation and development of wine regions. Accordingly, we initiated the requisite studies to investigate the differences in the dry red wine metabolites of different grape varieties. The proton-nuclear magnetic resonance technique (1H-NMR) combined with multivariate statistical analysis was used to investigate the changes of metabolite levels in Cabernet Sauvignon, Merlot and Cabernet Gernischt dry red wines vinified in Changli, Hebei province, China, in 2017. The results showed that the types of metabolites in different varieties of dry red wines were similar, but the content was significantly different. The main contributors to the differences in Cabernet Sauvignon, Merlot and Cabernet Gernischt dry red wines were ethyl acetate, lactic acid, alanine, succinic acid, proline, malic acid, and gallic acid, indicating 1H-NMR method combined with multivariate statistical analysis can distinguish these three types of dry red wines from each other. It provides a benchmark for further comparative study on wine quality and the verification of wine authenticity.