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Shen Zhou,Liping Li,Zhimin An,Hongliang Liu,Guangyu Yang,Pengfei Zhou 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.6
The proportion of large-span tunnels in newly-built highway tunnels is getting higher and higher, revealing the stress release law and deformation characteristics of the tunnel at different excavation steps has important guiding significance for the rational design of the supporting structure parameters. In this paper, a typical section of the Laohushan Tunnel was selected to analyze the stress and deformation response of the large-span tunnel excavated with the semi central diaphragm method (SCDM), with the numerical simulation and field monitoring method. The study found that during the excavation of the large-span tunnel with the SCDM, the stress and deformation response characteristics are different from those ordinary tunnels. Influenced by the settlement of the vault, there was a significant outward expansion tendency, and a high degree of stress concentration in the sidewall. In particular, the supporting structure at the sidewall has a deformation characteristic of expanding outward and then converging inward. In this paper, the in-depth analysis of the stress release law and deformation characteristics of the excavation process of large-span tunnels can provide reference for the excavation and support parameter design of similar projects.
Qikai Xing,Zhimin Zheng,Xiangui Zhou,Xujun Chen,Zejian Guo 한국식물학회 2015 Journal of Plant Biology Vol.58 No.1
Heading date is one of the most important agronomic traits in rice. Here, we analyzed an early flowering mutant ds9 under long day (LD) conditions and found that the early flowering phenotype was controlled by a single dominant gene. Mapping the Ds9 revealed that it was located near SSR marker RM5432 on chromosome 8, close to the known heading date-related DTH8/Ghd8 locus. Sequence analysis indicated that Ds9 was allelic to Ghd8, encoding the OsHAP3H subunit of CCAAT-box binding proteins (HAPs), and transformation of ds9 mutant with the OsHAP3H gene from wild type XS11 plants significantly increased the heading date under LD conditions. Yeast two hybrid and three hybrid assays revealed that the C-terminus of OsHAP3H is required for its interactions with OsHAP2 and OsHAP5. The data demonstrated that OsHAP3H plays a critical role as a repressor of photoperiodic flowering in rice.
Pengyan Zhang,Jianjian He,Wang Huili,Zhimin Zhou 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9
With the acceleration of urbanization, the resources and environment problem has become more and more prominent in Zhongyuan urban agglomerations. Based on evaluation model of resources and environment coordination degree of Pressure-State-Response (PSR), this study adopted the coordination degree analysis methods to calculate and evaluate the resources and environment coordinated development of nine central cities in Zhongyuan Urban Agglomerations from 2006 to 2013. Results showed that: (1) from 2006 to 2013, the statuses of the nine central cities in Zhongyuan Urban Agglomerations were in moderate coordination, elementary coordination, on the verge of imbalance and moderate imbalance, the economic development and the resources and environment statuses were not optimistic; (2) from 2006 to 2009, those cities’ statuses were in moderate imbalance, on the verge of imbalance and elementary coordination, the overall development coordination degree was not high, could not reach the state of coordinated development. Luoyang, Jiaozuo, Xuchang and Luohe’s coordinated development situation was not up to standard, whose status was in moderate imbalance; (3) from 2010 to 2013, the nine cities were on the verge of imbalance, elementary coordination and moderate coordination, coordinated development was improved.
Effects of solvent extraction on the microstructure of bituminous coal-based graphite
Wang Lipeng,Yao Zongxu,Guo Zhimin,Shen Xiaofeng,Li Zhiang,Zhou Zhengqi,Wang Yuling,Yang Jian-Guo 한국탄소학회 2022 Carbon Letters Vol.32 No.3
Coal-based graphite has become the main material of emerging industries. The microstructure of coal-based graphite plays an important role in its applications in many fields. In this paper, the effect of carbon disulfide/N-methyl-2-pyrrolidone solvent mixture extraction on the microstructure of bituminous coal-based graphite was systematically studied through preliminary extraction coupled with high-temperature graphitization. The graphitization degree g (75.65%) of the coal residue-based graphite was significantly higher than that of the raw coal-based graphite. The crystallite size La of the coal residue-based graphite was reduced by 47.06% compared with the raw coal-based graphite. The ID/ IG value of the coal residue-based graphite is smaller than that of the raw coal-based graphite. The specific surface area (16.72 m2/g) and total pore volume (0.0567 m3/g) of the coal residue-based graphite are increased in varying degrees compared with the raw coal-based graphite. This study found a carbon source that can be used to prepare coal-based graphite with high graphitization degree. The results are expected to provide a theoretical basis for further clean and efficient utilization of the coal residue resources.
Ze-Hua Zhao,Feng-Zhi Xin,Yaqian Xue,Zhimin Hu,Yamei Han,Fengguang Ma,Da Zhou,Xiao-Lin Liu,Aoyuan Cui,Zhengshuai Liu,Yuxiao Liu,Jing Gao,Qin Pan,Yu Li,Jian-Gao Fan 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show that indole-3-propionic acid (IPA), a tryptophan metabolite produced by gut bacteria, is a potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. Here, we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. Interestingly, IPA inhibits NF-κB signaling and reduces the levels of proinflammatory cytokines, such as TNFα, IL-1β, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. Moreover, IPA is sufficient to inhibit the expression of fibrogenic and collagen genes and attenuate diet-induced NASH phenotypes. The beneficial effects of IPA on the liver are likely mediated through inhibiting the production of endotoxin in the gut. These findings suggest a protective role of IPA in the control of metabolism and uncover the gut microbiome and liver cross-talk in regulating the intestinal microenvironment and liver pathology via a novel dietary nutrient metabolite. IPA may provide a new therapeutic strategy for treating NASH.