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      • KCI등재

        Knockdown of lncRNA PVT1 Inhibits Vascular Smooth Muscle Cell Apoptosis and Extracellular Matrix Disruption in a Murine Abdominal Aortic Aneurysm Model

        Zhang, Zhidong,Zou, Gangqiang,Chen, Xiaosan,Lu, Wei,Liu, Jianyang,Zhai, Shuiting,Qiao, Gang Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.3

        This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. After injection of PVT1-silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient ($ApoE^{-/-}$) male mice by angiotensin II (Ang II) infusion for four weeks. After Ang II infusion, mouse serum levels of pro-inflammatory cytokines were analysed, and aortic tissues were isolated for histological, RNA, and protein analysis. Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls. Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1. Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model.

      • KCI등재

        Knockdown of lncRNA PVT1 Inhibits Vascular Smooth Muscle Cell Apoptosis and Extracellular Matrix Disruption in a Murine Abdominal Aortic Aneurysm Model

        Zhidong Zhang,Gangqiang Zou,Xiaosan Chen,Wei Lu,Jianyang Liu,Shuiting Zhai,Gang Qiao 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.3

        This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. After injection of PVT1-silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient (ApoE?/?) male mice by angiotensin II (Ang II) infusion for four weeks. After Ang II infusion, mouse serum levels of pro-inflammatory cytokines were analysed, and aortic tissues were isolated for histological, RNA, and protein analysis. Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls. Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1. Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased proinflammatory cytokines. In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model.

      • SCISCIESCOPUS

        Controlled synthesis of Co<sub>2</sub>C nanochains using cobalt laurate as precursor: Structure, growth mechanism and magnetic properties

        Zhang, Yajing,Zhu, Yuan,Wang, Kangjun,Li, Da,Wang, Dongping,Ding, Fu,Meng, Dan,Wang, Xiaolei,Choi, Chuljin,Zhang, Zhidong Elsevier 2018 Journal of magnetism and magnetic materials Vol.456 No.-

        <P><B>Abstract</B></P> <P>Cobalt carbides (Co<SUB>2</SUB>C and Co<SUB>3</SUB>C) nanocomposites exhibit interesting hard magnetic property, controlled synthesis of individual phase facilitates to clarify the magnetism of each, but it is difficult to obtain the single phase. We present a new approach to address this issue via a polyol refluxing process, using cobalt laurate as the precursor. The single phase Co<SUB>2</SUB>C magnetic nanochains self-assembled by nanoparticles are synthesized. The precursor is the key factor for controlling the growth kinetics of the Co<SUB>2</SUB>C nanochains. Cobalt, instead of cobalt carbides, is produced if cobalt chloride, acetate and acetylacetonate replace cobalt laurate as the precursor, respectively. The evolution of the growth process has been studied. In the formation of Co<SUB>2</SUB>C, first fcc-Co produces, then it transforms into Co<SUB>2</SUB>C by carbon diffusion process, and the produced carbon first exists in disordered state and then a small amount of them transforms into graphite. Saturation magnetization (<I>Ms</I>) of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. The decrease of <I>Ms</I> caused by increasing carbon content, and the carbon content are much larger than the stoichiometric ratio value of Co<SUB>2</SUB>C (9.2 wt%). The Co<SUB>2</SUB>C nanochains have mesoporous pore of 3.8 nm and the specific surface area of 48.6 m<SUP>2</SUP> g<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Co<SUB>2</SUB>C magnetic nanochains are synthesized using cobalt laurate as the precursor in TEG. </LI> <LI> The precursor of cobalt laurate is the key factor for controlling the growth kinetics of Co<SUB>2</SUB>C nanochains. </LI> <LI> Ms of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. </LI> <LI> The decrease of Ms is caused by increasing carbon content with increasing reaction time. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We present a new approach to obtain single phase Co<SUB>2</SUB>C nanochains by using cobalt laurate as the precursor.</P> <P>[DISPLAY OMISSION]</P>

      • KCI등재

        Constant Envelope Enhanced FQPSK and Its Performance Analysis

        Zhidong Xie,Gengxin Zhang,Dongming Bian 한국통신학회 2011 Journal of communications and networks Vol.13 No.5

        It’s a challenging task to design a high performance modulation for satellite and space communications due to the limited power and bandwidth resource. Constant envelope modulation is an attractive scheme to be used in such cases for their needlessness of input power back-off about 2∼3 dB for avoidance of nonlinear distortion induced by high power amplifier. The envelope of Feher quadrature phase shift keying (FQPSK) has a least fluctuation of 0.18 dB (quasi constant envelope) and can be further improved. This paper improves FQPSK by defining a set of new waveform functions, which changes FQPSK to be a strictly constant envelope modulation. The performance of the FQPSK adopting new waveform is justified by analysis and simulation. The study results show that the novel FQPSK is immune to the impact of HPA and outperforms conventional FQPSK on bit error rate (BER) performance. The BER performance of this novel modulation is better than that of FQPSK by more than 0.5 dB at least and 2 dB at most.

      • Brep2Seq: a dataset and hierarchical deep learning network for reconstruction and generation of computer-aided design models

        Zhang Shu-Ming,Guan Zhidong,Jiang Hao,Ning Tao,Wang Xiao-Dong,Tan Pingan 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.1

        Three-dimensional (3D) reconstruction is a significant research topic in the field of computer-aided design (CAD), which is used to recover editable CAD models from original shapes, including point clouds, voxels, meshes, and boundary representations (B-rep). Recently, there has been considerable research interest in deep model generation due to the increasing potential of deep learning methods. To address the challenges of 3D reconstruction and generation, we propose Brep2Seq, a novel deep neural network designed to transform the B-rep model into a sequence of editable parametrized feature-based modeling operations comprising principal primitives and detailed features. Brep2Seq employs an encoder-decoder architecture based on the transformer, leveraging geometry and topological information within B-rep models to extract the feature representation of the original 3D shape. Due to its hierarchical network architecture and training strategy, Brep2Seq achieved improved model reconstruction and controllable model generation by distinguishing between the primary shape and detailed features of CAD models. To train Brep2Seq, a large-scale dataset comprising 1 million CAD designs is established through an automatic geometry synthesis method. Extensive experiments on both DeepCAD and Fusion 360 datasets demonstrate the effectiveness of Brep2Seq, and show its applicability to simple mechanical components in real-world scenarios. We further apply Brep2Seq to various downstream applications, including point cloud reconstruction, model interpolation, shape constraint generation, and CAD feature recognition.

      • Exact tracking control of uncertain non-linear systems with additive disturbance

        Zhengqiang Zhang,Park, Ju H.,Hanyong Shao,Zhidong Qi IET 2015 IET CONTROL THEORY AND APPLICATIONS Vol.9 No.5

        <P>This study deals with adaptive control of non-linear systems in the strict-feedback form with parametric uncertainties and additive disturbance. The disturbance in the systems is assumed to be bounded. No knowledge of the uncertain parameters, an upper bound of the uncertain parameter vector, a bound of unknown disturbance and the differentiability of the external disturbance is required. Under the weakened assumptions, two continuous robust adaptive control schemes are proposed. In the first control scheme, a modified adaptive backstepping design procedure is proposed to remove overparameterisation. A novel damping term with the estimate of unknown disturbance bound and a positive time-varying integral function are introduced in the control law to counteract the destabilising effects of the external disturbance. In the second scheme, an alternative continuous adaptive controller is designed. Instead of the estimate of the disturbance bound, an adaptive parameter is incorporated into the control design. In both of the two control schemes, the design parameters are freely chosen to improve the control performance. It is proved that the proposed two adaptive control schemes can guarantee that the closed-loop signals are bounded and the output tracking error converges to zero asymptotically in spite of the disturbance. Finally, a numerical example is included to show the effectiveness of the presented control methods.</P>

      • KCI등재

        Carbon Coated α‑Fe2O3 Photoanode Synthesized by a Facile Anodic Electrodeposition for Highly Efficient Water Oxidation

        Honglei Zhang,Longzhu Li,Changhai Liu,Wenchang Wang,Penghua Liang,Naotoshi Mitsuzak,Zhidong Chen 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.3

        This work provides a facile anodic electrodeposition method for synthesizing carbon coated α-Fe2O3 photoanode followedby annealing treatment with argon atmosphere. Compared with bare hematite photoanode, the carbon coated α-Fe2O3 photoanodesannealed at lower temperature (Fe2O3/C-L) and higher temperature (Fe2O3/C-H) have higher photocurrent densityas 0.3 and 0.5 mA cm−2 (at 1.23 V vs. RHE), respectively. The excellent PEC performance is attributed to the synergisticreaction of carbon and vacancy oxygen. The morphology and properties of the sample were characterized with scanningelectron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectra, X-raydiffractometry, X-ray photoelectron spectra, and photoelectrical measurements.

      • KCI등재

        Color-tunable nanopigments of ZnSxSe1−x: Preparation, optical properties, and first-principles evaluation

        Ti Zhang,Yanmin Wang,Shanjun Ke,Zhidong Pan 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.4

        In this work, the effects of the crystalline structure and charge state distribution on the bandgap, dominant wavelength, andoptical properties of ZnSxSe1−x color-tunable nanopigments were investigated for the first time. The first-principles calculationresults of ZnSxSe1−x pigment based on density functional theory demonstrate that ZnSxSe1−x becomes a material with anadjustable optical bandgap due to the similarity of S and Se. Furthermore, the ZnSxSe1−x pigment color gradually changedfrom ivory white to bright yellow with increasing anion composition of x = [S]/([S] + [Se]), thereby obtaining tunable colorsand optical properties to meet visual and aesthetic requirements.

      • KCI등재

        Synthesis, crystal structure, and near-infrared reflective properties of ZnSxSe1-x nanopigments

        Ti Zhang,Yanmin Wang,Shanjun Ke,Zhidong Pan 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.4

        In this research, a series of near-infrared (NIR) reflecting nanopigments, based on ZnSxSe1-x (x = 1, 0.75, 0.55, and 0.35), havebeen synthesized via a coprecipitation reaction and subsequent calcination. Furthermore, their crystal structure, particlemorphology, chromatic properties, and NIR reflectance have been investigated in detail; the results show that ZnSxSe1-xpigments have a cubic zinc-blende structure with a space group of F-43m(216), and the pigments’ microstructure presents theagglomerates composed of the spherical particles of different nanosizes. ZnSxSe1-x pigments exhibit not only colors rangingfrom ivory white to bright yellow but also significant NIR solar reflectance, ranging from 80.96% to 86.65%.

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