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      • KCI등재

        Vibration control of a stay cable with a rotary electromagnetic inertial mass damper

        Zhi Hao Wang,Yan Wei Xu,Hui Gao,Zheng Qing Chen,Kai Xu,Shun Bo Zhao 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6

        Passive control may not provide enough damping for a stay cable since the control devices are often restricted to a low location level. In order to enhance control performance of conventional passive dampers, a new type of damper integrated with a rotary electromagnetic damper providing variable damping force and a flywheel serving as an inertial mass, called the rotary electromagnetic inertial mass damper (REIMD), is presented for suppressing the cable vibrations in this paper. The mechanical model of the REIMD is theoretically derived according to generation mechanisms of the damping force and the inertial force, and further validated by performance tests. General dynamic characteristics of an idealized taut cable with a REIMD installed close to the cable end are theoretically investigated, and parametric analysis are then conducted to investigate the effects of inertial mass and damping coefficient on vibration control performance. Finally, vibration control tests on a scaled cable model with a REIMD are performed to further verify mitigation performance through the first two modal additional damping ratios of the cable. Both the theoretical and experimental results show that control performance of the cable with the REIMD are much better than those of conventional passive viscous dampers, which mainly attributes to the increment of the damper displacement due to the inertial mass induced negative stiffness effects of the REIMD. Moreover, it is concluded that both inertial mass and damping coefficient of an optimum REIMD will decrease with the increase of the mode order of the cable, and oversize inertial mass may lead to negative effect on the control performance.

      • Regulatory Network of MicroRNAs, Host Genes, Target Genes and Transcription Factors in Human Esophageal Squamous Cell Carcinoma

        Wang, Tian-Yan,Xu, Zhi-Wen,Wang, Kun-Hao,Wang, Ning Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

        Abnormally expressed microRNAs (miRNAs) and genes have been found to play key roles in esophageal squamous cell carcinoma (ESCC), but little is known about the underlying mechanisms. The aim of this paper was to assess inter-relationships and the regulatory mechanisms of ESCC through a network-based approach. We built three regulatory networks: an abnormally expressed network, a related network and a global network. Unlike previous examples, containing information only on genes or miRNAs, the prime focus was on relationships. It is worth noting that abnormally expressed network emerged as a fault map of ESCC. Theoretically, ESCC might be treated and prevented by correcting the included errors. In addition, the predicted transcription factors (TFs) obtained by the P-match method also warrant further study. Our results may further guide gene therapy researchers in the study of ESCC.

      • KCI등재

        Impact of cable sag on the efficiency of an inertial mass damper in controlling stay cable vibrations

        Zhi-hao Wang,Hui Gao,Yan-wei Xu,Zheng-qing Chen,Hao Wang 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.1

        Passive negative stiffness dampers (NSDs) that possess superior energy dissipation abilities, have been proved to be more efficient than commonly adopted passive viscous dampers in controlling stay cable vibrations. Recently, inertial mass dampers (IMDs) have attracted extensive attentions since their properties are similar to NSDs. It has been theoretically predicted that superior supplemental damping can be generated for a taut cable with an IMD. This paper aims to theoretically investigate the impact of the cable sag on the efficiency of an IMD in controlling stay cable vibrations, and experimentally validate superior vibration mitigation performance of the IMD. Both the numerical and asymptotic solutions were obtained for an inclined sag cable with an IMD installed close to the cable end. Based on the asymptotic solution, the cable attainable maximum modal damping ratio and the corresponding optimal damping coefficient of the IMD were derived for a given inertial mass. An electromagnetic IMD (EIMD) with adjustable inertial mass was developed to investigate the effects of inertial mass and cable sag on the vibration mitigation performance of two model cables with different sags through series of first modal free vibration tests. The results show that the sag generally reduces the attainable first modal damping ratio of the cable with a passive viscous damper, while tends to increase the cable maximum attainable modal damping ratio provided by the IMD. The cable sag also decreases the optimum damping coefficient of the IMD when the inertial mass is less than its optimal value. The theoretically predicted first modal damping ratio of the cable with an IMD, taking into account the sag generally, agrees well with that identified from experimental results, while it will be significantly overestimated with a taut-cable model, especially for the cable with large sag.

      • KCI등재

        Node Incentive Mechanism in Selfish Opportunistic Network

        ( Hao-tian Wang ),( Zhi-gang Chen ),( Jia Wu ),( Lei-lei Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.3

        In opportunistic network, the behavior of a node is autonomous and has social attributes such as selfishness.If a node wants to forward information to another node, it is bound to be limited by the node's own resources such as cache, power, and energy.Therefore, in the process of communication, some nodes do not help to forward information of other nodes because of their selfish behavior. This will lead to the inability to complete cooperation, greatly reduce the success rate of message transmission, increase network delay, and affect the overall network performance. This article proposes a hybrid incentive mechanism (Mim) based on the Reputation mechanism and the Credit mechanism.The selfishness model, energy model (The energy in the article exists in the form of electricity) and transaction model constitute our Mim mechanism. The Mim classifies the selfishness of nodes and constantly pay attention to changes in node energy, and manage the wealth of both sides of the node by introducing the Central Money Management Center. By calculating the selfishness of the node, the currency trading model is used to differentiate pricing of the node's services. Simulation results show that by using the Mim, the information delivery rate in the network and the fairness of node transactions are improved. At the same time, it also greatly increases the average life of the network

      • Preventive Effect of Actinidia Valvata Dunn Extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced Gastrointestinal Cancer in Rats

        Wang, Xia,Liu, Hao,Wang, Xin,Zeng, Zhi,Xie, Li-Qun,Sun, Zhi-Guang,Wei, Mu-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

        Purpose: This study was conducted to assess the preventive effect of Actinidia valvata Dunn (AVD) extract on an animal model of gastrointestinal carcinogenesis on the basis of changes in tumor incidence, cell proliferation, and apoptosis. Materials and Methods: Seventy-five male Wistar rats were divided into five different treatment groups with 15 rats in each group. Group I was given normal feed, whereas Groups II to IV were treated with 10% sodium chloride in the first six weeks and 100ug/mL of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 24 weeks. Group II was then given normal feed, whereas Group III was given AVD extract (0.24g/kg/day) for 12 weeks. Group IV was given AVD extract from the first week to the 36th week, whereas Group V was treated with AVD extract alone for 36 weeks. All rats were sacrificed at the end of the 36-week experiment and assessed for the presence of gastrointestinal tumors. The occurrence of cancer was evaluated by histology. Bax, Bcl-2, Caspase-3, and cyclinD1 were determined by immunohistochemical staining and Western blotting. Results: The incidences of gastric cancer were 0% in Group I, 73.3% in Group II, 33.3% in Group III, 26.7% in Group IV, and 0% in Group V. Bcl-2 and cyclinD1 expression was decreased in AVD extract treated groups, whereas Bax and Caspase-3 expression was increased. Comparison with group II revealed significant differences (p<0.01). Conclusions: AVD extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis induced by MNNG in rats through the regulation of cell proliferation and apoptosis.

      • KCI등재

        중국 북위 시대 윈강석굴에 나타난 복식 특징을 활용한 라운지 웨어 디자인 -CLO 3D 프로그램을 활용하여-

        왕지호 ( Wang Zhi-hao ),김현주 ( Kim Hyun-joo ),윤지영 ( Youn Ji-young ) 커뮤니케이션디자인학회 2024 커뮤니케이션 디자인학연구 Vol.88 No.0

        본 연구의 목적은 중국 윈강석굴 담요오굴의 복식과 문양의 디자인 특성을 분석하고, 이를 접목하여 3D 프로그램 CLO를 활용한 라운지 웨어 디자인을 개발하는 것이다. 연구방법은 먼저, 이론적 배경으로 윈강석굴과 현대 라운지 웨어의 선행연구 및 자료 수집을 통해 본 연구의 실행 가능성을 탐색하였다. 이를 기반으로 3D CLO 프로그램을 활용하여 디자인 전개과정을 설계하고 작품을 디자인하였다. 주요 연구 과정 및 결과는 다음과 같다. 첫째, 윈강석굴 담요오굴의 불상 복식과 문양의 특징을 분석하고 디자인 개발을 위한 영감을 얻는다. 둘째, 현대 라운지웨어의 디자인 특성을 담요오굴 불상 복식의 외형적 특징 및 문양과 접목하여 라운지 웨어의 창의적인 디자인 개발을 진행하였다. 디자인 전개는 불상의 특징적인 패턴을 그래픽으로 재해석하였고, 불상 복식의 윤곽과 선형적 특징을 실루엣으로 적용하였다. 라운지 웨어 디자인은 윈강석굴의 문화적 멋과 역동성을 함축적으로 표현함으로써 복식의 문화적 함의를 높일 뿐만 아니라 착용자에게 독특한 편안함을 부여한다. 또한, 3D 디지털 프로그램을 통하여 중국 전통문화가 융합된 캐주얼 의류 디자인의 혁신성과 합리성을 구현할 수 있는 계기가 되었다. 본 연구는 문화유산을 현대적 디자인에 접목하는 방법을 모색하고, 아울러 캐주얼 의류 디자인 분야에 새로운 영감과 가치를 부여함에 그 의의가 있다. The purpose of this study is to analyze the design characteristics of the costumes and patterns of the Yunnan Grottoes in China, and to develop a loungewear design using the 3D program CLO by incorporating them. As for the research method, first, the feasibility of this study was explored through prior research and data collection on the Yunnan Grottoes and modern loungewear with a theoretical background. Based on this, the design development process was designed and the work was designed using the 3D CLO program. The main research development and results are as follows. First, the characteristics of the Buddha statue costumes and patterns of the Yunnan Grottoes are analyzed, and inspiration for design development is obtained. Second, creative design development of loungewear was carried out by combining the design characteristics of the modern loungewear with the external characteristics and patterns of the Buddha statue costumes. The design development reinterpreted the characteristic pattern of the Buddha statue graphically, and the outline and linear characteristics of the Buddha statue costumes were applied as silhouettes. The loungewear design not only enhances the cultural implications of the costumes by implicitly expressing the cultural beauty and dynamics of the Yunnan Grottoes, but also gives unique comfort to the wearer. In addition, it became an opportunity to realize the innovation and rationality of casual clothing design in which traditional Chinese culture was fused through a 3D digital program. This study is meaningful in that it seeks ways to incorporate cultural heritage into modern design and also gives new inspiration and value to the field of casual clothing design.

      • KCI등재

        RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

        Tian-Hao Weng,Min-Ya Yao,Xiang-Ming Xu,Chen-Yu Hu,Shu-Hao Yao,Yi-Zhi Liu,Zhi-Gang Wu,Tao-Ming Tang,Pei-Fen Fu,Ming-Hai Wang,Hang-Ping Yao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3

        Purpose Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for treating this malignant cancer. Here, we identified RON (macrophage-stimulating 1 receptor) and MET (MET proto-oncogene, receptor tyrosine kinase) as a prognostic biomarker and therapeutic targets for potential TNBC treatment. Materials and Methods We analyzed RON and MET expression in 187 primary TNBC clinical samples with immunohistochemistry. We validated the targeted therapeutic effects of RON and MET in TNBC using three tyrosine kinase inhibitors (TKIs): BMS-777607, INCB28060, and tivantinib. The preclinical therapeutic efficacy of the TKIs was mainly estimated using a TNBC xenograft model. Results Patients with TNBC had widespread, abnormal expression of RON and MET. There was RON overexpression, MET overexpression, and RON and MET co-overexpression in 63 (33.7%), 63 (33.7%), and 43 cases (23.0%), respectively, which had poor prognosis and short survival. In vivo, the TKI targeting RON ant MET inhibited the activation of the downstream signaling molecules, inhibited TNBC cell migration and proliferation, and increased TNBC cell apoptosis; in the xenograft model, they significantly inhibited tumor growth and shrank tumor volumes. The TKI targeting RON and Met, such as BMS-777607 and tivantinib, yielded stronger anti-tumor effects than INCB28060. Conclusion RON and MET co-overexpression can be significant pathological characteristics in TNBC for poor prognosis. TKIs targeting RON and MET have stronger drug development potential for treating TNBC.

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