Dislocation Density-Based Constitutive Model and Processing Map for T2 Copper During Isothermal and Time-Variant Deformation

Gang Chen,Yu Jin,Jing Wang,Cheng Zhang,Qiang Chen,Hongming Zhang,Xingjian Zhao,Zhiyong Li,Changhai Xie,Zhiming Du 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9

Isothermal compression tests were carried out to study the hot deformation behavior of T2 copper under various conditions. The deformation parameters, such as temperature and strain rate, have strong influence on flow stress and microstructureevolution of the alloy. A unified dislocation density-based model considering dynamic recovery and recrystallization wasestablished. And material parameters of the developed model were optimized by genetic algorithm. Comparisons betweenthe experimental and model data demonstrates that the developed model can precisely describe the flow behavior at quitewide range of deformation conditions. Meanwhile, the designed iterative procedure allows the model to be applied in timevariantdeformation conditions. Processing map and microstructure examination were constructed to optimize the processingwindow of the studied alloy. According to the processing maps, flow instability mainly appeared at low temperatures of500–650 °C and strain rates higher than 0.1 s−1. The optimum deformation parameters of T2 copper was concluded as thetemperature range of 700–800 °C and the strain rate of 0.1–1 s−1.

Characterization of proteolysis in muscle tissues of sea cucumber Stichopus japonicus

Chen-Chen Zhao,Yang Yang,Hai-tao Wu,Zhi-Mo Zhu,Yue Tang,Cui-Ping Yu,Na Sun,Qiang Lv,Jia-Run Han,Ao-Ting Li,Jia-Nan Yan,Yue Cha 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

The proteolysis in muscle tissues of sea cucumber Stichopus japonicus (sjMTs) was characterized. The proteins from sjMTs were primarily myosin heavy chains (MHCs), paramyosin (Pm), and actin (Ac) having a molecular mass of approximately 200, 98, and 42 kDa, respectively. Based on SDS-PAGE analysis and quantification of trichloroacetic acid (TCA)-soluble peptides released, degradation of muscle proteins from sjMTs was favorable at pH 5 and 50°C. Proteolysis of MHCs was mostly inhibited by cysteine protease inhibitors, including trans-epoxysuccinyl-L-leucyl-amido (4- guanidino) butane (E-64) and antipain (AP). E-64 and AP completely inhibited the degradation of Pm and Ac, while iodoacetic acid showed a partially inhibitory effect. These results indicated that the proteolysis of sjMTs was mainly attributed to cysteine proteases. Avoidance of setting the tissues at 40–50oC and slightly acidic condition and inhibition of cysteine proteases are helpful for decreasing sea cucumber autolysis.

Analysis and comparison of the 2D/1D and quasi-3D methods with the direct transport code SHARK

Chen Zhao,Xingjie Peng,Hongbo Zhang,Wenbo Zhao,Qing Li,Zhang Chen 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.1

The 2D/1D method has become the mainstream of the direct transport calculation considering the balance of accuracy and efficiency. However, the 2D/1D method still suffers from stability issues. Recently, a quasi-3D method has been proposed with axial Legendre expansion. Analysis and comparison of the 2D/1D and quasi-3D method is conducted in theory from the equation derivation. Besides, the C5G7 benchmark, the KUCA benchmark and the macro BEAVRS benchmark are calculated to verify the theory comparisons of these two methods with the direct transport code SHARK. All results show that the quasi-3D method has better stability and accuracy than the 2D/1D method with worse efficiency and memory cost. It provides a new option for direct transport calculation with the quasi-3D method.

공통주택 개방형 발코니에 대한 사용자 인식 및 요구

자오천천(Zhao, Chen-Chen),한정원(Han, Jeong-Won) 한국실내디자인학회 2024 한국실내디자인학회 학술대회논문집 Vol.26 No.2

The apartment balcony serves as the only buffer space connecting the interior and exterior of the building, making it an important element that can enhance the quality of living. This study aims to understand the perceptions and demands of residents regarding open balconies in multi-family housing, which are becoming increasingly necessary. To achieve this, the definition of open balconies and the changes in related regulations were examined through a literature review and surveys among apartment residents were conducted to identify their awareness, preferences, and needs concerning open balconies. The results of this study are as follows: Most residents displayed a positive attitude toward the installation of open balconies and preferred them to be located in the living room or between the living room and the bedroom. When installing open balconies, residents favored a large size that could accommodate about 4-6 people for the living room balcony and a relatively smaller size that could accommodate about 2-4 people for the bedroom and kitchen balconies. The majority preferred linear-shaped balconies. To improve the residential environment of apartments, which have become a representative housing type in Korea, it is necessary to actively consider the installation of open balconies that reflect the demands and preferences of apartment residents.

COVID-19 발생 전후 아파트 발코니에 대한 사용자 인식과 이용실태 변화

자오천천(Chen-Chen Zhao),한정원(Jeong-Won Han) 한국주거학회 2023 한국주거학회 논문집 Vol.34 No.6

The apartment balcony is the only space that connects the inside and outside of the house, but it is often used to increase the usable area in Korean apartments. The purpose of this study is to identify changes in residents’ perception and use of balcony space before and after the outbreak of COVID-19 targeting apartment residents. To this end, big data analysis using social network data and a survey of apartment residents were conducted. The results are as follows. 1) When compared to before COVID-19, many words related to nature and new activities were being searched after the outbreak. 2) In terms of the balcony functions before and after COVID-19, storage and utility functions, which were typical roles of balconies, are relatively reduced after COVID-19. On the other side, the ratio of natural contact functions, indoor environment control functions, and living space functions increased. 3) A comparative analysis on the frequency of balcony use before and after the COVID-19 showed increases in the frequency of use for all types of balconies, and the statistical significance of these changes was confirmed. Since the demands for the original function of balconies are increasing after COVID-19, it is necessary to consider the various activities and contact with nature in designing apartment balconies.

Exploring the Significance and Interpretation of Animal Motifs in Rock Art: A Systematic Review

Tie Zhao(Tie Zhao),Daorina(Daorina ),Guofeng Chen(Guofeng Chen),M. Omer(M. Omer ) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.1

Rock art has been a subject of fascination for scholars, archaeologists, and enthusiasts for centuries due to its unique aesthetic qualities and cultural significance. This systematic review paper provides an overview of the significance of rock art motifs and their interpretations. Through a comprehensive analysis of the literature, we identified common rock art motifs and themes, as well as various interpretative approaches and theoretical frameworks used to understand the meanings and contexts of these motifs. The review also explores variations in interpretations across time and space and discusses the implications of these findings for rock art studies. The results reveal that rock art motifs and their interpretations are shaped by diverse cultural, social, and historical contexts, and that interdisciplinary and community-engaged research is needed to better understand, preserve, and appreciate this unique cultural heritage. The limitations and recommendations for future research are also discussed. This review contributes to our understanding of the cultural, symbolic, and aesthetic significance of rock art and highlights the importance of interdisciplinary perspectives and engagement with local communities in the study and conservation of rock art sites and cultural heritage.

Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

Chen, Qiang,Luo, Zhao-Yun,Lin, Min,Lin, Qi-Li,Chen, Chan-Yu,Yang, Chun,Xie, Long-Xu,Li, Hui,Zheng, Jia-Kun,Yang, Li-Ye,Ju, Gui-Zhi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Limited epidemiologic data of HPV prevalence are available for women attending hospitals in southern China. This study aimed to evaluate the profiles of HPV infection and cytology status in gynecological outpatients in Chaozhou City. Methods: A total of 2833 eligible women were enrolled. The HPV GenoArray test was used for HPV detection and genotyping. Nearly one half of the HPV positive women received liquid-based cytology test. Logistic regression analysis was performed to assess the predictable effects of age and genotype for categories of abnormal cytology. Results: The prevalence of overall, high-risk, and low-risk HPV infection were 24.5%, 19.5% and 8.4%, respectively. A U-shaped age-specific prevalence curve was observed in overall HPV and high-risk HPV, but not in low-risk HPV, which declined with age increasing. The 6 most common high-risk HPV type in descending order, were types 52, 16, 58, 18, 68, and 33. Age and HPV genotype were both important determinants of abnormal cytology incidence, the older women (>45 years) and those infected with HPV type 16 and/or 18 having the highest risk for abnormal cytology. Conclusion: Our findings support the hypothesis that second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women residing in Chaozhou and neighboring cities in Guangdong.

In-pile tritium release behavior and the post-irradiation experiments of Li4SiO4 fabricated by melting process

Zhao Linjie,Yang Mao,Xiao Chengjian,Gong Yu,Ran Guangming,Chen Xiaojun,Li Jiamao,Yue Lei,Chen Chao,Hou Jingwei,Wang Heyi,Long Xinggui,Peng Shuming 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1

Understanding the tritium release and retention behavior of candidate tritium breeder materials is crucial for breeder blanket design. Recently, a melt spraying process was developed to prepare Li4SiO4 pebbles, which were subsequently subjected to the in-pile tritium production and extraction platform in China Mianyang Research Reactor (CMRR) to investigate their in-situ tritium release behavior and irradiation performance. The results demonstrate that HT is the main tritium release form, and adding hydrogen to the purge gas reduces tritium retention while increasing the HT percent in the purge gas. Post-irradiation experiments reveal that the irradiated pebbles darken in color and their grains swell, but the mechanical properties remain largely unchanged. It is concluded that the tritium residence time of Li4SiO4 made by melt spraying method at 467 ◦C is approximately 23.34 h. High-density Li4SiO4 pebbles exhibit tritium release at relatively low temperatures (<600 ◦C) that is mainly controlled by bulk diffusion. The diffusion coefficient at 525 ◦C and 550 ◦C is 1.19 × 10 11 cm2/s and 5.34 × 10 11 cm2/s, respectively, with corresponding tritium residence times of 21.3 hours and 4.7 hours.

R&D Performance in High-Tech Firms in China

Chen, Zhao,Lee, Sang-Ho,Xu, Wei MIT Press 2017 ASIAN ECONOMIC PAPERS Vol.16 No.3

A possible mechanism to the antidepressant-like effects of 20 (S)-protopanaxadiol based on its target protein 14-3-3 ζ

Chen, Lin,Li, Ruimei,Chen, Feiyan,Zhang, Hantao,Zhu, Zhu,Xu, Shuyi,Cheng, Yao,Zhao, Yunan The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.5

Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated ginsenoside metabolite. Methods: Corticosterone (CORT) was administered repeatedly to induce the depression model, and PPD was given concurrently. The tail suspension test (TST) and the forced swimming test (FST) were used for behavioral evaluation. All mice were sacrificed. Golgi-cox staining, GSK 3β activity assay, and Western blot analysis were performed. In vitro, the kinetic binding analysis with the Biolayer Interferometry (BLI) was used to determine the molecular interactions. Results: TST and FST both revealed that PPD reversed CORT-induced behavioral deficits. PPD also ameliorated the CORT-induced expression alterations of hippocampal Ser9 phosphorylated glycogen synthase kinase 3β (p-Ser9 GSK 3β), Ser133 phosphorylated cAMP response element-binding protein (p-Ser133 CREB), and brain-derived neurotrophic factor (BDNF). Moreover, PPD attenuated the CORT-induced increase in GSK 3β activity and decrease in dendritic spine density in the hippocampus. In vitro, 14-3-3 ζ protein specifically bound to p-Ser9 GSK 3β polypeptide. PPD promoted the binding and subsequently decreased GSK 3β activity. Conclusion: These findings demonstrated the antidepressant-like effects of PPD on the CORT-induced mouse depression model and indicated a possible target-based mechanism. The combination of PPD with the 14-3-3 ζ protein may promote the binding of 14-3-3 ζ to p-GSK 3β (Ser9) and enhance the inhibition of Ser9 phosphorylation on GSK 3β kinase activity, thereby activating the plasticity-related CREBeBDNF signaling pathway.