Extremal problems on the Cartan-Hartogs domains

An Wang,Xin Zhao,Zhiyin Liu 대한수학회 2007 대한수학회지 Vol.44 No.6

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Zhao, Ji-An,Peng, Li,Geng, Cui-Zhi,Liu, Yue-Ping,Wang, Xu,Yang, Hui-Chai,Wang, Shi-Jie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model. One hundred and twenty male SD rats used in this study were divided into six groups. Those receiving DEN with curcumin (CUR) or HZC were studied compared with the DEN-alone group. The study demonstrated that DEN induced severe histological and immunohistochemical changes in liver tissues, significantly increasing the levels of liver marker enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), ${\gamma}$-glutamyltransferase (GGT) and total bilirubin level (TBL)). The hepatocarcinoma incidences were 100.0%, 36.7% and 20.0% in the DEN-alone, DEN-CUR and DEN-HZC groups, respectively. Although macroscopic and microscopic features suggested that both CUR and HZC were effective in inhibiting DEN-induced hepatocarcinogenesis, HZC was exerted a stronger influence. Immunohistochemical analysis with PCNA demonstrated significantly differences among the groups (all P < 0.05). Taken together, the results suggested application of CUR and HZC could prevent the occurrence of carcinogenesis and HZC may be a more potent compound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR.

Unconventional superconductivity of NdFeAsO_0.82F_0.18 indicated by the low temperature dependence of the lower critical field <i>H</i>_c1

Wang, X L,Dou, S X,Ren, Zhi-An,Yi, Wei,Li, Zheng-Cai,Zhao, Zhong-Xian,Lee, Sung-IK IOP Pub 2009 Journal of physics, an Institute of Physics journa Vol.21 No.20

<P>We measured the initial <I>M</I>–<I>H</I> curves for a sample of the newly discovered superconductor NdFeAsO<SUB>0.82</SUB>Fe<SUB>0.18</SUB>, which had a critical temperature, <I>T</I><SUB>c</SUB>, of 51 K and was fabricated at the high pressure of 6 GPa. The lower critical field, <I>H</I><SUB>c1</SUB>, was extracted from the deviation point of the Meissner linearity in the <I>M</I>–<I>H</I> curves, which show linear temperature dependence in the low temperature region down to 5 K. The <I>H</I><SUB>c1</SUB>(<I>T</I>) indicates no s-wave superconductivity, but rather an unconventional superconductivity with a nodal gap structure. Furthermore, the linearity of <I>H</I><SUB>c1</SUB> at low temperature does not hold at high temperature, but shows other characteristics, indicating that this superconductor might have multi-gap features. Based on the low temperature nodal gap structure, we estimate that the maximum gap magnitude Δ<SUB>0</SUB> = (1.6 ± 0.2)  <I>k</I><SUB>B</SUB><I>T</I><SUB>c</SUB>.</P>

Decellularized Matrices for the Treatment of Tissue Defects: from Matrix Origin to Immunological Mechanisms

Wang Xinyue,Guo Jiqiang,Yu Qing,Zhao Luyao,Gao Xiang,Wang Li,Wen Meiling,Yan Junrong,An Meiwen,Liu Yang 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.5

Decellularized matrix transplantation has emerged as a promising therapeutic approach for repairing tissue defects, with numerous studies assessing its safety and efficacy in both animal models and clinical settings. The host immune response elicited by decellularized matrix grafts of natural biological origin plays a crucial role in determining the success of tissue repair, influenced by matrix heterogeneity and the inflammatory microenvironment of the wound. However, the specific immunologic mechanisms underlying the interaction between decellularized matrix grafts and the host immune system remain elusive. This article reviews the sources of decellularized matrices, available decellularization techniques, and residual immunogenic components. It focuses on the host immune response following decellularized matrix transplantation, with emphasis on the key mechanisms of Toll-like receptor, T-cell receptor, and TGF-β/SMAD signaling in the stages of post-transplantation immunorecognition, immunomodulation, and tissue repair, respectively. Furthermore, it highlights the innovative roles of TLR10 and miR-29a-3p in improving transplantation outcomes. An in-depth understanding of the molecular mechanisms underlying the host immune response after decellularized matrix transplantation provides new directions for the repair of tissue defects.

Overexpression of the maize ZmAMT1;1a gene enhances root ammonium uptake efficiency under low ammonium nutrition

Yang Zhao,Zhi Liu,Fengying Duan,Xia An,Xiangguo Liu,Dongyun Hao,Riliang Gu,Zhangkui Wang,Fanjun Chen,Lixing Yuan 한국식물생명공학회 2018 Plant biotechnology reports Vol.12 No.1

High-affinity ammonium uptake in maize roots is mainly mediated by AMT1-type ammonium transporters ZmAMT1;1a and ZmAMT1;3, but whether the increased expression of ZmAMTs genes is able to enhance ammonium uptake capacity and subsequently improves overall nitrogen use efficiency remains to be elucidated. In this work, ZmAMT1;1a-overexpression transgenic maize plants were generated with the elevated levels of transcripts and proteins, and phenotypically analyzed together with wild-type plants grown in nutrient solution under two regimes of ammonium supply. Under low ammonium nutrition (0.04 mM), in relative to wild-type plants, the maize transgenic lines showed an approximately 17% increases in the high-affinity ammonium uptake capacity of roots as revealed by 15N-labeled ammonium influx assay and further contributed to about 7% increases in the total nitrogen uptake at the whole plant level. By contrast, when ammonium was supplied in high amounts (1 mM), wild-type plants expressed higher levels of ZmAMT1;1a, but exhibited a lower ammonium uptake capacity in roots. Furthermore, the transgenic maize line accumulated more amounts of ZmAMT1;1a protein, but did not translate into an enhanced ammonium acquisition, suggesting a possible post-translational down-regulation of ZmAMT1;1a by high ammonium. This study proved the possibility to enhance ammonium acquisition by elevating ZmAMTs expression in maize roots and provided an effective transgenic approach on developing high nitrogen use efficient maize cultivars.

Numerical simulations and surrogate-based optimization of cavitation performance for an aviation fuel pump

Xing’an Zhao,Biao Huang,Tairan Chen,Guoyu Wang,Deming Gao,Jing Zhao 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2

We used computational modeling to investigate the cavitation performance of an aviation fuel pump, and optimize structural parameters using the surrogate-based method. In the numerical simulation, a rotation-curvature correction was adapted to the k-ε turbulence model, and a four-component surrogate fuel was selected to reproduce the physical properties of the China RP-3 kerosene. Then the performance of the aviation fuel pump was predicted. In the optimization, based on the series of the numerical results, Surrogate-based analysis and optimization (SBAO) was used to optimize the structural parameters of the fuel pump (the variation of the outlet blade angle for the inducer △β b1 and the variation of the inlet blade angle for the impeller △β b2 ). The results show that the prediction of cavitation performance agrees well with the experimental data. The results show that cavitation areas are mainly distributed in the inlet of the inducer. The volume of cavities grows with the decreasing NPSHa. The head of the fuel pump has a sudden head-drop when NPSHa ≤ 5.64 m. Furthermore, the surrogate-based approach is available in structural optimization of the fuel pump. The cavitation performance of the optimized pump improved about 22 % with a little drop of head coefficient when △β b1 = 4.33° and △β b2 = 3.24°. The numerical approach employed in this paper can accurately predict the cavitating flow of the high rotating speed fuel pump and the surrogate-based method is available in the structural optimization for a better cavitation performance.

Right-to-Left Displacement of an Airgun Lead Bullet after Transorbital Entry into the Skull Complicated by Posttraumatic Epilepsy : A Case Report

Chao-bin Wang,Hui Wang,Jun-shuang Zhao,Ze-jun Wu,Hao-dong Liu,Chao-jia Wang,An-rong Li,Dawei Wang,Juntao Hu 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5

Penetrating head injury is a serious open cranial injury. In civilians, it is often caused by non-missile, low velocity flying objects that penetrate the skull through a weak cranial structure, forming intracranial foreign bodies. The intracranial foreign body can be displaced due to its special quality, shape, and location. In this paper, we report a rare case of right-to-left displacement of an airgun lead bullet after transorbital entry into the skull complicated by posttraumatic epilepsy, as a reminder to colleagues that intracranial metal foreign bodies maybe displaced intraoperatively. In addition, we have found that the presence of intracranial metallic foreign bodies may be a factor for the posttraumatic epilepsy, and their timely removal appears to be beneficial for epilepsy control.

The Retention Behavior of Ginsenosides in HPLC and Its Application to Quality Assessment of Radix Ginseng

Hu, Ping,Luo, Guo-An,Wang, Qing,Zhao, Zhong-Zhen,Wang, Wan,Jiang, Zhi-Hong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

This study systematically investigated the retention behavior of seven neutral ginsenosides $Rg_1$, Re, Rf, $Rb_1$, $Rb_2$, Rc, Rd, and an acidic ginsenoside $R_0$, the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides' retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

The Retention Behavior of Ginsenosides in HPLC and Its Application to Quality Assessment of Radix Ginseng

Ping Hu,Guo-An Luo,Zhong-Zhen Zhao,Wan Wang,Qing Wang,Zhi-Hong Jiang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

This study systematically investigated the retention behavior of seven neutral ginsenosides Rg₁, Re, Rf, Rb₁, Rb₂, Rc, Rd, and an acidic ginsenoside R0, the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides’ retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

Postmenopausal Hormone Therapy is Associated with in Situ Breast Cancer Risk

Ni, Xiao-Jian,Xia, Tian-Song,Zhao, Ying-Chun,Ma, Jing-Jing,Zhao, Jie,Liu, Xiao-An,Ding, Qiang,Zha, Xiao-Ming,Wang, Shui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: The relationship between postmenopausal hormone therapy (HT) and invasive breast cancer has been extensively investigated, but that with breast carcinoma in situ (BCIS) has received relatively little attention. The aim of our present study was to review and summarize the evidence provided by longitudinal studies on the association between postmenopausal HT use and BCIS risk. Methods: A comprehensive literature search for articles published up to May 2012 was performed. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Relative risk (RR) or odds ratio (OR) values were calculated using 14 reports (8 case-control studies and 6 cohort studies), published between 1986 and 2012. Results: There was evidence of an association between ever postmenopausal estrogen use and BCIS based on a random-effects model (RR = 1.25, 95% confidence interval (CI) = 1.01, 1.55). However, we found no strong evidence of an association between ever postmenopausal estrogen combined with progesterone use and BCIS using a randomeffects model (RR = 1.55, 95% CI = 0.95, 2.51). Furthermore, our analysis showed a strong association between "> 5 years duration" of estrogen or estrogen combined with progesterone use and BCIS. Furthermore, current use of any HT is associated with increased risk of BCIS in cohort studies. Additional well-designed large studies are now required to validate this association in different populations.