Influence of Intravenous Contrast Medium on Dose Calculation Using CT in Treatment Planning for Oesophageal Cancer

Li, Hong-Sheng,Chen, Jin-Hu,Zhang, Wei,Shang, Dong-Ping,Li, Bao-Sheng,Sun, Tao,Lin, Xiu-Tong,Yin, Yong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: To evaluate the effect of intravenous contrast on dose calculation in radiation treatment planning for oesophageal cancer. Methods: A total of 22 intravein-contrasted patients with oesophageal cancer were included. The Hounsfield unit (HU) value of the enhanced blood stream in thoracic great vessels and heart was overridden with 45 HU to simulate the non-contrast CT image, and 145 HU, 245 HU, 345 HU, and 445 HU to model the different contrast-enhanced scenarios. 1000 HU and -1000 HU were used to evaluate two non-physiologic extreme scenarios. Variation in dose distribution of the different scenarios was calculated to quantify the effect of contrast enhancement. Results: In the contrast-enhanced scenarios, the mean variation in dose for planning target volume (PTV) was less than 1.0%, and those for the total lung and spinal cord were less than 0.5%. When the HU value of the blood stream exceeded 245 the average variation exceeded 1.0% for the heart V40. In the non-physiologic extreme scenarios, the dose variation of PTV was less than 1.0%, while the dose calculations of the organs at risk were greater than 2.0%. Conclusions: The use of contrast agent does not significantly influence dose calculation of PTV, lung and spinal cord. However, it does have influence on dose accuracy for heart.

miR-124 Inhibits Growth and Invasion of Gastric Cancer by Targeting ROCK1

Hu, Cong-Bing,Li, Qiao-Lin,Hu, Jian-Fei,Zhang, Qiang,Xie, Jian-Ping,Deng, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers, including gastric cancer (GC), but the molecular mechanisms are not well understood. Herein, we investigated the role of miR-124 in GC. We found that its expression was significantly reduced in both GC tissue samples and cell lines. Forced expression of miR-124 suppressed GC cell proliferation, migration, and invasion. Furthermore, the Rho-associated protein kinase (ROCK1) was identified as a direct target of miR-124 in GC cells. Finally, silencing of ROCK1 showed similar effects as miR-124 overexpression, while supplementation of ROCK1 remarkably restored the cell growth and invasion inhibited by miR-124. Together, our data demonstrate that miR-124 acts as a tumor suppressor by targeting ROCK1, and posit miR-124 as a novel strategy for GC treatment.

Effects of early commercial milk supplement on the mucosal morphology, bacterial community and bacterial metabolites in jejunum of the pre- and post-weaning piglets

Hu, Ping,Niu, Qingyan,Zhu, Yizhi,Shi, Chao,Wang, Jing,Zhu, Weiyun Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.3

Objective: Sow milk (SM) may not be able to meet the piglet's nutritional needs in late lactation. Hence, this study was conducted to investigate the effects of early commercial milk (CM) supplement on the mucosal morphology, bacterial community and bacterial metabolites in jejunum of piglets. Methods: Ten litters of newborn piglets ([Yorkshire×Landrace]×Duroc) were randomly divided into 2 groups of 5 litters. The piglets in the control group were suckled by the sow (SM), while the piglets in the treatment group (CM supplement) were supplemented with a CM supplement along with suckling from d 4 to d 28 of age. Results: No significant differences were observed about jejunal mucosal morphology on d 28 and d 35 between two groups. On d 28, the activity of lactase in the jejunum was significantly decreased in the CM group, while the activity of sucrase and the ratio of maltase to lactase were significantly increased (p<0.05). On d 35, the activity of maltase in the jejunum was significantly increased in the CM group (p<0.05), and maltase to lactase ratio tended to increase in the CM group (p = 0.065). In addition, piglets in the CM group had a higher abundance of Clostridium XI, Tuicibater, and Moraxella in the jejunum on d 28, while the abundance of Lactobacillus was significantly increased on d 35 (p<0.05). Conclusion: The early CM supplement improved the maturation of the jejunum to some extent by enhancing the maltase and sucrase activities. Moreover, the early CM supplement could help maintain the homeostasis of internal environment in jejunum by increasing the microbial-derived metabolites.

Preparation of Nanoflake Bi₂MoO₆ Photocatalyst Using CO(NH₂)₂ as Structure Orientation and Its Visible Light Degradation of Tetracycline Hydrochloride

Hu, Pengwei,Zheng, Dewen,Xian, Yuxi,Hu, Xianhai,Zhang, Qian,Wang, Shanyu,Li, Mingjun,Cheng, Congliang,Liu, Jin,Wang, Ping Materials Research Society of Korea 2021 한국재료학회지 Vol.31 No.6

Bi₂MoO₆ (BMO) via the structure-directing role of CO(NH₂)₂ is successfully prepared via a facile solvothermal route. The structure, morphology, and photocatalytic performance of the nanoflake BMO are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), fluorescence spectrum analysis (PL), UV-vis spectroscopy (UV-vis) and electrochemical test. SEM images show that the size of nanoflake BMO is about 50 ~ 200 nm. PL and electrochemical analysis show that the nanoflake BMO has a lower recombination rate of photogenerated carriers than particle BMO. The photocatalytic degradation of tetracycline hydrochloride (TC) by nanoflake BMO under visible light is investigated. The results show that the nanoflake BMO-3 has the highest degradation efficiency under visible light, and the degradation efficiency reached 75 % within 120 min, attributed to the unique hierarchical structure, efficient carrier separation and sufficient free radicals to generate active center synergies. The photocatalytic reaction mechanism of TC degradation on the nanoflake BMO is proposed.

DISCOVERY OF AN X-RAY-EMITTING CONTACT BINARY SYSTEM 2MASS J11201034−2201340

Hu, Chin-Ping,Yang, Ting-Chang,Chou, Yi,Liu, L.,Qian, S.-B.,Hui, C. Y.,Kong, Albert K. H.,Lin, L. C. C.,Tam, P. H. T.,Li, K. L.,Ngeow, Chow-Choong,Chen, W. P.,Ip, Wing-Huen American Astronomical Society 2016 The Astronomical journal Vol.151 No.6

<P>We report the detection of orbital modulation, a model solution, and the X-ray properties of a newly discovered contact binary, Two Micron All Sky Survey (2MASS) J11201034-2201340. We serendipitously found this X-ray point source outside the error ellipse when searching for possible X-ray counterparts of 7-ray millisecond pulsars among the unidentified objects detected by the Fermi Gamma-ray Space Telescope. The optical counterpart of the X-ray source (unrelated to the 7-ray source) was then identified using archival databases. The long-term Catalina Real-Time Transient Survey detected a precise signal with a period of P = 0.28876208 (56) days. A follow-up observation made by the Super Light Telescope of Lulin Observatory revealed the binary nature of the object. Utilizing archived photometric data of multi-band surveys, we construct the spectral energy distribution (SED), which is well fit by a K2V spectral template. The fitting result of the orbital profile using the Wilson Devinney code suggests that 2MASS J11201034-2201340 is a short-period A-type contact binary and the more massive component has a cool spot. The X-ray emission was first noted in observations made by Swift, and then further confirmed and characterized by an XMM-Newton observation. The X-ray spectrum can be described by a power law or thermal Bremsstrahlung. Unfortunately, we could not observe significant X-ray orbital modulation. Finally, according to the SED, this system is estimated to be 690 pc from Earth with a calculated X-ray intensity of (0.7 - 1.5) x 10(30) erg s(-1), which is in the expected range of an X-ray emitting contact binary.</P>

Study on Traditional Chinese Medicine against Liver Fibrosis

Hu, Xiao-Ping,Son, Chang-Gue,Shin, Jang-Woo,Cho, Jung-Hyo,Cho, Chong-Kwan,Yoo, Hwa-Seung,Lee, Yeon-Weol Research Institute of Korean Medicine 2006 한의학연구소 논문집 Vol.15 No.2

간섬유화는 다양한 만성 간질환에 기인하는 간실질의 결합조직의 과도한 증식을 말하며, 간경화로 발전하는 중간과정이다. 중국과 한국에는 많은 간섬유화 환자가 있지만 현재까지 서양의학에서 간섬유화를 효과적으로 치료할 수 있는 치료법은 발견되지 않고 있다. 최근 수년간 중국전통의학의 임상과 실험연구에서 많은 발전이 있었다. 전통의학이론을 바탕으로 활혈거어(活血祛瘀), 익기(益氣)의 효능이 있는 한약제가 항섬유화 효능을 보였다. 전통중국의학에서 간섬유화에 대한 일반적인 치료는 유효 성분, 단방 및 복방 처방의 세 부분으로 나뇐다. 우리는 중국전통의학에서 간섬유화의 효과적인 치료와 관련된 작용기작을 소개하였다.

The Retention Behavior of Ginsenosides in HPLC and Its Application to Quality Assessment of Radix Ginseng

Hu, Ping,Luo, Guo-An,Wang, Qing,Zhao, Zhong-Zhen,Wang, Wan,Jiang, Zhi-Hong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

This study systematically investigated the retention behavior of seven neutral ginsenosides $Rg_1$, Re, Rf, $Rb_1$, $Rb_2$, Rc, Rd, and an acidic ginsenoside $R_0$, the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides' retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

An Application of Hilbert-Huang Transform on the Non-Stationary Astronomical Time Series: The Superorbital Modulation of SMC X-1

Hu, Chin-Ping,Chou, Yi,Wu, Ming-Chya,Yang, Ting-Chang,Su, Yi-Hao 한국우주과학회 2013 Journal of Astronomy and Space Sciences Vol.30 No.2

We present the Hilbert-Huang transform (HHT) analysis on the quasi-periodic modulation of SMC X-1. SMC X-1, consistingof a neutron star and a massive companion, exhibits superorbital modulation with a period varying between ~40 d and ~65 d.We applied the HHT on the light curve observed by the All-Sky Monitor onboard Rossi X-ray Timing Explorer (RXTE) to obtainthe instantaneous frequency of the superorbital modulation of SMC X-1. The resultant Hilbert spectrum is consistent with thedynamic power spectrum while it shows more detailed information in both the time and frequency domains. According to theinstantaneous frequency, we found a correlation between the superorbital period and the modulation amplitude. Combiningthe spectral observation made by the Proportional Counter Array onboard RXTE and the superorbital phase derived in theHHT, we performed a superorbital phase-resolved spectral analysis of SMC X-1. An analysis of the spectral parameters versusthe orbital phase for different superorbital states revealed that the diversity of nH has an orbital dependence. Furthermore,we obtained the variation in the eclipse profiles by folding the All Sky Monitor light curve with orbital period for differentsuperorbital states. A dip feature, similar to the pre-eclipse dip of Her X-1, can be observed only in the superorbital ascendingand descending states, while the width is anti-correlated with the X-ray flux.

APPLICATIONS OF THE HILBERT-HUANG TRANSFORM ON THE NON-STATIONARY ASTRONOMICAL TIME SERIES

HU, CHIN-PING,CHOU, YI,YANG, TING-CHANG,SU, YI-HAO,HSIEH, HUNG-EN,LIN, CHING-PING,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

The development of time-frequency analysis techniques allow astronomers to successfully deal with the non-stationary time series that originate from unstable physical mechanisms. We applied a recently developed time-frequency analysis method, the Hilbert-Huang transform (HHT), to two non-stationary phenomena: the superorbital modulation in the high-mass X-ray binary SMC X-1 and the quasi-periodic oscillation (QPO) of the AGN RE J1034+396. From the analysis of SMC X-1, we obtained a Hilbert spectrum that shows more detailed information in both the time and frequency domains. Then, a phase-resolved analysis of both the spectra and the orbital profiles was presented. From the spectral analysis, we noticed that the iron line production is dominated by different regions of this binary system in different superorbital phases. Furthermore, a pre-eclipse dip lying at orbital phase ~0:6-0:85 was discovered during the superorbital transition state. We further applied the HHT to analyze the QPO of RE J1034+396. From the Hilbert spectrum and the O-C analysis results, we suggest that it is better to divide the evolution of the QPO into three epochs according to their different periodicities. The correlations between the QPO periods and corresponding fluxes were also different in these three epochs. The change in periodicity and the relationships could be interpreted as the change in oscillation mode based on the diskoseismology model.

Functional regression with dependent error and missing observation in reproducing kernel Hilbert spaces

Hu Yan-Ping,Liang Han-Ying 한국통계학회 2023 Journal of the Korean Statistical Society Vol.52 No.3

In this paper, we focus on the partial functional linear model with missing observation, which allows the responses or part of the covariates or responses and part of the covariates simultaneously missing at random, where the regression error is a linear process deduced by not necessarily independent random variables. Under the reproducing kernel Hilbert space setting, we construct the estimators of the slope parameter and coefficient function in the model based on the inverse probability weighting methods, and establish their asymptotic normality and weak convergence with rates, respectively. Meanwhile, the penalized estimator of the parameter is defined by the SCAD penalty and its oracle property is investigated. In addition, we construct a test statistic to check a linear hypothesis of the nonzero parameters and discuss its asymptotic distribution. Simulation study and real data analysis are conducted to investigate the finite sample performance of the proposed methods.