Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives

Mou-Ze Liu,Hai-Yan He,Jian-Quan Luo,Fa-Zhong He,Zhang-Ren Chen,Yi-Ping Liu,Da-Xiong Xiang,Hong-Hao Zhou,Wei Zhang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.7

Drug-induced diabetes is widely reported inclinical conditions, and it is becoming a global issuebecause of its potential to increase the risk of severe cardiovascularcomplications. However, which drug mechanismsexert their diabetogenic effects and why the effectspresent significant inter-individual differences remain largelyunknown. Pharmacogenomics, which is the study ofhow genomic variation influences drug responses, providesan explanation for individual differences in drug-induceddiabetes. We highlight that pharmacogenomics can beinvolved in regulating the expression of genes in signalingpathways related to the pharmacokinetics or pharmacodynamicsof drugs or the pathogenesis of diabetes, contributingto the differences in drug-induced glucoseimpairment. The pharmacogenomics studies of the majordiabetogenic drugs are reviewed, including calcineurininhibitors, antipsychotics, hormones, and antihypertensivedrugs. We intend to elucidate the genetic basis of druginduceddiabetes and pave the way for the precise use ofthese drugs in the clinic.

Study on Joint Simulation of Very Fast Transient Overvoltage and Transient Enclosure Voltage in 1000 kV GIS

Zhang Yan-Ze,Chen Xiao-Yue,Si Jun-Jie,He Ze-Yu,Wen Xi-Shan 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5

Disconnector operation in GIS generates VFTO and TEV, which threaten device insulation and personnel safety. In order to calculate VFTO and TEV more accurately, this paper proposes a VFTO-TEV joint simulation model. Among them, dynamic arc model is used to reflect the dynamic characteristics of high frequency AC arc. In order to reflect the electromagnetic leakage phenomenon caused by the impedance mismatch of high-frequency electromagnetic waves, and the influence of the transient potential difference formed by the transient electromagnetic field on grounding grid on TEV, the geometric structures of high-voltage bushing, grounding pillars and grounding grid are modeled to obtain their respective frequency-dependent admittance matrices, which are converted into corresponding broadband equivalent circuit models by combining vector fitting method and impedance synthesis method. The above modeling method is applied to the 1000 kV GIS test circuit, and the simulation model is built in the ATP-EMTP electromagnetic transient program, and the joint simulation research of VFTO and TEV is carried out. The results show that at each measurement point of the test circuit, the amplitude error of the VFTO obtained by simulation and actual measurement is mostly less than 7%, and the frequency spectrum both contains the main frequency components of 18 MHz and 25 MHz; Compared with the traditional calculation model of obtaining VFTO/TEV using CIGRE model/Petersen's law, the amplitude of VFTO and TEV obtained by joint simulation model is lower and contains richer high-frequency components. In addition, the opening speed of 0.8 m/s also corresponds to the maximum point of the VFTO amplitude of the test circuit. Finally, based on the above modeling method, the effectiveness of adding ferrite beads to suppress VFTO is verified by simulation. © 2017 Elsevier Inc. All rights reserved.

Phylogenetic Diversity and Antifungal Activity of Endophytic Fungi Associated with Tephrosia purpurea

( Ze Ping Luo ),( Hai Yan Lin ),( Wen Bing Ding ),( Hua Liang He ),( You Zhi Li ) 한국균학회 2015 Mycobiology Vol.43 No.4

Sixty-one endophytic fungus strains with different colony morphologies were isolated from the leaves, stems and roots of Tephrosia purpurea with colonization rates of 66.95%, 37.50%, and 26.92%, respectively. Based on internal transcribed spacer sequence analysis, 61 isolates were classified into 16 genera belonging to 3 classes under the phylum Ascomycota. Of the 61 isolates, 6 (9.84%) exhibited antifungal activity against one or more indicator plant pathogenic fungi according to the dual culture test. Isolate TPL25 had the broadest antifungal spectrum of activity, and isolate TPL35 was active against 5 plant pathogenic fungi. Furthermore, culture filtrates of TPL25 and TPL35 exhibited greater than 80% growth inhibition against Sclerotinia sclerotiorum. We conclude that the endophytic fungal strains TPL25 and TPL35 are promising sources of bioactive compounds.

Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

He Zhou,XiaoFan Wang,Juntang Lin,Ze Zhao,Cheng Chang 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.1

Hippocampal formation is important in spatial learning and memory. Members of the cadherin superfamily are observed in the neural system with diverse spatial and temporal expression patterns and are involved in many biological processes. To date, the avian hippocampal formation is not well understood. In this study, we examined the expression of cadherin mRNA in chicken and mouse brains to investigate the morphological and cytoarchitectural bases of hippocampal formation. Profiles of the spatiotemporal expression of cadherin mRNAs in the developing chicken embryonic parahippocampal area (APH) are provided, and layer-specific expression and spatiotemporal expression were observed in different subdivisions of the APH. That fact that some cadherins (Cdh2, Cdh8, Pcdh8 and Pcdh10) showed conserved regional expression both in the hippocampus and entorhinal cortex of mice and the hippocampal formation of chickens partially confirmed the structural homology proposed by previous scientists. This study indicates that some cadherins can be used as special markers of the avian hippocampal formation.

Research on the Impact of China’s High-Speed Railway Construction on Regional Economy-Take Xibao High-Speed R ail as an Example-

He, Jia(하가),Chen, Lu(션루),Zhang, Meng-Ze(장몽택),Bae, Ki-Hyung(배기형) 한국물류학회 2019 물류학회지 Vol.29 No.5

서보(西寶) 고속철도는 산시성(陕西省) 서안(西安)에서 보계(寶雞)까지 산시성 관중(關中) 지역에 있다. 서보 고속철도는 국가 중점 철도 인프라 건설 프로젝트이고 서안, 함양(鹹陽), 보계, 양릉시범구(楊淩示範區)를 지나며 서안북(西安北), 함양진도(鹹陽秦都), 양릉남(楊淩南), 기산(岐山)과 보계남(寶雞南) 등 5개 역이 있다. 본문은 고속철도는 지역 경제 발전에 미치는 영향에 관한 이론과 문헌을 고찰하여 고속철도 발전이 지역 경제 발전에 관련 메커니즘을 요약하였다. 이를 바탕으로 본문은 서보 고속철도를 대상으로 DID모델을 사용하여 서보고속 철도가 연선 지역의 경제 발전에 미치는 영향을 실증 분석을 실행하였다. 연구 결과에 따르면 서보 고속철도는 연선의 경제 성장을 촉진하는 데 중요한 역할을 한다. 따라서 고속철도는 철도 연선 지역 경제 발전을 촉진하는 데 중요한 역할을 한다는 결론을 내릴 수 있고 고속철도의 건선은 연선 지역의 경제 발전에 큰 도움이 된다는 것을 알 수 있다. 또한 본문은 산시성 고속철도 건설에 대한 정책적 조언과 고속철도 건설을 가속화하기 위한 제안도 제시하였다. Xibao High-speed Railway is located in Guanzhong area of S haanxi Province, from Xi’an City in Shaanxi Province to Baoji City in Shaanxi Province in the west. It passes through Xi’an, Xianyang, Baoji and Yangling Demonstration Zones. There are five stations in the whole line, including Xi’an North Station and Xianyang. Qindu Station, Yangling South Station, Qishan Station, Baoji South Station, and Xibao High-speed Railway are key national railway infrastructure construction projects. The paper summarizes the relevant theories and literatures of the impact of high-speed rail on regional economic development, and summarizes the relevant mechanisms of high-speed rail development on regional economic development. By using Xibao high-speed rail as an example, the DID model is used to study the area along the Xibao high-speed railway. The impact of economic development has found that Xibao High-speed Railway has a significant role in promoting economic growth along the route. Therefore, it is concluded that high-speed rail has an important role in promoting and promoting the economic development along the line. The construction of high-speed rail will be of great help to the regional economic development along the line. Finally, relevant policy recommendations were put forward for the construction of high-speed railways in Shaanxi Province, and relevant suggestions for accelerating the construction of high-speed railways in Shaanxi Province were put forward.

A Study of Natural Convection Heat Transfer in a Maximum Eccentric Horizontal Annulus

Ze Liang Yang,Jie He,Jain Min Wang 대한기계학회 1998 Heat transter conference Vol.3 No.1

Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma

He, Jian-Rong,Xi, Jing,Ren, Ze-Fang,Qin, Han,Zhang, Ying,Zeng, Yi-Xin,Mo, Hao-Yuan,Jia, Wei-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Purpose: Complement receptor 1 (CR1) is induced by Epstein-Barr virus (EBV) and may be a potential biomarker of nasopharyngeal carcinoma (NPC). We conducted the present study to evaluate the association of CR1 expression with clinicopathological features and prognosis of NPC. Methods: We enrolled 145 NPC patients and 110 controls. Expression levels of CR1 in peripheral blood mononuclear cells (PBMCs) were detected using quantitative real-time PCR and associations with clinicopathological features and prognosis were examined. Results: CR1 levels in the NPC group [3.54 (3.34, 3.79)] were slightly higher than those in the controls [3.33 (3.20, 3.47)] (P<0.001). Increased CR1 expression was associated with histology classification (type III vs. type II, P=0.002), advanced clinical stage (P=0.003), high T stage (P=0.017), and poor overall survival (HR, 4.89; 95% CI, 1.23-19.42; P=0.024). However, there were no statistically significant differences in CR1 expression among N or M stages. Conclusion: These findings indicate that CR1 expression in PBMCs may be a new biomarker for prognosis of NPC and a potential therapeutic target.

Comparative analysis of the volatile components in Chinese breast milk from three regions

Yangzheng He,Li Chen,Wenqun Liu,Ze-Yuan Deng,Jing Li 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.7

In this study, gas chromatography–mass spectrometry (GC–MS) coupled with Partial least squares Discriminant Analysis (PLS-DA) was used to analyze the volatiles in Chinese breast milk from different cities (Wuhan, Qingdao and Hohhot) and different lactation stages (colostrum and mature milk). The results showed that breast milk contained 122 volatile substances in 9 major groups, with the largest number of olefins (36) and the highest content of acids. The different volatile compounds of breast milk in three cities were heptanal, 2-pentylfuran, (E)-2,4-decadienal, (E)-2-heptenal, (E)-2-nonenal and 1-octen-3-one, colostrum and mature milk were (E)-2-heptenal, (E)-2-decenal, lauric acid, n-decanoic acid, (E)-2-nonenal and octanoic acid. This study might provide scientific data for the development and optimization of formulas that were more suitable for the health of Chinese infants.

广东省内居民粤语语言态度探究

ZIYANG HE,KANG’EN SHAN,Ting Lei,ZE’NAN TONG 한국중국어교육학회 2023 중국어교육과연구 Vol.- No.40

The purpose of this article is to study the language attitudes of residents in Guangdong Province towards Cantonese. The research focuses on two different types of residents in Guangdong Province: local indigenous residents and non-indigenous residents, with regards to their attitudes towards Cantonese identification, proficiency, usage, and future prospects. The research data are mainly obtained through a questionnaire survey that collects the thoughts of the two types of residents in Guangdong Province on Cantonese and conducts corresponding data analysis to obtain more effective results. The analysis results show that family environment has an important impact on Cantonese acquisition; identity recognition and language recognition have a corresponding relationship with mutual influence, but this does not lead to most people having language discrimination psychology. Cantonese has a high affinity for most interviewees, and people whose mother tongue is not Cantonese have a higher willingness to use it. However, people generally hold a pessimistic attitude towards the future of Cantonese. How to preserve the uniqueness of Cantonese under the increasingly strengthened Mandarin environment, establish and maintain the sense of identity of local residents towards Cantonese, and better inherit Cantonese culture are still issues worthy of attention.

Smads, p38 and ERK1,2 are involved in BMP9-induced osteogenic differentiation of C3H10T1,2 mesenchymal stem cells

( Dao Jing Xu ),( Ying Ze Zhao ),( Jin Wang ),( Juan Wen He ),( Ya Guang Weng ),( Jin Yong Luo ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.4

Although previous studies have demonstrated that BMP9 is highly capable of inducing osteogenic differentiation of mesenchymal stem cells, the molecular mechanism involved remains to be fully elucidated. In this study, we showed that BMP9 simultaneously promotes the activation of Smad1/5/8, p38 and ERK1/2 in C3H10T1/2 cells. Knockdown of Smad4 with RNA interference reduced nuclear translocation of Smad1/5/8, and disrupted BMP9-induced osteogenic differentiation. BMP9-induced osteogenic differentiation was blocked by p38 inhibitor SB203580, whereas enhanced by ERK1/2 inhibitor PD98059. SB203580 decreased BMP9-activated Smads singling, and yet PD98059 stimulated Smads singling in C3H10T1/2 cells. The effects of inhibitor were reproduced with adenovirus expressing siRNA targeted p38 and ERK1/2, respectively. Taken together, our findings revealed that Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation. Also, it is noteworthy that p38 and ERK1/2 may play opposing regulatory roles in mediating BMP9-induced osteogenic differentiation of C3H10T1/2 cells. [BMB reports 2012; 45(4): 247-252]