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NLRP6 as a Negative Regulator of Innate Immunity
Zahid Manzoor,Young-Sang Koh 대한미생물학회 2013 Journal of Bacteriology and Virology Vol.43 No.1
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported asnegative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.
cGAS-cGAMP Signaling and Antiviral Defense
Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2014 Journal of Bacteriology and Virology Vol.44 No.1
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, $cGas^{-/-}$ mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.
Zahid Manzoor,김소현,채두병,유은숙,강희경,현진원,이남호,서인수,고영상 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.3
This report was designed to study inhibitory effect of sea lettuce (Ulva fasciata) extract (UFE) on proinflammatory cytokine production in bone marrow-derived macrophages (BMDM) and dendritic cells (BMDC). The UFE (0-50 μg/mL) pre-treatment showed a dose dependant inhibitory effect on interlukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α productions in CpG-stimulated BMDMs and BMDCs as compared to non-treated controls. The UFE pre-treatment exhibited strong inhibitory effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK) while it showed moderate inhibition on nuclear factor (NF)-κB activation as indirectly evaluated by degradation of IκBα. In activator protein (AP)-1 and NF-κB reporter gene assay, the UFE pre-treatment showed moderate inhibitory effect on both AP-1- and NF-κBdependent reporter gene activities. Thus, these results suggest that inhibitory effect of UFE on pro-inflammatory cytokine production may correlate with partial inhibition of both AP-1 and NF-κB pathways. Hence, our data warrant further studies concerning potentials of sea lettuce for medicinal food.
Zahid Manzoor,Vivek Bhakta Mathema,채두병,유은숙,강희경,현진원,이남호,고미희,고영상 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The anti-inflammatory effects of extracts of theseaweed Sargassum macrocarpum (SME) in bone marrowderivedmacrophages (BMDMs) and dendritic cells (BMDCs)were investigated. Primary BMDMs and BMDCs wereused for cytokine production and western blot analysis. SME (0-50 μg/mL) pre-treatment resulted in a stronginhibitory effect against interleukin (IL)-12 p40, IL-6, andtumor necrosis factor (TNF)-α production in CpG-stimulatedBMDMs and BMDCs. SME pre-treatment caused a stronginhibitory effect against NF-κB activation, as evaluatedusing degradation of IκBα and the NF-κB reporter geneassay. SME has significant anti-inflammatory propertiesand warrants further study regarding potential use as amedicinal food.
NLRP6 as a Negative Regulator of Innate Immunity
Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2013 Journal of Bacteriology and Virology Vol.43 No.1
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.