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유승수,( Hyo Gyoung Kang ),( Jin Eun Choi ),( Hyo Sung Jeon ),( Jae Hee Lee ),( Shin Yup Lee ),( Seung Ick Cha ),( Chang Ho Kim1 ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Purpose: A genome-wide association study has identified the 15q25 region as being associated with the risk of chronic obstructive pulmonary disease (COPD) in Caucasians. This study intended as a confirmatory assessment of this association in a Korean population. Methods: The rs6495309C>T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (CHRNA3) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control subjects. Results: The rs6495309 CT or TT genotype was associated with a significantly decreased risk of COPD when compared to the rs6495309 CC genotype (adjusted odds ratio=0.69, 95% confidence interval=0.50-0.95, P=0.02). The effect of the rs6495309 C>T on the risk of COPD was more evident in moderate to very severe COPD than in mild COPD under a dominant model for the variant T allele (P-value of test for homogeneity=0.02). Conclusions: We confirmed the association between the 15q25 region and the risk of COPD in a Korean population.
Hayeon Kim(Hayeon Kim),Bumhee Park(Bumhee Park),Shin-Young Kim(Shin-Young Kim),Jiyea Kim(Jiyea Kim),Bora Kim(Bora Kim),Kyu-In Jung(Kyu-In Jung),Seung-Yup Lee(Seung-Yup Lee),Yerin Hyun(Yerin Hyun),Bung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents. Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6−9, 10−13, and 14−17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis. Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6−9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10−13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14−17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation. Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.
Effects of N-acetyl Cysteine as Precursor of GSH in RA-induced Neuronal Differentiation of P19 ESCs
Joon Yup Kim,Jiae Park,Yoo Hun Noh,Do Hee Kim,Ok Hyeon Kim,Yoon Hee Chung,Kyung Yong Kim,Seung Ho Han,Sung Su Kim,Won Bok Lee 중앙대학교 의과대학 의과학연구소 2013 中央醫大誌 Vol.38 No.2
N-acetyl cysteine (NAC), estradiol and melatonin are well-known as antioxidant, and these reagents have a strong influence on many cellular events. Therefore, we compared effects of NAC in Retinoic acid (RA)-induced embryonic body's (EB) formation and neuronal differentiation of P19 embryonic stem cells (P19 ESCs) with estradiol and melatonin. NAC dramatically increased EB formation and neuronal differentiation in terms of neuronal marker, MAP-2, and neuronal maturation. However, in additional treated groups with estradiol and melatonin, no differences were founded as contrasted with NAC treatment. Furthermore, in NAC-enhanced neuronal differentiation, intracellular glutathione (GSH) contents was only increased, and co-treatment with buthionine sulphoximine (BSO), a GSH-synthesis inhibitor, effectively reduced the EB formation and neuronal differentiation. These results demonstrated that NAC increase EB formation and neuronal differentiation by up-regulation of intracellular GSH contents. NAC-enhanced neuronal differentiation effects may be as donor of GSH, not as antioxidant.
김한(Hahn Kim),김양식(Yangsik Kim),김장래(Jangrae Kim),김정화(Junghwa Kim),김태형(Tae-Hyeong Kim),김화영(Whayoung Kim),백수현(Soo-Hyun Paik),장옥진(Og-Jin Jang),정현숙(Hyunsuk Jeong),이승엽(Seung-Yup Lee) 한국중독정신의학회 2024 중독정신의학 Vol.28 No.1
Objectives: To determine Korean national priority for research and development planning for drug abuse and substance use disorder treatment. Methods: A Delphi survey methodology was employed, involving 19 experts in the field of addiction. Their potential priorities were assessed based on the size of the problem, urgency, effectiveness, budget size, and feasibility of research execution. Results: After three rounds, the expert consensus was reached for 13 research plans of universal therapeutic agenda and 7 plans for specific drugs. These included developing guidelines for children and adolescents on substance use, a community-based long-term management program, and the development of intervention programs and clinical guidelines for stimulant, cannabis, and opioid use disorders. However, consensus was not reached for research on therapeutic options such as digital therapeutics. Conclusion: This study highlights priority areas for systematic and effective development of treatment programs and research agenda against illicit use of drugs. By integrating insights from multidisciplinary experts, a comprehensive research and development blueprint is proposed to address drug use, which is on the rise and threatening public health and social security in the Republic of Korea.
Kim, Jae-Yup,Kim, Jin Young,Lee, Doh-Kwon,Kim, BongSoo,Kim, Honggon,Ko, Min Jae American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.43
<P>The photovoltaic performance of dye-sensitized solar cells (DSSCs) employing SnO<SUB>2</SUB> electrodes was investigated while increasing the content of 4-<I>tert</I>-butylpyridine (TBP) in the conventional liquid-type electrolyte. As the added TBP content increased, the open circuit voltage (<I>V</I><SUB>oc</SUB>) and conversion efficiency were highly enhanced while the short circuit current (<I>J</I><SUB>sc</SUB>) was not much affected. With the electrolyte of 2.0 M TBP, the <I>V</I><SUB>oc</SUB> and conversion efficiency were increased by 26 and 33%, respectively, compared with the conventional electrolyte (0.5 M TBP). The electrochemical impedance spectra revealed that the enhancement of <I>V</I><SUB>oc</SUB> resulted from the negative shift of the SnO<SUB>2</SUB> conduction band potential and the increase in resistance of electron recombination by 1 order of magnitude. It is noteworthy that the optimized concentration of TBP for the SnO<SUB>2</SUB> electrode is greatly larger than that for the TiO<SUB>2</SUB> electrode. This may be due to the much faster electron recombination rate and more positive conduction band potential of the SnO<SUB>2</SUB> electrode. The SnO<SUB>2</SUB> electrode modified with TiO<SUB>2</SUB> shell showed only slightly enhanced performance due to the similar effects of shell layer and those of the TBP. In contrast to the SnO<SUB>2</SUB>, TiO<SUB>2</SUB> electrodes did not show performance enhancement with the electrolyte of TBP concentration larger than 0.5 M. The impedance spectra of symmetric dummy cells employing Pt counter electrodes indicated that the catalytic effect of Pt was deteriorated, and the resistance of electrolyte diffusion was increased by the higher concentration of TBP. This brings up the need for development of a counter electrode that TBP is not easily adsorbed on, and alternative additives to TBP which are not highly viscous.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-43/jp307783q/production/images/medium/jp-2012-07783q_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp307783q'>ACS Electronic Supporting Info</A></P>
Kim, Do Yup,Choi, Hyun Nam,Park, Jin Hyung,Kim, Sin Rak,Kim, Hyun,Han, Yea Sik Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.2
Background Various shapes and designs of the gluteal artery perforator flap have been used for treating sacral pressure sores and reconstructing breasts. To establish the ideal fasciocutaneous flap design for use in the gluteal area, the soft tissue thickness distribution was measured. Methods Twenty-one buttocks of adult Korean cadavers were analyzed through rectangular subfascial dissection. Each buttock was divided horizontally into 10 sections and vertically into 10 sections, and then, the thickness at the corners of the sections was measured. For the sake of comparison and statistical verification with living bodies, computed tomography (CT) images of 120 buttocks of patients were randomly selected. Five horizontal sections and 4 vertical sections were made, and the thickness at each corner was recorded. Results According to the dissection and the CT images, the area with the thinnest soft tissues in the buttock was around the posterior superior iliac spine, close to the sacral area. The thickest area was the superolateral area of the buttock, which was 3.24 times and 2.15 times thicker than the thinnest area in the studies on cadaver anatomy and the CT images, respectively. Conclusions The thickness of the soft tissues in the buttocks differed by area. The superolateral area had the thickest soft tissues, and the superomedial area had the thinnest. This study includes information on the distribution of the thickness of the gluteal soft tissues of Koreans. The outcome of this study may contribute to the design of effective local flaps for pressure sore reconstruction and free flaps for breast reconstruction.