논문 : Top-Down 공법이 적용된 흙막이벽의 역해석을 이용한 거동분석

홍원표 ( Won Pyo Hong ),강철중 ( Chul Joong Kang ),윤중만 ( Jung Mann Yun ) 대한지질공학회 2012 지질공학 Vol.22 No.1

본 연구에서는 흙막이벽 설계시 널리 사용되고 있는 SUNEX 프로그램을 이용하여 Top-Down 공법이 적용된 지중연 속벽, 주열식 흙막이벽 (CIP벽, SCW벽)의 변형거동을 분석하였다. 해석프로그램에 Rankine의 토압(l857), Terzaghi and Peck의 토압(1967), Tschebotarioff의 토압(1973), 홍원표·윤중만의 토압(1995a)을 적용하여 흙막이벽의 수평변위를 예측하였다. 프로그램 해석결과, 흙막이벽의 수평변위량은 토압의 종류에 따라 큰 차이를 나타내고 있다. 홍원표·윤중만의 토압(I995a)을 적용하여 얻은 흙막이벽의 예측수평변위량이 실측수평변위량과 가장 유사하게 나타났다. 따라서 프로 그램 해석시 홍원표·윤중만의 경험토압(l995a)을 적용하면, Top-Down 공법이 적용된 흙막이벽의 변형거동을 비교적 정확히 예측할 수 있다. Abstract: The behaviors of a diaphragm wall and a contiguous pile wall such as CIP (Case-in-place pile) and SCW (Soil-cement wall), applied to the top-down construction method, were analyzed using the SUNEX program, which is widely used to design earth retaining walls. Four types of earth pressures, as described by Rankine (1857), Terzaghi and Peck (1967), Tchbotarioff (1973), and Hong and Yun (1995a), were applied to the analysis program to predict the lateral displacement of walls, The results show that the displacements of an earth retaining walls vary with the applied earth pressure. The predicted lateral displacement based on Hong & Yun`s (1995a) earth pressure is similar to the measured displacement. Therefore, the actual lateral displacement of an earth retaining wall, as applied to top-down construction method, can be accurately predicted by using an analysis program considering Hong and Yun`s (1995a) earth pressure.

Top-Down 공법이 적용된 지중연속벽의 설계시 측방토압의 적합성 평가

홍원표(Hong Won-Pyo),강철중(Kang Chul-Joong),윤중만(Yun Jung-Mann) 한국토목섬유학회 2012 한국지반신소재학회 논문집 Vol.11 No.1

본 연구에서는 지중연속벽 설계시 사용되는 범용 해석프로그램에 Rankin(1857)의 이론토압과 홍원표와 윤중만(1995a)의 경험 토압을 각각 적용하여 Top-Down 공법에 적용된 지중연속벽의 수평변위를 분석하였다. 그리고 이들 해석 프로그램에서 산정된 예측변위량과 지중경사계로 측정된 실측변위량을 비교 검토하였다. 현재 지중연속벽 설계에 적용되는 해석프로그램에는 Rankine의 토압이 주로 적용되고 있다. 검토결과, 지중연속벽의 예측수평변위는 적용되는 토압에 따라 상당히 큰 차이를 나타내고 있다. Rankine의 토압을 적용하여 산정된 예측수평변위 형상은 실측결과와 큰 차이를 보이고 있으며 벽체의 하부에서 예측치가 실측치보다 과다하게 산정되었다. 반면, 홍원표·윤중만의 토압을 적용하여 얻은 예측수평변위 형상과 최대수평변위 량은 실측결과와 유사하게 나타났다. 따라서 Top-Down 공법이 적용된 지중연속벽의 설계시 Rankine의 토압보다는 홍원표·윤중만의 경험토압을 적용하는 것이 적합함을 알 수 있다. The Rankine(1857)'s earth pressure and the Hong and Yun(1995a)'s earth pressure was applied to analyze the lateral displacement of diaphragm wall applied to the Top-Down construction method using the computer program, which is a common design program for diaphragm wall. The lateral displacement estimated by the computer program was compared with the lateral displacement measured by inclinometer. The Rankine's earth pressure has been widely used to design the diaphragm wall in the analysis of computer program. As the result of comparison, the lateral displacement of diaphragm wall was predicted differently according to the applied earth pressures. The behavior of lateral displacement predicted by the Rankine's earth pressure was different with displacement measured by inclinometer and the lateral displacement at the bottom part was overestimated. However, the lateral displacement predicted by the Hong and Yun's earth pressure is similar to the behavior and maximum value of real displacement. Therefore, the Hong and Yun's earth pressure is more suitable than the Rankine' earth pressure to design the diaphragm walls applied to the Top-Down Construction Method.

Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

800㎿급 발전소 복수기의 최적 운전점 및 운전방법에 대한 연구

장철호(Cheol-Ho Jang),홍은기(Eun-Kee Hong),황광원(Kwang-Won Hwang),윤린(Rin Yun) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.5

Along with the recent construction of a 800㎿ thermal power plant it is necessary to check the soundness of the current operation of the condenser, and to investigate the effects of vacuum level of it on the turbine efficiency for the power plant. In this study, the performances of the condenser and the turbine for the 800㎿ thermal power plant were tested based on the ASME PTC 6 and ASME PTC 12.2 with the variation of the vacuum level. When the condenser vacuum levels were 719.91 ㎜Hg, 724.5 ㎜Hg, and 729.6 ㎜Hg, the turbine efficiencies were 47.36%, 47.47%, and 47.55%, respectively. From the regression analysis of the present data, it was estimated that the optimal vacuum point is between 729 ㎜Hg and 731 ㎜Hg. When this optimal point is to be applied to the condenser, the profit of 5.5 billion won/year is expected based on the '09 caloric cost.

The Korean Society of Gastroenterology& SLDDS 2052 : Slide Session ; K-MO-02 : GI Motility ; The Value of Multiple Rapid Swallow in Assessment of Esophageal Motor Function

( Yun Soo Hong ),( Yang Won Min ),( Poong Lyul Rhee ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Multiple rapid swallow (MRS) during esophageal manometry is a simple provocative maneuver, which could predict esophageal peristaltic reserve. We aimed to assess the value of MRS in patients with ineffective esophageal motility. Methods: Between November 2013 and July 2014, a total of 36 patients showing ineffective esophageal motility (IEM) on esophageal manometry were included in the study. We analyzed contractions after MRS. If a contraction after MRS stronger than that of single swallow, MRS was considered normal. The patients were classifi ed as having normal/abnormal MRS and differences between groups were tested in terms of proportions of gastroesophageal refi ux disease (GERD), pathologic acid exposure (PAE) and pathologic bolus exposure (PBE) and total AE and BE times (%). PAE and PBE was defi ned as an intraesophageal pH of <4 for more than 4.2% and refi uxate in contact with distal impedance electrodes for more than 1.4% of the recording time, respectively. Results: After exclusion of 4 patients with unavailable MRS results, 32 were analyzed. Of them, 15 patients (46.9%) had abnormal post-MRS response. The proportion of GERD, PAE and PBE did not show statistically signifi cant differences between the two groups (abnormal MRS group vs normal MRS group, 46.7% vs 35.3%, P=0.513; 40.0% vs 8.3%, P=0.135; 60.0% vs 33.3%, P=0.391). Total AE and BE time (%) was longer in abnormal MRS group than normal MRS group although it did not reach statistical signifi cance (4.2% vs 1.6%, P=0.125 and 3.7% vs 1.4%, P=0.237, respectively). Conclusions: Our results show that ineffective esophageal motility patients with abnormal post-MRS response have a tendency to be accompanied by more prolonged acid and/or bolus refi ux than those with normal response. Further large scaled study is warranted to confi rm out results in the future.

LC, Acute : PE-117 ; Incidence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal

( Yun Jung Choi ),( Jeong Han Kim ),( Ja Kyung Koo ),( Cho I Lee ),( Ji Young Lee ),( Jae Hoon Yang ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: In year 2011, a revised classification system of renal dysfunction in patients with cirrhosis was proposed by the acute dialysis quality initiative (ADQI) and the international ascites club (IAC) Working Group [Gut 2011;60:702-709]. We aimed to evaluate the incidence of renal dysfunction according to this proposal. Methods: We retrospectively reviewed medical records of cirrhotic patients who admitted at konkuk university hospital from year 2008 to 2010. The data of first admission date was used for data collection. Definitions of acute kidney injury (AKI) and chronic kidney disease (CKD) were made by proposed diagnostic criteria of kidney dysfunction in cirrhosis. Results: Total 590 patients admitted. Child-Pugh class A/B/C were 178/242/170 (30.2%, 41%, 28.8%). 70 patients (11.9%) were diagnosed with AKI. Most common cause was dehydration, 28 patients. 3 patients were type 1 hepatorenal syndrome and 16 patients were pre-renal type AKI caused by volume deficiency after variceal bleeding. 3 patients were diagnosed with AKI induced by septic shock. On the other hand, 10 patients (1.7%) were diagnosed with CKD. Among these, 1 patient was already diagnosed with end stage renal disease because of IgA nephropathy and 6 patients had underlying diabetes or hypertension. 3 patients had unknown cause of chronic renal insufficiency. Presence of type 2 hepatorenal syndrome was not found. 6 patients (1%) were diagnosed with AKI on CKD. Conclusions: Incidence of renal dysfunction in cirrhosis is not infrequent (Total 14.6%). Diagnosis of type 2 hepatorenal syndrome was still difficult and that of acute-on-chronic kidney disease needs long term follow up evaluation of renal function in cirrhotic patients. Prospective cohort study is warranted for the evaluation of clinical course in cirrhotic patients with renal dysfunction.

Magnetism and Magnetocrystalline Anisotropy in Tetragonally Distorted γ-Fe (001) Surface

Won Seok Yun,Gi-Beom Cha,Soon Cheol Hong 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Photopatternable Poly(4-styrene sulfonic acid)-Wrapped MWNT Thin-Film Source/Drain Electrodes for Use in Organic Field-Effect Transistors

Hong, Kipyo,Kim, Se Hyun,Yang, Chanwoo,Yun, Won Min,Nam, Sooji,Jang, Jaeyoung,Park, Chanjun,Park, Chan Eon American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.1

<P>We describe the cross-linking of poly(4-styrene-sulfonic acid) (PSS) by exposure to ultraviolet (UV) light (λ = 255 nm) under a vacuum. Fourier transform infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS) showed that the photo-crosslinking of PSS resulted from coupling between radicals that were generated in the polymer chains by UV excitation. The photo-cross-linkable characteristics of PSS were employed to fabricate solution-processable, photopatternable, and conductive PSS-wrapped multiwalled carbon nanotube (MWNT) composite thin films by wrapping MWNTs with PSS in water. During photo-cross-linking, the work function of the PSS-wrapped MWNTs decreased from 4.83 to 4.53 eV following cleavage of a significant number of sulfonic acid groups. Despite the decreased work function of the PSS-wrapped MWNTs, the photopatterned PSS-wrapped MWNTs produced good source/drain electrodes for OFETs, yielding a mobility (0.134 ± 0.056 cm<SUP>2</SUP>/(V s)) for the TIPS-PEN field-effect transistors fabricated using PSS-wrapped MWNTs as source/drain electrodes that was higher than the mobility of gold-based transistors (0.011 ± 0.004 cm<SUP>2</SUP>/(V s)).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-1/am1008826/production/images/medium/am-2010-008826_0004.gif'></P>

Poster Session : PS 0943 ; Liver : Early Monitoring and Risk Factors for Detection of Antituberculosis Treatment-Induced Hepatotoxicity

( Yun Won Jo ),( Chang Min Lee ),( Sang Soo Lee ),( Hong Jun Kim ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Pulmonary tuberculosis (TB) is considerably common in Korea. Also, adverse drug reactions associated with anti- tuberculosis drugs occurs frequently. We analyzed occurrence rate, onset time and risk factors of the hepatotoxicity Methods: The review of electronic medical record about clinical features in 1,020 TB patients treated at Gyeongsang national university hospital from February 2009 to January 2013 was performed retrospectively. Results: Anti-tuberculosis drug-induced hepatotoxicity occurred at a mean of 40.29 ± 44.20 days after treatment initiation in 104 (10.2%) out of 1,020 patients. The patient group with hepatotoxicity had higher baseline AST, ALT, total bilirubin and comorbidity rate of hepatitis C infection (HCV) than the patient group without hepatotoxicity . Hepatotoxicity emerged in 70 patients (67.3%) of the group with hepatotoxicity within 30 days from the anti-tuberculosis drug administration. Twenty six patients (25.0%) showed the hepatotoxicity within 7 days (very early onset group). Among the patients with hepatotoxicity within 7 days, frequency of extrapulmonary TB was higher than that of pulmonary TB (53.8% vs. 29.5%, p = 0.025). Conclusions: One patient out of 10 suffered from anti-tuberculosis drug-induced hepatotoxicity. Hepatotoxicity occurred in two third patients of the hepatotoxicity group within 30 days from the anti-tuberculosis drug treatment. The baseline abnormal LFT and HCV coinfection were associated with hepatotoxicity, but not related withonset time. Patients with abnormal LFT and HCV comorbidity should be thoroughly monitored for hepatotoxicity. Early LFT monitoring should be commenced especially in extrapulmonary TB patients.

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-090 : COPD ; Emphysema Is a Risk Factor for Severe Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confi dence interval, 1.144 7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no signifi cant difference in severity of the air ow limitation, presence of bronchiectasis, previous COPD medicationincluding inhaled corticosteroids, or pathogens was identifi ed between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.