Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

Urun, Yuksel,Utkan, Gungor,Cangir, Ayten Kayi,Oksuzoglu, Omur Berna,Ozdemir, Nuriye,Oztuna, Derya Gokmen,Kocaman, Gokhan,Coskun, Hasan Senol,Kaplan, Muhammet Ali,Yuksel, Cabir,Demirkazik, Ahmet,Icli, Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.

Diagnostic Importance of 3D CT Images in Klippel-Feil Syndrome with Multiple Skeletal Anomalies: A Case Report

Murvet Yuksel,Hamza Karabiber,K. Zafer Yuksel,Gonul Parmaksiz 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.4

We present here the case of a 12-year-old boy who had Klippel-Feil syndrome with renal, cardiac and multiple skeletal anomalies, and we show the relevent three-dimensional computed tomography images. Our patient had a triple renal pelvis, mitral valve prolapsus, multiple cervical vertebrae fusions, cervical ribs, hypoplasia of the right thumb, spina bifida of L5, lumbalization at the right side of S1 and a sacral curved defect. In this study, we discuss the atypical clinical features and the diagnostic value of three-dimensional CT for evaluating the skeletal anomalies of the Klippel-Feil syndrome cases.

Predictive Value of the Platelet-To-Lymphocyte Ratio in Diagnosis of Prostate Cancer

Yuksel, Ozgur Haki,Urkmez, Ahmet,Akan, Serkan,Yldirim, Caglar,Verit, Ayhan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Purpose: To predict prostatic carcinoma using a logistic regression model on prebiopsy peripheral blood samples. Materials and Methods: Data of a total of 873 patients who consulted Urology Outpatient Clinics of Fatih Sultan Mehmet Training and Research Hospital between February 2008 and April 2014 scheduled for prostate biopsy were screened retrospectively. PSA levels, prostate volumes, prebiopsy whole blood cell counts, neutrophil and platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), biopsy results and Gleason scores in patients who had established diagnosis of prostate cancer (PCa) were evaluated. Results: This study was performed on a total of 873 cases, with an age range 48-76 years, divided into three groups as for biopsy results. with diagnoses of benign prostatic hyperplasia (BPH) (n=304, 34.8 %), PCa (n=265, 30.4 %) and histological prostatitis (n=304; 34.8 %). Intra- and intergroup comparative evaluations were performed. White blood cell and neutrophil counts in the histological prostatitis group were significantly higher than those of the BPH and PCa groups (p=0.001; p=0.004; p<0.01). A statistically significant intergroup difference was found for PLR (p=0.041; p<0.05) but not lymphocyte count (p>0.05). According to pairwise comparisons, PLR were significantly higher in the PCa group relative to BPH group (p=0.018, p<0.05, respectively). Though not statistically significant, higher PLR in cases with PCa in comparison with the prostatitis group was remarkable (p=0.067, and p>0.05, respectively). Conclusions: Meta-analyses showed that in patients with PSA levels over 4 ng/ml, positive predictive value of PSA is only 25 percent. Therefore, novel markers which can both detect clinically significant prostate cancer, and also prevent unnecessary biopsies are needed. Relevant to this issue in addition to PSA density, velocity, and PCA3, various markers have been analyzed. In the present study, PLR were found to be the additional predictor of prostatic carcinoma.

The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

Yuksel Toplu,Emrah Sapmaz,Hakan Parlakpinar,Mehmet Kelles,M. Tayyar Kalcioglu,Kevser Tanbek,Ahmet Kizilay 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.1

Objectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.

Effect of High Temperature in Concrete for Different Mineral Additives and Rates

Yuksel Esen,Alper Kurt 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.4

In this study, the change of the effect of high temperature in concrete by the types of mineral additives was examinedexperimentally. For this purpose, CEM I 42,5 R cement was used together with different minerals such as Barite, Diatomite, Silicafume, F class Fly ash that are added in a substituted manner at the rates of 10%, 20%, 30% and 40% by volume. Dry unit weights,underwater weights and water saturated weights of these concrete samples with mineral additives with 28-day strength werefound. Ultrasonic Pulse Velocity (UPV) measurements of the concrete samples, the water absorption percentages by weight ofwhich were determined, were performed. The samples which were then exposed to high temperatures such as 200, 400, 600 and800°C were left for cooling at room temperature, and then, their compressive strength was measured. While the highest waterabsorption rates were in Diatomite reinforced concrete, the highest compressive strengths were obtained in Silica fume reinforcedconcrete.

Quasi-static cyclic displacement pattern for seismic evaluation of reinforced concrete columns

Yuksel, E.,Surmeli, M. Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.3

Although earthquakes generate random cyclic lateral loading on structures, a quasi-static cyclic loading pattern with gradually increasing amplitude has been commonly used in the laboratory tests because of its relatively low cost and simplicity compared with pseudo-dynamic and shake table tests. The number, amplitudes and sequence of cycles must be chosen appropriately as important parameters of a quasi-static cyclic loading pattern in order to account for cumulative damage matter. This paper aims to reach a new cyclic displacement pattern to be used in quasi-static tests of well-confined, flexure-dominated reinforced concrete (RC) columns. The main parameters of the study are sectional dimensions, percentage of longitudinal reinforcement, axial force intensity and earthquake types, namely, far-fault and near-fault.

Cetuximab Related Eyelash Elongations for Patients with Metastatic Rectum Carcinoma: Metabolic Complete Response

( Yuksel Urun ),( Gungor Utkan ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4

Behavior of tunnel form buildings under quasi-static cyclic lateral loading

Yuksel, S. Bahadir,Kalkan, Erol Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.1

In this paper, experimental investigations on the inelastic seismic behavior of tunnel form buildings (i.e., box-type or panel systems) are presented. Two four-story scaled building specimens were tested under quasi-static cyclic lateral loading in longitudinal and transverse directions. The experimental results and supplemental finite element simulations collectively indicate that lightly reinforced structural walls of tunnel form buildings may exhibit brittle flexural failure under seismic action. The global tension/compression couple triggers this failure mechanism by creating pure axial tension in outermost shear-walls. This type of failure takes place due to rupturing of longitudinal reinforcement without crushing of concrete, therefore is of particular interest in emphasizing the mode of failure that is not routinely considered during seismic design of shear-wall dominant structural systems.

Effects of Grafting in Saline Conditions

Yuksel Tuzel,Golgen Oztekin,Hakki Tuzel,Ayse Gul 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

A review of ICT related courses in pre-service teacher education programs

Yuksel Goktas 서울대학교 교육연구소 2008 Asia Pacific Education Review Vol.9 No.2

This study investigated teacher educators', prospective teachers', and K-12 teachers' opinions about the effectiveness of ICT related courses and the ways to improve the courses in Turkey's pre-service teacher education programs. The researchers used both quantitative and qualitative research approaches within the data collection and analysis processes. The data were collected from 111 teacher educators, 1,330 prospective teachers, and 1,429 K-12 teachers through questionnaires; and from 6 teacher educators, 6 prospective teachers, and 6 K-12 teachers through interviews. Even though a majority of the participants felt that ICT related courses are effective, most participants recommended that these courses need to be redesigned to be more beneficial in practice.