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- 저자 : Yuanfang Chen (검색결과 5 건)
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SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration
Xuri Chen,Shaoyun Chen,Yao Li,Yanling Gao,Shuying Huang,Hongping Li,Yuanfang Zhu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Rho GTPase-activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small GTPbinding protein RhoA (GTP-RhoA) to its inactive GDP-bound form and is a putative tumor suppressor gene associated with cell growth and migration. Here, the involvement of ARHGAP26 in ovarian cancer cell proliferation and migration was investigated. In this study, low ARHGAP26 expression was observed in ovarian cancer tissues and was associated with a poor overall survival and higher β-catenin expression in patients with ovarian cancer. A2780 and HEY cells with ARHGAP26 upregulation showed decreased cell proliferation, migration, and invasion, along with decreased GTPRhoA, β-catenin, VEGF, MMP2, and MMP7 expression. ARHGAP26 upregulation in A2780 cells also inhibited lung metastasis in vivo. SKOV3 cells with ARHGAP26 downregulation demonstrated an inverse effect, which was inhibited by ARHGAP26 overexpression or DKK1, an antagonist of the β-catenin pathway. SMURF1, an E3 ubiquitin ligase, interacted with and induced ubiquitination of ARHGAP26. ARHGAP26 upregulation in SKOV3 cells significantly inhibited SMURF1 upregulation-induced cell migration and invasion. Overall, SMURF1-mediated ubiquitination of ARHGAP26 may promote invasion and migration of ovarian cancer cells via the β-catenin pathway.
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Simin Li,Yuanfang Luo,Chen Yongjun,Tiwen Xu,Bangchao Zhong,Zhixin Jia,Demin Jia 한국섬유공학회 2019 Fibers and polymers Vol.20 No.8
To simultaneously improve processing performances of rubber composites and avoid additive-blooming problem,the concept of “supported rubber additives” was introduced and reactive processing additive oleic acid (OA) was chemicallyimmobilized onto the surface of silica to obtain silica-supported processing additive (SiO2-s-OA). In this study, SiO2-s-OAwas uniformly dispersed into styrene-butadiene rubber (SBR) and gained improved interfacial interaction with rubber matrixdue to its good compatibility and the reaction during vulcanization. Consequently, SBR compounds with SiO2-s-OApossessed lower vulcanizing torque and viscosity under high shear frequency, showing improved processing performance. Moreover, the tensile modulus and strength of SBR/SiO2-s-OA could be enhanced by as much as 88.40 % and 11.44 %compared to SBR/SiO2, respectively, which is also higher than SBR/m-SiO2. Taken together, these results indicate that thismethod for the surface treatment of silica to prepare supported rubber additives may be extended for other nanofillers andrubber additives, which has better processing performance and improved mechanical property simultaneously.
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A New Stability Condition for Uncertain Fuzzy Hopfield Neural Networks with Time-varying Delays
Jing Wang,Xia Liu,Jianjun Bai,Yuanfang Chen 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5
In this paper, the global asymptotic stability of uncertain fuzzy Hopfield neural networks(UFHNNs) withtime-varying delays is investigated. Firstly, a new fuzzy Lyapunov function comprising a special line-integral functionof fuzzy vector is proposed. Then by using theWirtinger-based integral inequality to determine the upper boundof the derivative term of the Lyapunov function more accurately, a new stability criterion with less conservatism isderived in the form of linear matrix inequality(LMI). At last, an examples is given to show the effectiveness andsuperiority of our result.
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The Value of Infectious Biomarkers for Prediction of Complication after Pancreatic Surgery
( Yuan Fang ),( Gang Jin ),( Xubao Liu ),( Yajin Chen ),( Bei Sun ),( Zhongtao Zhang ),( Wenchuan Wu ),( Wenhui Lou ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: To assess the predictive value of biomarkers for early complication after pancreatic surgery. Methods: 950 cases were recruited from 6 centers in China. Procalcitonin,C-reactive protein and WBC were measured on 1st, 3rd and 5th postoperative day . Chi-square test was for the complication risk factors. One-way ANOVA was for the com parison between the biomarkers in these 4 days. ROC curves was for the complication predictive value. Results: 1) 502 with and 448 without complication, pancreatic fistula (380,40%) had the highest morbidity, while the level A B C fistula were 278,90 and 12. 2) In the non-complica tion subgroup, the mean baseline,POD1, POD3 and POD 5 of PCT were 0.1, 0.81, 0.93, 0.57ug/L (P=0.118); CRP were 8.39, 70.81,99.59, 49.49mg/L (P=0.000). In the complication subgroup, the mean baseline,POD1, POD3 and POD 5 of PCT were 0.09, 0.93, 0.77, 0.37(P=0.000), CRP were 9.30, 79.70, 153.01, 85.83. (P=0.000) 3) There were significant differences in the subgroups classified by occurrence of infectious compli cation, abdominal infection and sepsis in POD3 and POD 5 of PCT, and significant difference by occurrence of complication, pancreatic fistula in POD3 and POD 5 of CRP, WBC and neutro phil%. 5) The AUC of POD3 and POD 5 of PCT were 0.8, 0.7, 0.6 (P=0.000) to predict sepsis, abdominal infection and infectious complication. AUC of POD3 and POD5 of CRP and WBC were 0.7,0.6 (P=0.000)to predict complication and pancreatic fistula. Conclusions: PCT is better to predict infectious complication, abdominal infection and sepsis while CRP, WBC and Neutrophil % are better to predict complication and pancreatic fistula.
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An analytical model for PVC-FRP confined reinforced concrete columns under low cyclic loading
Yuan Fang,Feng Yu,Anchun Chen,Shilong Wang,Guoshi Xu 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.77 No.2
Experimental investigations on the seismic behaviors of the PVC-FRP Confined Reinforced Concrete (PFCRC) columns under low cyclic loading are carried out and two variable parameters including CFRP strips spacing and axial compression ratio are considered. The PFCRC column finally fails by bending and is characterized by the crushing of concrete and yielding of the longitudinal reinforcement, and the column with a high axial compression ratio is also accompanied by the cracking of the PVC tube and the fracture of CFRP strips. The hysteretic curves and skeleton curves of the columns are obtained from the experimental data. With the increase of axial compression ratio, the stiffness degradation rate accelerates and the ductility decreases. With the decrease of CFRP strips spacing, the unloading sections of the skeleton curves become steep and the ductility reduces significantly. On the basis of fiber model method, a numerical analysis approach for predicting the skeleton curves of the PFCRC columns is developed. Additionally, a simplified skeleton curve including the elastic stage, strengthening stage and unloading stage is suggested depending on the geometric drawing method. Moreover, the loading and unloading rules of the PFCRC columns are revealed by analyzing the features of the skeleton curves. The quantitative expressions that are used to predict the unloading stiffness of the specimens in each stage are proposed. Eventually, an analytical model for the PFCRC columns under low cyclic loading is established and it agrees well with test data.
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