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- 검색키워드
- 저자 : Yuan-Feng Gong (검색결과 18 건)
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Gong, Xiao-Di,Wang, Jiong-Yi,Liu, Feng,Yuan, Hai-Hua,Zhang, Wen-Ying,Guo, Yue-Hui,Jiang, Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Backgrounds: Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain. This study aimed to investigate the association of both two polymorphisms with opioid requirements in Chinese patients with cancer pain. Methods: The genotypes of rs1799971 (OPRM1) and rs1045642 (ABCB1) were determined by PCR-RFLP and direct sequencing methods respectively in 112 patients with cancer-related pain. Comparisons between the different genotype or allele groups were performed with t-tests or one-way ANOVA tests, as appropriate. The potential relationship of allele number with opioid response was performed with a trend Jonckheere-Terpstra test. Results: In the 112 subjects, the frequencies of variant 118 G and 3435T allele were 38.4% and 37.9%, respectively. Significant higher 24h-opioid doses were observed in patients with GG (P=0.0004) and AG + GG (P=0.005) genotypes than the AA carriers. The dominant mutant 118G allele tended to be associated with progressively increasing 24h-opioiddoses (P=0.001). Compared with CC/CT, patients with ABCB1 TT genotype received higher 24h- and weight-surface area-adjusted-24h- opioids doses (P=0.057 and 0.028, respectively). Conclusions: The OPRM1 A118G single nucleotide polymorphism (SNP) is a key contributor for the inter-individual variability in opioidrequirements in Chinese cancer pain patients. This may possibly extend to the ABCB1 C3435T SNP.
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Numerical Simulation of Cold Storage and Preservation of Hanfu Apple
Gong, Yuan Juan,Zhang, Yan,Ning, Xiao Feng Korean Society for Agricultural Machinery 2016 바이오시스템공학 Vol.41 No.3
Purpose: To solve the decay phenomenon of Hanfu apples that occurs during storage and obtain the best environmental parameters for preserving Hanfu apples using Fluent. Methods: Preservation storage was designed by analyzing the characteristics of Hanfu-apple storage and the natural environment in northeast China. The boundary conditions and simulation of a preservation model were established. Results: Compared with the initial values, the hardness decreased by $1.95kg/cm^2$, the sugar-acid ratio decreased by 20.43, and weight-loss rate was 3.98%. Conclusion: The results for the temperature field and velocity field of the empty storage were analyzed using Fluent. Hanfu apples can maintain good quality during the period of storage, according to our analysis of the Hanfu-apple hardness, weight loss, and change in the sugar-acid ratio during the 90-day preservation period.
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Buckling response of offshore pipelines under combined tension and bending
Gong, Shun-Feng,Ni, Xing-Yue,Yuan, Lin,Jin, Wei-Liang Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.6
Offshore pipelines have to withstand combined actions of tension and bending during deepwater installation, which can possibly lead to elliptical buckle and even catastrophic failure of whole pipeline. A 2D theoretical model initially proposed by Kyriakides and his co-workers which carried out buckling response analysis of elastic-plastic tubes under various load combinations, is further applied to investigate buckling behavior of offshore pipelines under combined tension and bending. In association with practical pipe-laying circumstances, two different types of loadings, i.e., bent over a rigid surface in the presence of tension, and bent freely in the presence of tension, are taken into account in present study. In order to verify the accuracy of the theoretical model, numerical simulations are implemented using a 3D finite element model within the framework of ABAQUS. Excellent agreement between the results validates the effectiveness of this theoretical method. Then, this theoretical model is used to study the effects of some important factors such as load type, loading path, geometric parameters and material properties etc. on buckling behavior of the pipes. Based upon parametric studies, a few significant conclusions are drawn, which offer a theoretical reference for design and installation monitoring of deepwater pipelines.
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( Yuan Juan Gong ),( Ying Sui ),( Chung Su Han ),( Xiao Feng Ning ) 한국농업기계학회 2016 바이오시스템공학 Vol.41 No.1
Purpose: This study was performed to improve the drying quality and drying rate of ginseng slices by combining microwave and far-infrared drying techniques. Methods: Based on single-factor experiments and analyses, a quadratic regression orthogonal rotation combination design was adopted to study the effects of the moisture content at the conversion point between the microwave and far-infrared techniques, the ginseng slice thickness and the far-infrared drying temperature on the chip drying time, the surface color difference value, the nutritional composition and the surface shrinkage rate index. Results: Compared to the far-infrared drying alone, the combined microwave and far-infrared drying resulted in an increase in the saponin content of the ginseng slices and reductions in the drying time, surface color difference, and shrinkage rate. Conclusions: We established a mathematical model of the relationships between the surface shrinkage rate index and the experimental factors using the multi-objective nonlinear optimization method to determine the optimal parameter combination, which was confirmed to be the following: microwave and far-infrared moisture contents of 65%, a ginseng slice thickness of 1 mm, and a far-infrared drying temperature of 54℃.
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Drying Ginseng Slices Using a Combination of Microwave and Far-Infrared Drying Techniques
Gong, Yuan Juan,Sui, Ying,Han, Chung Su,Ning, Xiao Feng Korean Society for Agricultural Machinery 2016 바이오시스템공학 Vol.41 No.1
Purpose: This study was performed to improve the drying quality and drying rate of ginseng slices by combining microwave and far-infrared drying techniques. Methods: Based on single-factor experiments and analyses, a quadratic regression orthogonal rotation combination design was adopted to study the effects of the moisture content at the conversion point between the microwave and far-infrared techniques, the ginseng slice thickness and the far-infrared drying temperature on the chip drying time, the surface color difference value, the nutritional composition and the surface shrinkage rate index. Results: Compared to the far-infrared drying alone, the combined microwave and far-infrared drying resulted in an increase in the saponin content of the ginseng slices and reductions in the drying time, surface color difference, and shrinkage rate. Conclusions: We established a mathematical model of the relationships between the surface shrinkage rate index and the experimental factors using the multi-objective nonlinear optimization method to determine the optimal parameter combination, which was confirmed to be the following: microwave and far-infrared moisture contents of 65%, a ginseng slice thickness of 1 mm, and a far-infrared drying temperature of $54^{\circ}C$.
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Numerical Simulation of Cold Storage and Preservation of Hanfu Apple
( Yuan Juan Gong ),( Yan Zhang ),( Xiao Feng Ning ) 한국농업기계학회 2016 바이오시스템공학 Vol.41 No.4
To solve the decay phenomenon of Hanfu apples that occurs during storage and obtain the best environmental parameters for preserving Hanfu apples using Fluent. Methods: Preservation storage was designed by analyzing the characteristics of Hanfu-apple storage and the natural environment in northeast China. The boundary conditions and simulation of a preservation model were established. Results: Compared with the initial values, the hardness decreased by 1.95 kg/cm² , the sugar-acid ratio decreased by 20.43, and weight-loss rate was 3.98%. Conclusion: The results for the temperature field and velocity field of the empty storage were analyzed using Fluent. Hanfu apples can maintain good quality during the period of storage, according to our analysis of the Hanfu-apple hardness, weight loss, and change in the sugar-acid ratio during the 90-day preservation period.
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Yuan Gao,Jianjun Zhang,Li Li,Feng Su,Zhenhua Gong,Yisheng Lai,Yihua Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
ZCVI4-2 was a novel nitric oxide-releasing glycosyl derivative of oleanolic acid that displayed strong cytotoxicity selectively against human hepatocellular carcinoma in vitro and in vivo. In this study, ZCVI4-2 was characterized by FT-IR spectroscopy, differential scanning calorimetry,powder X-ray diffractometry, Raman spectroscopy, hygroscopicity and stability. A high performance liquid chromatography method was also established for the quantitative determination of solubility and additional stability profile of ZCVI4-2. ZCVI4-2 was found to be an amorphous and stable solid with low solubility of less than 10 μg/mL. Based on the solubilization tests that included methods of cosolvency and micellization, the solution mixture of 5% Solutol HS-15, 5% 1, 2-propylene glycol and 5% anhydrous ethanol was determined to be the system for the preparation of the ZCVI4-2 early injection solution. The effect of pH, temperature, light and injectable isotonic glucose or NaCl solution on ZCVI4-2 injection was also investigated. Good stability was observed at all testing conditions. Under the conditions studied, the NO-releasing rate and amount of ZCVI4-2 from the early injection solution in rat plasma demonstrated a promising therapeutic efficacy while maintaining a good safety profile.
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Buckling response of offshore pipelines under combined tension and bending
Shun-feng Gong,Xing-yue Ni,Lin Yuan,Wei-liang Jin 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.6
Offshore pipelines have to withstand combined actions of tension and bending during deepwater installation, which can possibly lead to elliptical buckle and even catastrophic failure of whole pipeline. A 2D theoretical model initially proposed by Kyriakides and his co-workers which carried out buckling response analysis of elastic-plastic tubes under various load combinations, is further applied to investigate buckling behavior of offshore pipelines under combined tension and bending. In association with practical pipe-laying circumstances, two different types of loadings, i.e., bent over a rigid surface in the presence of tension, and bent freely in the presence of tension, are taken into account in present study. In order to verify the accuracy of the theoretical model, numerical simulations are implemented using a 3D finite element model within the framework of ABAQUS. Excellent agreement between the results validates the effectiveness of this theoretical method. Then, this theoretical model is used to study the effects of some important factors such as load type, loading path, geometric parameters and material properties etc. on buckling behavior of the pipes. Based upon parametric studies, a few significant conclusions are drawn, which offer a theoretical reference for design and installation monitoring of deepwater pipelines.
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