Hybrid Evaluation Method for Dispatching Control Level of Smart Distribution Network

Yu‑Qian Wang,Leijiao Ge,Na Zhang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.6

Smart distribution network (SDN) is an important part of smart grid (SG), and its dispatching control level is closely related to the safety and reliability of power system. In order to comprehensively and systematically evaluate the dispatching and control level of smart distribution network, this paper constructs an evaluation index system based on the considerations of reliability, economy, efectiveness, adaptability and cleanness. Taking into account the disadvantages of subjective weighting methods and the objective weighting methods, this paper puts forward a kind of subjective and objective mixed evaluation method for dispatching control level of SDN. In view of the great infuence of expert opinions of subjective weighting method and the high data dependence of objective weighting method, the binomial coefcient method of subjective weighting is combined with the multi-objective programming method of objective weighting to give weight to each index in the comprehensive evaluation index system of dispatching control level of SDN. Case studies verify the proposed method has great signifcance to the evaluation of the dispatching control level of SDN. It can efectively evaluate the dispatching level of SDN and provide a reference for the improvement of the dispatching control level of SDN.

The catalytic core of DEMETER guides active DNA demethylation in <i>Arabidopsis</i>

Zhang, Changqing,Hung, Yu-Hung,Rim, Hyun Jung,Zhang, Dapeng,Frost, Jennifer M.,Shin, Hosub,Jang, Hosung,Liu, Fang,Xiao, Wenyan,Iyer, Lakshminarayan M.,Aravind, L.,Zhang, Xiang-Qian,Fischer, Robert L. National Academy of Sciences 2019 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.116 No.35

<P><B>Significance</B></P><P>Flowering plants reproduce via a unique double-fertilization event, producing the zygote and the nutritive endosperm. The genome of the central cell, the precursor of the endosperm, undergoes extensive demethylation prior to fertilization. This epigenetic reconfiguration, directed by the DEMETER (DME) glycosylase at thousands of loci in <I>Arabidopsis</I>, differentiates the epigenetic landscapes of parental genomes and establishes parent of origin-specific expression of many imprinted genes in endosperm essential for seed development. However, how DME is targeted to various locations remains unknown. Here we show that the multidomain DME is organized into 2 functional regions: the C-terminal region, which guides localization and catalysis, and the N-terminal region, which likely recruits chromatin remodelers to facilitate demethylation within heterochromatin.</P><P>The <I>Arabidopsis</I> DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability. DME preferentially targets small transposons that flank coding genes, influencing their expression and initiating plant gene imprinting. DME also targets intergenic and heterochromatic regions, but how it is recruited to these differing chromatin landscapes is unknown. The C-terminal half of DME consists of 3 conserved regions required for catalysis in vitro. We show that this catalytic core guides active demethylation at endogenous targets, rescuing <I>dme</I> developmental and genomic hypermethylation phenotypes. However, without the N terminus, heterochromatin demethylation is significantly impeded, and abundant CG-methylated genic sequences are ectopically demethylated. Comparative analysis revealed that the conserved DME N-terminal domains are present only in flowering plants, whereas the domain architecture of DME-like proteins in nonvascular plants mainly resembles the catalytic core, suggesting that it might represent the ancestral form of the 5mC DNA glycosylase found in plant lineages. We propose a bipartite model for DME protein action and suggest that the DME N terminus was acquired late during land plant evolution to improve specificity and facilitate demethylation at heterochromatin targets.</P>

Prognostic Values of VEGF and Endostatin with Malignant Pleural Effusions in Patients with Lung Cancer

Zhang, Yu,Yu, Li-Ke,Lu, Guo-Jun,Xia, Ning,Xie, Hai-Yan,Hu, Wei,Hao, Ke-Ke,Xu, Chun-Hua,Qian, Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Aims: Angiogenesis is important in malignant pleural effusion (MPE) formation and it is regulated by a number of pro- and anti-angiogenic cytokines. The purpose of this study was to evaluate the prognostic value of angiogenic factor vascular endothelial growth factor (VEGF) and angiogenesis inhibitor endostatin in lung cancer patients with MPE, and investigate the relationship between these two kinds of agent. Methods: Using enzyme-linked immunoadsorbent assay, the concentrations of VEGF and endostatin were measured in pleural effusions (PE) and serum from a total of 70 lung cancer patients with MPE and 20 patients with tuberculosis. Results: Compared to patients with tuberculosis, the levels of VEGF and endostatin in both PE and serum were significantly higher in patients with lung cancer. There were statistically significant correlations between VEGF levels in PE and serum (r=0.696, p<0.001), endostatin levels in PE and serum (r=0.310, p=0.022), and VEGF and endostatin levels in PE (r=0.287, p=0.019). Cox multivariate analysis revealed that elevated pleural VEGF and endostatin levels and serum endostatin level were independent predictors of shorter overall survival. Conclusion: Both pro- and anti-angiogenic factors are likely contributors to PE formation. Our results suggest that the levels of VEGF and endostatin in PE, together with endostatin in serum, may be potential prognostic parameters for lung cancer patients with MPE.

Correlation Between Auto-antibodies to Survivin and MUC1 Variable Number Tandem Repeats in Colorectal Cancer

Wang, Yu-Qian,Zhang, Hai-Hong,Liu, Chen-Lu,Xia, Qiu,Wu, Hui,Yu, Xiang-Hui,Kong, Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Aim: The aim of this study was to investigate the frequency and correlation between auto-antibodies to survivin and MUC1 variable number tandem repeats (VNTR) in colorectal cancer (CRC), which can provide valuable information for the design of immunotherapeutic vaccines for this disease. Methods: Enzyme-linked immunosorbent assays (ELISA) were used to examine the level of auto-antibodies against survivin and MUC1 VNTR in the serum of 135 CRC patients and 95 healthy volunteers. Results: Using mean absorbance + 2 standard deviations (SD) of the healthy samples as a cut-off value, the positive rates of survivin and MUC1 VNTR auto-antibodies in CRC were 31.1% and 18.5%, respectively. Altogether, the survivin and MUC1 VNTR positive samples accounted for 36.3% of the CRC patients, and 7.4% were positive for both. Conclusion: A significant positive correlation was found between levels of specific antibodies against survivin and MUC1 VNTR in the serum of CRC patients (r = 0.3652, P < 0.0001), suggesting that vaccines against both targets would elicit immune responses more effectively.

The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis

Qian Ding,Xiao-Li Xie,Miao-Miao Wang,Jie Yin,Jin-Mei Tian,Xiao-Yu Jiang,Di Zhang,Jing Han,Yun Bai,Zi-Jin Cui,Hui-Qing Jiang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an important role in apoptosis. However, the role of mitophagy in apoptosis in HSCs and hepatic fibrosis is still unclear. Here, we show that mitophagy is enhanced in parallel with increased apoptosis in hepatic stellate cells during the reversal of hepatic fibrosis. The inhibition of mitophagy suppressed apoptosis in HSCs and aggravated hepatic fibrosis in mice. In contrast, the activation of mitophagy induced apoptosis in HSCs. Furthermore, we confirmed that BCL-B, which is a member of the BCL-2 family, is a regulator mediating mitophagy-related apoptosis. The knockdown of BCL-B resulted in increased apoptosis and mitophagy in HSCs, while the overexpression of BCL-B caused the opposite effects. BCL-B inhibited the phosphorylation of Parkin (a key regulator of mitophagy) and directly bound phospho-Parkin. Altogether, enhanced mitophagy promotes apoptosis in HSCs during the reversal of hepatic fibrosis. BCL-B suppresses mitophagy in HSCs by binding and suppressing phospho-Parkin, thereby inhibiting apoptosis. BCLB- dependent mitophagy is a new pathway for the regulation of apoptosis in HSCs during the regression of hepatic fibrosis

Autophagy Inhibition Sensitizes Cisplatin Cytotoxicity in Human Gastric Cancer Cell Line Sgc7901

Zhang, Hui-Qing,He, Bo,Fang, Nian,Lu, Shan,Liao, Yu-Qian,Wan, Yi-Ye Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

We aimed to investigate the mechanism and effects of autophagy on cisplatin (DDP)-induced apoptosis in human gastric cancer cell line SGC7901. After SGC7901 cells were treated with DDP and/or chloroquine, cell proliferation was measured using MTT assay; cell apoptosis was determined by flow cytometry; autophagy and apotosis-related proteins expression were detected by Western blot; and quantitative analysis of autophagy after monodansylcadaverine (MDC) staining was performed using fluorescence microscopy. We found after treatment with 5 mg/L DDP for 24 h, the rates of cell apoptosis were ($21.07{\pm}2.12$)%. Autophagy, characterized by an increase in the number of autophagic vesicles and the level of LC3-II protein was observed in cells treated with DDP. After inhibition of autophagy by chloroquine, the rates of cell apoptosis were increased to ($30.16{\pm}3.54$)%, and the level of Caspase-3 and P53 protein were increased, and Bcl-2 protein was decreased. Therefore, autophagy protects human gastric cancer cell line SGC7901 against DDP-induced apoptosis, inhibition of autophagy can promote apoptosis, and combination therapy with DDP and chloroquine may be a promising therapeutic strategy for gastric cancer.

A Two-Step Screening Algorithm to Solve Linear Error Equations for Blind Identification of Block Codes Based on Binary Galois Field

( Qian Liu ),( Hao Zhang ),( Peidong Yu ),( Gang Wang ),( Zhaoyang Qiu ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.9

Existing methods for blind identification of linear block codes without a candidate set are mainly built on the Gauss elimination process. However, the fault tolerance will fall short when the intercepted bit error rate (BER) is too high. To address this issue, we apply the reverse algebra approach and propose a novel “two-step-screening” algorithm by solving the linear error equations on the binary Galois field, or GF(2). In the first step, a recursive matrix partition is implemented to solve the system linear error equations where the coefficient matrix is constructed by the full codewords which come from the intercepted noisy bitstream. This process is repeated to derive all those possible parity-checks. In the second step, a check matrix constructed by the intercepted codewords is applied to find the correct parity-checks out of all possible parity-checks solutions. This novel “two-step-screening” algorithm can be used in different codes like Hamming codes, BCH codes, LDPC codes, and quasi-cyclic LDPC codes. The simulation results have shown that it can highly improve the fault tolerance ability compared to the existing Gauss elimination process-based algorithms.

Protective Effect of Sodium Ferulate on Acetaldehyde-Treated Precision-Cut Rat Liver Slices

Yu Guo,Xiao-Qian Wu,Chun Zhang,Zhang-Xiu Liao,Yong Wu,Hui Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.6

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis, and inhibition of HSC activation may prevent liver fibrosis. Acetaldehyde, the most deleterious metabolite of alcohol, triggers HSC activation in alcoholic liver injury. In the present study, we investigated the protective effect of sodium ferulate (SF), a sodium salt of ferulic acid that is rich in fruits and vegetables, on acetaldehyde-stimulated HSC activation using precision-cut liver slices (PCLSs). Rat PCLSs were co-incubated with 700 lM acetaldehyde and different concentrations of SF. Hepatotoxicity was assessed by measuring enzyme leakage and malondialdehyde content in tissue. a-Smooth muscle actin, transforming growth factor-b1, and hydroxyproline were determined to assess the activation of HSCs. In addition, matrix metalloproteinase (MMP)-1 and the tissue inhibitor of metalloproteinase (TIMP-1) were determined to evaluate collagen degradation. SF prominently prevented the enzyme leakage in acetaldehyde-treated slices and also inhibited HSC activation and collagen production stimulated by acetaldehyde. In addition, SF increased MMP-1 expression and decreased TIMP-1 expression. These results showed that SF protected PCLSs from acetaldehyde-stimulated HSC activation and liver injury, which may be associated with the attenuation of oxidative injury and acceleration of collagen degradation

Modeling and Analysis of an Avionic Battery Discharge Regulator

Qian Chen,Haihong Yu,Xiaoming Huang,Yi Lu,Peng Qiu,Kai Tong,Jiazhuo Xuan,Feng Xu,Xiaohua Xuan,Weibo Huang,Yajing Zhang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

The avionic battery discharge regulator (BDR) plays an important role in a power-conditioning unit. With its merits of high efficiency, stable transfer function, and continuous input and output currents, the non-isolated Weinberg converter (NIWC) is suitable for avionic BDR. An improved peak current control strategy is proposed to achieve high current-sharing accuracy. Current and voltage regulators are designed based on a small signal model of a three-module NIWC system. The system with the designed regulators operates stably under any condition and achieves excellent transient response and current-sharing accuracy.

Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats

Qian Zhang,Meng-Meng Shang,Qu-Fei Ling,Xiao-Ping Wu,Chun-Yu Liu 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8

This study investigates the hepatoprotectiveeffects and the potential therapeutic mechanisms of loach(Misgurnus anguillicaudatus) lyophilized powder (MLP)on dimethylnitrosamine (DMN) induced liver fibrosis inrats. After treatment with MLP (50, 100, 200 mg/kg),alanine aminotransferase (ALT), aspartate aminotransferase(AST), albumin (Alb), total protein (TP) andhydroxyproline (Hyp) levels were detected, to assess thedestruction of hepatocytes and the extent of liver fibrosis. Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), hyaluronic acid (HA), Laminin (LN),procollagen type-III (PC-III), collagen type-IV (C-IV), andtransforming growth factor-b1 (TGF-b1) contents in serumwere all tested using ELISA kits. Alpha-smooth muscleactin (a-SMA) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) protein contents and distribution wereevaluated using western blot and immunohistochemicalanalysis. MLP significantly decreased the serum concentrationsof ALT, AST, Hyp, HA, LN, PC-III, C-IV, MMP-2,TIMP-1, a-SMA and TGF-b1, while increasing the contentsof Alb and MMP-9. No significant changes on TP serum concentrations were observed. These results suggest thatMLP has anti-hepatic fibrosis effects and its mechanism maybe associated with the attenuation of extracellular matrix(ECM) synthesis, the acceleration of ECM degradation,inhibition of hepatic stellate cells (HSCs) activation andTGF-b1 expression.