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Youngheun Jee, Hyunyoung Oh, So Jin Bing, Areum Kim, Jinhee Cho 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.4
Our previous research on sulfated polysaccharide purified from Ecklonia cava, a brown alga found in Jeju island, Korea, showed that sulfated polysaccharides modulate the apoptotic threshold of intestinal cells, thereby preventing intestinal damage caused by ionizing radiation. In this study, we investigated the ability of sulfated polysaccharide to augment restoration of small intestinal stem cells from γ-ray-induced damage. In our results, sulfated polysaccharide treatment increased the numbers of Ki-67-positive cells as well as inducible nitric oxide synthase (iNOS)-expressing cells in the small intestine compared with those of irradiated only mice. Meanwhile, exposure to irradiation increased the number of paneth cells, which are frequently associated with intestinal inflammation, whereas sulfated polysaccharide treatment reduced the number of paneth cells in the small intestinal crypt. Conclusively, our data suggest that reduction of iNOS-expressing cells and paneth cells in sulfated polysaccharide-treated mice contributes to the inhibition of radiation-induced intestinal inflammation.
Involvement of the Fas and Fas ligand in testicular germ cell apoptosis by zearalenone in rat
Youngheun Jee,Eun-Mi Noh,Eun-Sang Cho,Hwa-Young Son 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.2
Zearalenone (ZEA), a nonsteroidal estrogenic mycotoxin, is known to cause testicular toxicity in animals. In the present study, the effects of ZEA on spermatogenesis and possible mechanisms involved in germ cell injury were examined in rats. Ten-week-old Sprague-Dawley rats were treated with 5 mg/kg i.p. of ZEA and euthanized 3, 6, 12, 24 or 48 h after treatment. Histopathologically, spermatogonia and spermatocytes were found to be affected selectively. They were TUNEL-positive and found to be primarily in spermatogenic stages I-VI tubules from 6 h after dosing, increasing gradually until 12 h and then gradually decreasing. Western blot analysis revealed an increase in Fas and Fas ligand (Fas-L) protein levels in the ZEAtreated rats. However, the estrogen receptor (ER)α expression was not changed during the study. Collectively, our data suggest that acute exposure of ZEA induces apoptosis in germ cells of male rats and that this toxicity of ZEA is partially mediated through modulation of Fas and Fas-L systems, though ERα may not play a significant role.
Spermatogenic Germ Cell Apoptosis by Long-Term Sustained Delivery of β-Estradiol 3-benzoate in Rats
Hye-Sung Kim,Youngheun Jee,Si-Yun Ryu,Sung-Whan Cho,Jaekwon Lee,Hwa-Young Son 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
The correct mechanism of estrogen-induced spermatogenesis impairment is still not clear. In the present study, we investigated the role of long-term sustained delivery of β-estradiol 3-benzoate (EB) on spermatogenesis and possible mechanisms involved in which focused on the germ cell apoptosis. Tenweek old Sprague-Dawley rats were implanted subcutaneously with fused pellet containing of 0.5 mg EB and were sacrificed at 12 hr, 24 hr, 48 hr, 72 hr, 1 week, 2 weeks, 4 weeks and 6 weeks. Body, testis, and epididymis weights were significantly decreased from 2 weeks. Degenerating germ cells were first found from 48 hr and progressively increased with time-dependent manner. At 2 weeks, germ cell depletion and degeneration of spermatocytes were observed in the seminiferous tubules. At 4 and 6 weeks, massive degenerating changes of the seminiferous tubules characteristics of epithelial structural disorganization and multinucleated giant cells formation and decrease of interstitial cell number were noted. Apoptosis of germ cells was identified in pachytene spermatocytes in stages VII-VIII from 48 hr. Mean number of apoptotic germ cells were progressively increased and peaked at 2 weeks and then decreased but higher than normal level. ERα expression was not changed but Fas and Fas lignad (FasL) protein levels were increased in EB-treated rat. In conclusion, sustained increase level of estrogen was impaired spermatogenesis with an increase of germ cell apoptosis mediated through modulation of Fas/FasL system partially in which ERα may not play a significant role.
Antioxidant System-Inducing Effects of Jeju Ground Water in C57BL,6 Mice against Gamma-ray Radiation
( Areum Daseul Kim ),( Youngheun Jee ),( Ho Jin You ),( Jin Won Hyun ) 한국응용생명화학회 2012 Journal of Applied Biological Chemistry (J. Appl. Vol.55 No.1
Recently, we reported that Jeju ground water contains vanadium components and exerts antioxidant effects in vitro and in vivo via the scavenging of reactive oxygen species and enhancement of antioxidant enzyme activities. In the present study, the antioxidant actions of Jeju ground water were compared with those of tap water against gamma-ray radiation in mice. C57BL/6 mice were irradiated with gamma-ray at a dose rate of 2 Gy. The mice were then given tap water or Jeju ground water for 90 days. Jeju ground water compared with tap water enhanced the activities and levels of superoxide dismutase, catalase, and glutathione peroxidase in irradiated liver tissues. Jeju ground water also enhanced the levels of intracellular reduced glutathione, which is vital for normal liver function and repair. These results suggest that vanadium-containing Jeju ground water can safeguard against the harmful actions of gamma-ray radiation through the support of hepatic antioxidant processes.
Antioxidant effects of Phloroglucinol on gamma radiation-induced oxidative stress on mice skin
Areum Kim,KHINM Herath,Youngheun Jee,Taeseong Moon,Jinhee Cho,Sojin Bing,Ginnae Ahn 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.1
The seaweed Ecklonia cava, a brown algae abundant in JeJu Island, South Korea, has large amounts of the polyphenol compound phloroglucinol (PG, 1,3,5-trihydroxybenzene), which has been proposed to exert interesting biological properties including antioxidant and radioprotective effects against ionizing radiation-induced damages in various cells and tissues. To identify antioxidant and radioprotective effects of PG in skin tissues, we exposed mice to 8.5 Gy whole body irradiation (WBI) at day 6 after depilation with and without PG treatment. In PG treated cases, PG was applied twice, once at 17.8 hours before and then at the time of WBI. At 8 hours after WBI, a reduction in the formation of thiobarbituric acid-reactive substrates (TBARS) was observed in the PG treated group. Upon western blot analysis, PG treatment overexpressed the MnSOD, catalase, and GPx-1, although the difference was not significant. In parallel with the results of western blot analysis, the percentage of MnSOD-and catalase-positive cells was significantly increased at 8 and 24 hours after WBI, while no significant difference was observed over 48 hours in PG treated skins. Moreover, PG treatment increased the percentage of Ki-67 positive cells compared with that of irradiated only mice at 8 hours after WBI. Our results suggest that PG is effective at attenuating oxidative stress, and that the promotion of antioxidant enzymes such as MnSOD and catalase may be an important aspect for its radioprotection in skin.
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan
Kim, Heechul,Moon, Changjong,Park, Eun-jin,Jee, Youngheun,Ahn, Meejung,Wie, Myung Bok,Shin, Taekyun John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.3
<P>We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats with EAE intraperitoneally, either in the EAE induction phase from either 1 day before immunization to day 7 post-immunization (PI), or the effector phase from day 8 to 14 PI, to test which phase of rat EAE is affected by fucoidan treatment.</P><P>The onset, severity and duration of EAE paralysis in the fucoidan-treated group in the days 8–14 PI-treated rats, but not in days −1–7 PI-treated rats, were significantly delayed, suppressed and reduced, respectively, compared with the vehicle-treated controls. Treatment with fucoidan reduced the encephalitogenic response and TNF-&agr; production during EAE. Moreover, the clinical amelioration coincided with decreased infiltration of inflammatory cells in the EAE-affected spinal cord. The ameliorative effect of fucoidan on clinical paralysis in EAE-affected rats may be mediated, in part, by the suppression of the autoreactive T cell response and inflammatory cytokine production. Copyright © 2009 John Wiley & Sons, Ltd.</P>