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The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution
Seo, Youngbeom,Kim, Yong Hwy,Dho, Yun-Sik,Kim, Jung Hee,Kim, Jin Wook,Park, Chul-Kee,Kim, Dong Gyu Elsevier 2018 World neurosurgery Vol.115 No.-
<P><B>Objective</B></P> <P>Pituitary apoplexy is an unpredictable complication caused by hemorrhage or infarction in a pituitary adenoma. We retrospectively analyzed the radiologic and clinical outcomes of patients with conservatively managed pituitary apoplexy.</P> <P><B>Methods</B></P> <P>A total of 32 patients who had undergone conservative treatment with high-dose corticosteroid replacement were enrolled in this study. This cohort study consisted of 20 male and 12 female patients. The median patient age was 60 years. Five patients had a previously diagnosed pituitary tumor, and one third of the patients had a history of hypertension.</P> <P><B>Results</B></P> <P>The median follow-up duration was 50 months. The median tumor volumes at the initial and final assessments were 2.75 cm<SUP>3</SUP> (range, 0.32–10.7 cm<SUP>3</SUP>) and 0.64 cm<SUP>3</SUP> (range, 0–8.74 cm<SUP>3</SUP>), respectively. Complete radiographic regression occurred in 9 of the 32 patients, partial regression occurred in 14 patients, and no change in size or progression occurred in 9 patients. Eighteen of the 32 patients had visual disturbances at the initial presentation; in this subgroup, 17 patients showed improvement over the course of the study. One patient had newly developed diplopia related to tumor progression. Nineteen of the 32 patients had ≥1 hormonal deficiency at the initial assessment, 8 of whom recovered to normal endocrine status. Three patients developed a new hormonal deficiency during the follow-up, and 3 patients experienced tumor recurrence.</P> <P><B>Conclusions</B></P> <P>This study showed the regression of tumors related to pituitary apoplexy, with favorable ophthalmologic and endocrinologic recovery. Conservative management should be considered in patients without severe or progressive neuro-ophthalmic deficits.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We investigated the radiologic and clinical outcome of 32 patients with consertavtively treated pituitary apoplexy. </LI> <LI> Conservative management resulted in acceptable neuro-ophthalmic and endocrinologic outcomes. </LI> <LI> Tumor volume pattern within 1–3 three months after apoplexy might be an important prognostic factor of tumor regression. </LI> <LI> Conservative management should be considered if the visual disturbance has not deteriorated. </LI> </UL> </P>
여성형탈모에서 저용량 경구 미녹시딜의 효과 및 안정성: 44명의 환자를 대상으로 한 단일기관 연구
김영범 ( Youngbeom Kim ),이기욱 ( Giwook Lee ),신준오 ( Jun-oh Shin ),노동영 ( Dong Young Roh ),김연아 ( Yeona Kim ),원상현 ( Sang-hyeon Won ),이정수 ( Jungsoo Lee ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoonsoo Kim ),고현창 ( Hyun-chan 대한피부과학회 2024 대한피부과학회지 Vol.62 No.3
Background: Female-pattern hair loss (FPHL) is characterized by diffuse hair thinning in the mid-frontal scalp and increased hair shedding. Although the use of low-dose oral minoxidil (LDOM) is increasing significantly in Korea, data on its use are limited. Objective: To determine the efficacy and safety of LDOM in Korean patients with FPHL. Methods: This retrospective, single-center study was conducted at Pusan National University Hospital. The study included female patients with pattern hair loss who received treatment with LDOM at 1.25 mg/d for a minimum of 6 months in combination with other treatments. Patients were eligible for LDOM addition if their previous treatments showed a limited response and the previous treatment regimen remained unchanged throughout the evaluation period. Clinical response to treatment was evaluated using the Sinclair hair loss severity scale. Results: The study included 44 females with FPHL. Before treatment, the mean Sinclair scale score was 2.77, which decreased to 2.27 after treatment. By the 3rd month, one patient (2.3%) experienced worsening, while seven patients (15.9%) showed slight improvement. By the 6th month, the treatment response was as follows: stabilization in 30 patients (68.2%), slight improvement in 13 patients (29.5%), and substantial improvement in one patient (2.3%). Adverse effects, predominantly hypertrichosis, were observed in nine patients. All adverse effects improved upon discontinuation of LDOM and no life-threatening adverse effects were observed during the study. Conclusion: This study provides evidence that LDOM can be an effective therapeutic option with a good safety profile for FPHL. (Korean J Dermatol 2024;62(3):136∼142)
김태형(Taehyung Kim),최진혁(Jin-Hyuck Choi),천영범(Youngbeom Cheon),이태호(Tae-Ho Lee),김남권(Namgwon Kim),이호일(Hoil Lee),김창민(Chang-Min Kim),최이레(Iyre Choi),배한경(Hankyung Bae),김영석(Young-Seog Kim),류충렬(Chung-Ryul Ryoo) 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
제4기 동안 활동했던 단층은 가까운 미래에 다시 움직일 가능성이 높은 단층으로 평가되며, 단층 정보에 기초한 지진재해평가 관점에서 단층의 제4기 시공간적 지진 거동 이력에 대한 이해는 반드시 선행되어야 한다. 우리는 남부 양산단층의 월산-인보 구간(경주시 내남면 월산리–울산시 울주군 두서면 인보리)의 4지점(월산, 미호, 인보N, 인보S)에서 수행된 고지진 굴착 조사와 연대측정 분석 결과를 바탕으로 해당 고지진 단층 파열 시나리오를 제안하고자 한다. 지형 분석과 굴착면 조사 결과, 고지진 단층파열은 양산단층대를 구성하는 일부 단층면이 우수향 운동감각으로 재활성 된 결과임을 알 수 있다. 월산지점에서는 최소 2회의 고지진을 인지하였으며, 그 시기는 37–33 ka와 33 ka 이후이다. 미호지점에서도 역시 2회의 고지진이 발생하였으며, 그 시기는 35 ka 이전과 35–30 ka 사이이다. 인보리에서는 인접한 두 지점(인보N, 인보S)에서의 조사 결과를 종합하여, 2회의 고지진을 인지하였으며, 발생 시기는 각각 70–52 ka와 37–17 ka 사이로 제한된다. 이러한 조사결과는 월산-미호 구간과 인보 구간의 최후기 직전 고지진(penultimate event)이 서로 다른 시기에 발생한 개별적인 고지진의 결과임을 지시한다. 반면 최후기 고지진(most recent event)의 경우, OSL 연대 측정의 오차 범위를 고려하면 두 개의 고지진 단층 파열 시나리오를 제안할 수 있다. 우선, 월산–미호–인보지점을 포함하는 전체 구간이 약 30 ka에 발생한 한 번의 고지진을 동시에 겪었을 가능성이다. 다음으로 월산–미호 구간이 약 33–30 ka에 발생한 고지진단층파열을 겪고, 이후 인보 구간이 약 29–17 ka에 발생한 별도의 고지진을 겪었을 가능성이 있다. 향후 추가적인 고지진 조사 결과가 확보된다면, 남부 양산단층에서 발생했던 고지진에 대한 보다 정확한 시공간적 이력을 이해할 수 있을 것이다.
Youngbeom Kim,Sangchoon Kim 한국인터넷방송통신학회 2017 Journal of Advanced Smart Convergence Vol.6 No.3
In this paper, an improved ordered block minimum mean squared error (OB- MMSE) detector for generalized spatial modulation (GSM) systems is presented. It is based on an ordered successive interference cancellation (OSIC) technique. Its bit error rate (BER) performance and computational complexity are compared with those of the corresponding original OB-MMSE detector. It is shown that the proposed OSIC-based OB-MMSE detector outperforms the OB-MMSE detector in terms of BER without noticeable complexity increase.