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Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats
Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*
Status and Human Rights Situation of North Korean Defectors in China
( Yeo Sang Yoon ) 이화여자대학교 통일학연구원 2012 Journal of peace and unification Vol.2 No.2
The status of North Korean defectors in China has been a critical pending issue not only for North and South Korea but for international society. Currently, over 10,000 North Korean defectors are estimated to reside in China under a critical human rights situation. Many suffer from the threat of being arrested, tortured, and sent back to North Korea. Women are exposed to dangers of human trafficking and forced marriages. China, considering North Korean defectors as illegal immigrants rather than refugees, has arrested and forcibly repatriated North Korean defectors. Furthermore, it has disallowed international agencies and non-governmental organizations (NGOs) from helping this group of people within their country. China must switch its policy toward North Korean defectors by recognizing them as worthy of humanitarian assistance and strengthen its cooperation with international society, the South Korean government, and human rights organizations to help these refugees return to North Korea, settle in China, or immigrate to South Korea all according to their wishes.
Structure and electrochemical applications of boron-doped graphitized carbon nanofibers
Yeo, Jae-Seong,Jang, Sang-Min,Miyawaki, Jin,An, Bai,Mochida, Isao,Rhee, Choong Kyun,Yoon, Seong-Ho IOP Pub 2012 Nanotechnology Vol.23 No.31
<P>Boron-doped graphitized carbon nanofibers (CNFs) were prepared by optimizing CNFs preparation, surface treatment, graphitization and boron-added graphitization. The interlayer spacing (d<SUB>002</SUB>) of the boron-doped graphitized CNFs reached 3.356 Å, similar to that of single-crystal graphite. Special platelet CNFs (PCNFs), for which d<SUB>002</SUB> is less than 3.400 Å, were selected for further heat treatment. The first heat treatment of PCNFs at 2800 °C yielded a d<SUB>002</SUB> between 3.357 and 3.365 Å. Successive nitric acid treatment and a second heat treatment with boric acid reduced d<SUB>002</SUB> to 3.356 Å. The resulting boron-doped PCNFs exhibited a high discharge capacity of 338 mAh g<SUP>−1</SUP> between 0 and 0.5 V versus Li/Li<SUP>+</SUP> and 368 mAh g<SUP>−1</SUP> between 0 and 1.5 V versus Li/Li<SUP>+</SUP>. The first-cycle Coulombic efficiency was also enhanced to 71–80%. Such capacity is comparable to that of natural graphite under the same charge/discharge conditions. The boron-doped PCNFs also exhibited improved rate performance with twice the capacity of boron-doped natural graphite at a discharge rate of 5 C. </P>
Yeo Sung Yoon,Eun Sung Park,Seong Joon YI,Jin Sang Kim,이흥식,In Se Lee,Je Kyung Seong,Hee Kyung Jin 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.4
This study was aimed to investigate the changes of orexin-A (OXA) and neuropeptide Y (NPY) expression in the hypothalamus of the fasted and high-fat diet fed rats. For the experiments, the male Sprague-Dawley (SD) rats were used as the model of high-fat diet-induced obesity. The mean loss of body weight (MLBW) did not show the linear pattern during the fasting; from 24 h to 84 h of fastings, the MLBW was not significantly changed. The numbers of OXA-immunoreactive (IR) neurons were decreased at 84 h of fasting compared with those in other five fasting subgroups. The NPY immunoreactivities in the arcuate nucleus (ARC) and the suprachiasmatic nucleus (SCN) observed at 84 h of fasting were higher than that observed at 24 h of fasting. The number of OXA-IR neurons of the LHA (lateral hypothalamic area) in the high-fat (HF) diet fed group was more increased than that of the same area in the normal-fat (NF) diet fed group. The NPY immunoreactivities of the ARC and the SCN were higher in HF group than those observed in the same areas of NF group. Based on these results, it is noteworthy that the decrease of the body weight during the fast was not proportionate to the time-course, implicating a possible adaptation of the body for survival against starvation. The HF diet might activate the OXA and the NPY in the LHA to enhance food intake. This study was aimed to investigate the changes of orexin-A (OXA) and neuropeptide Y (NPY) expression in the hypothalamus of the fasted and high-fat diet fed rats. For the experiments, the male Sprague-Dawley (SD) rats were used as the model of high-fat diet-induced obesity. The mean loss of body weight (MLBW) did not show the linear pattern during the fasting; from 24 h to 84 h of fastings, the MLBW was not significantly changed. The numbers of OXA-immunoreactive (IR) neurons were decreased at 84 h of fasting compared with those in other five fasting subgroups. The NPY immunoreactivities in the arcuate nucleus (ARC) and the suprachiasmatic nucleus (SCN) observed at 84 h of fasting were higher than that observed at 24 h of fasting. The number of OXA-IR neurons of the LHA (lateral hypothalamic area) in the high-fat (HF) diet fed group was more increased than that of the same area in the normal-fat (NF) diet fed group. The NPY immunoreactivities of the ARC and the SCN were higher in HF group than those observed in the same areas of NF group. Based on these results, it is noteworthy that the decrease of the body weight during the fast was not proportionate to the time-course, implicating a possible adaptation of the body for survival against starvation. The HF diet might activate the OXA and the NPY in the LHA to enhance food intake.
Sung Min Nam,김종휘,유대영,Woosuk Kim,Hyo Young Jung,Jung Hoon Choi,In Koo Hwang,Je Kyung Seong,Yeo Sung Yoon 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.2
Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer’s disease. In this study, we investigated the effects of Al and/or D-galactose on neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons in the hippocampal dentate gyrus. AlCl3 (40 mg/kg/day) was intraperitoneally administered to C57BL/6J mice for 4 weeks. In addition, vehicle (physiological saline) or D-galactose (100 mg/kg) was subcutaneously injected to these mice immediately after AlCl3 treatment. Neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons were detected using the relevant marker for each cell type, including nestin, Ki67, doublecortin, and NeuN, respectively, via immunohistochemistry. Subchronic (4 weeks) exposure to Al in mice reduced neural stem cells, proliferating cells, and differentiating neuroblasts without causing any changes to mature neurons. This Al-induced reduction effect was exacerbated in D-galactose-treated mice compared to vehicle-treated adult mice. Moreover, exposure to Al enhanced lipid peroxidation in the hippocampus and expression of antioxidants such as Cu, Zn- and Mn-superoxide dismutase in D-galactose-treated mice. These results suggest that Al accelerates the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in D-galactose-treated mice via oxidative stress, without inducing loss in mature neurons.
Sung Min Nam,Jong Whi Kim,Daeyoung Yoon,Hyo Young Jung,최정훈,In Koo Hwang,Je Kyung Seong,Yeo Sung Yoon 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.1
In the present study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old Zucker diabetic fatty (ZDF) and Zucker lean control (ZLC) rats were selected and randomly divided into Al- and non-Al-groups. Al was administered via drinking water for 10 weeks, after which the animals were sacrificed at 16 weeks of age. ZDF rats in both Al- and non-Al-groups showed increases in body weight and blood glucose levels compared to ZLC rats. Al exposure did not significantly affect body weight, blood glucose levels or pancreatic b-cells and morphology of the pancreas in either ZLC or ZDF rats. However, exposure to Al reduced cell proliferation and neuroblast differentiation in both ZLC and ZDF rats. Exposure to Al resulted in poor development of the dendritic processes of neuroblasts in both ZLC and ZDF rats. Furthermore, onset and continuation of diabetes reduced cell proliferation and neuroblast differentiation, and Al exposure amplified reduction of these parameters. These results suggest that Al exposure via drinking water aggravates the impairment in hippocampal neurogenesis that is typically observed in type 2 diabetic animals.
Status and Human Rights Situation of North Korean Defectors in China
Yoon, Yeo Sang Ewha Institute of Unification Studies 2012 Journal of peace and unification Vol.2 No.2
The status of North Korean defectors in China has been a critical pending issue not only for North and South Korea but for international society. Currently, over 10,000 North Korean defectors are estimated to reside in China under a critical human rights situation. Many suffer from the threat of being arrested, tortured, and sent back to North Korea. Women are exposed to dangers of human trafficking and forced marriages. China, considering North Korean defectors as illegal immigrants rather than refugees, has arrested and forcibly repatriated North Korean defectors. Furthermore, it has disallowed international agencies and non-governmental organizations (NGOs) from helping this group of people within their country. China must switch its policy toward North Korean defectors by recognizing them as worthy of humanitarian assistance and strengthen its cooperation with international society, the South Korean government, and human rights organizations to help these refugees return to North Korea, settle in China, or immigrate to South Korea all according to their wishes.
Yeo-Myeong Kim,Han-Byeol Kang,Gi-Heon Kim,Chi-Sun Hwang,Sung-Min Yoon IEEE 2017 IEEE electron device letters Vol.38 No.10
<P>Technical strategies for improving the device characteristics of the In-Ga-Zn-O (IGZO) vertical channel thin-film transistors (VTFTs) were presented and investigated. The vertical sidewall was constructed by dry-etch process and subsequently covered with IGZO, Al2O3, and AZO as active, gate insulator, and gate electrode layers by means of conformal atomic-layer-deposition. An abrupt profile and flat back-channel were achieved by employing the spin-coated polyimide (PI) spacer. The Off-current was additionally alleviated simply by cutting the area of an active layer. The fabricated IGZO VTFT using PI spacer with an 'active-cut' structure exhibited an On/off ratio of 10(3), a linear mobility of 7.1 cm(2)/Vs, and a subthreshold swing of 1.2 V/decade.</P>