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A Development of Assessment Model for Maintenance of Type R Fire Alarm System in the Building
Lee,Su-Kyung,Yoo,Sang-Bin,Nam,Yang-Won 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
Type R fire alarm is required intelligent buildings and height buildings which was based on automatic system. But in Korea, maintenance of fire alarm system is very poor. In this study, we developed assessment model for the type R fire alarm system which was assessed by using 96 checklist items. The assessment model was tested through the actual 4 buildings with type R fire alarm system. It is shown that present model can be applied for the assessment of all buildings through the examination of the suitability of assessment model by actual assessment. Also, it was made easily fire manager to carry out checklist for type R fire alarm system in buildings.
LCC 분석을 통한 도시가스와 지열 냉 난방설비의 경제성 평가
이일규(Lee, Il-Gyu),강현욱(Kang, Hyun-Wook),원유만(Won, Yoo-Man),김용수(Kim, Yong-Su) 대한건축학회 2011 大韓建築學會論文集 : 構造系 Vol.27 No.10
The purpose of this study is economic analysis of heating and cooling systems that are using gas, geothermal energy through life cycle cost analysis. The adapted research method selected the office building in Seoul region. The building is 15 stories and have total floor area of 270,000㎡. And the capacity of heating and cooling system applied in new building is 700RT to 750RT as a scale of heating and cooling system that can provide same capacity. The Adapted LCC Analysis period on 40 years. Comparing and analyzing life cycle cost about each heating and cooling system in cases, economical evaluation is estimated. The results are as follows: 1) The total life cycle cost of gas heating and cooling system is approximately 7,979million won, the total life cycle cost of geothermal heating and cooling system is approximately 8,073million won. 2) The cost of the geothermal heating and cooling system is higher than gas heating and cooling system about 1.18%. Thus, optimal plan is the gas heating and cooling system.
Cystic Medullary Thyroid Carcinoma: A Case of Undergoing Endoscopic Thyroid Lobectomy
Dong Hae Chung,Jae Yeon Seok,Yoo Seung Chung1,Eun Mee Oh1,Jung Won Ryu1,Young Don Lee1 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.1
On ultrasonography, medullary thyroid carcinoma (MTC) shows hypoechogenicity, an irregular margin, a predominantly solid composition, and microcalcifications, similar to those observed in papillary thyroid carcinoma (PTC). MTC presenting as a cystic lesion is rare, and endoscopic thyroidectomy can be performed for benign thyroid masses and early stage PTC, however it is inappropriate for MTC regardless of cystic change. The authors report a case of cystic MTC found after endoscopic thyroid lobectomy and provide a review of the literature on this topic.
Genotoxic Effects of the Cooked - Food - Related Mutagens IQ and Trp - p - 2 in Drosophila
Lee, Won Ho,Yoo, Mi Ae,Park, Tae Dong,Choo, Jong Kil 한국유전학회 1987 Genes & Genomics Vol.9 No.4
The heterocyclic amines, IQ and Trp-p-2 are the cooked-food-related carcinogens. To know genotoxic effects of IQ and Trp-p-2 in Drosophila, sensitivity to killing, somatic gene mutations and somatic chromosome mutations were measured in repair-deficient strain and repair-proficient strain after larval treatment. Gene mutations were detected with eye-color spot test system and chromosome mutations with wing spot test system. The relative potency of these two compounds in Drosophila will be discussed with the different response of mammalian system and Salmonella system.
Lee, Hye-Lim,Lim, Sung-Ah,Lee, Hye-Won,Yoo, Ho-Ryong,Kim, Hyeong-Geug Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>We evaluated neuropharmacological properties of Yuk-Mi-Jihwang-Tang (YJT) against scopolamine injection-induced memory impairment mice model. Mice were orally administered with YJT (50, 100, or 200 mg/kg) or tacrine (TAC, 12.5 mg/kg) for 10 days. At the first day of Morris water maze task, scopolamine (2 mg/kg) was intraperitoneally injected before 30 min of it. The hippocampal memory function was determined by the Morris water maze task for 5 days consecutively. Scopolamine drastically increased escape latency and decreased time spent in target quadrant. Pretreatment YJT properly improved them. Regarding the redox status, YJT significantly reduced the oxidative stress and it also exerted much effort to improve both superoxide dismutase and catalase activities in hippocampal gene expression and protein levels. These effects were well coincided with immunohistochemical analysis of 4-hydroxyneal-positive signals in hippocampal areas. Additionally, acetylcholine esterase activities and brain-derived neurotrophic factor abnormalities in the hippocampal protein levels were significantly normalized by YJT, and their related molecules were also improved. The neuronal proliferation in hippocampal regions was markedly inhibited by scopolamine, whereas YJT notably recovered them. Collectively, YJT exerts much effort to enhance memorial functions through improving redox status homeostasis and partially regulates acetylcholine esterase activities as well as neuronal cell proliferation.</P>
Lee, Jae-Hwan,Park, Seon Young,Ahn, Changhwan,Kim, Cho-Won,Kim, Ji-eun,Jo, Na Rae,Kang, Hee Young,Yoo, Yeong-Min,Jung, Eui-Man,Kim, Eun Mi,Kim, Ki-Suk,Choi, Kyung-Chul,Lee, Sung Duck,Jeung, Eui-Bae Elsevier 2019 Food and chemical toxicology Vol.123 No.-
<P><B>Abstract</B></P> <P>The embryoid body test (EBT) is a developmental toxicity test method that assesses the half inhibitory concentrations of substances in the area of embryoid bodies (EBs), and in the viability of mouse embryonic stem cells (ESCs) and fibroblasts (3T3 cells) following chemical exposure for three and four days, respectively. In the previous study, the EBT showed more advanced than the embryonic stem cell test (EST) from the European Centre for the Validation of Alternative Methods (ECVAM) applying cardiac differentiation of mouse ESCs, because the EBT greatly reduced the exposure time, labor, and amount of materials required, and misclassification of embryotoxic potential. This pre-validation study evaluated the predictive accuracy of the EBT using 26 coded test substances by two steps: intra-laboratory and inter-laboratory reproducibility tests. Since some substances have different embryotoxic potentials at different pregnancy periods, in this study, a new prediction model consisting of non-toxic and toxic classes was used, instead of the existing prediction model assessing embryotoxicants in four classes. The results of the intra- and inter-laboratory tests were highly accurate (above 80%) when substances were classified using the predictive model. In conclusion, EBT can accurately classify various embryotoxicants in a short time with less effort and greater validation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The experiment was conducted to verify the embryo body test (EBT) method. </LI> <LI> Predictive models were created for two classifications (non-toxic and toxic). </LI> <LI> Experimental results showed high accuracy (above 80%). </LI> <LI> EBT can be used to classify embryotoxicants in the short term. </LI> </UL> </P>
Lee, Won Kee,Lee, Shin Yup,Choi, Jin Eun,Seok, Yangki,Lee, Eung Bae,Lee, Hyun Cheol,Kang, Hyo‐,Gyoung,Yoo, Seung Soo,Lee, Myung Hoon,Cho, Sukki,Jheon, Sanghoon,Kim, Young Chul,Oh, In Jae,Na, Koo John WileySons Australia, Ltd 2017 Thoracic cancer Vol.8 No.3
<P><B>Background</B></P><P>This multicenter study was performed to develop a prognosis‐prediction model incorporating genetic polymorphism with pathologic stage for surgically treated non‐small cell lung cancer (NSCLC) patients.</P><P><B>Methods</B></P><P>A replication study including 720 patients and a panel of eight single nucleotide polymorphisms (SNPs), which predicted the prognosis of surgically treated NSCLC in our previous study, was conducted. Using the combined cohort of current and previous studies including 1534 patients, a nomogram for predicting overall survival was made using Cox proportional hazards regression.</P><P><B>Results</B></P><P>Among the eight SNPs, C3 rs2287845, GNB2L1 (alias RACK1), and rs3756585 were significantly associated with overall survival. A nomogram was constructed based on pathologic stage and the genotypes of the two SNPs, and the risk score was calculated for each patient in the combined cohort. Using the prognosis‐prediction model, we categorized patients into low, intermediate, and high‐risk groups, which had greater accuracy in predictive ability (log‐rank statistics = 54.66) than the conventional tumor node metastasis staging (log‐rank statistics = 39.56). Next, we generated a prognosis‐prediction model for stage I to identify a subgroup of potential candidates for adjuvant chemotherapy. Notably, 97 out of 499 stage IB patients were classified as high‐risk patients with a similar prognosis to stage II patients, suggesting the benefit of adjuvant chemotherapy.</P><P><B>Conclusions</B></P><P>This prognosis‐prediction model incorporating genetic polymorphism with pathologic stage may lead to more precise prognostication in surgically resected NSCLC patients. In particular, this model may be useful in selecting a subgroup of stage IB patients who may benefit from adjuvant chemotherapy.</P>