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Yoo Si Hyung,Hong Seung Hee,Jung Sa Rah,Park Su Jin,Lee Nam Kyung,Kim Soon Nam,Kang Sang Mo,Min Hong Ki,Park Sue Nie,Hong Seung Hwa The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.1
Plasma-derived products are produced from plasma via fractionation and chromatography techniques, but can also be produced by other methods. In the performance of nucleic acid amplification tests (NAT) with plasma-derived products, it is necessary to include an internal control for the monitoring of all procedures. In order to avoid false negative results, we confirmed the usefulness of the bovine viral diarrhoea virus (BVDV) for use as an internal control in the detection of hepatitis C virus (HCV) RNA in plasma-derived products. These products, which were spiked with BVDV, were extracted and then NAT was performed. Specificity and sensitivity were determined via the adjustment of primer concentrations and annealing temperatures. BVDV detection allows for validation in the extraction, reverse transcription, and amplification techniques used for HCV detection in plasma-derived products.
Apoptosis Induction by Menadione in Human Promyelocytic Leukemia HL-60 Cells
Sa, Duck-Jin,Lee, Eun-Jee,Yoo, Byung-Sun Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3
Cell death induced by menadione (vitamin K-3,2-methyl-1,4-naphthoquinone) has been investigated in human promyelocytic leukemia HL-60 cells. Menadione was found to induce both apoptosis and necrosis in HL-60 cells. Low concentration ($1{\sim}$50 ${\mu}$M) of menadione induced apoptotic cell death, which was demonstrated by typical DNA ladder patterns on agarose gel electrophoresis and flow cytometry analysis. In contrast, a high concentration of menadione (100 ${\mu}$M) induced necrotic cell death, which was demonstrated by DNA smear pattern in agarose gel electrophoresis. Necrotic cell death was accompanied with a great reduction of cell viability. Menadione activated caspase-3, as evidenced by both increased protease activity and proteolytic cleavage of 116 kDa poly(ADP-ribose) polymerase (PARP) into 85 kDa cleavage product. Caspase-3 activity was maximum at 50 ${\mu}$M of menadione, and very low at 100 ${\mu}$M of menadione. Taken together, our results showed that menadione induced mixed types of cell death, apoptosis at low concentrations and necrosis at high concentrations in HL-60 cells.
Yoo, Jin Woo,Chung, Yoong,Kim, Gwi Taek,Song, Chi Woo,Yoon, Pil Hyun,Sa, Yong Cheol,Kim, Min Soo Elsevier 2018 International Journal of Refrigeration Vol.96 No.-
<P><B>Abstract</B></P> <P>Naturally, frost forms at fin-tube evaporator surface when refrigerant below 0 °C flows inside the heat exchanger. Frost tends to block the evaporator, hinders efficient heat exchange and degrades the performance of the system. The determination of the start time for defrosting is one of the essential issues that most of air heat pumps are confronted with because it is directly connected to energy consumption. Many types of sensors can be installed for frost detection but they are usually not cost-effective or related logic is not so physically presented. In this study, a novel frost volume calculation method is suggested in order to determine the start time for defrosting in an air-to-air heat pump system. The detailed explanation of the method is presented and verified with experimental data. With this method, the start timing of defrosting can be appropriately judged. At the time of defrosting, the heating capacity decreased from 16.2 to 39.3% and the COP reduced from 12.3 to 26.4% compared with maximum values. The blocking ratio from image processing at the time was between 0.83 and 0.97.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A method for the determination of defrosting start time is proposed. </LI> <LI> Frost volume and blocking ratio are calculated from experimental data. </LI> <LI> Frost volume calculation method is verified by image processing of the evaporator. </LI> <LI> This method accurately determines the timing of deterioration of the system. </LI> </UL> </P>
( Yoo Hyung Kim ),( Hae Ri Kim ),( Hong Jae Jeon ),( Ye Jin Kim ),( Sa Ra Jung ),( Dae Eun Choi ),( Kang Wook Lee ),( Ki Ryang Na ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.3
Background/Aims: Fragmented care in nephrology can cause treatment delays. Nephrologists are qualified to perform vascular access-related procedures because they understand the pathophysiology of renal disease and perform physical examination for vascular access. We compared treatment delays associated with tunneled hemodialysis catheter (TDC) placement between interventional radiologists and nephrologists. Methods: We collected data by radiologists from January 1, 2011 through December 31, 2011 and by nephrologists from since July 1, 2012 through June 30, 2013. We compared the duration from the hemodialysis decision to TDC placement (D-P duration) and hemodialysis initiation (D-H duration), catheter success and the complication rate, and the frequency and the usage time of non-tunneled hemodialysis catheters (NDCs) before TDC placement. Results: The study analyzed 483 placed TDCs: 280 TDCs placed by radiologists and 203 by nephrologists. The D-P durations were 319 minutes (interquartile range [IQR], 180 to 1,057) in the radiologist group and 140 minutes (IQR, 0 to 792) in the nephrologist group. Additionally, the D-H durations were 415 minutes (IQR,260 to 1,091) and 275 minutes (IQR, 123 to 598), respectively. These differences were statistically significant (p = 0.00). The TDC success rate (95.3% vs. 94.5%, respectively; p = 0.32) and complication rate (16.2% vs. 11%, respectively; p = 0.11) did not differ between the groups. The frequency (24.5 vs. 26%, respectively; p = 0.72) and the usage time of NDC (8,451 vs. 8,416 minutes, respectively; p = 0.91) before TDC placement were not statistically significant. Conclusions: Trained interventional nephrologists could perform TDC placement safely, minimizing treatment delays.
( Yoo Hyung Kim ),( Hong Jae Jeon ),( Ye Jin Kim ),( Sa Ra Jung ),( Dae Eun Choi ),( Ki Ryang Na ),( Kang Wook Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Fragmented cares in nephrology have led to delays in treatment and losses of continued decision-making control for patients. Nephrologists are suited to procedures related to vascular access. Because they could understand the pathophysiology of renal disease and perform correct physical examination for vascular access. By combining this understandings with ability to perform procedures, we could expect minimizing treatment-delay and continuing decision-making for dialysis patients. In this context, we compared treatment-delay associated TDC placement between by radiologist and by nephrologist. Methods: Nephrologist in CNUH started vascular access related procedures since March 2012. We collected data by radiologist from since January 1, 2011 through December 31, 2011 and by nephrologist from since July 1, 2012 through June 30, 2013, retrospectively. We compared minute duration from hemodialysis decision to both TDC placement(D-I duration) and hemodialysis initiation(D-H duration), catheter success rate, complication rate and frequency and duration time of nontunneled hemodialysis catheter before TDC placement. Results: 483 placed TDC cases were analyzed. 280 TDCs was placed by radiologist, and 203 TDC was placed by nephrologist. D-I duration were 319 minutes(180.5 - 1057 minutes, IQR) in radiologist group and 140.5 minutes (0 - 792.75 minutes, IQR) in nephrologist group. Also, D-H duration were 415 minutes (260 - 1091 minutes, IQR) and 275 minutes (123 - 598 minutes, IQR), respectively. These results were statistically signifi cant (p=0.00). TDC catheter success rate(94.6% vs 93.1%, p=0.316) and complication rate(16.2% vs 11%, p=0.107) were not different between both groups. Frequency(24.5 vs 26%, p=0.72) and duration of using NDC(8804.9 ± 4935.72 vs 6999.05±4219.6 (p=0.189) before TDC placement were not also statistically signifi cant. Conclusions: Trained interventional nephrologist could perform TDC placement safely and effectively which minimized treatment-delay. It would improve patients convenience and lower hospital costs.
Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
( Hye Jin Cha ),( Min Ji Song ),( Kwang Wook Lee ),( Eun Jung Kim ),( Young Hoon Kim ),( Yun Je Lee ),( Won Keun Seong ),( Sa Ik Hong ),( Choon Gon Jang ),( Han Sang Yoo ),( Ho Sang Jeong ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.6
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.
사판식 피스톤 모터의 성능향상을 위한 설계변수 특성 연구
정유성(Yoo Seong Jeong),정원지(Won Jee Chung),사진웅(Jin Woong Sa),정용욱(Young Wook Jeong) 한국생산제조학회 2017 한국생산제조학회지 Vol.26 No.2
Hydraulic equipment have been traditionally used for constructing machines with high power density and durability. In particular, pumps and motors are considered essential equipment, and are consistently investigated to find suitable methods for optimal utilization of their characteristics. A kinematic analysis of a swash-platetype piston motor model using the hydraulic analysis program SimulationX® to model a nine-piston motor and simulate a swash-plate angle with a low-pulsation and high-efficiency performance of the motor has been provided in this paper. Finally, along with the theoretical consideration of the stroke, the effect of changing strokes and notch shape (V, U, non-type) on the pulsation is simulated to analyze and determine the effects of reduction in pulsation. The optimal swash-plate angle and stroke thus obtained will reduce the trial and error in future design.