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Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Yoo Youngbum,Yeon MyeongHoon,Kim Won-Kyung,Shin Hyeon-Bin,Lee Seung-Min,Yoon Mee-Sup,Ro Hyunju,Seo Young-Kyo 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Skeletal muscle aging results in the gradual suppression of myogenesis, leading to muscle mass loss. However, the specific role of cardiolipin in myogenesis has not been determined. This study investigated the crucial role of mitochondrial cardiolipin and cardiolipin synthase 1 (Crls1) in age-related muscle deterioration and myogenesis. Our findings demonstrated that cardiolipin and Crls1 are downregulated in aged skeletal muscle. Moreover, the knockdown of Crls1 in myoblasts reduced mitochondrial mass, activity, and OXPHOS complex IV expression and disrupted the structure of the mitochondrial cristae. AAV9-shCrls1-mediated downregulation of Crls1 impaired muscle regeneration in a mouse model of cardiotoxin (CTX)-induced muscle damage, whereas AAV9-mCrls1-mediated Crls1 overexpression improved regeneration. Overall, our results highlight that the age-dependent decrease in CRLS1 expression contributes to muscle loss by diminishing mitochondrial quality in skeletal muscle myoblasts. Hence, modulating CRLS1 expression is a promising therapeutic strategy for mitigating muscle deterioration associated with aging, suggesting potential avenues for developing interventions to improve overall muscle health and quality of life in elderly individuals.
Yoo, Youngbum,Yoon, Sun-Jung,Kim, So Yeon,Lee, Deok-Won,Um, Sewook,Hyun, Hoon,Hong, Sung Ok,Yang, Dae Hyeok TaylorFrancis 2018 Drug delivery Vol.25 No.1
<P><B>Abstract</B></P><P>Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel and doxorubicin⋅hydrochloride (DOX⋅HCl), called GC10/DOX, on thyroid cancer treatment <I>in vivo</I>. Visible light irradiation increased the storage modulus and swelling ratio of the GC10/DOX hydrogel precursor. The release of DOX⋅HCl from GC10/DOX exhibited two unique patterns comprising an initial burst within 18 hours, followed by a controlled and sustained release thereafter. <I>In vitro</I> cell viability testing showed that GC10/DOX had a greater antitumor effect than free DOX⋅HCl and GC10 hydrogel controls. <I>In vivo,</I> local injection of GC10/DOX near tumor tissue led to a superior antitumor effect compared with controls consisting of free DOX⋅HCl intravenously injected to the tail vein of thyroid cancer-bearing mouse and GC10 hydrogel subcutaneously injected near the tumor. Altogether, our results suggest that GC10/DOX may have clinical potential for thyroid cancer treatment.</P>
Yoo, Youngbum,Hyun, Hoon,Yoon, Sun-Jung,Kim, So Yeon,Lee, Deok-Won,Um, Sewook,Hong, Sung Ok,Yang, Dae Hyeok Elsevier 2018 Journal of industrial and engineering chemistry Vol.67 No.-
<P><B>Abstract</B></P> <P>Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF and GCH-EGF/FGF) and evaluated their efficacies on the improvement of wound healing <I>in vivo</I>. <I>In vitro</I> release test showed that the growth factors were released in a sustained manner along with initial burst for 24h. <I>In vitro</I> cell proliferation assay of L-929 mouse fibroblast cell line resulted in the superior ability of GCH-EGF/FGF on the rate. <I>In vivo</I> results demonstrated that the growth factor loaded GCHs further enhanced wound healing compared with GCH. In particular, GCH-EGF/EFG showed the most remarkable wound healing effect among the samples.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Antimicrobial Activity of Biosurfactants
( Dalsoo Yoo ),( Kapjung Kim ),( Youngbum Kim ),( Eunki Kim ) 대한화장품학회 2001 대한화장품학회지 Vol.27 No.2
Biosurfactant has antibiological activities. Due to its low toxicity, biosurfactant can be applied to human health care products. Posseing the antibiological activities as well as the surfactant properties implies that biosurfactant can be widely used in the cosmetic industry. In tiiis presentation, applications of biosurfactant have been reviewed including the antimicrobial activities of sophorolipid. Sophorolipid,a biosurfactant produced from Candida bombicola ATCC 22214,showed antimicrobial activity against Bacillus subtilis,Staphylococcus xylosus,Streptococcus mutans, and Propionibacterium acne at 4, 1,1,0.5 ppm as MIC (minimum inhibitory concentration^ Also 100 ppm of sophorolipid inhibited 50% of cell growth of plant pathogenic fungus, B. cinera. However, sophorolipid showed no effect on the Escherichia coli.,indicating its selective antimicrobial activity depending on the cell wall structure. Treatment of B. subtilis with sophorolipid increased the leakage of intracellular enzyme, malate dehydrogenase, indicating the possible interaction of sophorolipid with cellular membrane. Between lactone-type and acid-type sophorolipid, the former showed higher antimicrobial activity.
Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis
Lee, Wonhwa,Park, Seung-Yoon,Yoo, Youngbum,Kim, Soon-Young,Kim, Jung-Eun,Kim, Shin-Woo,Seo, Young-Kyo,Park, Eui Kyun,Kim, In-San,Bae, Jong-Sup F K SCHATTAUER VERLAGSGESELLSCHAFT MBH 2018 Thrombosis and Haemostasis Vol.118 No.10
Validity and reproducibility of a food frequency questionnaire for breast cancer survivors in Korea
Moon Sang-Eun,Shin Woo-kyoung,Song Sihan,Koh Dahye,Ahn Jeong Sun,Yoo Youngbum,Kang Minji,Lee Jung Eun 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.6
BACKGROUND/OBJECTIVES The aim of this study was to examine the validity and reproducibility of a food frequency questionnaire (FFQ) developed in Korea for breast cancer survivors. SUBJECTS/METHODS Ninety-nine breast cancer survivors who completed an FFQ twice and three 3-day dietary records (DRs) between 2016–2017 were included. Energy and 14 nutrient intakes were calculated from FFQs and DRs. To determine the validity of the FFQ, energy-adjusted de-attenuated Pearson correlations between two FFQ assessments and the average of the three 3-day DRs were calculated, and to determine reproducibility, energy-adjusted Pearson correlations and degrees of agreement were calculated between the first and second FFQ assessments. RESULTS Correlation coefficients of validity ranged from 0.29 (protein) to 0.47 (fat) (median value = 0.36) for the FFQ assessment and from 0.20 (riboflavin) to 0.53 (calcium) (median value = 0.37) for the second. Correlation coefficients of reproducibility ranged from 0.22 (sodium) to 0.62 (carbohydrate) (median value = 0.36). Regarding FFQ reproducibilities, percentage classifications of exact agreements for energy-adjusted nutrients ranged from 27.3% (sodium) and 45.5% (fat). A median 76.8% of participants were classified into the same or adjacent quartiles, while a median of 5.6% of participants were classified in extreme quartiles. Bland–Atman plots for the majority of data points of three macronutrients, calcium and vitamins A and C fell within limits of agreement. CONCLUSIONS These results indicated that the newly developed FFQ for Korean breast cancer survivors has acceptable validity and reproducibility as compared with three 3-day DRs collected over a one-year period.
Choi, Hye Yeon,Yang, Gwang-Mo,Dayem, Ahmed Abdal,Saha, Subbroto Kumar,Kim, Kyeongseok,Yoo, Youngbum,Hong, Kwonho,Kim, Jin-Hoi,Yee, Cassian,Lee, Kyung-Mi,Cho, Ssang-Goo BioMed Central 2019 Breast cancer research Vol.21 No.-
<P><B>Background</B></P><P>Epithelial-mesenchymal transition (EMT) occurs in the tumor microenvironment and presents an important mechanism of tumor cell intravasation, stemness acquisition, and metastasis. During metastasis, tumor cells enter the circulation to gain access to distant tissues, but how this fluid microenvironment influences cancer cell biology is poorly understood.</P><P><B>Methods and results</B></P><P>Here, we present both in vivo and in vitro evidence that EMT-like transition also occurs in circulating tumor cells (CTCs) as a result of hydrodynamic shear stress (+SS), which promotes conversion of CD24<SUP>middle</SUP>/CD44<SUP>high</SUP>/CD133<SUP>middle</SUP>/CXCR4<SUP>low</SUP>/ALDH1<SUP>low</SUP> primary patient epithelial tumor cells into specific high sphere-forming CD24<SUP>low</SUP>/CD44<SUP>low</SUP>/CD133<SUP>high</SUP>/CXCR4<SUP>high</SUP>/ALDH1<SUP>high</SUP> cancer stem-like cells (CSLCs) or tumor-initiating cells (TICs) with elevated tumor progression and metastasis capacity in vitro and in vivo. We demonstrate that conversion of CSLCs/TICs from epithelial tumor cells via +SS is dependent on reactive oxygen species (ROS)/nitric oxide (NO) generation, and suppression of extracellular signal-related kinase (ERK)/glycogen synthase kinase (GSK)3β, a mechanism similar to that operating in embryonic stem cells to prevent their differentiation while promoting self-renewal.</P><P><B>Conclusion</B></P><P>Fluid shear stress experienced during systemic circulation of human breast tumor cells can lead to specific acquisition of mesenchymal stem cell (MSC)-like potential that promotes EMT, mesenchymal-epithelial transition, and metastasis to distant organs. Our data revealed that biomechanical forces appeared to be important microenvironmental factors that not only drive hematopoietic development but also lead to acquisition of CSLCs/TIC potential in cancer metastasis. Our data highlight that +SS is a critical factor that promotes the conversion of CTCs into distinct TICs in blood circulation by endowing plasticity to these cells and by maintaining their self-renewal signaling pathways.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s13058-018-1071-2) contains supplementary material, which is available to authorized users.</P>