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Wang, Jin-Sheng,Ji, Ai-Fang,Wan, Hong-Jun,Lu, Ya-Li,Yang, Jian-Zhou,Ma, Li-Li,Wang, Yong-Jin,Wei, Wu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objectives: The aim of the present study was to explore mechanisms underlying the effects of down-regulating ${\beta}$-catenin expression on esophageal carcinoma (EC) cells. Methods: Cell cycle distribution and apoptosis were determined using flow cytometry and annexin V apoptosis assay, respectively. Transmission electron microscopy (TEM) was used to examine changes in ultrastructure, while expression of cyclin D1 protein and mRNA was detected by western blot and real-time PCR. Proliferating cell nuclear antigen (PCNA) and extracellular signal-regulated kinase (ERK) 1-2 were evaluated by Western blot analysis. PCNA labeling index (LI) was determined by immunocytochemistry. Results: Compared with pGen-3-con transfected and Eca-109 cells, the percentage of G0/G1-phase pGen-3-CTNNB1 transfected cells was obviously increased (P<0.05), with no significant difference among the three groups with regard to apoptosis (P>0.05). pGen-3-CTNNB1 transfected cells exhibited obvious decrease in cyclin D1 mRNA and protein expression (P<0.05) and the ultrastructure of Eca-109 cells underwent a significant change after being transfected with pGen-3-CTNNB1, suggesting that down-regulating ${\beta}$-catenin expression can promote the differentiation and maturation. The expression of PCNA and the ERKI/2 phosphorylation state were also down-regulated in pGen-3-CTNNB1 transfected cells (P<0.05). At the same time, the PCNA labeling index was decreased accordingly (P<0.05). Conclusion: Inhibition of EC Eca-109 cellproliferation by down-regulating ${\beta}$-catenin expression could improve cell ultrastructure by mediating blockade in G0/G1 through inhibiting cyclin D1, PCNA and the MAPK pathway (p-ERK1/2).
IN SITU UNZIPPING OF CARBON NANOTUBES TO FORM GRAPHENE NANORIBBONS
YONG-SHENG ZHOU,PAN JIN,TENG GUO,YING-CHUN ZHU,GAO-HUI DU,BING-SHE XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.1
We report the one step facile synthesis of graphene nanoribbons (GNRs) by unzipping carbonnanotubes (CNTs) from glucose (C 6 H 12 O 6 ) precursor, using a simple chemical vapor depositionmethod. Some nanotubes are partially cut resulting in a GNR – CNT hybrid whereas others arefully cut to form GNRs. The average length of GNRs achieved by this method is typically in therange of 1 – 10 ? m. The formation of GNRs is ascribed to the in situ oxygen-driven unzipping ofCNTs. The process is free from aggressive oxidants and utilizes the in situ unzipping. Thismethod o®ers an alternative approach for making GNRs, compared to previously used techniquesto synthesize GNRs.
Nonparametric estimation of multivariate multiparameter conditional copulas
Jin-Guan Lin,Kong-Sheng Zhang,Yan-Yong Zhao 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.1
Nonparametric estimation of conditional copulas with one parameter has been investigated in Acar et al. (2011). The estimation for multivariate multiparameter conditional copulas, however, has not been considered so far. This paper adopts the local linear smoothing technique and Newton–Raphson method to estimate those copulas. Under some regularity conditions, the asymptotic normality of the estimators is obtained. Simulation work shows the efficiency of the proposed method. As an application, we analyze a life expectancies data set and show that the conditional t copula outperforms the conditional Clayton, Frank and Gumbel copulas.
Huan-Yong Ji,Yong-Sheng Jin,Jing Li,Hui Tian,Shang-Zheng Feng 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11
As market competition continuously intensifies, how to cope with existing and potential market challenges in complex, dynamic environments is a major problem haunting Chinese e-commerce enterprises in their strategic planning. In order to solve this problem, the theory of organizational ambidexterity is applied in this paper to the strategic practices of Chinese e-commerce enterprises, and starting from the view of corporate leadership, the mediated role of top management’s behavioral integration (referred to as TMBI in the following content) in the relationship between transformational leadership behavior and organizational ambidexterity is discussed. In addition, against the practical background that Chinese e-commerce enterprises are facing highly competitive environments, further clarification is made herein by using environmental dynamics as the moderator variable for the mediated link. Through empirical tests on 198 samples of Chinese e-commerce enterprises, we find that: 1) transformational leadership has a positive influence on organizational ambidexterity, and TMBI plays a full mediated role in that influencing process; 2) environmental dynamics moderates the relationship between transformational leadership and TMBI, but don’t have a moderated effect on the relationship between TMBI and organizational ambidexterity. According to the research conclusion in this paper, the mechanism of transformational leadership influencing organizational ambidexterity can be better explained when two important factors, TMBI and environmental dynamics, are taken into consideration. The research in this paper provides not only important revelations for the development of organizational ambidexterity research as well as the application of relevant research achievements, but also supports for Chinese e-commerce enterprises’ effective strategic practices in theory.
Genetic Diversity for Rice Blast Management
(You Yong Zhu),(Hai Ru Chen),(Yun Yue Wang),(Zuos Hea Li),(Yan Li),(Jing Hua Fan),(Jian Bing Chen),(Jin Xiang Fan),(Shi Sheng Yang),(Guang Liang Ma),(Ling Ping Hu),(Jin Yu Zou),(Christopher C . Mundt) 한국균학회 2001 Proceedings of the Fifth Korea-China Joint Symposi Vol.- No.-
Xiao-Yong Gao,Hong-Liang Feng,Zeng-Yuan Zhang,Jiao-Min Ma,Meng-Ke Zhao,Chao Chen,Jin-Hua Gu,Shi-E Yang,Yong-Sheng Chen,Jing-Xiao Lu 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.2
Using values of the oxygen flux ratio (OFR = [O2]/[Ar]) ranging from 0 to 0.5, authors deposited a series of silver-oxide (Ag_xO) films on glass substrates by direct-current reactive magnetron sputtering (DC sputtering) at a substrate temperature of 150 ℃. The effect of the OFR on the film’s structural and optical properties was systematically investigated by using X-ray diffractometry, scanning electron microscopy and spectrophotometry. The Ag_xO films deposited clearly show an evolution of the film’s phase structure from the biphased (Ag + Ag_2O) structure to the biphased (AgO + Ag_2O) structure and then to the single-phased (Ag_2O) structure as value of the OFR increases. Accordingly, the film’s surface morphology, related to the film’s crystalline structure, clearly changes from a loose and porous surface structure to a compact surface structure and then to a pyramid-like surface structure with increasing value of the OFR. The novel porous structure may be attributed to the interruption of the silver’s growth course by the AgO on the film’s surface. Notably, a single-phased Ag_2O film is deposited by DC-sputtering at OFR = 0.5 due to the dual effects of thermal decomposition of the AgO phase and a combination reaction of AgO and Ag to Ag_2O. The oscillations both in the film’s reflectivity and transmissivity spectra are strengthened with increasing OFR, indicating an evolution from the metallic behavior of the biphased (Ag + Ag_2O) film to the dielectric behavior of the biphased (Ag_2O + AgO) film and the single-phased Ag2O film. The fitted optical absorption edges of the Ag_2O and the Ag_xO films deposited at values of the OFR of 0.5 and 0.33 are approximately 2.43 eV and 2.34 eV, respectively. The absorption edges are closely related to the direct interband transitions.
Cui, Sheng-Yun,Kim, Seung-Jin,Jo, Sung-Chan,Lee, Yong-Moon,Lee, Yong-Ill Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.8
A combination of electrospray ionization and tandem mass spectrometry was used to characterize the scavenging reactions of acrylamide (AA) in the presence of glutathione (GSH) in vitro. In the presence of GSH, AA was deactivated effectively and scavenged by reactions consuming small amount of GSH. Reaction products and structural information were identified using collision-induced dissociation (CID) in an ion trap mass spectrometer. In the mixture of GSH and AA, significant increase in abundance of fragment ion peak was observed at m/z 233, which was identified as $[Cys-Glu]^+$, formed by the elimination of glycine moiety of GSH. GSH also contributes to the AA scavenging reaction by conjugating with AA through the sulfhydryl group in cysteine moiety. The probable scavenging reaction pathway of AA in the presence of GSH has been proposed based on the CID experimental data.