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      • KCI등재

        Immunosuppressive Effects of New Cyclolanostane Triterpene Diglycosides from the Aerial Part of Cimicifuga foetida

        Rui-Le Pan,Di-Hua Chen,Jian-Yong Si,Xiao-Hong Zhao,Zhan Li,Li Cao 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2

        Two new cyclolanostane diglycosides, cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae). Using spectral data and chemical analysis, the structures of 1 and 2 were identified as (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→3')-β-D-xylopyranoside and (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→2')-β-D-xylopyranoside, respectively. The in vitro immunosuppressive effects of the two new compounds 1 and 2, as well as four other known cyclolanostane saponins 3-6 on T cells were evaluated. All the agents tested effectively inhibited the proliferation of murine splenocytes induced by Concanavalin A (ConA), with IC50 values ranging from 12.7 nM to 33.3 nM.

      • KCI등재

        Syntheses, Structure, and Properties of Four Metal-Organic Polymers Based on Rigid Multiple Carboxylate Ligands and N-Donor Ligands

        Yong Zhou,Wen-Hao Zhao,Jin Wang,Jin-Rui Wei,Xian-Hong Yin,Xiang-Bo Wei,Cui-Wu Lin 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.11

        Four metal-organic coordination polymers, {[Cd2(BIBP)2(H2DTDA)2]n  · 2(H2O)} (1), [Zn (BIBP) (H2TDA)2] n (2), [Cd2(BIBP)(H2TDA)2] n (3), and [Ni2(BIBP)2(H2DTDA)2(μ-O)] n , (4) [where BIBP = 4,4′-bis(1-imidazoly)biphenyl, H2TDA = [1,1′:4′1″-terphen-yl]-3,3″-dicarboxylic acid, and H2DTDA = 2′,5′-dimethyl-[1,1′:4′,1″-terphenyl]-3,3″-dicarboxylic acid] were hydrothermally synthesized and characterized by elemental analyses, IR, TG, luminescence, and single crystal X-ray diffraction. X-Ray diffraction analysis reveals that the four complexes exhibit new frameworks due to diverse coordination conformations. The different coordination modes of the ligands BIBP and two aromatic carboxylate acids play important roles in the construction of the final structure for the complexes. X-ray structure analysis reveals that 1, 2, and 4 are 3D coordination polymers, while complex 3 is a 2D network polymer.

      • KCI등재

        A transfer learning-based particle swarm optimization algorithm for travelling salesman problem

        Zheng Rui-zhao,Zhang Yong,Yang Kang 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.3

        To solve travelling salesman problems (TSPs), most existing evolutionary algorithms search for optimal solutions from zero initial information without taking advantage of the historical information of solving similar problems. This paper studies a transfer learning-based particle swarm optimization (PSO) algorithm, where the optimal information of historical problems is used to guide the swarm to find optimal paths quickly. To begin with, all cities in the new and historical TSP problems are clustered into multiple city subsets, respectively, and a city topology matching strategy based on geometric similarity is proposed to match each new city subset to a historical city subset. Then, on the basis of the above-matched results, a hierarchical generation strategy of the feasible path (HGT) is proposed to initialize the swarm to improve the performance of PSO. Moreover, a problem-specific update strategy, i.e. the particle update strategy with adaptive crossover and clustering-guided mutation, is introduced to enhance the search capability of the proposed algorithm. Finally, the proposed algorithm is applied to 20 typical TSP problems and compared with 12 state-of-the-art algorithms. Experimental results show that the transfer learning mechanism can accelerate the search efficiency of PSO and make the proposed algorithm achieve better optimal paths.

      • KCI등재

        Self-curling 3D oriented scaffolds from fish scales for skeletal muscle regeneration

        Shi Yong,Zhang Xiaoxuan,Liu Rui,Shao Xiaoyan,Zhao Yuanjin,Gu Zhuxiao,Jiang Qing 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Volumetric muscle loss (VML) due to various reasons may cause motor dysfunction and tissue engineering has been proposed for muscle regeneration. However, developing three-dimensional (3D) tissue-engineered scaffolds that can mimic oriented cell growth of muscle tissues are challenging for regeneration medicine. Herein, we propose a novel self-curling 3D oriented scaffold (SCOS) composed of fish derived gelatin methacrylate (GelMA) and fish scales for repairing skeletal muscles.Fish scales of tilapia were decellularized and decalcified. Then, SCOSs were constructed by ultraviolet-coating methylated fish gelatin on the back of fish scales. C2C12 myoblasts were cultured on SCOSs, and after induction of myogenic differentiation, SCOS/C2C12 transplants were prepared for in vivo experiments.Decellularized and decalcified fish scales (DDFSs) became soft and retained the original oriented microgroove surface structure that could induce oriented cell growth. SCOSs could self-curl into 3D structures when immersing in culture medium due to different swelling properties of fish GelMA and DDFSs. Cell experiments demonstrated that SCOSs enhanced the oriented growth and myogenic differentiation of C2C12 myoblasts. By integrating SCOSs and myogenic differentiated C2C12 myoblasts, the resultant SCOS/C2C12 transplants promoted de novo muscle regeneration and functional restoration of muscle activity in the mouse model of VML.Our results suggest that SCOSs loaded with myogenic differentiated C2C12 myoblasts can promote muscle regeneration in mice with skeletal muscle injuries, indicating application prospects of such scaffolds in muscle tissue engineering and other related fields.

      • SCIESCOPUSKCI등재

        African Maternal Origin and Genetic Diversity of Chinese Domestic Donkeys

        Lei, Chu-Zhao,Ge, Qing-Lan,Zhang, Hu-Cai,Liu, Ruo-Yu,Zhang, Wei,Jiang, Yong-Qing,Dang, Rui-Hua,Zheng, Hui-Ling,Hou, Wen-Tong,Chen, Hong Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5

        The origin of domestic donkeys in China has been controversial. To clarify the origin of Chinese domestic donkeys, we investigated the partial mitochondrial D-loop sequences of 126 samples from 12 native breeds. The results revealed two mitochondrial origins, lineage Somali and lineage Nubian of African wild ass detected in Chinese domestic donkeys. Lineage Somali was predominant in Chinese domestic donkey breeds. The pattern of genetic variation in ass mtDNA D-loop sequences indicated that the two lineages Somali and Nubian from China had undergone population expansion events. In a combined analysis of lineages Somali and Nubian between previously published sequences from other countries/regions and sequences of Chinese domestic donkeys, the results indicated that the two lineages of Chinese domestic donkeys were from Africa and supported the African maternal origins of Chinese domestic donkeys. There was no obvious geographical structure in Chinese domestic donkey breeds, but the population showed abundant mtDNA diversity. The spread routes of Chinese domestic donkeys were also discussed.

      • KCI등재

        Dissimilar Metal Joining of 304 Stainless Steel to SMA490BW Steel Using the Filler Metal Powders with a High-Entropy Design

        Dejia Liu,Rui Guo,Yong Hu,Mingxue Shen,Yanchuan Tang,Longzhi Zhao,Deying Li,Xiangjie Wang 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.6

        High-entropy alloys having excellent properties are particularly suitable for the application as the filler metals in welding. In the present study, multi-component mixed powders of FeCoCrNiMn and CrFeNi2.4Al0.6,based on a high-entropy design,as well as the comparative 316L stainless steel powders, were used as the filler metals, to achieve the dissimilar weldingbetween 304 stainless steel and SMA490BW steel by laser deposition welding. By comparative analysis of the microstructureand mechanical properties of three types of joints, the feasibility and weld-ability of the filler metal powders based on ahigh-entropy design were studied. It was found that the melting of base metal (BM) and weld metal dilution had an impacton the set high-entropy component in the weld zone. And high-entropy structures were achieved in the weld zone by usingthe powders of CrFeNi2.4Al0.6. Compared to the BM of SMA490BW steel, three types of joints presented a higher notchedtensile strength and had a better corrosion resistance. The joint welded using the powders of CrFeNi2.4Al0.6had the lowesthardness value in the weld zone, in which the joint was fractured during the notched tensile tests. The other two jointsfractured near the notch in the SMA490BW steel side. Transgranular fracture and a typical dimple fracture were observedin the fractured joints.

      • KCI등재

        Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora

        Wei-Lie Xiao,Rui-Rui Wang,Wei Zhao,Ren-Rong Tian,Shan-Zhai Shang,Liu-Meng Yang,Jian-Hong Yang,Jian-Xin Pu,Yong-Tang Zheng,Han-Dong Sun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5

        This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8) . The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26~20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.

      • KCI등재

        Microstructure control of Fe catalyst films for the growth of multiwalled carbon nanotube arrays

        Guo-an Cheng,Hua-ping Liu,Rui-ting Zheng,Yong Zhao,Chang-lin Liang 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.-

        Fe catalyst films were deposited on silicon substrates by using a metal vapor vacuum arc (MEVVA) ion deposition system for the growth of aligned multiwalled carbon nanotubes. The effects of deposition angle and film thickness on the morphologies of catalyst films before and after thermal treatment were investigated. The results show that the uniformities of both 5-nm and 10-nm films are enhanced as the deposition angle decreases. With increase from 5 nm to 10 nm, the surface uniformities of pristine films prepared at higher deposition angles (60˚ and 90˚) are increased, while that of the films produced at 30˚ deposition angle is slightly decreased. The uniformity of Fe catalyst particle sizes after thermal treatment on the whole, clearly decreases as the thickness is increased from 5 nm to 10 nm in the case of the same deposition angle. 5-nm films deposited at 30˚ deposition angle show the most uniform features before and after thermal treatment and can be used for the synthesis of high-quality carbon nanotube arrays. Fe catalyst films were deposited on silicon substrates by using a metal vapor vacuum arc (MEVVA) ion deposition system for the growth of aligned multiwalled carbon nanotubes. The effects of deposition angle and film thickness on the morphologies of catalyst films before and after thermal treatment were investigated. The results show that the uniformities of both 5-nm and 10-nm films are enhanced as the deposition angle decreases. With increase from 5 nm to 10 nm, the surface uniformities of pristine films prepared at higher deposition angles (60˚ and 90˚) are increased, while that of the films produced at 30˚ deposition angle is slightly decreased. The uniformity of Fe catalyst particle sizes after thermal treatment on the whole, clearly decreases as the thickness is increased from 5 nm to 10 nm in the case of the same deposition angle. 5-nm films deposited at 30˚ deposition angle show the most uniform features before and after thermal treatment and can be used for the synthesis of high-quality carbon nanotube arrays.

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