Seismic performance of Bujian Puzuo considering scale ratio and vertical load effects

Yong-Hui Jiang,Jun-Xiao He,Lei Zhu,Lin-Lin Xie,Shuo Fang 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.90 No.5

This study investigated the influence of scale ratio and vertical load on the seismic performance of Puzuo joints in traditional Chinese timber structures. Three low-cyclic reversed loading tests were conducted on three scaled specimens of Bujian Puzuo in Yingxian Wooden Pagoda. This study focused on the deformation patterns and analyzed seismic performance under varying scale ratios and vertical loads. The results indicated that the slip and rotational deformations of Bujian Puzuo were the primary deformations. The scale of the specimen did not affect the layer where the maximum interlayer slip occurred, but it did decrease the proportion of slip deformation. Conversely, the reducing vertical load caused the layer with the maximum slippage and the position of the damaged Dou components to shift upward, and the proportion of slip deformation increased. When the vertical load was decreased by 3.7 times, the maximum horizontal bearing capacity under positive and negative loadings, initial stiffness, and energy dissipation of the specimen decreased by approximately 60%, 58.79%, 69.62%, and 57.93%, respectively. The horizontal bearing capacity under positive loading and energy dissipation of the specimen increased by 35.63% and 131.54%, when the specimen scale was doubled and the vertical load was increased by 15 times.

A novel recyclable nano-adsorbent for enhanced oil recovery with efficient removal of Ca2+ and Cr6+ from oilfield wastewater

Lei He,Yong Dai,Zhe Wang,Lutao Yang,Luxia Zhang,Pengpeng Hu,Yutian Lei,Hong Mo,Haomiao Zhu,Jun Zhang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.8

Oilfield wastewater has a significantly negative influence on the recovery efficiency due to its hypersalinity. Therefore, magnetic graphene oxide (GO) modified with ethylene diamine tetraacetic acid (EDTA) and grafted bypolyethylene glycol (PEG) nano-adsorbent was prepared to remove the Ca2+ and Cr6+ in Jidong Oilfield wastewaterspecifically. It was noteworthy that PEG-g-EDTA/Fe3O4/GO nano-adsorbent had excellent adsorption performance,with removal ratios up to 71.6% for Ca2+ and 42.7% for Cr6+ at 30 min. After the fifth recycling run, the nano-adsorbentstill remained with high removal ratios (69.3% for Ca2+ and 30.5% for Cr6+) and high reuse rates (89.4% for Ca2+and 95.2% for Cr6+), indicating that the nano-adsorbent had outstanding adsorption-desorption efficacy and high reusability. The adsorption test results demonstrated that the total salinity of the treated oilfield wastewater decreased byabout 5,000 ppm, and the displacement efficiency further increased by 12.5% by chemical flooding compared with theuntreated wastewater. Therefore, PEG-g-EDTA/Fe3O4/GO nano-adsorbent is an adsorbent with excellent potentialwhich can effectively remove Ca2+ and Cr6+ in oilfield wastewater to enhance oil recovery (EOR).

Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer

Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.

Association Between C-reactive Protein and Risk of Cancer: A Meta-analysis of Prospective Cohort Studies

Guo, Yong-Zhong,Pan, Lei,Du, Chang-Jun,Ren, Dun-Qiang,Xie, Xiao-Mei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Associations between elevated C-reactive protein (CRP) and cancer risk have been reported for many years, but the results from prospective cohort studies remains controversial. A meta-analysis of prospective cohort studies was therefore conducted to address this issue. Methods: Eligible studies were identified by searching the PubMed and EMBASE up to October 2012. Pooled hazard ratios (HR) was calculated by using random effects model. Results: Eleven prospective cohort studies involving a total of 194,796 participants and 11,459 cancer cases were included in this meta-analysis. The pooled HR per natural log unit change in CRP was 1.105 (95% confidence interval (CI): 1.033-1.178) for all-cancer, 1.308 (95% CI: 1.097-1.519) for lung cancer, 1.040 (95% CI: 0.910-1.170) for breast cancer, 1.063 (95% CI: 0.965-1.161) for prostate cancer, and 1.055 (95% CI: 0.925-1.184) for colorectal cancer. Dose-response analysis showed that the exponentiated linear trend for a change of one natural log unit in CRP was 1.012 (95% CI: 1.006-1.018) for all-cancer. No evidence of publication bias was observed. Conclusions: The results of this meta-analysis showed that the elevated levels of CRP are associated with an increased risk of all-cancer, lung cancer, and possibly breast, prostate and colorectal cancer. The result supports a role of chronic inflammation in carcinogenesis. Further research effort should be performed to identify whether CRP, as a marker of inflammation, has a direct role in carcinogenesis.

Multi-domain Security Authentication Protocol for Hybrid Cloud

Zhang Qikun,Zhang Lei,Gan Yong,Duan zhaolei,Zheng Jun 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.8

In recent years, with the high-speed development of cloud computing and its universal application, the cloud security technology is more and more important. In cloud computing, it is mainly through the resource sharing and collaborative action to meet the demand for an unlimited access speed, unlimited storage space and a reliable resource protection for users. For the secure access resources among different domains in cloud network, today most Cloud Computing Systems provide data security and mutual authentication with asymmetric and traditional public key cryptography. For these researches, the authentication process is cumbersome, and the certificate management is complex, which would bring some inconvenience for mutual authentication among servers or users in a Hybrid Cloud. This paper provides a security authentication protocol among multiple domains. It adopts the direct product decomposition and linear mapping technology of cyclic group to achieve mutual authentication between members in multi-domain systems or heterogeneous networks. Extensive security and performance analysis show that the proposed schemes have the advantages of in security, computation consumption and Communication consumption. It is suitable for safety authentication in large-scale Cloud computing environment.

A high-stability neutron generator for industrial online elemental analysis

Xiang-quan Chen,Lei Xiong,Hui Xie,Jing-fu Guo,Xue-ming Zhang,Yong-jun Dong Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.4

The yield stability of the neutron generator directly affects the accuracy of elemental analysis. This paper presents an industrial fully automatic neutron generator with a 48 mm neutron tube based on PLC to improve the stability and reliability of the neutron generator in industrial applications. By integrating a Kalman Filter with the PID algorithm in a PLC, the neutron yield of the generator is remarkably stabilized, achieving 1 × 10⁸n/s. The neutron generator has been employed for industrial online elemental analysis. The results demonstrate that only a slight fluctuation of ±0.82 % exists in the neutron yield, and the reproducibility of the generator holds at a significant level of 0.05. This improved neutron generator can be applied to the online bulk analysis of carbon in coal-fired power stations and absolute measurement of neutron source emission rate.

Research Paper : Influences of long-term different types of fertilization on weed community biodiversity in rice paddy fields

( Kai Yuan Wan ),( Yong Tao ),( Ru Hai Li ),( Jun Feng Pan ),( Lei Lei Tang ),( Fang Chen ) 한국잡초학회 2012 Weed Biology and Management Vol.12 No.1

In order to provide a scientific basis for developing integrated weed management strategies in rice paddy fields, this study investigated the influences of different types of fertilization on weed biodiversity. The experiment was conducted at Long-term-located Monitoring Station for Soil Fertility, Agricultural Science Academy, of Jiangxi Province, China. Five fertilization treatments were set: no fertilization (NOF), PK, NP, NK, and NPK. The results showed that the influence of different fertilization treatments on weed community traits followed the models PK > NOF > NK > NP > NPK for species richness, PK > NOF > NK > NP > NPK for species diversity, NPK > NP > NK > NOF > PK for community dominance, and PK > NOF > NK > NP > NPK for community evenness. Under NPK (i.e. balanced fertilization), the weed species diversity and richness and weed community evenness were the lowest. The principal component analysis showed that the weed community was divided into three groups: (i) NK and a part of NOF; (ii) NP and NPK; and (iii) PK and NOF. The correlation analysis indicated that the influence of each macro-element on the weed community followed the model N > P > K. The organic content in the paddy soil might have played an equally important role with the amount of available N in determining the weed community`s characteristics. Regarding the way by which N, P, and K influenced the weed community, the amount of available P and K mainly influenced the organic content, while the amount of available N influenced both the organic content and light transmittance within the canopy, thereby enhancing the capacity of rice to compete with weeds.

The effects of different factors on obstacle strength of irradiation defects: An atomistic study

Lin Pan-dong,Nie Jun-feng,Lu Yu-peng,Xiao Gui-yong,Gu Guo-chao,Cui Wen-dong,He Lei 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.6

In this work we study the effects of different factors of dislocation loop on its obstacle strength when interacting with an edge dislocation. At first, the interaction model for dislocation and dislocation loop is established and the full and partial absorption mechanism is obtained. Then, the effect of temperature, size and burgers vector of dislocation loop are investigated. The relation between the obstacle strength and irradiation dose has been established, which bridges the irradiation source and microscale properties. Except that, the obstacle strength of C, Cr, Ni, Mn, Mo and P decorated dislocation loop is studied. Results show that the obstacle strength for dislocation loop decorated by alloy element decreases in the sequence of Cr, Ni, Mn, C, P and Mo, which could be used to help parameterize and validate crystal plasticity finite element model and therein integrated constitutive laws to enable accounting for irradiation-induced chemical segregation effects.

Vibration analysis of viscoelastic single-walled carbon nanotubes resting on a viscoelastic foundation

Da-Peng Zhang,Yong-Jun Lei,Cheng-Yuan Wang,Zhi-Bin Shen 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.1

Vibration responses were investigated for a viscoelastic Single-walled carbon nanotube (visco-SWCNT) resting on a viscoelastic foundation. Based on the nonlocal Euler-Bernoulli beam model, velocity-dependent external damping and Kelvin viscoelastic foundation model, the governing equations were derived. The Transfer function method (TFM) was then used to compute the natural frequencies for general boundary conditions and foundations. In particular, the exact analytical expressions of both complex natural frequencies and critical viscoelastic parameters were obtained for the Kelvin-Voigt visco-SWCNTs with full foundations and certain boundary conditions, and several physically intuitive special cases were discussed. Substantial nonlocal effects, the influence of geometric and physical parameters of the SWCNT and the viscoelastic foundation were observed for the natural frequencies of the supported SWCNTs. The study demonstrates the efficiency and robustness of the developed model for the vibration of the visco-SWCNT-viscoelastic foundation coupling system.

Upregulation and biological function of transmembrane protein 119 in osteosarcoma

Zhen-Huan Jiang,Jun Peng,Hui-Lin Yang,Xing-Li Fu,Jin-Zhi Wang,Lei Liu,Jian-Nong Jiang,Yong-Fei Tan,Zhi-Jun Ge 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development. However, the level of TMEM119 expression and its roles in osteosarcoma have not yet been elucidated. In the present study, TMEM119 mRNA and protein expression was found to be up-regulated in osteosarcoma compared with normal bone cyst tissues. The level of TMEM119 protein expression was strongly associated with tumor size, clinical stage, distant metastasis and overall survival time. Moreover, gene set enrichment analysis (GSEA) of the Gene Expression Omnibus (GEO) GSE42352 dataset revealed TMEM119 expression in osteosarcoma tissues to be positively correlated with cell cycle, apoptosis, metastasis and TGF-β signaling. We then knocked down TMEM119 expression in U2OS and MG63 cells using small interfering RNA, which revealed that downregulation of TMEM119 could inhibit the proliferation of osteosarcoma cells by inducing cell cycle arrest in G0/G1 phase and apoptosis. We also found that TMEM119 knockdown significantly inhibited cell migration and invasion, and decreased the expression of TGF-β pathway-related factors (BMP2, BMP7 and TGF-β). TGF-β application rescued the inhibitory effects of TMEM119 knockdown on osteosarcoma cell migration and invasion. Further in vitro experiments with a TGF-β inhibitor (SB431542) or BMP inhibitor (dorsomorphin) suggested that TMEM119 significantly promotes cell migration and invasion, partly through TGF-β/BMP signaling. In conclusion, our data support the notion that TMEM119 contributes to the proliferation, migration and invasion of osteosarcoma cells, and functions as an oncogene in osteosarcoma.