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Lai, Er-Yong,Chen, Zhen-Guo,Zhou, Xuan,Fan, Xiao-Rong,Wang, Hua,Lai, Ping-Lin,Su, Yong-Chun,Zhang, Bai-Yu,Bai, Xiao-Chun,Li, Yun-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers, including colorectal cancer (CRC). DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. However, the role of DEPTOR in the development of CRC is not known. The aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival. Here, Immunohistochemical expression of P-S6 (S235/236) and DEPTOR were evaluated in 1.5 mm tumor cores from 90 CRC patients and in 90 samples of adjacent normal mucosa by tissue microarray. The expression of P-S6 (S235/236) was upregulated in CRC, with the positive rate of P-S6 (S235/236) in CRC (63.3%) significantly higher than that in control tissues (36.7%, 30%) (p<0.05). P-S6 (S235/236) also correlated with high tumor histologic grade (p=0.002), and positive nodal metastasis (p=0.002). In contrast, the expression level of DEPTOR was correlated with low tumor histological grade (p=0.006), and negative nodal metastasis (p=0.001). Interestingly, P-S6 (S235/236) expression showed a significant negative association with the expression of DEPTOR in CRC (p=0.011, R= -0.279). However, upregulation of P-S6 (S235/236) (p=0.693) and downregulation of DEPTOR (p=0.331) in CRC were not significantly associated with overall survival. Thus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC. DEPTOR is a potential marker for prognostic evaluation and a target for the treatment of CRC.
Yong-An Lai,Pei-Tzu Chang,Yan-Liang Kuo 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.32 No.5
The purpose of this study is to demonstrate and verify the application of phase-control absolute-acceleration-feedback active tuned mass dampers (PCA-ATMD) to multiple-degree-of-freedom (MDOF) building structures. In addition, servo speed control technique has been developed as a replacement for force control in order to mitigate the negative effects caused by friction and inertia. The essence of the proposed PCA-ATMD is to achieve a 90° phase lag for a structure by implementing the desired control force so that the PCA-ATMD can receive the maximum power flow with which to effectively mitigate the structural vibration. An MDOF building structure with a PCA-ATMD and a real-time filter forming a complete system is modeled using a state-space representation and is presented in detail. The feedback measurement for the phase control algorithm of the MDOF structure is compact, with only the absolute acceleration of one structural floor and ATMD’s velocity relative to the structure required. A discrete-time direct output-feedback optimization method is introduced to the PCA-ATMD to ensure that the control system is optimized and stable. Numerical simulation and shaking table experiments are conducted on a three-story steel shear building structure to verify the performance of the PCA-ATMD. The results indicate that the absolute acceleration of the structure is well suppressed whether considering peak or root-mean-square responses. The experiment also demonstrates that the control of the PCA-ATMD can be decentralized, so that it is convenient to apply and maintain to real highrise building structures.
김용신,신준호,신동하,강용원,김흥대,한원곤,배원길,박용래 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6
Background/Aims: Pseudocysts of the pancreas are a localized collection of fluid occurring within pancreatic mass or peripancreatic region and are enclosed by a fibrous tissue wall. The diagnosis and follow-up of the disease has been facilitated with the advent of ultrasound and computed tomographic scanning. In terms of therapy, surgery was the only option available in the past. Recently, new me thods such as percutaneous catheter drainage and endoscopic cystenterostomy are used. The aim o this study was to review the characteristics and results of various therapeutic methods for the management of pancreatic pseudocysts. Methods: We reviewed retrospectively 42 cases of pancreatic pseudocysts admitted at the Kangbuk Samsung Hospital from January, 1985 to December, 1997 Results: Twenty-six patients (61.9%) were managed non-operatively, and the remaining 16 patients were treated operatively. Twenty-seven patients (64.3%) had showed complete resolution of pseudo cysts ultrasonographically or roentgenographically with a mean follow-up period of 8.9 months. One operative and seven underlying disease-related deaths occurred. Conclusions: There are various management methods for pancreatic pseudocysts such as expectant treatment, operation, percutaneous catheter drainage and endoscopic cystoenterostomy. Thus, it is important to choose the appropriate management method considering the status of each individual patient.
Bao-yong Lai,Li-yan Jia,Bo-Wen Yu,Shi-Bing Liang,Ai-Jing Chu,Hui-juan Cao,Jian-ping Liu,Xiao-Hua Pei 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.
Recent developments in superhydrophobic surfaces with unique structural and functional properties
Zhang, Yong-Lai,Xia, Hong,Kim, Eunkyoung,Sun, Hong-Bo The Royal Society of Chemistry 2012 SOFT MATTER Vol.8 No.44
<P>The surface wettability control of solid materials has been considered as an essential aspect of surface chemistry. In the past decade, superhydrophobic surfaces have revealed a cornucopia of novel structural and functional properties, exhibiting considerable importance in both fundamental research and practical applications. In this review, we summarize the recent developments of superhydrophobic surfaces with unique structural and functional properties. Both the fabricative methods and the working performance of superhydrophobic surfaces with multidisciplinary functionalities including self-cleaning, icephobicity, anti-corrosion, drag reduction, transparency, anti-reflection, structural color, droplet transportation, anisotropy, oil–water separation, water supporting force, superamphiphobicity and responsive switching, have been discussed briefly. Finally, the current challenges and future prospects of this dynamic field are discussed based on our own opinion.</P> <P>Graphic Abstract</P><P>This review highlights the recent developments in superhydrophobic surfaces with unique structure-defined functionalities towards a wide range of applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2sm26517f'> </P>
Acupuncture for Treatment of Erectile Dysfunction: A Systematic Review and Meta-Analysis
Bao-yong Lai,Hui-juan Cao,Guo-yan Yang,Li-yan Jia,Suzanne Grant,Yu-tong Fei,Emma Wong,Xin-lin Li,Xiao-ying Yang,Jian-ping Liu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.3
ChinaPurpose: To assess the effectiveness and safety of acupuncture for erectile dysfunction (ED).Materials and Methods: We searched six major English and Chinese databases included randomized controlled trials (RCTs) testing acupuncture alone or in combination for ED. Dichotomous data were presented as risk ratio (RR) and continuous data were presented as mean difference (MD) both with 95% confidence interval (CI). The Revman (v.5.3) was used for data analyses. Quality of evidence across studies was assessed by the online GRADEpro tool.Results: We identified 22 RCTs, fourteen of them involving psychogenic ED. Most of the included RCTs had high or unclear risk of bias. There was no difference between electro-acupuncture and sham acupuncture with electrical stimulation on the rate of satisfaction and self-assessment (RR, 1.50; 95% CI, 0.71–3.16; 1 trial). Acupuncture combined with tadalafil appeared to have better effect on increasing cure rate (RR, 1.31; 95% CI, 1.00–1.71; 2 trials), and International Index of Erectile Function-5 scores (MD, 5.38; 95% CI, 4.46–6.29; 2 trials). When acupuncture plus herbal medicine compared with herbal medicine alone, the combination therapy showed significant better improvement in erectile function (RR, 1.68; 95% CI, 1.31–2.15; 7 trials). Only two trials reported facial red and dizziness cases, and needle sticking and pruritus cases in acupuncture group. Conclusions: Low quality evidence shows beneficial effect of acupuncture as adjunctive treatment for people mainly with psychogenic ED. Safety of acupuncture was insufficiently reported. The findings should be confirmed in large, rigorously designed and well-reported trials.