http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Li Zhi-yu,Liu Ying,Han Zhuo-na,Li Xiang,Wang Yue-ying,Cui Xun,Zhang Ying 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. Therefore, the purpose of this study was to investigate the effect of Wnt agonist 1 (Wnta1) on ANP secretion and mechanical dynamics in beating rat atria. Wnta1 treatment significantly increased atrial ANP secretion and pulse pressure; these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. In addition, Wnta1 upregulated levels of phospho-transforming growth factor-β activated kinase 1 (p-TAK1), TAK1 banding 1 (TAB1) and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ATF2 was abrogated by inhibition of TAK1. Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC–TAK1–ATF2–TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca2+ pathway. It is also suggested that WNT–ANP signaling is implicated in cardiac physiology and pathophysiology.
Structural behavior of the stiffened double-skin profiled composite walls under compression
Ying Qin,Yong-Wei Li,Xu-Zhao Lan,Yu-Sen Su,Xiang-Yu Wang,Yuan-De Wu 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.1
Steel-concrete composite walls have been proposed and developed for applications in various types of structures. The double-skin profiled composite walls, as a natural development of composite flooring, provide structural and architectural merits. However, adequate intermediate fasteners between profiled steel plates and concrete core are required to fully mobilize the composite action and to improve the structural behavior of the wall. In this research, two new types of fasteners (i.e., threaded rods and vertical plates) were proposed and three specimens with different fastener types or fastener arrangements were tested under axial compression. The experimental results were evaluated in terms of failure modes, axial load versus axial displacement response, strength index, ductility index, and load-strain relationship. It was found that specimen with symmetrically arranged thread rods sustained more stable axial strain than that with staggered arranged threaded rods. Meanwhile, vertical plates are more suitable for practical use since they provide stronger confinement to profiled steel plate and effectively prevent the steel plate from early local buckling, which eventually enhance the composite action and increase the axial compressive capacity of the wall. The calculation methods were then proposed and good agreement was observed between the test results and the predicted results.
Experimental and numerical study of large high strength bolt shear connector embedded in HFRC
Yu Liang He,Zhengxin Wang,Weiming Wu,Ying Yang,Yi Qiang Xiang 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.49 No.2
To investigate the static properties of large high strength bolt shear connector in hybrid fiber-reinforced concrete (HFRC) and normal concrete (NC), eight push-out test specimens with single/double nut and HFRC/NC slabs were designed and push-out tests were conducted. A fine 3D nonlinear finite element (FE) model including HFRC constitutive model was established by using ANSYS 18.0, and the test results were used to verify FE models of the push-out test specimens. Then a total of 13 FE models were analyzed with various parameters including fiber volume fractions of HFRC, bolt diameter and thickness of steel flange. Finally, the empirical equations considering the contribution of polypropylene fiber (PF) and steel fiber (SF) obtained from the regression of the test results and FE analysis were recommended to evaluate the load-slip curve and ultimate capacity of the large high strength bolt shear connector embedded in HFRC/NC.
Yu-Ping Hua,Hong-Liang Chai,Si-Yuan Yang,Xiang-Wei Zeng,Ying Sun 대한수의학회 2005 Journal of Veterinary Science Vol.6 No.4
Two hundred thirty specimens of wild birds were collected from some areas in Heilongjiang Province during the period of 2003~2004, including two batches of specimens collected randomly from a same flock of mallards in Zhalong Natural Reserve in August and December, 2004, respectively. Primary virus isolation and identification for avian influenza virus (AIV) and Newcastle disease virus (NDV) were performed. The results showed that only two specimens of young mallards collected from Zhalong Natural Reserve in August, 2004 were positive to AIV (isolation rate 0.9%), and one strain (D57) of these two virus isolates was identified to be H9 subtype by hemagglutination inhibition test. Meanwhile, the two batches of blood serum samples of mallards from Zhalong were also examined for antibodies against AIV and NDV. Among 38 blood serum samples collected in August, antibodies against the hemagglutinin of H1, H3, H5, H6 and H9 subtypes of AIV were found in 1, 0, 2, 0 and 8 samples, respectively; and 11 samples were found with antibody against NDV. Whereas the NDV isolation in both two batches of specimens of mallard was negative, all of the 32 blood serum samples collected in December were negative for antibodies against AIV and NDV.
Numerical analysis of large stud shear connector embedded in HFRC
Yu Liang He,Chong Zhang,Li Chao Wang,Ying Yang,Yi Qiang Xiang 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.5
To investigate the mechanical behavior of large stud shear connector embedded in hybrid fiber-reinforced concrete (HFRC), a refined 3D nonlinear finite element (FE) model incorporating the constitutive model of HFRC was developed using ANSYS. Firstly, the test results conducted by the authors (He et al. 2017) were used to validate FE model of push out tests. Secondly, a total of 27 specimens were analyzed with various parameters including fiber volume fractions of HFRC, diameter of studs and HFRC strength. Finally, an empirical equation considering the contribution of steel fiber (SF) and polypropylene fiber (PF) was recommended to estimate the ultimate capacity of large stud shear connector embedded in HFRC.
Yu, Shu-Min,Yan, Xing-Rong,Chen, Dong-Mei,Cheng, Xiang,Dou, Zhong-Ying Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.1
Parthenogenetic embryonic stem (pES) cells could provide a valuable model for research into genomic imprinting and X-linked diseases. In this study, pES cell lines were established from oocytes of hybrid offspring of Kunming and 129/Sv mice, and pluripotency of pES cells was evaluated. The pES cells maintained in the undifferentiated state for more than 50 passages had normal karyotypes with XX sex chromosomes and exhibited high activities of alkaline phosphatase (AKP) and telomerase. Meanwhile, these cells expressed ES cell molecular markers SSEA-1, Oct-4, Nanog, and GDF3 but not SSEA-3 detected by immunohistochemistry and RT-PCR. The pES cells could be differentiated into various types of cells from three germ layers in vitro by analysis of embryoid bodies (EBs) with immunohistochemistry and RT-PCR, and in vivo by observation of pES cell-derived teratoma sections. Therefore, the established pES cell lines contained all features of mouse ES cells. This work provides a new strategy for isolating pES cells from Kunming mice, and the pES cell lines could be applied as the cell model in research into genomic imprinting and epigenetic regulation of Kunming mice.
Compressive behavior of profiled double skin composite wall
Ying Qin,Yong-Wei Li,Yu-Sen Su,Xu-Zhao Lan,Yuan-De Wu,Xiang-Yu Wang 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.30 No.5
Profiled composite slab has been widely used in civil engineering due to its structural merits. The extension of this concept to the bearing wall forms the profiled composite wall, which consists of two external profiled steel plates and infill concrete. This paper investigates the structural behavior of this type of wall under axial compression. A series of compression tests on profiled composite walls consisting of varied types of profiled steel plate and edge confinement have been carried out. The test results are evaluated in terms of failure modes, load-axial displacement curves, strength index, ductility ratio, and load-strain response. It is found that the type of profiled steel plate has influence on the axial capacity and strength index, while edge confinement affects the failure mode and ductility. The test data are compared with the predictions by modern codes such as AISC 360, BS EN 1994-1-1, and CECS 159. It shows that BS EN 1994-1-1 and CECS 159 significantly overestimate the actual compressive capacity of profiled composite walls, while AISC 360 offers reasonable predictions. A method is then proposed, which takes into account the local buckling of profiled steel plates and the reduction in the concrete resistance due to profiling. The predictions show good correlation with the test results.
Xiang-Yu LI,J. Wu,W.Q. Chen,Hui-Ying Wang,Z.Q. Zhou 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.42 No.3
This paper examines the problem of a penny-shaped crack in a thermoporoelastic body. On the basis of the recently developed general solutions for thermoporoelasticity, appropriate potentials are suggested and the governing equations are solved in view of the similarity to those for pure elasticity. Exact and closed form fundamental solutions are expressed in terms of elementary functions. The singularity behavior is then discussed. The present solutions are compared with those in literature and an excellent agreement is achieved. Numerical calculations are performed to show the influence of the material parameters upon the distribution of the thermoporoelastic field. Due to its ideal property, the present solution is a natural benchmark to various numerical codes and simplified analyses.