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Mao, Ying-Ying,Jing, Fang-Yuan,Jin, Ming-Juan,Li, Ying-Jun,Ding, Ye,Guo, Jing,Wang, Fen-Juan,Jiang, Long-Fang,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Accumulated evidence has indicated that Ephrin A1 (EFNA1) is associated with angiogenesis and tumorigenesis in various types of malignancies, including colorectal cancer (CRC). In the current study, we performed an online search using the public microarray database to investigate whether EFNA1 expression might be altered in CRC tissues. We then conducted a case-control study including 306 subjects (102 cases and 204 well-matched controls) in Xiaoshan County to assess any association between genetic polymorphisms in EFNA1 and CRC susceptibility. Searches in the Oncomine expression profiling database revealed EFNA1 to be overexpressed in CRC tissue compared with adjacent normal tissue. The rs12904 G-A variant located in the 3' untranslated region (UTR) of EFNA1 was observed to be associated with CRC susceptibility. Compared with the AA homozygous genotype, those carrying GA genotype had a decreased risk of developing CRC (odds ratio (OR)=0.469, 95% confidence interval (CI): 0.225-0.977, and P=0.043). The association was stronger among smokers and tea drinkers, however, no statistical evidence of interaction between rs12904 polymorphism and smoking or tea drinking on CRC risk was found. Our results suggest that EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC susceptibility. Larger studies and further mechanistic investigations are warranted to confirm our findings.
ESSAYS : Policy dilemma of Government-Subsidized Student Loans (GSSLs) program in China
( Ying Jiang ) 고려대학교 중국학연구소 2013 中國學論叢 Vol.40 No.-
自從``年開始實施國家助學貸款政策以來, 高違約率一直是國家貸款政策所面臨的巨大挑戰. 爲何中國國家助學貸款政策會面臨這樣一改政策困境: 學生不願還款(高違約率)和銀行不願發放貸款? 本文指出全國性信用體系的不健全, 過短的還款期限, 以及政府的參與度過低導致了高違約率的發生. 進而, 高違約率降低了銀行發放貸款的積極性, 甚至停止了國家助學貸款的發放. 國家助學貸款的可持續性發展依賴于銀行風險的降低以及畢業生的還款情況. 因此, 政策指定應該考慮一下幾改方面: 政府是否應該參與國家助學貸款的단保? 政府如何盡快建立全國性的信用系統? 是否應該延長還款期限? 混合式還款計劃是否可行?
Jiang, Xiao-Ting,Ma, Ying-Yu,Guo, Kun,Xia, Ying-Jie,Wang, Hui-Ju,Li, Li,He, Xu-Jun,Huang, Dong-Sheng,Tao, Hou-Quan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: This study aimed to summarize the potential diagnostic value of serum DKK1 levels in cancer detection. Materials and Methods: Serum DKK1 was measured using enzyme-linked immunosorbent assay in a case-control study. Then we performed a meta-analysis and the pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic (sROC) curves were used to evaluate the overall test performance. Results: Serum DKK1 levels were found to be significantly upregulated in gastric cancer as compared to controls. ROC curve analysis revealed an AUC of 0.636, indicating the test has the potential to diagnose cancer with poor accuracy. The summary estimates of the pooled sensitivity, specificity and diagnostic odds ratio in meta-analysis were 0.55 with a 95% confidence interval (CI) (0.53-0.57), 0.86 (95%CI, 0.84-0.88) and 12.25 (95%CI, 5.31-28.28), respectively. The area under the sROC was 0.85. Subgroup analysis revealed that the diagnostic accuracy of serum DKK1 in lung cancer (sensitivity: 0.69 with 95%CI, 0.66-0.74; specificity: 0.95 with 95%CI, 0.92-0.97; diagnostic odds ratio: 44.93 with 95%CI, 26.19-77.08) was significantly higher than for any other cancer. Conclusions: Serum DKK1 might be useful as a noninvasive method for confirmation of cancer diagnosis, particularly in the case of lung cancer.
Yingli Jiang,Jie Cui,Yanlong Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8
Flood has become the main hidden threat to the safety of the karst tunnel. Scientific and reasonable flood classification assessment and prevention measures have also become the main problems to be solved urgently in the construction and operation of tunnels. Aiming at the problems of multiple influencing factors, complex index systems, and linear processing of the connection degree of set pair analysis, a set pair cloud model based on cloud theory eigenvalues is proposed to optimize the connection degree of set pair analysis. Regarding the uncertainty of the evaluation system and the ambiguity of the evaluation grade boundary, firstly, the ridge-type membership function is used to determine the basic probability distribution of each measured index. Secondly, the distance discrimination weighting theory based on the index distance is also established, so that each measured index can assign the dynamic weight of the evaluation system. It can comprehensively determine the weight of the cloud connection degree for the system, and draw the cloud level diagram to determine the tunnel flood risk level. Finally, the proposed model is verified with tunnel flood. The results show that the evaluation results are consistent with other evaluation models and actual tunnel conditions. This model can provide guidance for flood prediction and prevention in karst tunnels.
Tensile Properties and Structure Characterization of Palm Fibers by Alkali Treatment
Ying Jiang,Penghu Deng,Lingxiao Jing,Tonghua Zhang 한국섬유공학회 2019 Fibers and polymers Vol.20 No.5
This work aims to reveal how the alkali influences the mechanical behavior and structural stability of palm fiber. First, palm fiber samples were treated with 20 % and 40 % NaOH solutions separately for approximately 1, 2, 3, and 4 h atroom temperature. Then the samples were characterized using tensile testing, Fourier transform infrared spectroscopy, X-raydiffraction, and thermogravimetric analysis. Results showed the tensile properties of alkali-treated fibers exceeded those ofuntreated fibers. Notably, the fibers treated with 40 % NaOH for 1 h yielded the most significant improvements. The tensilestrength, elongation at break, Young’s modulus, and yield point increased by 28.8 %, 38 %, 52.1 %, and 64.7 %, respectively,compared with the untreated fibers. The increase appeared to be due to the removal of non-cellulosic materials andrearrangement of the cellulose chains.
Inhomogeneity of Hot Rolling Texture in Cu/Nb Added Ultra Low Carbon Steels
Jiang, Ying-Hua,Park, Young-Koo,Lee, Oh-Yeon Materials Research Society of Korea 2007 한국재료학회지 Vol.17 No.12
The texture and microstructure in Cu/Nb added ultra low carbon steels through the different thickness layer were studied after hot rolling. It was found that the two ultra low carbon steels all show the inhomogeneity of hot rolling texture and the Cu-added ultra low carbon steel was far more inhomogeneous than Nb-added one. In the center layer, the strong ${\alpha}\;fibre,\;{\gamma}\;fibre$ textures and the shear textures including 001<110>, 111<112> were founded. Near the surface, the ${\alpha}\;fibre$ texture and the orientation texture caused by a typical plane-strain deformation condition of bcc metals were observed.
Jiang, Ying,Hong, Sanghyun,Oh, Joon Hak,Mondal, Rajib,Okamoto, Toshihiro,Verploegen, Eric,Toney, Michael F.,McGehee, Michael D.,Bao, Zhenan The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.10
<P>Regioregular pentacene-containing polymers were synthesized with alkylated bithiophene (<B>BT</B>) and cyclopentadithiophene (<B>CPDT</B>) as comonomers. Among them, 2,9-conjugated polymers <B>PnBT-2,9</B> and <B>PnCPDT-2,9</B> achieved the best performance in transistor and photovoltaic devices respectively. The former achieved the most highly ordered structures in thin films, yielding ambipolar transistor behavior with hole and electron mobilities up to 0.03 and 0.02 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> on octadecylsilane-treated substrates. The latter achieved photovoltaic power conversion efficiencies up to 0.33%. The impact of regioregularity and direction of conjugation-extension (2,9 <I>vs.</I> 2,10), on thin-film order and device performance has been demonstrated for the pentacene-containing polymers for the first time, providing insight towards future functional material design.</P> <P>Graphic Abstract</P><P>Regioregular pentacene-bithiophene-based polymers exhibit disparate solid-state packing and field-effect transistor performance, with the 2,9-conjugation-extended polymer showing the highest molecular order and hole mobility. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm15483h'> </P>