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Mao, Ying-Ying,Jing, Fang-Yuan,Jin, Ming-Juan,Li, Ying-Jun,Ding, Ye,Guo, Jing,Wang, Fen-Juan,Jiang, Long-Fang,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Accumulated evidence has indicated that Ephrin A1 (EFNA1) is associated with angiogenesis and tumorigenesis in various types of malignancies, including colorectal cancer (CRC). In the current study, we performed an online search using the public microarray database to investigate whether EFNA1 expression might be altered in CRC tissues. We then conducted a case-control study including 306 subjects (102 cases and 204 well-matched controls) in Xiaoshan County to assess any association between genetic polymorphisms in EFNA1 and CRC susceptibility. Searches in the Oncomine expression profiling database revealed EFNA1 to be overexpressed in CRC tissue compared with adjacent normal tissue. The rs12904 G-A variant located in the 3' untranslated region (UTR) of EFNA1 was observed to be associated with CRC susceptibility. Compared with the AA homozygous genotype, those carrying GA genotype had a decreased risk of developing CRC (odds ratio (OR)=0.469, 95% confidence interval (CI): 0.225-0.977, and P=0.043). The association was stronger among smokers and tea drinkers, however, no statistical evidence of interaction between rs12904 polymorphism and smoking or tea drinking on CRC risk was found. Our results suggest that EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC susceptibility. Larger studies and further mechanistic investigations are warranted to confirm our findings.
Yingli Jiang,Jie Cui,Yanlong Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8
Flood has become the main hidden threat to the safety of the karst tunnel. Scientific and reasonable flood classification assessment and prevention measures have also become the main problems to be solved urgently in the construction and operation of tunnels. Aiming at the problems of multiple influencing factors, complex index systems, and linear processing of the connection degree of set pair analysis, a set pair cloud model based on cloud theory eigenvalues is proposed to optimize the connection degree of set pair analysis. Regarding the uncertainty of the evaluation system and the ambiguity of the evaluation grade boundary, firstly, the ridge-type membership function is used to determine the basic probability distribution of each measured index. Secondly, the distance discrimination weighting theory based on the index distance is also established, so that each measured index can assign the dynamic weight of the evaluation system. It can comprehensively determine the weight of the cloud connection degree for the system, and draw the cloud level diagram to determine the tunnel flood risk level. Finally, the proposed model is verified with tunnel flood. The results show that the evaluation results are consistent with other evaluation models and actual tunnel conditions. This model can provide guidance for flood prediction and prevention in karst tunnels.
A Data Transmission Method for Resource Monitoring under Cloud Computing Environment
Ying Jiang,Heng Sun,Jiaman Ding,Yingli Liu 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.2
Currently, the combined push-pull model is usually applied in the resource monitoring under cloud computing environment. However, the quantity of data gathered by the producers is much less than those received by the monitor so that a lot of resource is wasted. In order to maintain the data consistency of real time system, an improved adaptive algorithm based on combined push-pull model is proposed. The adaptive strategy is added on the producers that aims to predict when refreshes data came from the monitor using the history data. Experimental result shows that the algorithm can decrease the resource consumption while exchanging data effectively.
Ying Jiang,Chaoyang Guan,Xu Liu,Yushan Wang,Huaqin Zuo,Tian Xia,Peipei Xu,Jian Ouyang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.1
Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NPs), their enhanced permeability and retention (EPR) effect, and surface modifiability. Nanocarriers can also be specifically enzymatically hydrolyzed by cathepsin (Cath) B, a kind of enzyme highly expressed in tumor cells. In this work, we proposed a novel drug delivery system comprising GFLG conjugated with copper sulfide (CuS) NPs loaded with DOX. The system, designated as CuS-GFLG-DOX, could be used for NP-based targeted combination chemotherapy. Results showed that the drug delivery system had an appropriate diameter, good dispersibility, high encapsulation efficiency and high drug loading. The system also exhibited an excellent targeting of lymphoma cells and an enhanced antitumor activity. The possible pathway to induce cytotoxic effects was Bcl-2/caspase-mediated apoptosis pathway. In conclusion, CuS-GFLG-DOX could precisely deliver drugs to lymphoma cells and could be a novel and promising therapeutic option for lymphoma.
Ying Jiang,Jiewu Cui,Jiaqin Liu,Yan Wang,Xia Shu,Yong Zhang,Yucheng Wu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3
Nitrogen-enriched porous carbon materials have been successfully synthesized via a template carbonization method, in which nicotinic acid acts as carbon/nitrogen sources, and Ca(OAc)2 · H2O as a template. It reveals that the mass ratio of Ca(OAc)2 · H2O-to-nicotinic acid and the carbonization temperature dominate the morphology of carbon materials as well as capacitive performances. The sample obtained with the ratio of Ca(OAc)2 · H2O-to-nicotinic acid as 1.5 at 800℃, namely the C-1.5-800 sample, displays the optimum capacitive behavior. It is amorphous with low-graphitization degree, possessing hierarchical porous structure, high nitrogen content (14.5%), large specific surface area (788 m2 g-1) and high total pore volume (3.56 cm3 g-1). As a result, the as-made C-1.5-800 electrode exhibits a maximum specific capacitance of 216 F g-1 at a current density of 1 A g-1 in 6 M KOH aqueous solution. It also displays a maximum energy density of 45.9 Wh kg-1 at 2050 W kg-1 and a maximum power density of 20100 W kg-1 at 19.2 Wh kg-1 at operation temperature of 50℃ in [EMIm]BF4/AN organic electrolyte. More importantly, the C-1.5-800 electrode exhibits an excellent cycling stability within 5000 cycles at 5 A g-1. This work may enrich and broaden the field of porous carbon and its potential application for supercapacitors under high temperature.
Inhomogeneity of Hot Rolling Texture in Cu/Nb Added Ultra Low Carbon Steels
Jiang, Ying-Hua,Park, Young-Koo,Lee, Oh-Yeon Materials Research Society of Korea 2007 한국재료학회지 Vol.17 No.12
The texture and microstructure in Cu/Nb added ultra low carbon steels through the different thickness layer were studied after hot rolling. It was found that the two ultra low carbon steels all show the inhomogeneity of hot rolling texture and the Cu-added ultra low carbon steel was far more inhomogeneous than Nb-added one. In the center layer, the strong ${\alpha}\;fibre,\;{\gamma}\;fibre$ textures and the shear textures including 001<110>, 111<112> were founded. Near the surface, the ${\alpha}\;fibre$ texture and the orientation texture caused by a typical plane-strain deformation condition of bcc metals were observed.
( Ying Jiang ),( Yue Wu ),( Huixin Li ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.12
Xylanase plays important roles in a broad range of industrial production as a biocatalyst, and its applications commonly require immobilization on supports to enhance its stability. Aluminum hydroxide, a carrier material with high surface area, has the advantages of simple and low-cost preparation and resistance to biodegradation, and can be potentially used as a proper support for xylanase immobilization. In this work, xylanase from Thermomyces lanuginosus was immobilized on two types of aluminum hydroxide particles (gibbsite and amorphous Al(OH)3) through adsorption, and the properties of the adsorbed enzymes were studied. Both particles had considerable adsorptive capacity and affinity for xylanase. Xylanase retained 75% and 64% of the original catalytic activities after adsorption to gibbsite and amorphous Al(OH)3. Both the adsorptions improved pH and thermal stability, lowered activation energy, and extended lifespan of the immobilized enzyme, as compared with the free enzyme. Xylanase adsorbed on gibbsite and amorphous Al(OH)3 retained 71% and 64% of its initial activity, respectively, after being recycled five times. These results indicated that aluminum hydroxides served as good supports for xylanase immobilization. Therefore, the adsorption of xylanase on aluminum hydroxide particles has promising potential for practical production.