Video Learning Enhances Financial Literacy: A Systematic Review Analysis of the Impact on Video Content Distribution

Yin Yin KHOO,Mohamad Rohieszan RAMDAN,Rohaila YUSOF,Chooi Yi WEI 한국유통과학회 2023 유통과학연구 Vol.21 No.9

Purpose: This study aims to examine the demographic similarities and differences in objectives, methodology, and findings of previous studies in the context of gaining financial literacy using videos. This study employs a systematic review design. Research design, data and methodology: Based on the content analysis method, 15 articles were chosen from Scopus and Science Direct during 2015-2020. After formulating the research questions, the paper identification process, screening, eligibility, and quality appraisal are discussed in the methodology. The keywords for the advanced search included “Financial literacy”, “Financial Education”, and “Video”. Results: The results of this study indicate the effectiveness of learning financial literacy using videos. Significant results were obtained when students interacted with the video content distribution. The findings of this study provide an overview and lead to a better understanding of the use of video in financial literacy. Conclusions: This study is important as a guide for educators in future research and practice planning. A systematic review on this topic is the research gap. Video learning was active learning that involved student-centered activities that help students engage with financial literacy. By conducting a systematic review, researchers and readers may also understand how extending an individual's financial literacy may change after financial education.

Lactobacillus Strains Alleviated Aging Symptoms and Aging-Induced Metabolic Disorders in Aged Rats

HOR YAN YAN,Cheong-Hwa Ooi,Boon-Yin Khoo,Sy-Bing Choi,Azman Seeni,Shaharum Shamsuddin,Chern-Ein Oon,Kee-Leong Ong,정우식,Min-Tze Liong 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.1

Aging is an inevitable and ubiquitous progress that affects all living organisms. A total of 18 strains of lactic acid bacteria (LAB) were evaluated on the activation of adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor mediating lifespan extension. The cell-free supernatant (CFS) of Lactobacillus fermentum DR9 (LF-DR9), Lactobacillus paracasei OFS 0291 (LP-0291), and Lactobacillus helveticus OFS 1515 (LH-1515) showed the highest activation of AMPK and was further evaluated. The phosphorylation of AMPK by these three LAB strains was more evident in U2OS and C2C12 cells, compared to the other cell lines and control (P < .05). Using premature senescent Sprague-Dawley rats induced by D-galactose (D-gal), the administration of LAB (10 log CFU/rat/day) for 12 weeks prevented the shortening of telomere length in D-gal-treated rats compared to the untreated control (P < .05). LF-DR9 lowered gene expression of p53, a known senescent biomarker, in gastrocnemius muscle and tibia compared to the control. The selected LAB strains also enhanced lipid, renal, and liver profile of rats, suggesting added potential of the strains in preventing aging-induced metabolic diseases. Strain LP-0291 and LH-1515 showed ability to adhere to mucin, no antibiotic resistance, tolerated and proliferated under gastric and intestinal simulated conditions, and inhibited the growth of pathogens Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis, comparable to commercial probiotic LF-DR9 and Lactobacillus sakei Probio 65. This study provided an insight into the potential of LAB for exhibiting antisenescence effects, with potentials as new medicinal foods for targeted antiaging therapies.

Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study

Yong Kuei Lim,Rama Padma,Lilian Foo,Yin Nin Chia,Philip Yam,John Chia,HS Khoo-Tan,Swee Peng Yap,Richard Yeo 대한부인종양학회 2011 Journal of Gynecologic Oncology Vol.22 No.4

Objective: Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. Methods: This is a retrospective cohort study in a large tertiary institution in Singapore. The sample consists of women with endometrial and epithelial ovarian cancers followed up over a period of 10 years from 2000 to 2009. The epidemiological and clinical factors include age at diagnosis, histology types, grade and stage of disease. Results: A total of 75 patients with synchronous ovarian and endometrial cancers were identified. However, only 46 patients met the inclusion criteria. The median follow-up was 74 months. The incidence rate for synchronous cancer is 8.7% of all epithelial ovarian cancers and 4.9% of all endometrial cancers diagnosed over this time frame. Mean age at diagnosis was 47.3 years old. The most common presenting symptom was abnormal uterine bleeding (36.9%) and 73.9% had endometrioid histology for both endometrial and ovarian cancers. The majority of the women (78%) presented were at early stages of 1 and 2. There were 6 (13.6%) cases of recurrence and the 5 year cumulative survival rate was at 84%. Conclusion: In our cohort, we found that majority of women afflicted with synchronous cancer of the endometrium and ovary were younger at age of diagnosis, had early stage of cancer and good survival. Objective: Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. Methods: This is a retrospective cohort study in a large tertiary institution in Singapore. The sample consists of women with endometrial and epithelial ovarian cancers followed up over a period of 10 years from 2000 to 2009. The epidemiological and clinical factors include age at diagnosis, histology types, grade and stage of disease. Results: A total of 75 patients with synchronous ovarian and endometrial cancers were identified. However, only 46 patients met the inclusion criteria. The median follow-up was 74 months. The incidence rate for synchronous cancer is 8.7% of all epithelial ovarian cancers and 4.9% of all endometrial cancers diagnosed over this time frame. Mean age at diagnosis was 47.3 years old. The most common presenting symptom was abnormal uterine bleeding (36.9%) and 73.9% had endometrioid histology for both endometrial and ovarian cancers. The majority of the women (78%) presented were at early stages of 1 and 2. There were 6 (13.6%) cases of recurrence and the 5 year cumulative survival rate was at 84%. Conclusion: In our cohort, we found that majority of women afflicted with synchronous cancer of the endometrium and ovary were younger at age of diagnosis, had early stage of cancer and good survival.

Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulatedthe mRNA Expression of HMG-CoA Reductase

Lee-ching Lew,Sy-bing Choi,Boon-yin Khoo,Sasidharan Sreenivasan,Kee-leong Ong,Min-tze Liong 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.2

Hypercholesterolemia is one of the primary risk factors for cardiovascular diseases. The use of lactobacilli probiotics to reduce blood cholesterol levels have been extensively reported. However, more information is needed to evaluate the possible mechanisms involved and to identify possible targets for further therapeutic development. In this study, strains of lactobacilli were screened based on the ability to assimilate cholesterol, and prevention of cholesterol accumulation in hepatic (HepG2) and intestinal (HT-29) cells. Cell free supernatant (CFS) from Lactobacillus plantarum DR7 showed a higher ability to assimilate cholesterol, reduction in cholesterol accumulation in both HepG2 and HT-29 cells, accompanied by reduced mRNA expression of HMG-CoA reductase (HMGCR) in HepG2 (p<0.05), compared to other lactobacilli. The reduction of HMGCR expression was also diminished in the presence of an AMPK inhibitor (Compound C), suggesting that L. plantarum DR7 exerted its effect via the AMPK pathway, typically via the phosphorylation of AMPK instead of the AMPK mRNA expression in HepG2 (p<0.05). Altogether, our present study illustrated that lactobacilli could exert cholesterol lowering properties along the AMPK pathway, specifically via phosphorylation of AMPK that led to reduced expression of HMGCR.

Prospective application of Pichia pastoris-expressed DNA topoisomerase I in DNA relaxation assay for growth inhibitor screening

Chan Mooi Kwai,Wai Wen Xuan,Ang Ruo Ping,Chew Ai Lan,Khoo Boon Yin 한국미생물학회 2020 미생물학회지 Vol.56 No.1

The expression of in-house DNA topoisomerase I (Topo1) was optimized in order to develop a gel-based DNA relaxation assay for the screening of potential bioactive compounds. Results showed that nearly 4-fold increment in total protein level was achieved in the culture supernatant with 1.0% (v/v) methanol feeding every 24 h and cultivated for 72 h at 28°C. Crude recombinant TopoI was shown to relax the supercoiled plasmid DNA completely in the developed gel-based assay and reactions were not affected by DMSO addition and the features on electrophoresed gel could be improved by chloroform: isoamylalcohol extraction. The recombinant protein was then purified and the enzymatic activity of the recombinant TopoI in the crude and purified culture supernatant was studied and compared with a commercial TopoI. DNA relaxation assay showed that the purified recombinant TopoI is a more reliable source with an activity of approximately 20~30 U/μl. The developed assay was finally evaluated by determining the inhibitory effects of flavonoids and positive control Camptothecin on the recombinant TopoI catalytic activity. The efficiency of the gel-based assay using purified recombinant TopoI was further evaluated against a cell-based cytotoxicity assay in which the inhibitory effects on cell growth by the flavonoids and Camptothecin were assessed. The similar inhibitory trends shown by both assays demonstrated that potential inhibitors can be preliminarily screened using a gel-based assay prior to identification of the inhibitors using a cell-based assay to detect the DNA intercalating agents that interrupt the TopoI catalytic activity.