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Yijie Deng,김보연,Min-Ji Park,Min Ok,Kwang Sik Lee,BYUNG RAE JIN 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.3
Ascocarps of some species of the genus Cordyceps have long been used as a traditional medicine and food source for promoting human health. The compound cordycepin, isolated from C. militaris ascocarps (CE), show similar health effects to CE. In this study, we investigated and compared the anti-obesity and antidiabetic effects of dietary CE and Paecilomyces tenuipes ascocarps (PE) in mice. In addition, we investigated their effects on the expression of genes related to the regulation of obesity and diabetes. We found that dietary CE and PE suppressed body weight gain and fat accumulation in the liver and adipocyte tissues of mice fed a high-fat diet (HFD). Enzyme and lipid profiles induced by HFD returned to normal with CE or PE treatment. Dietary CE or PE reduced fasting blood glucose and serum insulin levels in HFD-fed mice. Finally, we show that CE and PE treatment restored to normal the hyperlipidemia- and hyperglycemia-related gene expressions in HFD-fed mice. These results indicate that dietary CE or PE exert their anti-obesity and antidiabetic effects by regulating adipogenesis and insulin signaling pathways. Finally, we show that dietary CE or PE have similar anti-obesity and antidiabetic effects even when included in a normal mouse diet. Although cordycepin is not found in PE, PE treatment improves lipid and glucose metabolic parameters in a manner similar to CE. We find that PE provides alternative potential therapeutic treatments for obesity and diabetes.
박희근,Yijie Deng,Kwang Sik Lee,Bo Yeon Kim,Hyung Joo Yoon,Kyeong Yong Lee,BYUNG RAE JIN 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.1
The honeybee inhibitor cysteine knot (ICK) peptide acts as an antifungal peptide and insecticidal venom toxin. However, the ICK peptide from bumblebees has not been characterized. Here, we report the molecular cloning and antifungal activity of a bumblebee (Bombus ignitus) ICK peptide (BiICK).We identified a BiICK that contains an ICK fold. The BiICK was expressed in the epidermis, fat body, and venomgland of B. ignitusworker bees. A 6.7- kDa recombinant BiICK peptide was expressed in baculovirus-infected insect cells. Recombinant BiICK peptides directly bound to Beauveria bassiana, Ascosphaera apis, and Fusarium graminearum, but they did not bind to Escherichia coli, Paenibacillus larvae, or Bacillus thuringiensis. Consistent with this finding, BiICK exhibited antifungal activity against fungi. These results demonstrate that BiICK acts as an antifungal peptide.
Zheng, Yijie,Lee, Seonjin,Liang, Xiaoliang,Wei, Shuquan,Moon, Hyung-Geun,Jin, Yang Oxford University Press 2013 The Journal of infectious diseases Vol.208 No.11
<P><B><I>Background.</I></B> Sepsis and sepsis-associated organ failure are devastating conditions. Understanding the detailed cellular/molecular mechanisms involved in sepsis should lead to the identification of novel therapeutic targets.</P><P><B><I>Methods.</I></B> Cecal ligation and puncture (CLP) was used as a polymicrobial sepsis model in vivo to determine mortality and end-organ damage. Macrophages were adopted as the cellular model in vitro for mechanistic studies.</P><P><B><I>Results.</I></B> PTRF+/− mice survived longer and suffered less organ damage after CLP. Reductions in nitric oxide (NO) and iNOS biosynthesis were observed in plasma, macrophages, and vital organs in the PTRF+/− mice. Using an acute sepsis model after CLP, we found that iNOS−/− mice had a comparable level of survival as the PTRF+/− mice. Similarly, polymerase I transcript release factor (PTRF) deficiency resulted in decreased iNOS and NO/ROS production in macrophages in vitro. Mechanistically, lipopolysaccharide (LPS) enhanced the co-localization and interaction between PTRF and TLR4 in lipid rafts. Deletion of PTRF blocked formation of the TLR4/Myd88 complex after LPS. Consistent with this, lack of PTRF impaired the TLR4 signaling, as shown by the decreased p-JNK, p-ERK, and p-p38, which are upstream factors involved in iNOS transcription.</P><P><B><I>Conclusion.</I></B> PTRF is a crucial regulator of TLR4 signaling in the development of sepsis.</P>
Zhihao Chen,Yijie Jin,Wenzhong Yang,Bin Xu,Yun Chen,Xiaoshuang Yin,Ying Liu 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-
Polypyrrole (PPy) coatings were successfully electrosynthesized on the carbon steel by embedding SnO2and Sb-SnO2 nanoparticles (NPs). The associated structural, morphology, hydrophobic, physicalproperties, anti-corrosion and self-healing performance of these coatings were systematically studiedby several tests. XRD results showed that SnO2 had a tetragonal rutile structure and the lattice parametersindicated that Sb ions were successful substituted into SnO2 lattice. The average size of SnO2 NPs wasdecreased by the incorporation of Sb-SnO2 NPs, which were found through TEM images. The contactangle test showed that the hydrophobic of PPy coatings was greatly enhanced by the incorporation of Sb-SnO2 NPs. SEM results revealed that Sb-SnO2/PPy coating exhibited a more compact and uniform surfacethan SnO2/PPy coating, hence the physical barrier effect was significantly strengthened. Theelectrochemical measurements confirmed the excellent anti-corrosion and self-healing ability of Sb-SnO2/PPy coating for a long immersion time in HCl solution. The superior anti-corrosion performance ofSb-SnO2/PPy coating was ascribed to the synergistic effects of the anodic protection combined with theself-healing effect, the excellent physical barrier effect with compact, smooth and hydrophobic coatingsurface as well as the formation of p-n junction with decreased charge transfer.
Hee Geun Park,Yijie Deng,Kwang Sik Lee,Bo Yeon Kim,Hyung Joo Yoon,Kyeong Yong Lee,Byung Rae Jin 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
The honeybee inhibitor cysteine knot (ICK) peptide acts as an antifungal peptide and insecticidal venom toxin. However, the ICK peptide from bumblebees has not been characterized. Here, we report the molecular cloning and antifungal activity of a bumblebee (Bombus ignitus) ICK peptide (BiICK). We identified a BiICK that contains an ICK fold. The BiICK was expressed in the epidermis, fat body, and venom gland of B. ignitus worker bees. A 6.7-kDa recombinant BiICK peptide was expressed in baculovirus-infected insect cells. Recombinant BiICK peptides directly bound to Beauveria bassiana, Ascosphaera apis, and Fusarium graminearum, but they did not bind to Escherichia coli, Paenibacillus larvae, or Bacillus thuringiensis. Consistent with this finding, BiICK exhibited antifungal activity against fungi. These results demonstrate that BiICK acts as an antifungal peptide.
Molecular characterization of a Niemann-Pick disease type C2 protein from the honeybee Apis cerana
Lee, Kwang Sik,Park, Hee Geun,Yijie, Deng,Kim, Bo Yeon,Kyung, Seung Su,Choi, Yong Soo,Yoon, Hyung Joo,Li, Mingshun,Jin, Byung Rae 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3
Drosophila Niemann-Pick disease type C2 (NPC2) proteins play roles in sterol homeostasis, steroid biosynthesis, and innate immune signaling pathways. In this study, a bee (Apis cerana) NPC2a protein (AcNPC2a) that might function in innate immune reactions was identified. AcNPC2a consisted of 148 amino acids, which included six conserved cysteine residues. Recombinant AcNPC2a protein (expressed in baculovirus-infected insect cells) bound directly to live Escherichia coli, Bacillus thuringiensis, and Beauveria bassiana; however, AcNPC2a did not show antimicrobial activity against these microorganisms. Nevertheless, the expression of AcNPC2a was significantly induced in the fat body of A. cerana worker bees after injection with E. coli, B. thuringiensis, or B. bassiana. Our data suggest a role for AcNPC2a in innate immunity that is induced in response to microbial challenge and binds directly to the cell walls of bacteria and fungi. These findings provide insight into the role of AcNPC2a during the innate immune response following bacterial and fungal infection.
Major royal jelly protein 2 acts as an antimicrobial agent and antioxidant in royal jelly
Min Ji Park,Bo Yeon Kim,Hee Geun Park,Yijie Deng,Hyung Joo Yoon,Yong Soo Choi,Kwang Sik Lee,Byung Rae Jin 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
Royal jelly (RJ) is a well-known functional and medicinal food for human health promotion. Major royal jelly proteins (MRJPs), which are the major protein components in RJ, exhibit antimicrobial activities. However, the identities of the MRJPs of RJ responsible for its antioxidant effects have remained unclear. Here, we report that honeybee (Apis cerana) MRJP 2 (AcMRJP2) acts as an antimicrobial and antioxidant agent in RJ. Using recombinant AcMRJP2, which was produced in baculovirus-infected insect cells, we established the antimicrobial and antioxidant roles of MRJP 2. AcMRJP2 bound to the surfaces of bacteria, fungi, and yeast, which then induced structural damage in the microbial cell walls and led to a broad spectrum of antimicrobial activities. AcMRJP2 protected mammalian and insect cells via the direct shielding of the cell against oxidative stress, which led to reduced levels of caspase-3 activity and oxidative stress-induced cell apoptosis, followed by increased cell viability. Moreover, AcMRJP2 exhibited DNA protection activity against reactive oxygen species (ROS). Our data indicate that AcMRJP2 could play a crucial role as an antimicrobial agent and antioxidant in RJ, suggesting that MRJP 2 is a component responsible for the antimicrobial and antioxidant activities of RJ.
Major royal jelly protein 2 acts as an antimicrobial agent and antioxidant in royal jelly
Park, Min Ji,Kim, Bo Yeon,Park, Hee Geun,Deng, Yijie,Yoon, Hyung Joo,Choi, Yong Soo,Lee, Kwang Sik,Jin, Byung Rae 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol. No.
<P><B>Abstract</B></P> <P>Royal jelly (RJ) is a well-known functional and medicinal food for human health promotion. Major royal jelly proteins (MRJPs), which are the major protein components in RJ, exhibit antimicrobial activities. However, the identities of the MRJPs of RJ responsible for its antioxidant effects have remained unclear. Here, we report that honeybee (<I>Apis cerana</I>) MRJP 2 (AcMRJP2) acts as an antimicrobial and antioxidant agent in RJ. Using recombinant AcMRJP2, which was produced in baculovirus-infected insect cells, we established the antimicrobial and antioxidant roles of MRJP 2. AcMRJP2 bound to the surfaces of bacteria, fungi, and yeast, which then induced structural damage in the microbial cell walls and led to a broad spectrum of antimicrobial activities. AcMRJP2 protected mammalian and insect cells via the direct shielding of the cell against oxidative stress, which led to reduced levels of caspase-3 activity and oxidative stress-induced cell apoptosis, followed by increased cell viability. Moreover, AcMRJP2 exhibited DNA protection activity against reactive oxygen species (ROS). Our data indicate that AcMRJP2 could play a crucial role as an antimicrobial agent and antioxidant in RJ, suggesting that MRJP 2 is a component responsible for the antimicrobial and antioxidant activities of RJ.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Apis cerana</I> major royal jelly protein 2 (AcMRJP2) exhibits antimicrobial activities. </LI> <LI> AcMRJP2 protects insect and mammalian cells against oxidative stress. </LI> <LI> AcMRJP2 exhibits DNA protection activity against reactive oxygen species (ROS). </LI> <LI> AcMRJP2 acts as an antimicrobial agent and antioxidant in royal jelly. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>