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김영숙,이정연 慶星大學校 1998 論文集 Vol.19 No.2
The purpose of this study was to examine the housewives' leisure activity and leisure life satisfaction. This study analysed the effects of socio-demographic and economic variables on the housewives' leisure activity. For these purpose, questionnaire was given to the 316 housewives who were lived in Pusan. The data were analysed by Frequency, Percentage, Mean, ANOVA, T-test, Pearson's Correlation and Multiple Regression Analysis. The main findings of the research are as follows: 1. Leisure activities are classified in physical, children and social concerned, self-developing, restful, religious-social, home-oriented, time-spending by factor analysis. The level of average participation are high in time-spending type, but low in self-developing type. 2. There are significant differences in participation level of leisure activities according to related variables. Physical and children-concerned type shows significant differences by age of housewife's education level, income and houses type. Self-developing type differs by husband's occupation, housewife's education level and income. Restful and time-spending type are differed to age of housewife, age of the youngest child and housewife's education level. 3. Leisure life satisfaction shows significant differences by employment type. Fulltime housewives are more satisfied than working housewives. 4. Leisure life satisfaction is high when participation level is high in children-concerned, self-developing, religious-social type and employment type. But leisure life satisfaction is low when preference level is high in self-developing type. The results of this study show the housewives' leisure activity and leisure life satisfaction differ by related variables. For further study and practice, I suggest politic development of leisure programs and increase the level of housewives's life satisfaction.
Dysphagia in Infants After Open Heart Procedures
Yi, Sook-Hee,Kim, Sang-Jun,Huh, June,Jun, Tae-Gook,Cheon, Hee Jung,Kwon, Jeong-Yi Lippincott Williams Wilkins, Inc. 2013 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.92 No.6
OBJECTIVE: The aims of this study were to evaluate the prevalence and the clinical predictors of dysphagia and to determine the characteristics of videofluoroscopic swallowing study findings in infants after open heart procedures. DESIGN: This study is a retrospective review of 146 infants who underwent open heart surgery. The infants with dysphagia were compared with those without dysphagia. The videofluoroscopic swallowing study findings of the infants with dysphagia were also evaluated. RESULTS: Of the 146 infants who underwent open heart surgery, 35 (24.0%) had dysphagia symptoms. The infants with dysphagia had lower body weight at operation, more malformation syndromes, longer operation times, and more complex operations than did the infants without dysphagia. In addition, the infants with dysphagia required more time to achieve full oral feeding and had longer hospital stays. Thirty-three infants underwent videofluoroscopic swallowing study: 32 (97.0%) exhibited at least one abnormal finding among the videofluoroscopic swallowing study parameters and 21 (63.6%) exhibited tracheal aspiration. CONCLUSIONS: Given the high rate of aspiration in the infants who underwent open heart procedures, monitoring and prompt recognition of the signs and the risk factors of dysphagia may substantially improve infant care with oral feeding and reduce the duration of hospital stays.
Jung, Yi-Sook,Lee, Sung-Hou,Shin, Hwa-Sup The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.6
The present study was undertaken to investigate the effects of age on angiotensin II (AII) response and antagonistic activity of losartan using aortic rings and liver homogenates from rats ranging in age from 0.7 to 20 months. Whether the endothelium was present or not, the maximum contractile response to AII decreased with age. Removal of the endothelium enhanced AII-induced maximum contraction and these endothelial effects seemed to be due to endothelium-derived relaxing factor (EDRF) in all ages. Equilibrium binding studies demonstrated an age-related decrease in maximum binding $(B_{max})$ with little change in binding affinity $(K_d)$. In rat aorta, the extent of losartan-induced parallel shifts $(K_B)$ in AII concentration-response curves was not significantly different between ages. In addition, $IC_{50}$ value of losartan in competition binding was not changed with age in rat liver homogenates. These results suggest that the potency of losartan is not altered with age in rat aorta and liver, although AII-induced contractile response and the maximum AII binding decreased significantly with age.
Jung, Yi-Sook,Jee, Sang-Deok,Kim, Chan-Shik,Lee, Su-Hwan,Moon, Chang-Hyun,Cho, Sung-Ig,Lee, Byung-Mu,Ryu, Kang-Sun,Ahn, Mi-Young 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
The present study examined the effect of the methanol extract of lsaria sinclairii, a kind of Donchunghacho (Tochukaso), on blood pressure in spontaneously hypertensive rats (SHR). Blood pressure and heart rate were measured after treatment with the methanol extract of l. sinclairii by the indirect tail-cuff method and the direct in vivo model. Starting at 12 weeks of age, male SHR were treated with the extracts for 2 or 4 weeks. We found that, when compared to untreated control SHR, oral treatment with l. sinclairii methanol extract (30 mg/kg/day) remarkably decreased systoiic blood pressure from 200 to 112 mmHg and decreased diastolic blood pressure from 114 to 88mmHg. Furthermore, efficacy of methanol extract of l. sinclairii was superior to captopril (30mg/kg/ml, positive control), an angiotensin-converting enzyme inhibitor, with a lowering effect that dropped systolic blood pressure from 201 to 130 mmHg and diastolic blood pressure from 102 to 92 mmHg. However, in normal Wistar Kyoto rats, l. sinclairii methanol extract did not significantly change the normal blood pressure, suggesting that this type of Dongchunghacho has a selective effect against hypertension. Therefore, methanol extract of l. sinclairii may be used as an anti-hypertensive food/agent. Furthermore, this extract also has multiple actions such as No production in endothelial cells, inhibiting thrombininduced blood coagulation by thrombin and mildly decreasing in prostaglandin E$_2$ levels in cultured macrophage cells, all of which might contribute to protection against atherogenesis and thrombus formation. HPLC and MS analysis of methanol extract of l. sinclairii revealed the presence of adenosine.
( Yi Sook Jung ),( Bo Kyung Lee ),( Sun Kyung Lee ),( Kyu Yang Yi ),( Sung Eun Yoo ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
Preciously, we demonstrated that a novel NHE-1 inhibitor, KR-33028 attenuated cortical neuronal apoptosis induced by glutamate. In the present study, we investigated the signaling mechanism of neuroprotective effect of KR-33028 against glutamate-induced neuronal apoptosis, especially focusing on mitochondrial death pathway. Our data showed that glutamate induces a biphasic rise in mitochondrial Ca2+ and that KR-33028 signifi cantly prevents the second phase increase, but not the fi rst phase increase in mitochondrial Ca2+. Furthermore, KR-33028 restored the ΔΨm dissipation and cytochrome c release into cytoplasm induced by glutamate in a concentration-dependent manner. The inhibition of mitochondrial Ca2+ overload by ruthenium red also inhibited glutamate-induced apoptotic cell death, mitochondrial membrane potential, ΔΨm dissipation and cytochrome c release. These data suggest that inhibition of mitochondrial Ca2+ overload is likely to be attributable to anti-apoptotic effect of KR-33028. Taken together, our results suggest that anti-apoptotic effects of NHE-1 inhibitor, KR-33028 may be mediated through maintenance of mitochondrial function.