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섬개야광나무 잎 추출물 및 분획물의 생리활성 평가 및 활성 물질 분리
유남호(Nam Ho Yoo),김희규(Hee Kyu Kim),송재모(Jae Mo Song),이찬옥(Chan Ok Lee),박주희(Ju Hee Park),박병준(Byung Jun Park),최영빈(Yeong Bin Choi),백영선(Young Sun Baek),황연지(Yeon Ji Hwang),김명조(Myong Jo Kim) 한국약용작물학회 2019 한국약용작물학회지 Vol.27 No.6
Background: Previously, studies have observed that the leaf extract of Cotoneaster wilsonii Nakai has potent antioxidant and anti-inflammatory activites. Therefore, further research was conducted to separate the active antioxidant and anti-inflammatory compounds in the leaf of the C. wilsonii. Methods and Results: The anti-oxidant effects were evaluated by analyzing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, estimating the totla phenolic content (TPC) and total flavonoid content (TFC), and using reducing power assay method. The ethyl acetate (EtOAc) fraction demonstrated the highest DPPH radical scavenging activity (IC<SUB>50</SUB>; 9.69 ㎍/㎖), and the highest TPC and TFC (345.98 ㎎·GAE/g, and 74.23 ㎎·QE/g). Moreover, it indicated the highest effects on nitric oxide production. Therefore, the active compound was separated using the EtOAc fraction, determined on the basis of spectral data, and identified as (+)-catechin. Conclusions: The first compound separated was made from the leaf of C. wilsonii was (+)-catechin, which produced potent anti-oxidant and anti-inflammatory effects.
김용수(Yong Soo Kim),방병기(Byung Kee Bang),양철우(Chul Woo Yang),박정희(Jung Hee Park),박주현(Joo Hyun Park),이광수(Kwang Soo Lee),최영빈(Young Bin Choi),한시령(Si Ryung Han),김영인(Yeong In Kim) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
N/A Hemodialysis is a safe and effective treatment for uremic patients but hemodynamic changes during he-modialysis is suggested to be the possible cause of encephalopathy. However, few studies have evaluated the cerebral circulation of and the effects of hemo-dialysis. Therefore, this study was performed to evaluate the cerebral blood flow by transcranial doppler. The study populations were 12 male patients who ranged in age from 28 to 58 years(mean:57) and were receiving maintenance hernodialysis for 3.8 years(0.5-11.5 years). Mean blood flow velocity(MFV), pulsatility index(PI) and resistance index(RI) were measured in carotid artery(CA), middle cerebral artery(MCA), anterior cerebral artery(ACA) and pos-terior cerebral artery(PCA) before, during and after hemodialysis. Simultaneously, we also checked vari- ables(body weight, blood pressure, arterial blood gases, hematocrits, and other biochemical parame-ters) which might affect cerebral blood flow. MFV during(70.5±20.3 vs. 60.0±211cm/sec) and after(vs. 60.6±13.7cm/sec, p<0.01) hemodialysis in CA showed significant reduction as compared to the that of before hemodialysis, but other vessels(MCA, ACA and PCA) showed no significant changes. There were no significant changes in PI and RI before, during and after hemodialysis. Body weight, PaCO₂, blood urea nitrogen and hematocrit changed significantly during and after hemodialysis as compared to those of before hemodialysis, but correlation between changes of MFV and these variables was not observed. Hemodialysis and its associated physiologic changes are not associated with cerebral blood flow, and this result suggests the well-preservation of autoregulation of cerebral blood flow during and after hemodialysis.