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( Min-jae Lee ),( Yewon Kang ),( Byung Sam Son ),( Min-jeong Kim ),( Tae Hyeon Park ),( Damee Park ),( Tae-jip Kim ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.2
Two α-L-arabinofuranosidases (BfdABF1 and BfdABF3) and a β-D-xylosidase (BfdXYL2) genes were cloned from Bifidobacterium dentium ATCC 27679, and functionally expressed in E. coli BL21(DE3). BfdABF1 showed the highest activity in 50 mM sodium acetate buffer at pH 5.0 and 25℃. This exoenzyme could hydrolyze p-nitrophenyl arabinofuranoside, arabino-oligosaccharides (AOS), arabinoxylo-oligosaccharides (AXOS) such as 3<sup>2</sup>-α-L-arabinofuranosyl-xylobiose (A<sup>3</sup>X), and 2<sup>3</sup>-α-Larabinofuranosyl- xylotriose (A<sup>2</sup>XX), whereas hardly hydrolyzed polymeric substrates such as debranched arabinan and arabinoxylans. BfdABF1 is a typical exo-ABF with the higher specific activity on the oligomeric substrates than the polymers. It prefers to α-(1,2)-L-arabinofuranosidic linkages compared to α-(1,3)-linkages. Especially, BfdABF1 could slowly hydrolyze 2<sup>3</sup>,3<sup>3</sup>-di-α-Larabinofuranosyl- xylotriose (A<sup>2+3</sup>XX). Meanwhile, BfdABF3 showed the highest activity in sodium acetate at pH 6.0 and 50℃, and it has the exclusively high activities on AXOS such as A<sup>3</sup>X and A<sup>2</sup>XX. BfdABF3 mainly catalyzes the removal of L-arabinose side chains from various AXOS. BfdXYL2 exhibited the highest activity in sodium citrate at pH 5.0 and 55℃, and it specifically hydrolyzed pnitrophenyl xylopyranoside and xylo-oligosaccharides (XOS). Also, BfdXYL2 could slowly hydrolyze AOS and AXOS such as A<sup>3</sup>X. Based on the detailed hydrolytic modes of action of three exo-hydrolases (BfdABF1, BfdABF3, and BfdXYL2) from Bf. dentium, their probable roles in the hemiceulloseutilization system of Bf. dentium are proposed in the present study. These intracellular exohydrolases can synergistically produce L-arabinose and D-xylose from various AOS, XOS, and AXOS.
( Yewon Kang ),( Kwangha Lee ),( Eun-jung Jo ),( Jung Seop Eom ),( Jeongha Mok ),( Mi-hyun Kim ),( Ki Uk Kim ),( Hye- Kyung Park ),( Min Ki Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: There are few data regarding effect of early tracheostomy on clinical outcomes in our country. Our study aimed to investigate effect of early tracheostomy on clinical outcomes (including long-term mortality) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ≥ 96 hrs). Methods: Data were obtained retrospectively from 575 patients, (69.4% male; median age 68 years) who hospitalized at a medical intensive care unit (ICU) of a single university-affiliated tertiary care hospital over 9 years (between March 2008 and February 2017). Early tracheostomy was defined as ≤ 10 days after translaryngeal intubation. Results: Their hospital and one-year cumulative mortality rate after ICU admission were 38.6 % (n=222) and 61.2 % (n=352), respectively. Also, one hundred forty-three patients (24.9%) underwent early tracheostomy, while others classified with late (n=115, 20.0 %) or no tracheostomy group (n=317, 55.1%). When total patients were divided two groups (early versus late or no tracheostomy), there were no significant differences of Acute Physiology and Chronic Health Evaluation II [median 22 interquartile range (16-25) vs 19 (15-25), p=0.172] and Sequential Organ Failure Assessment scores [7 (5-10) vs 6 (4-9), p=0.737] on ICU admission between both groups. However, early tracheostomy group showed higher medical costs during hospital stay [26,609 (17,634-44,066) vs 21,536 (13,974- 36,509) USD, p=0.013], ICU rehabilitation (46.2 vs 20.1%, p<0.001) and lower hospital mortality (21.7 vs 44.2% p<0.001). In stepwise multivariable Cox-proportional hazard model, early tracheostomy [Hazard ratio 1.550 (95% Confidence interval 1.197-2.006), p=0.011] was associated with one-year survival improvement. Conclusions: In our study, early tracheostomy group showed higher total hospital cost during hospital stay. Also, early tracheostomy was associated with higher hospital and one-year survival improvement.
( Yewon Kang ),( Eun-jung Jo ),( Jung Seop Eom ),( Mi-hyun Kim ),( Kwangha Lee ),( Ki Uk Kim ),( Hye-kyung Park ),( Min Ki Lee ),( Jeongha Mok ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.1
Background: This study compared the treatment outcomes of patients with multidrug-resistant tuberculosis (MDRTB) before and after the implementation of public-private mix (PPM). Factors affecting treatment success were also investigated. Methods: Data from culture-confirmed pulmonary MDR-TB patients who commenced MDR-TB treatment at Pusan National University Hospital between January 2003 and December 2017 were retrospectively reviewed. Patients were divided into two groups in terms of PPM status: pre-PPM period, patients who commenced MDR-TB treatment between 2003 and 2010; and post-PPM period, patients treated between 2011 and 2017. Results: A total of 176 patients were included (64 and 112 in the pre- and post-PPM periods, respectively). 36.9% of the patients were resistant to a fluoroquinolone or a second-line injectable drug, or both. The overall treatment success rate was 72.7%. The success rate of post-PPM patients was higher than that of pre-PPM patients (79.5% vs. 60.9%, p=0.008). Also, loss to follow-up was lower in the post-PPM period (5.4% vs. 15.6%, p=0.023). In multivariate regression analysis, age ≥65 years, body mass index ≤18.5 kg/m<sup>2</sup>, previous TB treatment, bilateral lung involvement, and extensively drug-resistant (XDR)- or pre-XDR-TB were associated with poorer treatment outcomes. However, the use of bedaquiline or delamanid for ≥1 month increased the treatment success. Conclusion: The treatment success rate in MDR-TB patients was higher in the post-PPM period than in the pre-PPM period, particularly because of the low rate of loss to follow-up. To ensure comprehensive patient-centered PPM in South Korea, investment and other support must be adequate.
소비자의 옴니채널 경험 개선을 위한 리뷰 데이터 기반 요인 분석 프레임워크
강예원(Yewon Kang),최예림(Yerim Choi),정민교(Min Gyo Chung) 한국정보기술학회 2022 Proceedings of KIIT Conference Vol.2022 No.12
최근 ICT의 발달로 인해 모바일 기기가 보편화됨에 따라 온라인과 오프라인 채널 간의 구분이 무너지고 있다. 또한, 기업들은 비즈니스 기회 창출을 위한 디지털 트랜스포메이션 과정에서 옴니채널 서비스를 제공하는 추세에 따라 옴니채널 전략 도출의 필요성이 증가하고 있다. 기존 연구들에서는 사례 분석 방법이나 선행 문헌을 통한 요인 도출 방법으로 이루어져 소비자 경험에 대한 연구는 단편적인 실정이다. 옴니채널의 경험을 개선하기 위해 다양하고 방대한 소비자 경험을 활용할 필요가 있으며, 리뷰 데이터는 소비자의 다양한 감성을 포함하고 있어 소비자의 경험을 파악 및 개선할 수 있는 자원이다. 따라서, 본 연구는 국내 대표 헬스&뷰티 옴니채널 브랜드인 올리브영의 리뷰 데이터를 활용하여 소비자의 옴니채널 경험을 개선할 수 있는 요인 분석 프레임워크를 제안한다. 제안한 프레임워크는 국내 옴니채널 브랜드인 올리브영 데이터를 이용해 검증하였으며, 채널과 관계없이 언급 빈도가 높은 동일한 요인이 소비자 만족도에 미치는 영향력도 높았다. 카테고리별 채널에 따라 소비자의 감성 차이가 있는 요인들은 건강/위생용품, 바디 케어, 푸드 카테고리의 ‘용량’이 공통적으로 도출되었으며, 네일 카테고리의 ‘지속력’, 헤어 케어 카테고리의 ‘가격’ 이 도출되었다. 연구에서 제안한 프레임워크는 옴니채널 개선 전략 수립 시 효율적인 전략 도출 과정의 기초자료로써 사용될 것으로 기대한다. Recently, online and offline channels distinction has been eliminated due to the development of ICT and mobile devices becoming common. Also, companies are increasingly in the necessity of omni-channel strategies according to the trend of providing omni-channel services, which is in the digital transformation process to create business opportunities. Prior studies on customer experience, which only exist for case analysis method or a factor extraction method through prior studies, are fragmentary. In order to improve the customer’s omni-channel experience, it is necessary to utilize a various and wide range of customer experiences and review data including customers’ sentiments can be used to understand the experience. Therefore, we propose a factor analysis framework that improves customers’ omni-channel experience by utilizing the review data of Olive Young, a representative health & beauty omni-channel brand in Korea. The proposed framework was verified by dataset a collected from domestic omni-channel brand Olive Young and the same factors with high frequency of mention regardless of the channel also had a high impact on consumer satisfaction. In addition, factors that differ in consumers sentiment according to channels by category include capacity in common in health/sanitary products, body care, and food categories, durability in nail categories, and price in hair care categories. The framework proposed in the study is expected to be used as basic data for the efficient strategy derivation process when establishing an omni-channel improvement strategy.
( Doyeon Chae ),( Junghyun Min ),( Yewon Cho ),( Chaeyoung Lee ),( Yunhee Kim ) 한국유아교육학회 2023 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.29 No.1
The purpose of the present study was to explore preschool teachers’ perceptions of early childhood creativity using the metaphorical analysis method, to understand the self-reported performance of these teachers in teaching creativity and the metaphorical image they associate with children’s creativity. We employed the Teaching Performance Scale for Enhancing Creativity in Young Children, developed by Moon (1995), along with an open-ended questionnaire to collect teachers’ metaphors regarding children’s creativity. A total of 211 preschool teachers from across the country participated in the online survey. After analyzing the metaphors for children’s creativity, initially, 21 categories were identified. These categories were then further consolidated into four main themes: ‘divergent thinking,’ ‘malleability’ ‘diverse characteristics,’ and ‘needs for investment.’ The metaphors related to ‘fluency’ and ‘originality’ were prevalent across the high-performing, middle-performing, and low-performing groups. However, there was a difference in the third-most-used metaphors among the different groups. Based on the key findings, the implications for the direction of early childhood creativity education were discussed.