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Yao, Wen-Jing,Sun, Wen,Wang, Nan,Han, Seung Zeon,Lee, Je-Hyun American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.11
<P>Under near-equilibrium solidification conditions, the Co-17.8 wt%Gd eutectic alloy forms rod-like eutectic microstructure of (αCo) solid solution and Co17Gd2 compound. When the solidification condition is far from the equilibrium, the rapid growth of nano-eutectic in Co-17.8 wt%Gd alloy ribbons is realized by the single-roller techniques. The average granular size (d) of nano-eutectic in the center of ribbons varies with the increase of wheel speed (V), d = 510.36-25.51 V+0.44 V2. XRD results of ribbons at different wheel speeds indicate that, with the rise of wheel speed, the main peak of Co17Gd2 compound becomes more and more notable, whereas the main peak of (αCo) solid solution tends to reduce. Along the length direction, the Co-17.8 wt%Gd alloy ribbons have the negative magnetostrictive strain. The magnetostrictive strain enhances with the increase of wheel speed. At the wheel speed of 40 m/s, the magnetostrictive coefficient of ribbons is measured to be - 733 ppm at the magnetic field of 6 kOe. The influence of the wheel speed and the magnetic field on the maanetostrictive coefficient is discussed.</P>
Solute Distribution Ahead of Interface during Heteroepitaxial Growth
Yao, Wen Jing,Jin, Zeng Jia,Wang, Nan,Lee, Jeh Yun Trans Tech Publications 2013 Advanced materials research Vol.690 No.-
<P>By establishing a diffusion model, the solute distribution is investigated during the growth of eutectic phase from the binary melt on the primary phase. Based on the eutectic reaction conditions, reasonable assumptions are carried out to build the partial differential equation. After the determination of the initial and boundary conditions, the analytical solutions have been derived from the method of variables separation. The solute distribution ahead of interface and the influence of this distribution on the growth rate of heteroepitaxial phase are discussed.</P>
Influence of Rear Earth Yb on the Specific Heat of Liquid Fe-Co-Yb Alloy
Yao, Wen Jing,Wang, Nan,Lee, Jeh Yun Trans Tech Publications 2013 Advanced materials research Vol.690 No.-
<P>By Monte Carlo method with EAM potentials, the specific heat of liquid Co50Fe50 and Co48Fe48Th4 alloys at different temperatures are obtained. The effect of Th on the thermophysical parameters is examined. Over the temperature range from 1400 to 2000 K, the specific heat decreases from to Jmol<SUP>-1</SUP>K<SUP>-1</SUP> after Th was added. It is the addition of Th element which has bigger atomic radius, larger atomic mass, and complex arrangement of extranuclear electron, leads to the reduced specific heat.</P>
( Wen Fei Xue ),( Jing Fu Peng ),( Xiao Li Yu ),( Shu Lin Zhang ),( Boping Zhou ),( Dan Qing Jiang ),( Jian Bo Chen ),( Bing Bing Ding ),( Bin Zhu ),( Yao Li ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
The widespread occurrence of drug-resistant Mycobacterium tuberculosis places importance on the detection of TB (tuberculosis) drug susceptibility. Conventional drug susceptibility testing (DST) is a lengthy process. We developed a rapid enzymatic color-reaction-based biochip assay. The process included asymmetric multiplex PCR/templex PCR, biochip hybridization, and an enzymatic color reaction, with specific software for data operating. Templex PCR (tem- PCR) was applied to avoid interference between different primers in conventional multiplex- PCR. We applied this assay to 276 clinical specimens (including 27 sputum, 4 alveolar lavage fluid, 2 pleural effusion, and 243 culture isolate specimens; 40 of the 276 were non-tuberculosis mycobacteria specimens and 236 were M. tuberculosis specimens). The testing process took 4.5 h. A sensitivity of 50 copies per PCR was achieved, while the sensitivity was 500 copies per PCR when tem-PCR was used. Allele sequences could be detected in mixed samples at aproportion of 10%. Detection results showed a concordance rate of 97.46% (230/236) in rifampicin resistance detection (sensitivity 95.40%, specificity 98.66%) and 96.19% (227/236) in isoniazid (sensitivity 93.59%, specificity 97.47%) detection with those of DST assay. Concordance rates of testing results for sputum, alveolar lavage fluid, and pleural effusion specimens were 100%. The assay provides a potential choice for TB diagnosis and treatment.
Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
Yao, Cheng Wen,Kang, Kyoung Ah,Piao, Mei Jing,Ryu, Yea Seong,Fernando, Pattage Madushan Dilhara Jayatissa,Oh, Min Chang,Park, Jeong Eon,Shilnikova, Kristina,Na, Soo-Young,Jeong, Seung Uk,Boo, Sun-Jin The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and flow cytometry following acridine orange staining, and the decreased level of GFP-LC3 puncta. In addition, expression of critical autophagic proteins such as Atg5, Beclin-1 and LC3-II and autophagic flux was diminished in SNUC5/5-FUR cells. Whereas production of reactive oxygen species (ROS) was significantly elevated in SNUC5/5-FUR cells, treatment with the ROS inhibitor N-acetyl cysteine further reduced the level of autophagy. Taken together, these results indicate that decreased autophagy is linked to 5-FU resistance in SNUC5 colon cancer cells.
6`-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
( Cheng Wen Yao ),( Mei Jing Piao ),( Ki Cheon Kim ),( Jian Zheng ),( Ji Won Cha ),( Jin Won Hyun ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.5
6`-O-galloylpaeonifl orin (GPF) is a galloylated derivate of paeonifl orin and a key chemical constituent of the peony root, a perennial fl owering plant that is widely used as an herbal medicine in East Asia. This study is the fi rst investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a signifi cant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 -), and the hydroxyl radical (?OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species. Taken together, these results indicate that GPF may be developed as a cytoprotector against ROS-mediated oxidative stress.
Membrane surface charge and morphological and mechanical properties of young and old erythrocytes
Xing-Yao Chen,Yao-Xiong Huang,Wen-jing Liu,Zhi-jian Yuan 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
ditions were studied as a function of cell age. The young and old cells were separated from fresh rabbit blood by using Percoll densitygradients. A novel multi-dimensional microscope was employed to perform real-time, non-invasivein situmeasurements on the mem-brane bending elastic modulus and the cell shape and size. A phase-analysis micro-electrophoresis laser scattering technique was usedto measure the surface charge density. The results show that the membrane Zeta potential of red blood cells is reduced when they become.
Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
( Cheng Wen Yao ),( Kyoung Ah Kang ),( Mei Jing Piao ),( Yea Seong Ryu ),( Pattage Madushan Dilhara Jayatissa Fernando ),( Min Chang Oh ),( Jeong Eon Park ),( Kristina Shilnikova ),( Soo-young Na ),( 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5- FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and flow cytometry following acridine orange staining, and the decreased level of GFP-LC3 puncta. In addition, expression of critical autophagic proteins such as Atg5, Beclin-1 and LC3-II and autophagic flux was diminished in SNUC5/5-FUR cells. Whereas production of reactive oxygen species (ROS) was significantly elevated in SNUC5/5-FUR cells, treatment with the ROS inhibitor N-acetyl cysteine further reduced the level of autophagy. Taken together, these results indicate that decreased autophagy is linked to 5-FU resistance in SNUC5 colon cancer cells.