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Hongli Cao,Ping Zhang,Hong Yu,Jianing Xi 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.6
Extracellular vesicles (EVs) play an essential role in the communication between cells and the tumor microenvironment. However, the effect of tumor-derived EVs on the growth and metastasis of lung adenocarcinoma (LUAD) remains to be explored. This study aimed to elucidate the role of miR-153-3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments. We found that miR-153-3p was specifically and highly expressed in LUAD and its secreted EVs. Furthermore, the expression of BANCR was negatively regulated by miR-153-3p and identified as a target gene of miR-153-3p using luciferase reporter assays. Through further investigation, we found that the downregulation of BANCR activates the PI3K/AKT pathway and accelerates the process of epithelial-mesenchymal transition (EMT), which ultimately leads to the aggravation of LUAD. The orthotopic xenograft mouse model was established to illustrate the effect of miR-153-3p-EVs on LUAD. Animal studies showed that miR-153-3p-EVs accelerated tumor growth in mice. Besides, we found that miR-153-3p-EVs could damage the respiratory ability of mice and produce a mass of inflammatory cells around the lung tissue of mice. Nevertheless, antagomir-153-3p treatment could inhibit the deterioration of respiratory function and inhibit the growth of lung tumors in mice. In conclusion, our study reveals the potential molecular mechanism of miR-153-3p-EVs in the development of LUAD and provides a potential strategy for the treatment of LUAD.
Development of Multidirectional Nonlinear Numerical Wave Tank by Naoe-FOAM-SJTU Solver
Cao, Hong-Jian,Wan, De-Cheng Korean Society of Ocean Engineers 2015 Journal of advanced research in ocean engineering Vol.1 No.1
A three-dimensional multidirectional nonlinear numerical wave tank (NWT) based on the Navier-Stokes equations and the Finite Volume Method (FVM) is developed by using the two-phase hydrodynamic flow solver naoe-FOAM-SJTU based on the open source toolbox OpenFOAM. The free surface is capturing with the Volume Of Fluids (VOF). The directional wave including Stokes wave, solitary wave and nonlinear wave are simulated and verified. The multi-directional waves are also simulated with particular wave spectral such as JONSWAP and wave directional spreading function. The obtained numerical results show the capability of the solver to generate different type of multidirectional nonlinear waves accurately. Meanwhile, it implies that the presented NWT can easily extend to model the wave-structures interactions, which will be great help to the offshore structures design.
Enhanced CO methanation over Ni-based catalyst using a support with 3D-mesopores
Hong-Xia Cao,Jun Zhang,Xiang-Kun Ren,Cheng-Long Guo 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.9
Ni-based catalysts supported on a support with 3D-mesopores, including Ni/KIT-6(EG), Ni/KIT-6(PS) and Ni/KIT-6(DS), were prepared by adding ethylene glycol, direct synthesis and post synthesis methods, respectively, and their catalytic properties were investigated for CO methanation as one of the core technologies of synthetic natural gas production in a continuous flow fixed-bed reactor. The catalysts were characterized by N2 adsorption-desorption, X-ray diffraction (XRD), transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS), hydrogen temperature-programmed reduction (H2-TPR), hydrogen temperature-programmed desorption (H2-TPD) and thermal gravimetric analysis (TGA), respectively. The results showed that Ni/KIT-6(EG) exhibited the best catalytic performance with CO conversion of almost 100% and CH4 yield of 75% at 450 oC, atmospheric pressure and 60,000 mL/g/h due to the higher dispersion of Ni species, stronger reducibility of NiO and formation of smaller Ni nanoparticles fixed into 3D-mesopores, indicating that adding ethylene glycol was effective to improve catalytic performance of Ni-based catalyst for CO methanation. Moreover, compared with Ni/Al2O3(EG) prepared using Al2O3 as a support, Ni/KIT- 6(EG) showed better catalytic performance owing to the higher specific surface area, stronger reducibility of NiO and confinement effect of 3D-mesopores promoting to produce more active sites. After 60h lifetime test of Ni/KIT-6(EG) at 500 oC, atmospheric pressure and 60,000mL/g/h, 3D-mesopores were still maintained and no obvious agglomeration of Ni nanoparticles was observed, meaning that Ni species were still well dispersed into 3D-mesopores. As a consequence, Ni/KIT-6(EG) exhibited superior catalytic performance and stability, which makes it a promising candidate for CO methanation.
Development of Multidirectional Nonlinear Numerical Wave Tank by Naoe-FOAM-SJTU Solver
Cao, Hong-Jian,Wan, De-Cheng Korean Society of Ocean Engineers 2014 International journal of ocean system engineering Vol.4 No.1
A three-dimensional multidirectional nonlinear numerical wave tank (NWT) based on the Navier-Stokes equations and the Finite Volume Method (FVM) is developed by using the two-phase hydrodynamic flow solver naoe-FOAM-SJTU based on the open source toolbox OpenFOAM. The free surface is capturing with the Volume Of Fluids (VOF). The directional wave including Stokes wave, solitary wave and nonlinear wave are simulated and verified. The multi-directional waves are also simulated with particular wave spectral such as JONSWAP and wave directional spreading function. The obtained numerical results show the capability of the solver to generate different type of multidirectional nonlinear waves accurately. Meanwhile, it implies that the presented NWT can easily extend to model the wave-structures interactions, which will be great help to the offshore structures design.