Efficacy and Safety of Neurokinin-1 Receptor Antagonists for Prevention of Chemotherapy-Induced Nausea and Vomiting: Systematic Review and Meta-analysis of Randomized Controlled Trials

Yuan, Dong-Mei,Li, Qian,Zhang, Qin,Xiao, Xin-Wu,Yao, Yan-Wen,Zhang, Yan,Lv, Yan-Ling,Liu, Hong-Bin,Lv, Tang-Feng,Song, Yong Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Objectives: Can addition of neurokinin-1 receptor antagonists (NK1-RAs) be considered as an ideal strategy for the prevention of chemotherapy-induced nausea and vomiting (CINV)? Researchers differ on this question. Materials and Methods: Electronic databases were searched for randomized control trials (RCTs) that evaluated the effectiveness and safety of NK1-RAs in preventing CINV. The primary end point was complete response (CR) in the acute, delayed, and overall phases after chemotherapy. Subgroup analyses evaluated the types of NK1-RAs, routines of administration, types of malignancies, regimens used in combination with NK1-RAs, and age of patients included in the studies. The incidences of different types of adverse events were also extracted to estimate the safety of NK1-RAs. Results: A total of 38 RCTs involving 13,923 patients were identified. The CR rate of patients receiving NK-RAs was significantly higher than patients in the control groups during overall phase (70.8% vs 56.0%, P<0.001), acute phase (85.1% vs 79.6%, P<0.001), and delayed phase (71.4% vs 58.2%, P<0.001). There were three studies including patients of children or adolescents, the CR rate was also significantly higher in the treatment group (overall phase: OR=2.807, P<0.001; acute phase: OR=2.863, P =0.012; delayed phase: OR=2.417, P<0.001). For all the other outcomes, patients in the NK1-RAs groups showed improvements compared to the control groups (incidence of nausea: 45.2% vs 45.9%, P<0.001; occurrence of vomiting: 22.6% vs 38.9%, P<0.001; usage of rescue drugs: 23.5% vs 34.1%, P<0.001). The pooled side effects from NK1-RAs did not significantly differ from previous reports and the toxicity rates in patients less than eighteen years old also did not diff between the two groups (P=0.497). However, we found that constipation and insomnia were more common in the patients of control groups, whereas diarrhea and hiccups were more frequently detected in patients receiving NK1-RAs. Conclusions: NK1-RAs improved the CR rate of CINV. They are effective for both adults and children. The use of NK1-RAs might be associated with the appearance of diarrhea and hiccups, while decreasing the possibility of constipation and insomnia.

Analysis on Postoperative Efficacy of Radical Hepatectomy for Patients with Non-HBV/HCV Hepatocellular Carcinoma

Zhang, Zhi-Ming,Zhang, Yu-Mei,Yao, Feng,Yi, Ping,Huang, Shang,Liu, Jian-Yong,Xiang, Bang-De,Yuan, Wei-Ping,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Objective: Patients with hepatocellular carcinoma (HCC) in stage Barcelona Clinic Liver Cancer (BCLC)-A were grouped based on whether they were accompanied with hepatitis B virus (HBV) infection or not so as to explore the clinical characteristics and prognostic conditions of HCC patients with non-HBV/hepatitis C virus (HCV). Materials and Methods: Clinical data of 64 stage BCLC-A HCC patients with non-HBV/HCV infection (observation group) who received radical hepatectomy in the Affiliated Cancer Hospital of Guangxi Medical University from January, 2006 to November, 2014 were retrospectively analyzed and compared with those of 409 stage BCLC-A HCC patients with HBV infection (control group) in corresponding period. Results: The postoperative 1-, 3- and 5-year recurrent rates of the observation group were 25%, 38.6% and 48.8%, with postoperative mean and median disease-free survival time being 49.1 months and 62.0 months, respectively. Additionally, the postoperative 1-, 3- and 5-year survival rates of observation group were 90.1%, 72.7% and 62.0%, with the mean and median survival times being 54.4 months and 70.0 months, respectively. Conclusions: The 1-year recurrent rate is the highest in HCC patients with non-HBV/HCV, and almost half of the patients have recurrence within 1 year, after which the recurrent rate decreases along with the time.

Diversity and geographic variation of endosymbiotic bacteria in natural populations of the pea aphid (Acyrthosiphon pisum) in China

Zhang Li,Cao Ya,Zhang Li-Jun,Wang Meng-Yao,Wang Xiao-Tong,Yang Xing-Zhuo,Duan Ting-Yu,Yuan Ming-Long 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3

Bacterial symbionts in aphids are known to benefit the insect host and associated with aphid’s ecological adaptation. The pea aphid (Acyrthosiphon pisum), an important legume pest worldwide, carries at least eight endosymbionts, providing a model system to study insect–bacteria interactions. However, species diversity and geographic variations of endosymbionts are unknown in Chinese populations; therefore, we characterized symbiont communities and diversity of 27 pea aphid samples from 13 geographic populations of China. Via amplicon high-throughput sequencing and diagnostic PCR, we found that bacterial communities of Chinese populations were dominated by Proteobacteria and Firmicutes. Among eight known endosymbionts, five (Buchnera, Serratia, Hamiltonella, Regiella, and Rickettsia) were detected by both methods, with a specific geographical distribution. The obligate symbiont, Buchnera, was present in all aphid samples, while the four facultative symbionts showed a significant geographic variation. Each population was randomly infected with distinct endosymbionts, ranging from three to five species. Serratia and Rickettsia showed relatively higher abundance in central regions of China, Regiella was predominant in eastern and western China, whereas Ham iltonella showed an extremely low abundance and was absent in four populations. Samples grouped by altitudes showed a significant diversity difference, whereas there was no significant difference between red and green body colors. Bacterial community structures of the Chinese pea aphid populations were mainly influenced by environmental factors, other than body colors. These data can guide the development of potential biocontrol techniques against this aphid.

A Multicast Search Scheme Based on Bipartite Graph Matching Model

Yuan Yao,Zhang Dalin,Wang Qing,Shi Jinglin 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11

This paper proposes an efficient multicast search scheme based on bipartite graph matching model, aiming at one of the most important problems in the multicast service, how can the wireless network track and locate the mobile uses in the idle state, under the tight bandwidth and delay constraints,. By quantifying the location uncertainty of mobile users with Shannon's entropy, the scheme adopts the LZ78 compression algorithm to design location update scheme and predict the location probability, in order to reduce the cost of location update. The multicast search system need to guarantee the maximum total probability that each user resides at the assigned paging area, for the purpose of an optimal performance on both expected paging delay and paging cost. Therefore, the bigraph-based multicast paging scheme (BMPS) firstly builds the bipartite graph model of multicast search problem, through converting the location probability into weight of the edge. BMPS decides the optimal allocation between the mobile users and location areas, which is mainly achieved by the maximum weight perfect matching in bipartite graph, while modifying the weights dynamically. Simulation results show that BMPS yields a low search delay as well as a low search cost, and reduces the impact of user collision.

Diversity and composition of microbiota during fermentation of traditional Nuodeng ham

Zhang Xiao-mei,Dang Xi-jun,Wang Yuan-bing,Sun Tao,Wang Yao,Yu Hong,Yang Wu-song 한국미생물학회 2021 The journal of microbiology Vol.59 No.1

The microbial community is one of the most important factors in shaping the characteristics of fermented food. Nuodeng ham, traditionally produced and subjected to 1–4 years of fermentation, is a dry fermented food product with cultural and economic significance to locals in southwestern China. In this study, we aimed to characterize the microbiota and physicochemical profiles of Nuodeng ham across different stages of fermentation. Ham samples from each of the four years were analyzed by sequencing bacterial 16S rRNA gene and fungal internal transcribed spacer sequence, in order to characterize the diversity and composition of their microflora. A total of 2,679,483 bacterial and 2,983,234 fungal sequences of high quality were obtained and assigned to 514 and 57 genera, respectively. Among these microbes, Staphylococcus and Candida were the most abundant genera observed in the ham samples, though samples from different years showed differences in their microbial abundance. Results of physicochemical properties (pH, water, amino acid, NaCl, nitrate and nitrite contents, and the composition of volatile compounds) revealed differences among the ham samples in the composition of volatile compounds, especially in the third year samples, in which no nitrite was detected. These results suggest that the structure and diversity of microbial communities significantly differed across different stages of fermentation. Moreover, the third year hams exhibits a unique and balanced microbial community, which might contribute to the special flavor in the green and safe food products. Thus, our study lends insights into the production of high quality Nuodeng ham.

A Novel Modulation Method for Three-Level Inverter Neutral Point Potential Oscillation Elimination

Yao, Yuan,Kang, Longyun,Zhang, Zhi The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

A novel algorithm is proposed to regulate the neutral point potential in neutral point clamped three-level inverters. Oscillations of the neutral point potential and an unbalanced dc-link voltage cause distortions of the output voltage. Large capacitors, which make the application costly and bulky, are needed to eliminate oscillations. Thus, the algorithm proposed in this paper utilizes the finite-control-set model predictive control and the multistage medium vector to solve these issues. The proposed strategy consists of a two-step prediction and a cost function to evaluate the selected multistage medium vector. Unlike the virtual vector method, the multistage medium vector is a mixture of the virtual vector and the original vector. In addition, its amplitude is variable. The neutral point current generated by it can be used to adjust the neutral point potential. When compared with the virtual vector method, the multistage medium vector contributes to decreasing the regulation time when the modulation index is high. The vectors are rearranged to cope with the variable switching frequency of the model predictive control. Simulation and experimental results verify the validity of the proposed strategy.

Preliminary Report on the Breeding of Robust and Resistant-NPV and High Quality Silkworm Race "Shengming No.1" for Summer-autumn Rearing

( Yuan Zhao ),( Ke Pin Chen ),( Qing Yao ),( Yang Chun Wu ),( Jian Zhang ),( Xi Jie Guo ) 한국잠사학회 2006 International Journal of Industrial Entomology Vol.13 No.2

Seveval Chinese and Japanese varieties with good characters were used in the breeding. After 5 years (15 generations), a pair of robust and high quality silkworm variety with NPV resistance was bred by means of a combination of crossing and pedigree selection complemented by the selection of NPV resistance. The variety was identified jointly nationwide in 2003 and 2004, and appraised by National Mulberry and Silkworm Appraising Committee. Results are as follows: its cocooning rate is over 93%, shell rate 23-25%, filament length 1200-1300 meters, reelability 75-88%, Length of non-broken cocoon filament 900-1100 meters, raw silk rate 17-19%, neatness 95-97 points, and cocoon crop, cocoon shell weight and raw silk weight per 10 000 larvae is higher than those of the control variety by 7-10%, 14-19% and 14-18%, respectively. The variety is not only robust, resistant to high temperature and NPV, easy to rear, uniform in hatching, molting and maturing, but also lays more eggs, and its fecundity is high. It is suitable to rear in the Yangtze River Basin, the Yellow River basin and the Pearl River basin of China.

A Novel Modulation Method for Three-Level Inverter Neutral Point Potential Oscillation Elimination

Yuan Yao,Longyun Kang,Zhi Zhang 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

A novel algorithm is proposed to regulate the neutral point potential in neutral point clamped three-level inverters. Oscillations of the neutral point potential and an unbalanced dc-link voltage cause distortions of the output voltage. Large capacitors, which make the application costly and bulky, are needed to eliminate oscillations. Thus, the algorithm proposed in this paper utilizes the finite-control-set model predictive control and the multistage medium vector to solve these issues. The proposed strategy consists of a two-step prediction and a cost function to evaluate the selected multistage medium vector. Unlike the virtual vector method, the multistage medium vector is a mixture of the virtual vector and the original vector. In addition, its amplitude is variable. The neutral point current generated by it can be used to adjust the neutral point potential. When compared with the virtual vector method, the multistage medium vector contributes to decreasing the regulation time when the modulation index is high. The vectors are rearranged to cope with the variable switching frequency of the model predictive control. Simulation and experimental results verify the validity of the proposed strategy.

Monitoring for Damage in Two-Dimensional Pre-Stress Scratching of SiC Ceramics

Gaofeng Zhang,Yijiang Zeng,Wenbo Zhang,Houming Zhou,Zhangya Wen,Yuan Yao 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.11

This paper reports an approach to use the acoustic emission (AE) technology for monitoring the surface/subsurface damage in twodimensional pre-stress scratching of SiC ceramics, in which the two-dimensional pre-stress is used to decrease the scratch-induced damage. Experiments in this study were conducted on a UMT-2 machine (CETR USA) utilizing a designed pre-stressing device under pressures of 0 MPa, 300 MPa and 500 MPa. The experimental results demonstrate that average frequency and magnitude of AE signals have a good correlation with the scratching tangential force and the scratch-induced surface /subsurface damage of materials. For a given normal load, the average frequency and magnitude of AE signals are observed to decrease with the increase in pre-stress, which indicates that surface/subsurface damage of SiC ceramics induced by two-dimensional pre-stress scratching is less than that induced by conventional scratching. The findings provide fundamental information for developing a practical on-line AE monitoring system that is effective in detecting surface/subsurface damage in scratching or grinding of ceramics. These results also demonstrate that two-dimensional pre-stress method contributes to decreasing the machining damage of brittle materials.

Evaluation of equivalent friction damping ratios at bearings of welded large-scale domes subjected to earthquakes

Huidong Zhang,Xinqun Zhu,Yuan-feng Wang,Shu Yao 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.4

The major sources of damping in steel structures are within the joints and the structural material. For welded large-scale single-layer lattice domes subjected to earthquake ground motions, the stick-slip phenomenon at the bearings is an important source of the energy dissipation. However, it has not been extensively investigated. In this study, the equivalent friction damping ratio (EFDR) at the bearings of a welded large-scale single-layer lattice dome subjected to earthquake ground motions is quantified using an approximate method based on the energy balance concept. The complex friction behavior and energy dissipation between contact surfaces are investigated by employing an equivalent modeling method. The proposed method uses the stick-slip-hook components with a pair of circular isotropic friction surfaces having a variable friction coefficient to model the energy loss at the bearings, and the effect of the normal force on the friction force is also considered. The results show that the EFDR is amplitude-dependent and is related to the intensity of the ground motions; it exhibits complex characteristics that cannot be described by the conventional models for damping ratios. A parametric analysis is performed to investigate in detail the effects of important factors on the EFDR. Finally, the friction damping mechanism at bearings is discussed. This study enables researchers and engineers to have a better understanding of the essential characteristics of friction damping under earthquake ground motions.