Minimizing hepatic trauma with a novel liver retraction method: a simple liver suspension using gauze suture.

Woo, Yanghee,Hyung, Woo Jin,Kim, Hyoung-Il,Obama, Kazutaka,Son, Taeil,Noh, Sung Hoon Springer International 2011 Surgical endoscopy Vol.25 No.12

<P>Prolonged liver retraction during radical gastrectomy for adequate exposure of the hepatogastric ligament may lead to hepatic trauma. The authors offer a new minimally traumatic liver retraction method using a simple liver suspension with a gauze suture and compare it with the modified liver-puncture method.</P>

멀티캐스트 경로 설정 알고리즘

이강원(Kang-Woo Lee),최양희(Yanghee Choi),김종상(Chong Sang Kim) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.2

본 논문에서는 WAN에서 효율적으로 멀티캐스트 경로를 계산하는 알고리즘을 제안한다. 여기서 제안되는 알고리즘의 목표는 전체 비용을 최소화하는 경로를 구하는 것이다. 네트워크는 무방향 그래프로 모델링하며, 여러개의 클러스터로 구성된 계층적 구조를 가진다고 가정한다. 또한 네트워크 내의 모든 경로배정기가 네트워크 전체의 토플로지를 알고 있다고 가정한다. 여기서 제안되는 알고리즘은 첫째, 처음 멀티캐스트 경로설정 요구가 들어오는 경우 이를 위한 경로를 계산하는 알고리즘과 둘째, 동적인 네트워크 환경에서 토플로지가 변동되는 경우 기존의 경로를 빠르게 갱신하는 알고리즘이다. 두번째의 경우 알고리즘의 성능은 갱신된 경로의 비용뿐만 아니라 기존의 경로를 얼마나 적게 변경하는가에도 좌우되는데 여기서 제시된 알고리즘들은 기존의 경로에 대한 변경이 없다. 그리고 마지막으로 이러한 알고리즘들을 계층적 경로배정을 위해 사용할 경우 고려해야 할 사항을 제시하였다.

In Vitro Adenosine Triphosphate Based Chemotherapy Response Assay in Gastric Cancer

Seulkee Park,Yanghee Woo,김호근,이용찬,최성호,형우진,노성훈 대한위암학회 2010 Journal of gastric cancer Vol.10 No.4

Purpose: The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. Materials and Methods: A total of 243 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2010. We evaluated the effectiveness of the ATP-CRA assay in determining the chemosensitivity of gastric cancer specimens using eleven chemotherapeutic agents – etoposide, doxorubicin, epirubicin, mytomicin, 5-fluorouracil, oxaliplatin, irinotecan, docetaxel, paclitaxel, methotraxate, and cisplatin – for chemosensitivity studies using ATP-CRA. We assessed the failure rate, the cell death rate, and the chemosensitivity index. Results: The failure rate of ATP-CRA was 1.6% (4/243). The mean coefficient of variation for triplicate ATP measurements was 6.5%. Etoposide showed the highest cell death rate (35.9%) while methotrexate showed the lowest (16.6%). The most active chemothera-peutic agent was etoposide, which most frequently ranked highest in the chemosensitivity test: 31.9% (51/160). Oxaliplatin was more active against early gastric cancers than advanced gastric cancers, whereas docetaxel was more active against advanced cancers. The lymph node negative group showed a significantly higher cell death rate than the lymph node positive group when treated with doxoru-bicin, epirubicin, and mitomycin. Conclusions: ATP-CRA is a stable and clinically applicable in vitro chemosensitivity test with a low failure rate. The clinical usefulness of ATP-CRA should be evaluated by prospective studies comparing the regimen guided by ATP-CRA with an empirical regimen.

Long-term oncologic outcomes of 714 consecutive laparoscopic gastrectomies for gastric cancer: results from the 7-year experience of a single institute.

Pak, Kyung Ho,Hyung, Woo Jin,Son, Taeil,Obama, Kazutaka,Woo, Yanghee,Kim, Hyoung-Il,An, Ji Yeong,Kim, Jong Won,Cheong, Jae-Ho,Choi, Seung Ho,Noh, Sung Hoon Springer International 2012 Surgical endoscopy Vol.26 No.1

<P>Although many reports have indicated the feasibility of laparoscopic gastrectomy (LG) regarding short-term surgical outcomes, the role of LG remains controversial because studies of long-term outcomes of LG are insufficient. The purpose of this study was to evaluate the long-term oncologic outcomes of patients who have undergone LG.</P>

Ethanolic Extract of Vaccinium corymbosum Alleviates Muscle Fatigue in Mice

Shintae Kim,Jeongjin Park,Jinseop Shin,Yanghee You,Ok-Kyung Kim,JeongMin Lee,Jin Woong Chung,SangInShim,Kyungmi Kim,Woo Jin Jung 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.11

The aim of this study was to evaluate the effects of ethanol extracts of Vaccinium corymbosum (VCE) on exercise-induced fatigue in mice. Mice were randomly divided into three groups; nonexercise control group (CON), exercise control group (Ex-CON), and exercise and VCE supplementation group (Ex-VCE). Compared with Ex-CON, Ex-VCE showed increased endurance exercise capacity on day 21. In Ex-VCE mice, the accumulation of lactate was inhibited and the consumption of fatty acids was enhanced, indicating the delay of muscle fatigue. In addition, VCE supplementation elevated mRNA expression levels of mitochondrial biogenesis-associated genes such as peroxisome proliferator-activated receptor-1γ coactivator 1α (PGC-1α), nuclear respiratory factor (NRF), and mitochondrial transcription factor A (Tfam) and fatty acid β-oxidation-associated genes such as carnitine palmitoyltransferase-1 (CPT-1), β-hydroxyacyl coenzyme A dehydrogenase (β-HAD), and peroxisome proliferator-activated receptor-δ (PPAR-δ). These results suggest that VCE can potentially prevent muscle fatigue by enhancing mitochondrial biogenesis and fatty acid β-oxidation.

New Surgical Approach for Gastric Bezoar: "Hybrid Access Surgery" Combined Intragastric and Single Port Surgery

손태일,박경호,형우진,노성훈,Kazuki Inaba,Yanghee Woo 대한위암학회 2011 Journal of gastric cancer Vol.11 No.4

Regarding the removal of a gastric bezoar, laparoscopic surgery was performed and it was shown that the laparoscopic approach is safe and feasible. However, the laparoscopic method has the risk of intraabdominal contamination, when the gastric bezoar is retrieved from the gastric lumen in the peritoneal cavity. We developed and applied a new procedure for the removal of the gastric bezoar using one surgical glove and two wound retractors as a fashion of intragastric single port surgery. Herein we present this new minimal invasive procedure, so named ""hybrid access surgery"" which involves the use of existing devices and overcomes the weakness of laparoscopic removal of the gastric bezoar. Our new procedure, combining the concept of intragastric and single port access, is acceptable and feasible to retrieve the gastric bezoar. In the future, this procedure may be one of the alternative procedures for retrieving gastric bezoar even when it is incarcerated in the pylorus.

Enhanced Recovery after Surgery for Gastric Cancer Patients Improves Clinical Outcomes at a US Cancer Center

Desiderio, Jacopo,Stewart, Camille L.,Sun, Virginia,Melstrom, Laleh,Warner, Susanne,Lee, Byrne,Schoellhammer, Hans F.,Trisal, Vijay,Paz, Benjamin,Fong, Yuman,Woo, Yanghee The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.3

Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GCERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Materials and Methods: We reviewed medical records of patients surgically treated for gastric cancer with curative intent from January 2012 to October 2016 and compared the GC-ERAS group (November 1, 2015-October 1, 2016) with the historical control (HC) group (January 1, 2012-October 31, 2015). Propensity score matching was used to adjust for age, sex, number of comorbidities, body mass index, stage of disease, and distal versus total gastrectomy. Results: Of a total of 95 identified patients, matching analysis resulted in 20 and 40 patients in the GC-ERAS and HC groups, respectively. Lower rates of nasogastric tube (35% vs. 100%, P<0.001) and intraabdominal drain placement (25% vs. 85%, P<0.001), faster advancement of diet (P<0.001), and shorter length of hospital stay (5.5 vs. 7.8 days, P=0.01) were observed in the GC-ERAS group than in the HC group. The GC-ERAS group showed a trend toward increased use of minimally invasive surgery (P=0.06). There were similar complication and 30-day readmission rates between the two groups (P=0.57 and P=0.66, respectively). Conclusions: The implementation of a GC-ERAS protocol significantly improved perioperative outcomes in a western cancer center. This finding warrants further prospective investigation.