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Development of UV-Curable Azidophenyl Alginate Derivatives for Drug Immobilization on Dressing Foam
손태일,김신웅,이태훈 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
The purpose of this study was to develop dressing foam with drug immobilization abilities by using Azidophenyl alginate (Az-alginate). We characterized prepared Az-alginate. Through the patterning test, immobilization of drug was confirmed. Degrees of photo-curing were identified by the photo-curing ratio test. Cytotoxicity test confirmed that Az-alginate was biocompatible. The protein release test measured the degree of drug released according to the concentration of Azalginate. By examination of the water absorbency and moisture vapor transmission rate, characteristics of the dressing foam with photocured Az-alginate were measured. From the results of these tests, Az-alginate can be applied to the dressing foam.
손태일,키타쯔메도모야 ( Tae Il Son,Tomoya Kitazume ) 한국공업화학회 1994 공업화학 Vol.5 No.1
시판되고 있는 4종류의 Lipase(talpase, paratase M1000L, SP398, SP435)를 이용하여, 2-[1-(1-acetoxy-2,2, 2-trifluoroethyl)]-5-trimethylsilylfuran(1)을 속도론적 광학분할에 의해서 가수분해반응을 검토했다. 그 결과 Novo Nordish사의 SP435가 속도론적 광학분할능을 가진다는 것을 확인했으며, 본 실험에서는 광학순도 92.4% enantiomeric excess(ee)를 가지는 생성물 2-[1-(2,2,2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2)를 얻었다. The hydrolysis of biochemical kinetic resolutions for 2-[1-(acetoxy-2, 2, 2-trifluoroethyl)] -5-trimethylsilylfuran(1) using four kinds of Lipase(talpase, paratase M1000L, SP398, SP435) was investigated. In the results, SP435 of Novo Nordish comp any was confirmed to show the capacity of biochemical kinetic resolutions, and 2-[1-(2, 2, 2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2) to have the optical purity expressed as 92.4% enantiomeric excess(ee) was produced in this studies.
Effect of Visible light-Curable Carrageenan Derivatives on anti-adhesion in medical field
손태일,김신웅,이태훈 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Carrageenan is a natural polymer having biodegradable and biocompatibility. Furfuryl carboxymethylated Carrageenan(F-Cm-Carrageenan) was prepared for tendon anti-adhesion and it was identified structure by FT-IR, 1H-NMR and GPC .When the tendon's wound heals, there is a physical side effect that the joint does not bend due to adhesion. To prevent these phenomenon, F-CM-Carrageenan derivative was used during tendon suturing. F-Cm-Carrageenan is photo-crosslinked by Furfuryl group introduced into carrageenan and the photo-initiator. F-Cm-Carrageenan can be expected to be application of tendon antiadhesion agent. To evaluate the potential applications as an antiadhesion agent, should be photo reacted by Cytotoxicity test, Antiadhesion test and Cell penetration test. F-Cm-carrageenan should be confirmed that through hen’s tendon anti-adhesion test, F-Cm-Carrageenan is used. So F-Cm-Carrageenan is considered that are able to develop as the anti-adhesion biomaterial.