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Methylome-wide Association Study of Patients with Recent-onset Psychosis
Yan-Hong Piao,Yin Cui,Fatima Zahra Rami,Ling Li,Maryam Karamikheirabad,Shi Hyun Kang,Sung-Wan Kim,Jung-Jin Kim,Bong Ju Lee,Young-Chul Chung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls. Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled. Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed. Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.
Virtual Environment Modeling for Battery Management System
Piao, Chang-Hao,Yu, Qi-Fan,Duan, Chong-Xi,Su, Ling,Zhang, Yan The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
The offline verification of state of charge estimation, power estimation, fault diagnosis and emergency control of battery management system (BMS) is one of the key technologies in the field of electric vehicle battery system. It is difficult to test and verify the battery management system software in the early stage, especially for algorithms such as system state estimation, emergency control and so on. This article carried out the virtual environment modeling for verification of battery management system. According to the input/output parameters of battery management system, virtual environment is determined to run the battery management system. With the integration of the developed BMS model and the external model, the virtual environment model has been established for battery management system in the vehicle's working environment. Through the virtual environment model, the effectiveness of software algorithm of BMS was verified, such as battery state parameters estimation, power estimation, fault diagnosis, charge and discharge management, etc.
Jia-Piao Lin,Chao-Qin Chen,Ling-Er Huang,Na-na Li,Yan Yang,Sheng-Mei Zhu,Yong-Xing Yao 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.4
α2-Adrenoceptor agonists attenuate hypersensitivity under neuropathic conditions. However, the mechanisms underlying this attenuation remain largely unknown. In the present study, we explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. An animal model of CCI was adopted to mimic the clinical neuropathic pain state. Behavioral hypersensitivity to mechanical and thermal stimuli was determined by von Frey filament and Hargreaves’ tests, and the spinal P2X7R expression level and ERK phosphorylation were analyzed using western blot analysis and immunohistochemistry. In parallel with the development of mechanical and thermal hyperalgesia, a significant increase in P2X7R expression was noted in the ipsilateral spinal cord on day 7 after CCI. Intrathecal administration of dexmedetomidine (2.5 μg) for 3 days not only attenuated neuropathic pain but also inhibited the CCI-induced P2X7R upregulation and ERK phosphorylation. Intrathecal dexmedetomidine administration did not produce obvious effects on locomotor function. The present study demonstrated that dexmedetomidine attenuates the neuropathic pain induced by CCI of the sciatic nerve in rats by inhibiting spinal P2X7R expression and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.
Virtual Environment Modeling for Battery Management System
Chang-hao Piao,Qi-fan Yu,Chong-xi Duan,Ling Su,Yan Zhang 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
The offline verification of state of charge estimation, power estimation, fault diagnosis and emergency control of battery management system (BMS) is one of the key technologies in the field of electric vehicle battery system. It is difficult to test and verify the battery management system software in the early stage, especially for algorithms such as system state estimation, emergency control and so on. This article carried out the virtual environment modeling for verification of battery management system. According to the input/output parameters of battery management system, virtual environment is determined to run the battery management system. With the integration of the developed BMS model and the external model, the virtual environment model has been established for battery management system in the vehicle’s working environment. Through the virtual environment model, the effectiveness of software algorithm of BMS was verified, such as battery state parameters estimation, power estimation, fault diagnosis, charge and discharge management, etc.
Le Thanh Bang,Yan-Ling Piao,김종재,김남 한국광학회 2016 Current Optics and Photonics Vol.20 No.1
This paper proposes an optical system for complex holographic display that enhances the quality ofthe reconstructed three-dimensional image. This work focuses on a new design for an optical system andthe evaluation of the complex holographic display, using a single spatial light modulator (SLM) and acircular grating. The optical system is based on a 4-f system in which the imaginary and real informationof the hologram is displayed on concentric rectangular areas of the SLM and circular grating. Thus, thismethod overcomes the lack of accuracy in the pixel positions between two window holograms in previousstudies, and achieves a higher intensity of the real object points of the reconstructed hologram than theoriginal phase-reconstructed hologram. The proposed method provides approximately 30% less NMRS(Normal Root Mean Square) error, compared to previous systems, which is verified by both simulationand optical experiment.
Munkh-Uchral Erdenebat,권기철,Erkhembaatar Dashdavaa,Yan-Ling Piao,유관희,Ganbat Baasantseren,김영민,김남 한국광학회 2014 Current Optics and Photonics Vol.18 No.6
An enhanced 360-degree integral-floating three-dimensional display system using a hexagonal lens array and a hidden point removal operator is proposed. Only the visible points of the chosen three-dimensional point cloud model are detected by the hidden point removal operator for each rotating step of the anamorphic optics system, and elemental image arrays are generated for the detected visible points from the corresponding viewpoint. Each elemental image of the elemental image array is generated by a hexagonal grid, due to being captured through a hexagonal lens array. The hidden point removal operator eliminates the overlap problem of points in front and behind, and the hexagonal lens array captures the elemental image arrays with more accurate approximation, so in the end the quality of the displayed image is improved. In an experiment, an anamorphic-optics-system-based 360-degree integral-floating display with improved image quality is demonstrated.
Erdenebat, Munkh-Uchral,Kim, Byeong-Jun,Piao, Yan-Ling,Park, Seo-Yeon,Kwon, Ki-Chul,Piao, Mei-Lan,Yoo, Kwan-Hee,Kim, Nam OSA OPTICAL SOCIETY OF AMERICA 2017 Applied Optics Vol.56 No.28
<P>A mobile three-dimensional image acquisition and reconstruction system using a computer-generated integral imaging technique is proposed. A depth camera connected to the mobile device acquires the color and depth data of a real object simultaneously, and an elemental image array is generated based on the original three-dimensional information for the object, with lens array specifications input into the mobile device. The three-dimensional visualization of the real object is reconstructed on the mobile display through optical or digital reconstruction methods. The proposed system is implemented successfully and the experimental results certify that the system is an effective and interesting method of displaying real three-dimensional content on a mobile device.(C) 2017 Optical Society of America</P>
Alam, Md Ashraful,Ki-Chul Kwon,Yan-Ling Piao,Young-Seok Kim,Nam Kim IEEE 2015 IEEE photonics journal Vol.7 No.1
<P>We propose and demonstrate a viewing-angle-enhanced integral imaging display (VAEIID) system that uses a time-multiplexed, two-directional sequential projection (TTSP) scheme and a directional elemental image generation and resizing (DEIGR) algorithm. The main idea behind the method is sharing the same image screen to display two-directional elemental image (DEI) sets with a time-multiplexed sequential projection scheme. The proposed system consists of three processes: acquisition of depth and color information of a real object using the Microsoft Kinect sensor, generation of two DEI sets considering two different angular perspectives using a DEIGR algorithm, and projection of two sets of DEIs using the TTSP scheme. Due to the two-directional projections, each elemental lens of the lens array collects two-directional illuminations from the two sets of elemental images (EIs) projected in a time-multiplexed sequential manner by using the TTSP scheme; this produces two point light sources (PLSs) at different positions on the focal plane of the lens array. The positions of the PLSs are predefined and are determined in terms of projection angle. In this case, the viewing angle comprises the combination of two diverging ray bundles emerging from the two DEI sets projected from two angular directions. As a result, the viewing angle of the proposed VAEIID system is enhanced by almost twice that of the conventional method.</P>