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RISS 인기검색어
- 검색키워드
- 저자 : Yan-Hong Piao (검색결과 4 건)
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Methylome-wide Association Study of Patients with Recent-onset Psychosis
Yan-Hong Piao,Yin Cui,Fatima Zahra Rami,Ling Li,Maryam Karamikheirabad,Shi Hyun Kang,Sung-Wan Kim,Jung-Jin Kim,Bong Ju Lee,Young-Chul Chung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls. Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled. Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed. Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.
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( Xue Li ),( Yan-hua Liu ),( Xin Zhang ),( Chang-ming Ge ),( Ren-zhe Piao ),( Wei-dong Wang ),( Zong-jun Cui ),( Hong-yan Zhao ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.3
The development and utilization of crop straw biogas resources can effectively alleviate the shortage of energy, environmental pollution, and other issues. This study performed a continuous batch test at 35°C to assess the methane production potential and volatile organic acid contents using the modified Gompertz equation. Illumina MiSeq platform sequencing, which is a sequencing method based on sequencing-by-synthesis, was used to compare the archaeal community diversity, and denaturing gradient gel electrophoresis (DGGE) was used to analyze the bacterial community diversity in rice straw, dry maize straw, silage maize straw, and tobacco straw. The results showed that cumulative gas production values for silage maize straw, rice straw, dry maize straw, and tobacco straw were 4,870, 4,032.5, 3,907.5, and 3,628.3 ml/g ·VS , respectively, after 24 days. Maximum daily gas production values of silage maize straw and rice straw were 1,025 and 904.17 ml/g ·VS, respectively, followed by tobacco straw and dry maize straw. The methane content of all four kinds of straws was > 60%, particularly that of silage maize straw, which peaked at 67.3%. Biogas production from the four kinds of straw was in the order silage maize straw > rice straw > dry maize straw > tobacco straw, and the values were 1,166.7, 1,048.4, 890, and 637.4 ml/g ·VS, respectively. The microbial community analysis showed that metabolism was mainly carried out by acetateutilizing methanogens, and that Methanosarcina was the dominant archaeal genus in the four kinds of straw, and the DGGE bands belonged to the phyla Firmicutes, Bacteroidetes, and Chloroflexi. Silage maize is useful for biogas production because it contains four kinds of straw.
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Development of the Korea-Polyenvironmental Risk Score for Psychosis
Jeon Eun-Jin,Kang Shi-Hyun,Yan-Hong Piao,Kim Sung-Wan,Kim Jung-Jin,Lee Bong-Ju,Yu Je-Chun,Lee Kyu-Young,Won Seunghee,Lee Seung-Hwan,Kim Seung-Hyun,Kim Eui-Tae,Clara Tammy Kim,Dominic Oliver,Paolo Fusa 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.3
Objective Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs).Methods We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for Western studies and the “population proportion” (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS).Results We first constructed the “K-PERS-I,” comprising five factors based on the PPS, and then the “K-PERS-II” comprising six factors based on the ERS. The instruments accurately predicted participants’ status (case vs. control). In addition, the K-PERS-I and -II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS.Conclusion The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia.
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Metabolite signature associated with stress susceptibility in socially defeated mice
Prabhu, Vishwanath Vasudev,Nguyen, Thong Ba,Cui, Yin,Oh, Young-Eun,Piao, Yan-Hong,Baek, Hyeon-Man,Kim, Joo-Yeon,Shin, Kwang-Hee,Kim, Ji-hyun,Lee, Keon-Hak,Chung, Young-Chul Elsevier 2019 Brain Research Vol.1708 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Social defeat represents a naturalistic form of conditioned fear and is often used as an animal model of depression. The present study aimed to identify the neurochemicals in select brain regions of mice exposed to social defeat stress.</P> <P><B>Methods</B></P> <P>Adult <I>C57BL/6N</I> mice were subjected social defeat stress for 10 days. Using high-resolution magic angle spinning <SUP>1</SUP>H nuclear magnetic resonance (HR-MAS <SUP>1</SUP>H NMR), untargeted metabolomes were measured in the amygdala (AMY), dorsal hippocampus (dHIP), dorsal striatum (dST), and prefrontal cortex (PFC).</P> <P><B>Results</B></P> <P>We observed perturbations of glutamine in the AMY; glutamate in the dHIP; glycine and myo-inositol in the dST; and aspartate, choline, and phosphoethanolamine in the PFC of susceptible and/or unsusceptible groups compared to the control group. The susceptible and unsusceptible groups significantly differed with regard to three metabolites: glutamine, glycine, and choline.</P> <P><B>Conclusion</B></P> <P>These findings suggest that social defeat stress induces disturbances in the metabolism of amino acids, lipids, and neurotransmitters in several brain areas. The resulting susceptibility-related metabolites may provide new insights into the pathophysiology underlying stress-related mental illness.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Defeated mice were classified as unsusceptible and susceptible groups. </LI> <LI> HR-MAS <SUP>1</SUP>H NMR revealed disturbances in the metabolites of defeated mice brain. </LI> <LI> Results may elucidate pathophysiological mechanisms related to stress susceptibility. </LI> </UL> </P>
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